{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:45:11Z","timestamp":1772203511394,"version":"3.50.1"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (BR)","award":["CNPq-400856\/2016-6"],"award-info":[{"award-number":["CNPq-400856\/2016-6"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq-465259\/2014-6"],"award-info":[{"award-number":["CNPq-465259\/2014-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"S\u00e3o Paulo State Research Support Foundation","award":["FAPESP: 2014\/50983-3"],"award-info":[{"award-number":["FAPESP: 2014\/50983-3"]}]},{"name":"S\u00e3o Paulo State Research Support Foundation","award":["FAPESP:2016\/21470-3"],"award-info":[{"award-number":["FAPESP:2016\/21470-3"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0200135","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T13:42:35Z","timestamp":1530798155000},"page":"e0200135","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of temperature induction in focal ischemic thermocoagulation model"],"prefix":"10.1371","volume":"13","author":[{"given":"Helio","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana P.","family":"Nucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier B.","family":"Mamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalia","family":"Mendez-Otero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo P.","family":"Nucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Tannus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3910-0047","authenticated-orcid":true,"given":"Lionel F.","family":"Gamarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"ref1","year":"2014"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12883-015-0297-1","article-title":"Influences of hyperlipidemia history on stroke outcome; a retrospective cohort study based on the Kyoto Stroke Registry","volume":"15","author":"K Shigematsu","year":"2015","journal-title":"BMC Neurology"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1258\/0007142001903238","article-title":"Animal models","volume":"56","author":"DL Small","year":"2000","journal-title":"Br Med Bull"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13287-015-0015-3","article-title":"Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis","volume":"6","author":"LP Nucci","year":"2015","journal-title":"Stem Cell Research & Therapy"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.brainresbull.2016.02.016","article-title":"A review on animal models of stroke: An update","volume":"122","author":"A Kumar","year":"2016","journal-title":"Brain Res Bull"},{"key":"ref6","first-page":"3445","article-title":"Animal models of ischemic stroke and their application in clinical research","volume":"9","author":"F Fluri","year":"2015","journal-title":"Drug Design, Development and Therapy"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/sj.jcbfm.9600560","article-title":"Neuronal HIF-1\u03b1 protein and VEGFR-2 immunoreactivity in functionally related motor areas following a focal M1 infarct","volume":"28","author":"AM Stowe","year":"2008","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1042\/bst0220991","article-title":"Energy metabolism, ion homeostasis, and cell damage in the brain","volume":"22","author":"K Katsura","year":"1994","journal-title":"Biochemical Society transactions"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0166-2236(94)90008-6","article-title":"The early events of oxygen and glucose deprivation: setting the scene for neuronal death?","volume":"17","author":"RL Martin","year":"1994","journal-title":"Trends in neurosciences"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1046\/j.1471-4159.1996.67041525.x","article-title":"Cerebral energy metabolism during severe ischemia of varying duration and following reperfusion","volume":"67","author":"JW Phillis","year":"1996","journal-title":"Journal of neurochemistry"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1523\/JNEUROSCI.15-06-04429.1995","article-title":"Expression of molecules associated with neuronal plasticity in the striatum after aspiration and thermocoagulatory lesions of the cerebral cortex in adult rats","volume":"15","author":"FG Szele","year":"1995","journal-title":"Journal of Neuroscience"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.STR.26.6.1072","article-title":"Experimental Stroke and Neuroprotection in the Aging Rat Brain","volume":"26","author":"M Davis","year":"1995","journal-title":"Stroke"},{"key":"ref13","article-title":"Cortical Bilateral Adaptations in Rats Submitted to Focal Cerebral Ischemia: Emphasis on Glial Metabolism","author":"Y Nonose","year":"2017","journal-title":"Molecular Neurobiology"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"e90693","DOI":"10.1371\/journal.pone.0090693","article-title":"The Potential Therapeutic Effect of Guanosine after Cortical Focal Ischemia in Rats","volume":"9","author":"G Hansel","year":"2014","journal-title":"PLoS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neures.2014.08.007","article-title":"Effect of age and gender on recovery after stroke in rats treated with bone marrow mononuclear cells","volume":"88","author":"BP Coelho","year":"2014","journal-title":"Neuroscience Research"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2009.01.062","article-title":"Treatment with bone marrow mononuclear cells induces functional recovery and decreases neurodegeneration after sensorimotor cortical ischemia in rats","volume":"1266","author":"A Giraldi-Guimar\u00e3es","year":"2009","journal-title":"Brain Research"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2009.09.094","article-title":"Therapeutic window for treatment of cortical ischemia with bone marrow-derived cells in rats","volume":"1306","author":"A de Vasconcelos dos Santos","year":"2010","journal-title":"Brain Research"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.brainres.2012.03.002","article-title":"Bone maroow mononuclear cells and mannose receptor expression. In focal cortical inschemia","volume":"1452","author":"A Giraldi-Guimar\u00e3es","year":"2012","journal-title":"Brain Research"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/cne.20609","article-title":"Mechanisms of subventricular zone expansion after focal cortical ischemic injury","volume":"488","author":"JE Gotts","year":"2005","journal-title":"Journal of Comparative Neurology"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.56499\/jppres16.126_4.4.153","article-title":"Therapeutic potential of the novel hybrid molecule JM-20 against focal cortical ischemia in rats","volume":"4","author":"YN Figueredo","year":"2016","journal-title":"Journal of Pharmacy & Pharmacognosy Research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2013.01.039","article-title":"Therapeutic potential of treatment with the flavonoid rutin after cortical focal ischemia in rats","volume":"1503","author":"AM Rodrigues","year":"2013","journal-title":"Brain Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainres.2012.11.026","article-title":"Does treatment with bone marrow mononuclear cells recover skilled motor function after focal cortical ischemia? Analysis with a forelimb skilled motor task in rats","volume":"1492","author":"M de F\u00e1tima Dos Santos Sampaio","year":"2012","journal-title":"Brain Res"},{"key":"ref23","article-title":"The Rat Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"1998"},{"issue":"18","key":"ref24","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1523\/JNEUROSCI.3233-16.2017","article-title":"ST2\/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury","volume":"37","author":"Y Yang","year":"2017","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ana.23815","article-title":"Adoptive regulatory T-cell therapy protects against cerebral ischemia","volume":"74","author":"P Li","year":"2013","journal-title":"Annals of Neurology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13041-016-0243-1","article-title":"Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow","volume":"9","author":"Q Pan","year":"2016","journal-title":"Mol Brain"},{"issue":"13","key":"ref27","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/dneu.20674","article-title":"Enhanced neurogenesis and cell migration following focal ischemia and peripheral stimulation in mice","volume":"68","author":"WL Li","year":"2008","journal-title":"Dev Neurobiol"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/cmr.b.20168","article-title":"Effects of Crossing Saddle Coil Conductors: Electric Length X Mutual Inductance","volume":"37B","author":"D Papoti","year":"2010","journal-title":"Concepts in Magnetic Resonance Part B (Magnetic Resonance Engineering)"},{"key":"ref29","article-title":"ImageJ","author":"WS Rasband","year":"2016"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"32291","DOI":"10.1038\/srep32291","article-title":"Meta-Analysis and Systematic Review of Neural Stem Cells therapy for experimental ischemia stroke in preclinical studies","volume":"6","author":"L Chen","year":"2016","journal-title":"Scientific Reports"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.nurx.2006.08.001","article-title":"Behavioral tests for preclinical intervention assessment","volume":"3","author":"T Schallert","year":"2006","journal-title":"NeuroRx"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1161\/01.STR.0000032302.91894.0F","article-title":"Behavioral tests after intracerebral hemorrhage in the rat","volume":"33","author":"Y Hua","year":"2002","journal-title":"Stroke"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"e5482","DOI":"10.1371\/journal.pone.0005482","article-title":"Striatal neuroinflammation promotes Parkinsonism in rats","volume":"4","author":"DY Choi","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.scr.2011.07.001","article-title":"Conditionally immortalised neural stem cells promote functional recovery and brain plasticity after transient focal cerebral ischaemia in mice","volume":"8","author":"S Patkar","year":"2012","journal-title":"Stem Cell Res"},{"issue":"7","key":"ref35","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1161\/STROKEAHA.113.004476","article-title":"Memantine enhances recovery from stroke","volume":"45","author":"HE L\u00f3pez-Vald\u00e9s","year":"2014","journal-title":"Stroke"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"e0148170","DOI":"10.1371\/journal.pone.0148170","article-title":"Neuroprotective Effect of a DJ-1 Based Peptide in a Toxin Induced Mouse Model of Multiple System Atrophy","volume":"11","author":"MJ Glat","year":"2016","journal-title":"PLoS One"},{"key":"ref37","unstructured":"IBM Corp. IBM SPSS statistics for Windows; 2016. S\u00e3o Paulo."},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1109\/TNSRE.2007.908429","article-title":"Thermal impact of an active 3-D microelectrode array implanted in the brain","volume":"15","author":"S Kim","year":"2007","journal-title":"IEEE Transactions on Neural Systems and Rehabilitation Engineering"},{"issue":"6229","key":"ref39","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1126\/science.1261821","article-title":"Wireless magnetothermal deep brain stimulation","volume":"347","author":"R Chen","year":"2015","journal-title":"Science"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1088\/1741-2560\/3\/4\/008","article-title":"Bio-heat transfer model of deep brain stimulation-induced temperature changes","volume":"3","author":"MM Elwassif","year":"2006","journal-title":"Journal of Neural Engineering"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/jappl.1948.1.2.93","article-title":"Analysis of tissue and arterial blood temperatures in the resting human forearm","volume":"1","author":"HH Pennes","year":"1948","journal-title":"Journal of Applied Physiology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1562\/2004-03-05-RA-102.1","article-title":"Chemical and structural changes in blood undergoing laser photocoagulation","volume":"80","author":"JF Black","year":"2004","journal-title":"Photochemistry and Photobiology"},{"key":"ref43","article-title":"Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment","author":"PD Wolf","year":"2008"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/lsm.20408","article-title":"The effects of intense pulsed light (IPL) on blood vessels investigated by mathematical modeling","volume":"39","author":"W B\u00e4umler","year":"2007","journal-title":"Lasers in Surgery and Medicine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.icheatmasstransfer.2011.03.027","article-title":"An analysis of heat transfer in liver tissue during microwave ablation using single and double slot antenna, International","volume":"38","author":"P Keangin","year":"2011","journal-title":"International Communications in Heat and Mass Transfer"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/stem.2578","article-title":"Intravenously Transplanted Human Bone Marrow Endothelial Progenitor Cells Engraft Within Brain Capillaries, Preserve Mitochondrial Morphology, and Display Pinocytotic Activity Toward Blood-Brain Barrier Repair in Ischemic Stroke Rats","volume":"35","author":"S Garbuzova-Davis","year":"2017","journal-title":"Stem Cells"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/jcbfm.2011.150","article-title":"Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives","volume":"32","author":"M Zille","year":"2012","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"3\u20134","key":"ref48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11011-007-9057-2","article-title":"Aquaporins in the brain: from aqueduct to "multi-duct"","volume":"22","author":"J Badaut","year":"2007","journal-title":"Metabolic Brain Disease"},{"issue":"17","key":"ref49","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1523\/JNEUROSCI.5438-05.2006","article-title":"In vivo magnetic resonance imaging and semiautomated image analysis extend the brain phenotype for cdf\/cdf mice","volume":"26","author":"NA Bock","year":"2006","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00221-005-2340-8","article-title":"White matter damage precedes that in gray matter despite similar magnetic resonance imaging changes following cerebral hypoxia-ischemia in neonatal rats","volume":"166","author":"S Meng","year":"2005","journal-title":"Experimental Brain Research"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijdevneu.2007.08.018","article-title":"Application of Magnetic Resonance Imaging in Animal Models of Perinatal Hypoxic-Ischemic Cerebral Injury","volume":"26","author":"GA Lodygensky","year":"2008","journal-title":"International journal of developmental neuroscience"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3892\/etm.2015.2450","article-title":"Study on the behavioral changes of a post-stroke depression rat model","volume":"10","author":"C Wu","year":"2015","journal-title":"Exp Ther Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"16171","DOI":"10.1038\/srep16171","article-title":"MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents","volume":"5","author":"AL Samson","year":"2015","journal-title":"Sci Rep"},{"key":"ref54","article-title":"Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage","author":"T Mutoh","year":"2017","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"10","key":"ref55","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/bph.13468","article-title":"Drp-1, a potential therapeutic target for brain ischaemic stroke","volume":"173","author":"W Zuo","year":"2016","journal-title":"Br J Pharmacol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4137\/JCNSD.S13194","article-title":"Manual versus Automated Rodent Behavioral Assessment: Comparing Efficacy and Ease of Bederson and Garcia Neurological Deficit Scores to an Open Field Video-Tracking System","volume":"6","author":"FA Desland","year":"2014","journal-title":"Journal of Central Nervous System Disease"},{"key":"ref57","first-page":"243","article-title":"Cerebral Cortex, volume 5, Sensory-Motor Areas and Aspects of Cortical Connectivity","author":"SP Wise","year":"1986"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0200135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T19:44:09Z","timestamp":1720381449000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0200135"}},"subtitle":[],"editor":[{"given":"Johannes","family":"Boltze","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":57,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0200135","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.17504\/protocols.io.pasdiee","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]}}}