{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:39:10Z","timestamp":1791463150951,"version":"4.3.4"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Bureau of Health Care for Senior Officials of National Health and Family Planning Commission of the People\u2019s Republic of China","award":["220935"],"award-info":[{"award-number":["220935"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81641034"],"award-info":[{"award-number":["81641034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0200337","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T13:53:30Z","timestamp":1530885210000},"page":"e0200337","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["Distinctions and associations between the microbiota of saliva and supragingival plaque of permanent and deciduous teeth"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-8624","authenticated-orcid":true,"given":"Weihua","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/1462-2920.12502","article-title":"Oral cavity contains distinct niches with dynamic microbial communities","volume":"17","author":"X Xu","year":"2015","journal-title":"Environ Microbiol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"R42","DOI":"10.1186\/gb-2012-13-6-r42","article-title":"Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples","volume":"13","author":"N Segata","year":"2012","journal-title":"Genome Biol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/08959374930070022001","article-title":"Microbiological predictors of caries risk","volume":"7","author":"J van Houte","year":"1993","journal-title":"Adv Dent Res"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1177\/0022034513488119","article-title":"Microbial geography of the oral cavity","volume":"92","author":"A Simon-Soro","year":"2013","journal-title":"J Dent Res"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"1270614","DOI":"10.1080\/20002297.2016.1270614","article-title":"Salivary microbiota in individuals with different levels of caries experience","volume":"9","author":"D Belstrom","year":"2017","journal-title":"J Oral Microbiol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ismej.2011.71","article-title":"Saliva microbiomes distinguish caries-active from healthy human populations","volume":"6","author":"F Yang","year":"2012","journal-title":"ISME J"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ijos.2016.38","article-title":"Saliva in the diagnosis of diseases","volume":"8","author":"CZ Zhang","year":"2016","journal-title":"Int J Oral Sci"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/nm0708-706","article-title":"Just spit it out","volume":"14","author":"T Gura","year":"2008","journal-title":"Nature medicine"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s00248-016-0854-1","article-title":"The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health","volume":"73","author":"A Gomez","year":"2017","journal-title":"Microb Ecol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/prd.12136","article-title":"The subgingival periodontal microbiota of the aging mouth","volume":"72","author":"M Feres","year":"2016","journal-title":"Periodontol 2000"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1600-051X.1990.tb01054.x","article-title":"Changes in subgingival microbiota during puberty. A 4-year longitudinal study","volume":"17","author":"FA Gusberti","year":"1990","journal-title":"J Clin Periodontol"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"e0146938","DOI":"10.1371\/journal.pone.0146938","article-title":"Supragingival Microbial Profiles of Permanent and Deciduous Teeth in Children with Mixed Dentition","volume":"11","author":"W Shi","year":"2016","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1755-8794-4-22","article-title":"Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health","volume":"4","author":"W Crielaard","year":"2011","journal-title":"BMC Med Genomics"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1601-0825.2012.01915.x","article-title":"Microbial profiles in saliva from children with and without caries in mixed dentition","volume":"18","author":"AH Luo","year":"2012","journal-title":"Oral Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"10948","DOI":"10.1038\/srep10948","article-title":"Subgingival microbiome in patients with healthy and ailing dental implants","volume":"5","author":"H Zheng","year":"2015","journal-title":"Sci Rep"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4236\/jbm.2015.36004","article-title":"Biodiversity of the Symbiotic Bacteria Associated with Toxic Marine Dinoflagellate Alexandrium tamarense","volume":"03","author":"X Zhang","year":"2015","journal-title":"Journal of Biosciences & Medicines"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"JG Caporaso","year":"2010","journal-title":"Nat Methods"},{"issue":"16","key":"ref18","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"RC Edgar","year":"2011","journal-title":"Bioinformatics"},{"issue":"23","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1057\/9780230509993","article-title":"Classification and Regression by randomForest","volume":"23","author":"A Liaw","year":"2002","journal-title":"R News"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Res"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"MG Langille","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/ismej.2016.199","article-title":"On the ecosystemic network of saliva in healthy young adults","volume":"11","author":"E Zaura","year":"2017","journal-title":"ISME J"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s12275-017-6474-8","article-title":"Exploring the oral microflora of preschool children","volume":"55","author":"W Ren","year":"2017","journal-title":"J Microbiol"},{"key":"ref24","author":"AE Magurran","year":"1988"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1177\/154405910808701104","article-title":"Pyrosequencing analysis of the oral microflora of healthy adults","volume":"87","author":"BJ Keijser","year":"2008","journal-title":"J Dent Res"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41467-018-02900-1","article-title":"A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow","volume":"9","author":"DM Proctor","year":"2018","journal-title":"Nat Commun"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1600-0722.1996.tb00094.x","article-title":"Influence of temperature on the co-adhesion of oral microbial pairs in saliva","volume":"104","author":"R Bos","year":"1996","journal-title":"Eur J Oral Sci"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1902\/jop.1969.40.11.630","article-title":"Oxidation reduction potential of developing plaque, periodontal pockets and gingival sulci","volume":"40","author":"EB Kenney","year":"1969","journal-title":"J Periodontol"},{"issue":"11","key":"ref29","article-title":"Interbacterial Adhesion Networks within Early Oral Biofilms of Single Human Hosts","volume":"83","author":"RJ Palmer Jr.","year":"2017","journal-title":"Appl Environ Microbiol"},{"key":"ref30","article-title":"Biofilm formation by the oral pioneer colonizer Streptococcus gordonii an experimental and numerical study","author":"H Rath","year":"2017","journal-title":"FEMS Microbiol Ecol"},{"issue":"13","key":"ref31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1128\/JB.02512-14","article-title":"The interaction between Streptococcus spp. and Veillonella tobetsuensis in the early stages of oral biofilm formation","volume":"197","author":"I Mashima","year":"2015","journal-title":"Journal of Bacteriology"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/BF01569826","article-title":"Oxygen metabolism, oxidative stress and acid-base physiology of dental plaque biofilms","volume":"15","author":"RE Marquis","year":"1995","journal-title":"J Ind Microbiol"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1177\/0022034509346811","article-title":"Bacterial interactions in dental biofilm development","volume":"88","author":"K Hojo","year":"2009","journal-title":"J Dent Res"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1038\/ijos.2017.35","article-title":"Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment","volume":"9","author":"AS Hemadi","year":"2017","journal-title":"Int J Oral Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.3389\/fmicb.2016.01145","article-title":"Bacterial Diversity and Community Structure of Supragingival Plaques in Adults with Dental Health or Caries Revealed by 16S Pyrosequencing","volume":"7","author":"C Xiao","year":"2016","journal-title":"Front Microbiol"},{"issue":"4","key":"ref36","first-page":"199","article-title":"Saliva and dental caries: diagnostic tests for normal dental practice","volume":"42","author":"M Larmas","year":"1992","journal-title":"International Dental Journal"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1399-302X.2008.00477.x","article-title":"Correlations of oral bacterial arginine and urea catabolism with caries experience","volume":"24","author":"MM Nascimento","year":"2009","journal-title":"Oral Microbiol Immunol"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ijos.2012.54","article-title":"Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries","volume":"4","author":"YL Liu","year":"2012","journal-title":"Int J Oral Sci"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2220\/biomedres.37.251","article-title":"Amino acid composition and amino acid-metabolic network in supragingival plaque","volume":"37","author":"J Washio","year":"2016","journal-title":"Biomed Res"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00248-014-0535-x","article-title":"Stability and resilience of oral microcosms toward acidification and Candida outgrowth by arginine supplementation","volume":"69","author":"JE Koopman","year":"2015","journal-title":"Microb Ecol"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/138920208783884900","article-title":"Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases","volume":"9","author":"TK Fabian","year":"2008","journal-title":"Curr Genomics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0200337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T01:17:43Z","timestamp":1540343863000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0200337"}},"subtitle":[],"editor":[{"given":"Kazuhiro","family":"Takemoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,6]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0200337","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,6]]}}}