{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:25:46Z","timestamp":1782167146042,"version":"3.54.5"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0200171","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T17:55:13Z","timestamp":1531418113000},"page":"e0200171","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ki67, CD105, and \u03b1-SMA expression supports the transformation relevant dysplastic features in the atrophic epithelium of oral submucous fibrosis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-7694","authenticated-orcid":true,"given":"Amol R.","family":"Gadbail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minal","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-0957","authenticated-orcid":true,"given":"Sachin C.","family":"Sarode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Gondivkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2288-5167","authenticated-orcid":true,"given":"Satyajit A.","family":"Tekade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajakta","family":"Zade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Hande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gargi S.","family":"Sarode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankargouda","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.oraloncology.2010.04.004","article-title":"Immunohistochemical expression of CD34 for characterization and quantification of mucosal vasculature and its probable role in malignant transformation of atrophic epithelium in oral submucous fibrosis","volume":"46","author":"RS Desai","year":"2010","journal-title":"Oral Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1365-2559.2002.01343.x","article-title":"Ki67 protein: the immaculate deception?","volume":"40","author":"DC Brown","year":"2002","journal-title":"Histopathology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/08820130600754960","article-title":"More than structural cells, fibroblasts create and orchestrate the tumor microenvironment","volume":"35","author":"CJ Baglole","year":"2006","journal-title":"Immunol Invest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.1038\/sj.onc.1206813","article-title":"Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels","volume":"22","author":"E Fonsatti","year":"2003","journal-title":"Oncogene"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.humpath.2006.02.006","article-title":"Comparative evaluation of microvessel density determined by CD34 or CD105 in benign and malignant gastric lesions","volume":"37","author":"S Ding","year":"2006","journal-title":"Hum Pathol"},{"key":"ref6","first-page":"224","article-title":"Oral submucous fibrosis as a precancerous condition","volume":"92","author":"JJ Pindborg","year":"1984","journal-title":"Scand J Dent Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/0030-4220(66)90367-7","article-title":"Oral submucous fibrosis","volume":"22","author":"JJ Pindborg","year":"1966","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1600-0714.1995.tb01209.x","article-title":"Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10-year experience with 150 cases","volume":"24","author":"DR Lai","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/jop.12699","article-title":"Dysplastic features relevant to malignant transformation in atrophic epithelium of oral submucous fibrosis: a preliminary study","volume":"47","author":"SC Sarode","year":"2018","journal-title":"J Oral Pathol Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199101033240101","article-title":"Tumor angiogenesis and metastasis\u2014correlation in invasive breast carcinoma","volume":"324","author":"N Weidner","year":"1991","journal-title":"N Engl J Med"},{"key":"ref11","first-page":"2912","article-title":"Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling","volume":"8","author":"JA Tuxhorn","year":"2002","journal-title":"Clin Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1600-0714.2009.00768.x","article-title":"Evaluation of myofibroblasts in oral epithelial dysplasia and squamous cell carcinoma","volume":"38","author":"S Etemad-Moghadam","year":"2009","journal-title":"J Oral Pathol Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.humpath.2010.12.009","article-title":"Ki67 and ProExC are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia","volume":"42","author":"WC Wang","year":"2011","journal-title":"Hum Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4103\/0973-029X.84478","article-title":"Proliferation and apoptosis markers in oral submucous fibrosis","volume":"15","author":"K Ranganathan","year":"2011","journal-title":"J Oral Maxillofac Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/jop.12483","article-title":"Identification of a combined biomarker for malignant transformation in oral submucous fibrosis","volume":"46","author":"S Bazarsad","year":"2017","journal-title":"J Oral Pathol Med"},{"key":"ref16","first-page":"2261","article-title":"Epithelial dysplasia and silver binding nucleolar organizer region proteins (<italic>agnors<\/italic>) in oral submucous fibrosis","volume":"3","author":"GR Chauhan","year":"2012","journal-title":"Int J Biol Med Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.oooo.2015.12.018","article-title":"Oral submucous fibrosis: review on mechanisms of malignant transformation","volume":"122","author":"RP Ekanayaka","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.mehy.2013.07.001","article-title":"Better grade of tumor differentiation of oral squamous cell carcinoma arising in background of oral submucous fibrosis","volume":"81","author":"SC Sarode","year":"2013","journal-title":"Med Hypotheses"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/0970-9290.80009","article-title":"Immunohistochemical evaluation of mast cells and vascular endothelial proliferation in oral submucous fibrosis","volume":"22","author":"B Sabarinath","year":"2011","journal-title":"Indian J Dent Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1158\/1078-0432.CCR-07-4478","article-title":"Endoglin (CD105): a marker of tumor vasculature and potential target for therapy","volume":"14","author":"NA Dallas","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/2047-783X-14-7-315","article-title":"Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions","volume":"14","author":"CH Siar","year":"2009","journal-title":"Eur J Med Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/hed.23962","article-title":"Computer-aided molecular pathology interpretation in exploring prospective markers for oral submucous fibrosis progression","volume":"38","author":"A Anura","year":"2016","journal-title":"Head Neck"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.oraloncology.2007.07.001","article-title":"Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation","volume":"44","author":"MG Kellermann","year":"2008","journal-title":"Oral Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1073\/pnas.0813306106","article-title":"Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast","volume":"106","author":"M Hu","year":"2009","journal-title":"ProcNatlAcadSci USA"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0714.2010.00995.x","article-title":"Evaluation of myofibroblasts in oral submucous fibrosis: correlation with disease severity","volume":"40","author":"P Angadi","year":"2011","journal-title":"J Oral Pathol Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/0976-433X.145126","article-title":"Immunohistochemical evaluation of myofibroblasts using alpha-smooth muscle actin in oral submucous fibrosis","volume":"5","author":"T Philip","year":"2014","journal-title":"SRM J Res Dent Sci"},{"key":"ref27","first-page":"ZC14","article-title":"Evaluation of myofibroblasts by expression of alpha smooth muscle actin: a marker in fibrosis, dysplasia and carcinoma","volume":"8","author":"KB Rao","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.4103\/0973-1482.147700","article-title":"Evaluation of stromal myofibroblasts in oral leukoplakia, oral submucous fibrosis, and oral squamous cell carcinoma\u2014an immunohistochemical study","volume":"11","author":"K Gupta","year":"2015","journal-title":"J Cancer Res Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0019-509X.175580","article-title":"Stromal myofibroblasts in oral squamous cell carcinoma and potentially malignant disorders","volume":"52","author":"G Jayaraj","year":"2015","journal-title":"Indian J Cancer"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-0714.2007.00609.x","article-title":"An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity","volume":"37","author":"A Lalli","year":"2008","journal-title":"J Oral Pathol Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0200171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T19:17:22Z","timestamp":1604603842000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0200171"}},"subtitle":[],"editor":[{"given":"Gururaj","family":"Arakeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,12]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0200171","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,12]]}}}