{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:21:53Z","timestamp":1791062513225,"version":"4.1.0"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["244444\/E40"],"award-info":[{"award-number":["244444\/E40"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["NFR 233858\/E40"],"award-info":[{"award-number":["NFR 233858\/E40"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0199842","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T13:37:18Z","timestamp":1530884238000},"page":"e0199842","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":57,"title":["Effects of cnidarian biofouling on salmon gill health and development of amoebic gill disease"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-331X","authenticated-orcid":true,"given":"Nina","family":"Bloecher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd","family":"Hytter\u00f8d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Gjessing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannicke","family":"Wiik-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima N.","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haakon","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Floerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Gerd","family":"Gjevre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2761.2011.01251.x","article-title":"A review of infectious gill disease in marine salmonid fish","volume":"34","author":"SO Mitchell","year":"2011","journal-title":"Journal of Fish Diseases"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11160-010-9182-6","article-title":"Non-infectious gill disorders of marine salmonid fish","volume":"21","author":"HD Rodger","year":"2011","journal-title":"Reviews in Fish Biology and Fisheries"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/jfd.12608","article-title":"Salmon gill poxvirus, a recently characterized infectious agent of multifactorial gill disease in freshwater- and seawater-reared Atlantic salmon","volume":"40","author":"MC Gjessing","year":"2017","journal-title":"Journal of Fish Diseases"},{"key":"ref4","unstructured":"Kvellestad A. Gill inflammation in Norwegian seawater-farmed Atlantic salmon: a study of aetiology and manifestation. [Doctoral Thesis]. Oslo: University of Oslo; 2013."},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3354\/dao02266","article-title":"Microbial and pathological findings in farmed Atlantic salmon <italic>Salmo salar<\/italic> with proliferative gill inflammation","volume":"91","author":"T Steinum","year":"2010","journal-title":"Diseases of Aquatic Organisms"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"e18529","DOI":"10.1371\/journal.pone.0018529","article-title":"Gill damage to Atlantic Salmon (<italic>Salmo salar<\/italic>) caused by the common jellyfish (<italic>Aurelia aurita<\/italic>) under experimental challenge","volume":"6","author":"EJ Baxter","year":"2011","journal-title":"PLOS ONE"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.aquaculture.2016.02.013","article-title":"Incidence and distribution of amoebic gill disease (AGD)\u2014An epidemiological review","volume":"457","author":"T Oldham","year":"2016","journal-title":"Aquaculture"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2761.2007.00893.x","article-title":"First cases of amoebic gill disease (AGD) in Norwegian seawater farmed Atlantic salmon, <italic>Salmo salar<\/italic> L., and phylogeny of the causative amoeba using 18S cDNA sequences","volume":"31","author":"T Steinum","year":"2008","journal-title":"Journal of Fish Diseases"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1111\/j.1095-8649.2008.02053.x","article-title":"Neoparamoebic gill infections: host response and physiology in salmonids","volume":"73","author":"MD Powell","year":"2008","journal-title":"Journal of Fish Biology"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"e32696","DOI":"10.1371\/journal.pone.0032696","article-title":"A novel betaproteobacterial agent of gill epitheliocystis in seawater farmed Atlantic salmon (<italic>Salmo salar<\/italic>)","volume":"7","author":"ER Toenshoff","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1128\/JCM.42.11.5286-5297.2004","article-title":"Characterization of &apos;<italic>Candidatus<\/italic> Piscichlamydia salmonis&apos; (order Chlamydiales), a Chlamydia-like bacterium associated with epitheliocystis in farmed Atlantic salmon (<italic>Salmo salar<\/italic>)","volume":"42","author":"A Draghi","year":"2004","journal-title":"Journal of Clinical Microbiology"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2761.2010.01171.x","article-title":"Epitheliocystis in Atlantic salmon, <italic>Salmo salar<\/italic> L., farmed in fresh water in Ireland is associated with \u2018<italic>Candidatus<\/italic> Clavochlamydia salmonicola\u2019 infection","volume":"33","author":"SO Mitchell","year":"2010","journal-title":"Journal of Fish Diseases"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00203-014-1038-3","article-title":"Characterization of \u2018<italic>Candidatus<\/italic> Syngnamydia salmonis\u2019 (Chlamydiales, Simkaniaceae), a bacterium associated with epitheliocystis in Atlantic salmon (<italic>Salmo salar<\/italic> L.)","volume":"197","author":"S Nylund","year":"2015","journal-title":"Archives of Microbiology"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1756-3305-2-58","article-title":"<italic>Desmozoon lepeophtherii<\/italic> n. gen., n. sp., (Microsporidia: Enterocytozoonidae) infecting the salmon louse <italic>Lepeophtheirus salmonis<\/italic> (Copepoda: Caligidae)","volume":"2","author":"MA Freeman","year":"2009","journal-title":"Parasites & Vectors"},{"issue":"18","key":"ref15","doi-asserted-by":"crossref","first-page":"9348","DOI":"10.1128\/JVI.01174-15","article-title":"Salmon gill poxvirus, the deepest representative of the Chordopoxvirinae","volume":"89","author":"MC Gjessing","year":"2015","journal-title":"Journal of Virology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3354\/aei00187","article-title":"Potential environmental risks associated with biofouling management in salmon aquaculture","volume":"8","author":"O Floerl","year":"2016","journal-title":"Aquacult Env Interac"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/08927014.2012.700478","article-title":"The impact and control of biofouling in marine aquaculture: a review","volume":"28","author":"I Fitridge","year":"2012","journal-title":"Biofouling"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0065-2881(04)47003-5","article-title":"Marine biofouling on fish farms and its remediation","volume":"47","author":"RA Braithwaite","year":"2005","journal-title":"Adv Mar Biol"},{"key":"ref19","first-page":"177","article-title":"Advances in Marine Antifouling Coatings and Technologies","author":"R de Nys","year":"2009"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/08927014.2015.1012713","article-title":"Amplified recruitment pressure of biofouling organisms in commercial salmon farms: potential causes and implications for farm management","volume":"31","author":"N Bloecher","year":"2015","journal-title":"Biofouling"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1365-2109.2010.02659.x","article-title":"Larval release and attachment modes of the hydroid <italic>Ectopleura larynx<\/italic> on aquaculture nets in Norway","volume":"42","author":"C Carl","year":"2011","journal-title":"Aquaculture Research"},{"key":"ref22","article-title":"Cost analysis of different antifouling strategies [in Norwegian: Kostnadsanalyse av ulike begroingshindrende strategier]","author":"T Olafsen","year":"2006","journal-title":"SINTEF Fisheries and Aquaculture"},{"issue":"1\u20134","key":"ref23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.aquaculture.2010.01.005","article-title":"The development of biofouling, particularly the hydroid <italic>Ectopleura larynx<\/italic>, on commercial salmon cage nets in Mid-Norway","volume":"300","author":"J Guenther","year":"2010","journal-title":"Aquaculture"},{"key":"ref24","first-page":"17","article-title":"Biofouling of the hydroid <italic>Ectopleura larynx<\/italic> on aquaculture nets in Ireland: implications for finfish health","volume":"13","author":"EJ Baxter","year":"2012","journal-title":"Fish Vet J"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/md11020523","article-title":"Jellyfish stings and their management: A review","volume":"11","author":"L Cegolon","year":"2013","journal-title":"Marine Drugs"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10750-010-0216-9","article-title":"Gill cell toxicity of northern boreal scyphomedusae <italic>Cyanea capillata<\/italic> and <italic>Aurelia aurita<\/italic> measured by an in vitro cell assay","volume":"645","author":"H Helmholz","year":"2010","journal-title":"Hydrobiologia"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/jfd.12623","article-title":"Physiological responses of reared sea bream (<italic>Sparus aurata<\/italic> Linnaeus, 1758) to an <italic>Amyloodinium ocellatum<\/italic> outbreak","volume":"40","author":"M Moreira","year":"2017","journal-title":"Journal of Fish Diseases"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s13344-015-0026-y","article-title":"Drag on hydroid-fouled nets\u2014An experimental approach","volume":"29","author":"P Lader","year":"2015","journal-title":"China Ocean Eng"},{"issue":"1\u20132","key":"ref29","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jembe.2007.06.033","article-title":"Functional characteristics of nematocysts found on the scyphomedusa <italic>Cyanea capillata<\/italic>","volume":"351","author":"SP Colin","year":"2007","journal-title":"Journal of Experimental Marine Biology and Ecology"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/jfd.12444","article-title":"Morphological diversity of <italic>Paramoeba perurans<\/italic> trophozoites and their interaction with Atlantic salmon, <italic>Salmo salar<\/italic> L., gills","volume":"39","author":"J Wiik-Nielsen","year":"2016","journal-title":"Journal of Fish Diseases"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2761.2004.00561.x","article-title":"The induction of laboratory-based amoebic gill disease revisited","volume":"27","author":"RN Morrison","year":"2004","journal-title":"Journal of Fish Diseases"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ijpara.2012.04.002","article-title":"In vitro cultured <italic>Neoparamoeba perurans<\/italic> causes amoebic gill disease in Atlantic salmon and fulfils Koch\u2019s postulates","volume":"42","author":"PBB Crosbie","year":"2012","journal-title":"International Journal for Parasitology"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3354\/aei00150","article-title":"A longitudinal study of amoebic gill disease on a marine Atlantic salmon farm utilising a real-time PCR assay for the detection of <italic>Neoparamoeba perurans<\/italic>","volume":"7","author":"JK Downes","year":"2015","journal-title":"Aquacult Env Interac"},{"issue":"1\u20132","key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2009.01.030","article-title":"Gill observations in Atlantic salmon (<italic>Salmo salar<\/italic>, L.) during repeated amoebic gill disease (AGD) field exposure and survival challenge","volume":"290","author":"RS Taylor","year":"2009","journal-title":"Aquaculture"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1550-7408.2009.00451.x","article-title":"<italic>Paranucleospora theridion<\/italic> n. gen., n. sp. (Microsporidia, Enterocytozoonidae) with a life cycle in the salmon louse (<italic>Lepeophtheirus salmonis<\/italic>, Copepoda) and Atlantic salmon (<italic>Salmo salar<\/italic>)","volume":"57","author":"S Nylund","year":"2010","journal-title":"Journal of Eukaryotic Microbiology"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3354\/dao02563","article-title":"<italic>Candidatus<\/italic> Branchiomonas cysticola is a common agent of epitheliocysts in seawater-farmed Atlantic salmon <italic>Salmo salar<\/italic> in Norway and Ireland","volume":"103","author":"SO Mitchell","year":"2013","journal-title":"Diseases of Aquatic Organisms"},{"key":"ref37","article-title":"PERMANOVA+ for PRIMER: Guide to Software and Statistical Methods","author":"M Anderson","year":"2008"},{"issue":"2","key":"ref38","first-page":"165","article-title":"Nematocysts in <italic>Tubularia larynx<\/italic> (Cnidaria, Hydrozoa) from Scandinavia and the northern coast of Spain","volume":"59","author":"C \u00d6stman","year":"1995","journal-title":"Sci"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s004420000372","article-title":"Hydroid defenses against predators: the importance of secondary metabolites versus nematocysts","volume":"124","author":"JJ Stachowicz","year":"2000","journal-title":"Oecologia"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"e0154239","DOI":"10.1371\/journal.pone.0154239","article-title":"Jellyfish stings trigger gill disorders and increased mortality in farmed <italic>Sparus aurata<\/italic> (Linnaeus, 1758) in the Mediterranean Sea","volume":"11","author":"M Bosch-Belmar","year":"2016","journal-title":"PLOS ONE"},{"key":"ref41","first-page":"1","article-title":"Acute lion&apos;s mane jellyfish, <italic>Cyanea capillata<\/italic> (Cnideria: Scyphozoa), exposure to Atlantic salmon (<italic>Salmo salar<\/italic> L.)","author":"MD Powell","year":"2018","journal-title":"Journal of Fish Diseases"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/jfd.12267","article-title":"Pathology and mortality associated with the mauve stinger jellyfish <italic>Pelagia noctiluca<\/italic> in farmed Atlantic salmon <italic>Salmo salar<\/italic> L","volume":"39","author":"M Marcos-L\u00f3pez","year":"2016","journal-title":"Journal of Fish Diseases"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"e100045","DOI":"10.1136\/vetreccr.100045rep","article-title":"Gill pathology in farmed salmon associated with the jellyfish <italic>Aurelia aurita<\/italic>","volume":"1","author":"SO Mitchell","year":"2011","journal-title":"Veterinary Record Case Reports"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3354\/aei00024","article-title":"Gill disorders in marine-farmed salmon: investigating the role of hydrozoan jellyfish","volume":"1","author":"EJ Baxter","year":"2011","journal-title":"Aquacult Env Interac"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13567-016-0383-4","article-title":"The impact of co-infections on fish: a review","volume":"47","author":"MH Kotob","year":"2016","journal-title":"Veterinary Research"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"e95397","DOI":"10.1371\/journal.pone.0095397","article-title":"Disease resistance in Atlantic salmon (<italic>Salmo salar<\/italic>): Coinfection of the intracellular bacterial pathogen <italic>Piscirickettsia salmonis<\/italic> and the sea louse <italic>Caligus rogercresseyi<\/italic>","volume":"9","author":"JP Lhorente","year":"2014","journal-title":"PLOS ONE"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3354\/dao005163","article-title":"<italic>Paramoeba pemaquidensis<\/italic> (Sarcomastigophora: Paramoebidae) infestation of the gills of coho salmon <italic>Oncorhynchus kisutch<\/italic> reared in sea water","volume":"5","author":"ML Kent","year":"1988","journal-title":"Diseases of Aquatic Organisms"},{"issue":"3","key":"ref48","first-page":"77","article-title":"Histology of gills of Atlantic salmon during the first few months following transfer to sea water","volume":"14","author":"BF Nowak","year":"1994","journal-title":"Bull Eur Assoc Fish Pathol"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2761.1988.tb00520.x","article-title":"Histological effects of the inert suspended clay kaolin on the gills of juvenile rainbow trout, <italic>Salmo gairdneri<\/italic> Richardson","volume":"11","author":"SA Goldes","year":"1988","journal-title":"Journal of Fish Diseases"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.aquaculture.2009.02.007","article-title":"Branchial mechanical injury does not accelerate the progression of experimentally induced amoebic gill disease (AGD) in Atlantic salmon <italic>Salmo salar<\/italic> L","volume":"290","author":"MB Adams","year":"2009","journal-title":"Aquaculture"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.aquaculture.2013.09.025","article-title":"Variability of biofouling communities on fish cage nets: A 1-year field study at a Norwegian salmon farm","volume":"416\u2013417","author":"N Bloecher","year":"2013","journal-title":"Aquaculture"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2761.2004.00526.x","article-title":"Gross pathology and its relationship with histopathology of amoebic gill disease (AGD) in farmed Atlantic salmon, <italic>Salmo salar<\/italic> L","volume":"27","author":"MB Adams","year":"2004","journal-title":"Journal of Fish Diseases"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/jfd.12546","article-title":"PCR survey for <italic>Paramoeba perurans<\/italic> in fauna, environmental samples and fish associated with marine farming sites for Atlantic salmon (<italic>Salmo salar<\/italic> L.)","volume":"40","author":"A Helleb\u00f8","year":"2016","journal-title":"Journal of Fish Diseases"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1365-2761.2001.00271.x","article-title":"Production of salmonid amoebic gill disease by exposure to <italic>Paramoeba<\/italic> sp. harvested from the gills of infected fish","volume":"24","author":"D Zilberg","year":"2001","journal-title":"Journal of Fish Diseases"},{"issue":"Part 1","key":"ref55","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.aquaculture.2016.10.011","article-title":"Temporal changes in infections with some pathogens associated with gill disease in farmed Atlantic salmon (<italic>Salmo salar<\/italic> L)","volume":"468","author":"GS Gunnarsson","year":"2017","journal-title":"Aquaculture"},{"key":"ref56","unstructured":"Marine Harvest. Salmon Farming Industry Handbook 2017. Bergen: 2017."},{"key":"ref57","article-title":"The health situation in Norwegian aquaculture 2016. Report","author":"B Hjeltnes","year":"2017"},{"key":"ref58","article-title":"Precision fish farming: A new framework to improve production in aquaculture","author":"M F\u00f8re","year":"2017","journal-title":"Biosystems Engineering"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0199842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T20:04:24Z","timestamp":1540238664000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0199842"}},"subtitle":[],"editor":[{"given":"Uwe","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,6]]},"references-count":58,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0199842","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,6]]}}}