{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:35:08Z","timestamp":1778654108596,"version":"3.51.4"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","award":["Hatch W2005"],"award-info":[{"award-number":["Hatch W2005"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0199682","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T17:40:44Z","timestamp":1530553244000},"page":"e0199682","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8109-7566","authenticated-orcid":true,"given":"Sabrina N.","family":"Dumas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Ntambi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1080\/02640414.2015.1093650","article-title":"What is really causing the obesity epidemic? A review of reviews in children and adults","volume":"34","author":"SE Ross","year":"2016","journal-title":"Journal of sports sciences"},{"issue":"10031","key":"ref2","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/S0140-6736(16)00271-3","article-title":"Management of obesity","volume":"387","author":"GA Bray","year":"2016","journal-title":"The Lancet"},{"key":"ref3","unstructured":"CDC. Adult Obesity Facts | Overweight &amp; Obesity | CDC. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cdc.gov\/obesity\/data\/adult.html\" xlink:type=\"simple\">https:\/\/www.cdc.gov\/obesity\/data\/adult.html<\/ext-link>. Accessed August 22, 2017."},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"E28","DOI":"10.1152\/ajpendo.90897.2008","article-title":"Biochemical and physiological function of stearoyl-CoA desaturase","volume":"297","author":"CM Paton","year":"2009","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2008.07.048","article-title":"Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism","volume":"134","author":"H Cao","year":"2008","journal-title":"Cell"},{"issue":"17","key":"ref6","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1073\/pnas.132384699","article-title":"Loss of stearoyl\u2014CoA desaturase-1 function protects mice against adiposity","volume":"99","author":"JM Ntambi","year":"2002","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.cmet.2007.10.014","article-title":"Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis","volume":"6","author":"M Miyazaki","year":"2007","journal-title":"Cell metabolism"},{"issue":"30","key":"ref8","doi-asserted-by":"crossref","first-page":"19961","DOI":"10.1074\/jbc.M109.014225","article-title":"Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity","volume":"284","author":"H Sampath","year":"2009","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1172\/JCI0216390","article-title":"Cholesterol, lipid rafts, and disease","volume":"110","author":"K Simons","year":"2002","journal-title":"The Journal of clinical investigation"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4161\/derm.1.2.7811","article-title":"Epidermal surface lipids","volume":"1","author":"A Pappas","year":"2009","journal-title":"Dermato-endocrinology"},{"issue":"39","key":"ref11","doi-asserted-by":"crossref","first-page":"30132","DOI":"10.1074\/jbc.M005488200","article-title":"The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1","volume":"275","author":"M Miyazaki","year":"2000","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0021-9150(99)00155-0","article-title":"Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane","volume":"146","author":"G Kellner-Weibel","year":"1999","journal-title":"Atherosclerosis"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0022-2275(20)31498-X","article-title":"Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis","volume":"42","author":"AD Attie","year":"2001","journal-title":"Journal of lipid research"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1172\/JCI0216381","article-title":"Cholesterol in health and disease","volume":"110","author":"I Tabas","year":"2002","journal-title":"The Journal of clinical investigation"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.dld.2013.10.021","article-title":"The bile acid TGR5 membrane receptor: from basic research to clinical application","volume":"46","author":"H Duboc","year":"2014","journal-title":"Digestive and Liver Disease"},{"issue":"16","key":"ref16","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00018-008-7568-6","article-title":"Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics","volume":"65","author":"A Hofmann","year":"2008","journal-title":"Cellular and Molecular Life Sciences"},{"key":"ref17","article-title":"Biochemical, Physiological, &amp; Molecular Aspects of Human Nutrition","author":"M Stipanuk","year":"2006"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"DW Russell","year":"2003","journal-title":"Annual review of biochemistry"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"e19734","DOI":"10.1371\/journal.pone.0019734","article-title":"Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism","volume":"6","author":"MT Flowers","year":"2011","journal-title":"PloS one"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s11095-007-9289-1","article-title":"Bile acid transporters: structure, function, regulation and pathophysiological implications","volume":"24","author":"WA Alrefai","year":"2007","journal-title":"Pharmaceutical research"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2009.08.001","article-title":"TGR5-mediated bile acid sensing controls glucose homeostasis","volume":"10","author":"C Thomas","year":"2009","journal-title":"Cell metabolism"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.celrep.2017.01.062","article-title":"Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes","volume":"18","author":"JH Kreznar","year":"2017","journal-title":"Cell reports"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbalip.2014.04.008","article-title":"Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice","volume":"1851","author":"Y Qi","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.plipres.2009.11.001","article-title":"Bile acid-activated receptors in the treatment of dyslipidemia and related disorders","volume":"49","author":"S Fiorucci","year":"2010","journal-title":"Progress in lipid research"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.trsl.2016.12.001","article-title":"Bile acid receptor TGR5 overexpression is associated with decreased intestinal mucosal injury and epithelial cell proliferation in obstructive jaundice","volume":"182","author":"C-G Ji","year":"2017","journal-title":"Translational Research"},{"issue":"26","key":"ref26","doi-asserted-by":"crossref","first-page":"11055","DOI":"10.1074\/jbc.M117.784322","article-title":"Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism","volume":"292","author":"P Pathak","year":"2017","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s11306-014-0653-y","article-title":"De novo synthesize of bile acids in pulmonary arterial hypertension lung","volume":"10","author":"YD Zhao","year":"2014","journal-title":"Metabolomics"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"e7333","DOI":"10.1371\/journal.pone.0007333","article-title":"The bile acid synthesis pathway is present and functional in the human ovary","volume":"4","author":"LP Smith","year":"2009","journal-title":"PLoS One"},{"issue":"14","key":"ref29","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1161\/CIRCULATIONAHA.108.793182","article-title":"Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis","volume":"118","author":"JM Brown","year":"2008","journal-title":"Circulation"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/ATVBAHA.108.181099","article-title":"Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis","volume":"29","author":"ML MacDonald","year":"2009","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0199682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T21:36:32Z","timestamp":1661549792000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0199682"}},"subtitle":[],"editor":[{"given":"Herv\u00e9","family":"Guillou","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,2]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0199682","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,2]]}}}