{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:26:24Z","timestamp":1778081184191,"version":"3.51.4"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0200231","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T13:32:41Z","timestamp":1545312761000},"page":"e0200231","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Differential profiles of soluble and cellular toll like receptor (TLR)-2 and 4 in chronic periodontitis"],"prefix":"10.1371","volume":"13","author":[{"given":"Hawra","family":"AlQallaf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mythily","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,12,20]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1902\/jop.2003.74.8.1237","article-title":"Therapy Committee of the American Academy of P. Diagnosis of periodontal diseases","volume":"74","author":"GC Armitage","year":"2003","journal-title":"J Periodontol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/0022034514528212","article-title":"The Role of Oral Pathobionts in Dysbiosis during Periodontitis Development","volume":"93","author":"Y Jiao","year":"2014","journal-title":"J Dent Res"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1902\/jop.2012.110664","article-title":"Update of the case definitions for population-based surveillance of periodontitis","volume":"83","author":"PI Eke","year":"2012","journal-title":"Journal of periodontology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-0757.1997.tb00191.x","article-title":"The host response to the microbial challenge in periodontitis: assembling the players","volume":"14","author":"KS Kornman","year":"1997","journal-title":"Periodontol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"J Meyle","year":"2015","journal-title":"Periodontol 2000"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1902\/jop.2009.097001","article-title":"The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease","volume":"80","author":"VE Friedewald","year":"2009","journal-title":"J Periodontol"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/odi.12085","article-title":"Evaluation of salivary biomarker profiles following non-surgical management of chronic periodontitis","volume":"20","author":"S Prakasam","year":"2014","journal-title":"Oral Dis"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/18715303113139990040","article-title":"Associations between periodontitis and systemic inflammatory diseases: response to treatment","volume":"7","author":"U El-Shinnawi","year":"2013","journal-title":"Recent Pat Endocr Metab Immune Drug Discov"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S1532-3382(12)70006-4","article-title":"State of the science: chronic periodontitis and systemic health","volume":"12","author":"J Otomo-Corgel","year":"2012","journal-title":"J Evid Based Dent Pract"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-051X.2006.01000.x","article-title":"A three-year prospective study of adult subjects with gingivitis. I: clinical periodontal parameters","volume":"34","author":"A Bogren","year":"2007","journal-title":"J Clin Periodontol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/prd.12103","article-title":"Personalized medicine: an update of salivary biomarkers for periodontal diseases","volume":"70","author":"DL Korte","year":"2016","journal-title":"Periodontol 2000"},{"key":"ref12","first-page":"1","article-title":"TLR signaling","volume":"311","author":"S. Akira","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1399-302X.2008.00448.x","article-title":"Immunohistochemical localization of Toll-like receptors 1\u201310 in periodontitis","volume":"23","author":"A Beklen","year":"2008","journal-title":"Oral Microbiol Immunol"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.4049\/jimmunol.171.12.6680","article-title":"Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk","volume":"171","author":"E LeBouder","year":"2003","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3389\/fimmu.2018.00457","article-title":"The Soluble Form of Toll-Like Receptor 2 Is Elevated in Serum of Multiple Sclerosis Patients: A Novel Potential Disease Biomarker","volume":"9","author":"MJ Hossain","year":"2018","journal-title":"Front Immunol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2249.2009.03854.x","article-title":"Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-alpha secretion by macrophage-like cells","volume":"156","author":"SL Zunt","year":"2009","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nri1630","article-title":"Negative regulation of toll-like receptor-mediated immune responses","volume":"5","author":"FY Liew","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2334\/josnusd.53.263","article-title":"Toll-like receptors and their dual role in periodontitis: a review","volume":"53","author":"M Hans","year":"2011","journal-title":"J Oral Sci"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/odi.12468","article-title":"The role of Toll-like receptors in periodontitis","volume":"23","author":"B Song","year":"2017","journal-title":"Oral Dis"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1902\/jop.2004.75.4.578","article-title":"The in vivo expression of membrane-bound CD14 in periodontal health and disease","volume":"75","author":"L Jin","year":"2004","journal-title":"J Periodontol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1034\/j.1399-302X.2003.180109.x","article-title":"Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis","volume":"18","author":"Y Mori","year":"2003","journal-title":"Oral Microbiol Immunol"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1600-051X.2009.01505.x","article-title":"Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species","volume":"37","author":"PG Stathopoulou","year":"2010","journal-title":"J Clin Periodontol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/2380084416653596","article-title":"A Case-Control Study to Determine the Prognostic Features of Salivary Epithelial Cells in Periodontitis","volume":"1","author":"A Wang","year":"2016","journal-title":"JDR Clinical & Translational Research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fcimb.2015.00062","article-title":"Targeted salivary biomarkers for discrimination of periodontal health and disease(s)","volume":"5","author":"JL Ebersole","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/jcpe.12538","article-title":"Host-derived salivary biomarkers in diagnosing periodontal disease: systematic review and meta-analysis","volume":"43","author":"CL de Lima","year":"2016","journal-title":"J Clin Periodontol"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1089\/bio.2011.0039","article-title":"Quality assessment of saliva bank samples","volume":"10","author":"SB Janardhanam","year":"2012","journal-title":"Biopreserv Biobank"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/prd.12117","article-title":"Salivary cytokines as biomarkers of periodontal diseases","volume":"70","author":"KM Jaedicke","year":"2016","journal-title":"Periodontol 2000"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1600-051X.2010.01563.x","article-title":"Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis","volume":"37","author":"UK Gursoy","year":"2010","journal-title":"J Clin Periodontol"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10875-012-9771-3","article-title":"Patterns of salivary analytes provide diagnostic capacity for distinguishing chronic adult periodontitis from health","volume":"33","author":"JL Ebersole","year":"2013","journal-title":"Journal of clinical immunology"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/prd.12101","article-title":"Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases","volume":"70","author":"T Sorsa","year":"2016","journal-title":"Periodontol 2000"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1600-051X.2011.01702.x","article-title":"Stimulants of Toll-like receptors 2 and 4 are elevated in saliva of periodontitis patients compared with healthy subjects","volume":"38","author":"DF Lappin","year":"2011","journal-title":"J Clin Periodontol"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1902\/jop.2014.140414","article-title":"Correlation of Toll-like receptor 4, interleukin-18, transaminases, and uric acid in patients with chronic periodontitis and healthy adults","volume":"86","author":"S Banu","year":"2015","journal-title":"J Periodontol"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1902\/jop.2010.100467","article-title":"Salivary and plasma levels of Toll-like receptor 2 and Toll-like receptor 4 in chronic periodontitis","volume":"82","author":"N Buduneli","year":"2011","journal-title":"J Periodontol"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0003-9969(03)00014-1","article-title":"from salivary analyses, of the turnover time of the oral mucosal epithelium in humans and the number of bacteria in an edentulous mouth","volume":"48","author":"Dawes C. Estimates","year":"2003","journal-title":"Arch Oral Biol"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"6944","DOI":"10.1038\/s41598-018-25311-0","article-title":"Quantitation of the cellular content of saliva and buccal swab samples","volume":"8","author":"C Theda","year":"2018","journal-title":"Sci Rep"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1034\/j.1600-051x.2001.028007650.x","article-title":"CD9 and HLA-DR expression by crevicular epithelial cells and polymorphonuclear neutrophils in periodontal disease","volume":"28","author":"C Bisson-Boutelliez","year":"2001","journal-title":"J Clin Periodontol"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4103\/0976-237X.142818","article-title":"Cytological analysis of the periodontal pocket in patients with aggressive periodontitis and chronic periodontitis","volume":"5","author":"EC Cecilia","year":"2014","journal-title":"Contemp Clin Dent"},{"key":"ref38","first-page":"137","article-title":"Peridontal disease: Symptomes, treatment and prevention","author":"M Giannelli","year":"2011"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/jre.12066","article-title":"Role of salivary epithelial toll-like receptors 2 and 4 in modulating innate immune responses in chronic periodontitis","volume":"48","author":"V Swaminathan","year":"2013","journal-title":"J Periodontal Res"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1902\/jop.1959.30.1.7","article-title":"Alveolar Bone Loss as Related to Oral Hygiene and Age","volume":"30","author":"O Schei","year":"1959","journal-title":"Journal of Periodontotlogy"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.clim.2007.08.014","article-title":"Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome","volume":"126","author":"M Srinivasan","year":"2008","journal-title":"Clin Immunol"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/10454411000110040101","article-title":"Epithelial structural proteins of the skin and oral cavity: function in health and disease","volume":"11","author":"RB Presland","year":"2000","journal-title":"Crit Rev Oral Biol Med"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/j.0022-0337.2002.66.4.tb03536.x","article-title":"Making sense of the epithelial barrier: what molecular biology and genetics tell us about the functions of oral mucosal and epidermal tissues","volume":"66","author":"RB Presland","year":"2002","journal-title":"J Dent Educ"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1601-0825.2007.01400.x","article-title":"Estimation of sCD14 levels in saliva obtained from patients with various periodontal conditions","volume":"14","author":"DM Isaza-Guzman","year":"2008","journal-title":"Oral Dis"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/1753425908101577","article-title":"Soluble CD14 in periodontitis","volume":"15","author":"EA Nicu","year":"2009","journal-title":"Innate Immun"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1189\/jlb.2MR0316-117RR","article-title":"Molecular mechanisms of regulation of Toll-like receptor signaling","volume":"100","author":"CA Leifer","year":"2016","journal-title":"J Leukoc Biol"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1093\/jn\/135.11.2719","article-title":"Exfoliated colonic epithelial cells: surrogate targets for evaluation of bioactive food components in cancer prevention","volume":"135","author":"A Kamra","year":"2005","journal-title":"J Nutr"},{"issue":"11","key":"ref48","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1002\/ijc.22647","article-title":"Cell exfoliation in the human colon: myth, reality and implications for colorectal cancer screening","volume":"120","author":"A. Loktionov","year":"2007","journal-title":"Int J Cancer"},{"issue":"12","key":"ref49","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.2337\/diabetes.54.12.3427","article-title":"Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes","volume":"54","author":"H Rahmoune","year":"2005","journal-title":"Diabetes"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"G Hajishengallis","year":"2012","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-0765.2011.01405.x","article-title":"Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis","volume":"47","author":"NR Rojo-Botello","year":"2012","journal-title":"J Periodontal Res"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/adj.12089","article-title":"Comparison of relative TLR-2 and TLR-4 expression level of disease and healthy gingival tissue of smoking and non-smoking patients and periodontally healthy control patients","volume":"58","author":"K Fatemi","year":"2013","journal-title":"Aust Dent J"},{"issue":"6","key":"ref53","first-page":"ZC86","article-title":"Evaluation of TLR2 and 4 in Chronic Periodontitis","volume":"10","author":"P Ilango","year":"2016","journal-title":"J Clin Diagn Res"},{"issue":"6","key":"ref54","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1399-302X.2007.00377.x","article-title":"Quantitative messenger RNA expression of Toll-like receptors and interferon-alpha1 in gingivitis and periodontitis","volume":"22","author":"K Kajita","year":"2007","journal-title":"Oral Microbiol Immunol"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.chom.2011.09.008","article-title":"The relationship of the oral microbiotia to periodontal health and disease","volume":"10","author":"MA Curtis","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1099\/00222615-35-1-5","article-title":"Age-related microbiological changes in the salivary and plaque microflora of healthy adults","volume":"35","author":"RS Percival","year":"1991","journal-title":"J Med Microbiol"},{"issue":"8","key":"ref57","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/0022034514540173","article-title":"Impact of the Oral Commensal Flora on Alveolar Bone Homeostasis","volume":"93","author":"K Irie","year":"2014","journal-title":"J Dent Res"},{"issue":"11","key":"ref58","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1034\/j.1600-051X.2003.00419.x","article-title":"Bacterial colonization during de novo plaque formation","volume":"30","author":"P Ramberg","year":"2003","journal-title":"J Clin Periodontol"},{"issue":"12","key":"ref59","doi-asserted-by":"crossref","first-page":"e104624","DOI":"10.1371\/journal.pone.0104624","article-title":"Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production","volume":"9","author":"P Langjahr","year":"2014","journal-title":"PLoS One"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12865-014-0055-y","article-title":"The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases","volume":"15","author":"J Ten Oever","year":"2014","journal-title":"BMC Immunol"},{"issue":"6","key":"ref61","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.imbio.2011.10.023","article-title":"Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients","volume":"217","author":"E Candia","year":"2012","journal-title":"Immunobiology"},{"issue":"1","key":"ref62","first-page":"30","article-title":"Decreased levels of soluble Toll-like Receptor 2 in patients with asthma","volume":"1","author":"M Tehrani","year":"2012","journal-title":"Rep Biochem Mol Biol"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4049\/jimmunol.0802909","article-title":"Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering","volume":"183","author":"AC Raby","year":"2009","journal-title":"J Immunol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fimmu.2014.00316","article-title":"A comparative review of toll-like receptor 4 expression and functionality in different animal species","volume":"5","author":"C Vaure","year":"2014","journal-title":"Front Immunol"},{"issue":"11","key":"ref65","doi-asserted-by":"crossref","first-page":"6949","DOI":"10.4049\/jimmunol.173.11.6949","article-title":"Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling","volume":"173","author":"N Hyakushima","year":"2004","journal-title":"J Immunol"},{"issue":"5","key":"ref66","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1902\/jop.1996.67.5.478","article-title":"The effect of periodontal treatment on periodontal bacteria on the oral mucous membranes","volume":"67","author":"MM Danser","year":"1996","journal-title":"J Periodontol"},{"issue":"11","key":"ref67","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1600-051X.1995.tb01784.x","article-title":"Putative periodontal pathogens colonizing oral mucous membranes in denture-wearing subjects with a past history of periodontitis","volume":"22","author":"MM Danser","year":"1995","journal-title":"J Clin Periodontol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0200231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T18:13:31Z","timestamp":1662660811000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0200231"}},"subtitle":[],"editor":[{"given":"\u00d6zlem","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,20]]},"references-count":67,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0200231","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/355347","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,20]]}}}