{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:41:34Z","timestamp":1790329294876,"version":"4.1.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0200300","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T13:33:32Z","timestamp":1532525612000},"page":"e0200300","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Is genetic fatherhood within reach for all azoospermic Klinefelter men?"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7095-3996","authenticated-orcid":true,"given":"Veerle","family":"Vloeberghs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Verheyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Santos-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Staessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Verpoest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Gies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Tournaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,7,25]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/jc.2012-2382","article-title":"Clinical review: Klinefelter syndrome\u2014a clinical update","volume":"98","author":"KA Groth","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"S4","key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humrep\/11.suppl_4.1","article-title":"Cytogenetics of infertile men","volume":"11","author":"E Van Assche","year":"1996","journal-title":"Hum Reprod"},{"issue":"10","key":"ref3","first-page":"3807","article-title":"Analysis of Meiosis in Intratesticular Germ Cells from Subjects Affected by Classic Klinefelter\u2019s Syndrome","volume":"84","author":"C Foresta","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/jc.2002-021491","article-title":"Prenatal and postnatal prevalence of Klinefelter Syndrome: a national registry study","volume":"88","author":"A Bojesen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"ref5","first-page":"317","article-title":"Testicular Function in Klinefelter syndrome","volume":"69","author":"AM Wikstr\u00f6m","year":"2008","journal-title":"Horm Res"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/EJE-12-0934","article-title":"Testicular function and fertility in men with Klinefelter syndrome: a review","volume":"168","author":"I Aksglaede","year":"2013","journal-title":"European J of Endocrino"},{"issue":"3","key":"ref7","first-page":"88","article-title":"Ejaculated spermatozoa in patients with non-mosaic Klinefelter\u2019s syndrome","volume":"7","author":"M Kitamura","year":"2000","journal-title":"Int J Urology"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/andr.12249","article-title":"Testicular function during puberty and young adulthood in patients with Klinefelter\u2019s syndrome with and without spermatozoa in seminal fluid","volume":"4","author":"Y Royahem","year":"2016","journal-title":"Andrology"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/oxfordjournals.humrep.a019462","article-title":"Testicular sperm recovery in nine 47,XXY Klinefelter patients","volume":"11","author":"H Tournaye","year":"1996","journal-title":"Hum Reprod"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/humupd\/dmx008","article-title":"Sperm recovery and ICSI outcomes in Klinefelter syndrome: a systematic review and meta-analysis","volume":"23","author":"G Corona","year":"2017","journal-title":"Hum Reprod Update"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1093\/humrep\/deh490","article-title":"Should diagnostic testicular sperm retrieval followed by cryopreservation for later ICSI be the procedure of choice for all patients with non-obstructive azoospermia?","volume":"19","author":"G Verheyen","year":"2004","journal-title":"Hum Reprod"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/humrep\/14.1.131","article-title":"Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision","volume":"14","author":"PN Schlegel","year":"1999","journal-title":"Hum Reprod"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1093\/humrep\/13.10.2791","article-title":"Enzymatic digestion of testicular tissue may rescue the intracytoplasmic sperm injection cycle in some patients with non-obstructive azoospermia","volume":"13","author":"E Crabb\u00e9","year":"1998","journal-title":"Hum Reprod"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1093\/humrep\/deh447","article-title":"Should we advise patients undergoing IVF to start a cycle leading to a day 3 or a day 5 transfer?","volume":"19","author":"EM Kolibianakis","year":"2004","journal-title":"Hum Reprod"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1472-6483(10)61022-X","article-title":"New Belgian embryo transfer policy leads to sharp decrease in multiple pregnancy rate","volume":"13","author":"L Van Landuyt","year":"2006","journal-title":"Reprod Biomed Online"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1093\/oxfordjournals.humrep.a019463","article-title":"Preimplantation diagnosis for X and Y normality in embryos from three Klinefelter patients","volume":"11","author":"C Staessen","year":"1996","journal-title":"Hum Reprod"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/humrep\/17.3.671","article-title":"Neonatal data on a cohort of 2889 infants born after ICSI (1991\u20131999) and of 2995 infants born after IVF (1983\u20131999)","volume":"17","author":"M Bonduelle","year":"2002","journal-title":"Hum Reprod"},{"issue":"6840","key":"ref18","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1136\/bmj.304.6840.1465","article-title":"Expectations of assisted conception for infertility","volume":"304","author":"MG Hull","year":"1992","journal-title":"BMJ"},{"issue":"2","key":"ref19","first-page":"249","article-title":"Beware of the &apos;implantation rate&apos;! Why the outcome parameter &apos;implantation rate&apos; should be abandoned from infertility research","volume":"31","author":"G Griesinger","year":"2016","journal-title":"Hum Reprod"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/humrep\/dep431","article-title":"Should non-mosaic Klinefelter syndrome men be labeled as infertile in 2009?","volume":"25","author":"G Fullerton","year":"2010","journal-title":"Hum Reprod"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1464-410X.2012.11714.x","article-title":"Factors influencing intracytoplasmic sperm injection (ICSI) outcome in men with azoospermia","volume":"112","author":"A Abdel Raheem","year":"2013","journal-title":"BJU Int"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF00218909","article-title":"Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY\/XXY mosaic patient","volume":"93","author":"J Cozzi","year":"1994","journal-title":"Hum Genet"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1210\/jc.2014-3083","article-title":"Preliminary results of a prospective study of testicular sperm extraction in young versus adult patients with nonmosaic 47,XXY Klinefelter syndrome","volume":"100","author":"I Plotton","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/humrep\/dev139","article-title":"How successful is TESE-ICSI in couples with non-obstructive azoospermia","volume":"30","author":"V Vloeberghs","year":"2015","journal-title":"Hum Reprod"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.urology.2013.09.021","article-title":"Comparison of sperm retrieval and intracytoplasmic sperm injection outcome in patients with and without Klinefelter syndrome","volume":"83","author":"M Sabbaghian","year":"2014","journal-title":"Urology"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.fertnstert.2011.01.005","article-title":"Klinefelter syndrome: does it confer a bad prognosis in treatment of nonobstructive azoospermia?","volume":"95","author":"ME Bakircioglu","year":"2011","journal-title":"Fertil Steril"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/pd.4127","article-title":"Noninvasive prenatal detection of sex chromosomal aneuploidies by sequencing circulating cell-free DNA from maternal plasma","volume":"33","author":"AR Mazloom","year":"2013","journal-title":"Prenat Diagn"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/pd.5044","article-title":"The benefits and limitations of cell-free DNA screening for 47, XXY (Klinefelter syndrome)","volume":"37","author":"C Samango-Sprouse","year":"2017","journal-title":"Prenat Diagn"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0200300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T22:28:44Z","timestamp":1540247324000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0200300"}},"subtitle":[],"editor":[{"given":"Stefan","family":"Schlatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,25]]},"references-count":28,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0200300","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733694804.793555180","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,25]]}}}