{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:31:01Z","timestamp":1791822661014,"version":"4.3.4"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0200342","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T13:35:33Z","timestamp":1532525733000},"page":"e0200342","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Cardiac regenerative capacity is age- and disease-dependent in childhood heart disease"],"prefix":"10.1371","volume":"13","author":[{"given":"Alexandra","family":"Traister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvatit","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Plakhotnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gonzalez","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prutha","family":"Ruparel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Friedberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-3620","authenticated-orcid":true,"given":"Jason","family":"Maynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-5371","authenticated-orcid":true,"given":"John","family":"Coles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,7,25]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/CIRCRESAHA.116.309782","article-title":"A Deep Proteome Analysis Identifies the Complete Secretome as the Functional Unit of Human Cardiac Progenitor Cells","volume":"120","author":"S Sharma","year":"2017","journal-title":"Circ Res"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1161\/CIRCRESAHA.116.310253","article-title":"Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology: The PERSEUS (Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease) Randomized Phase 2 Trial","volume":"120","author":"S Ishigami","year":"2017","journal-title":"Circ Res"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCRESAHA.116.304671","article-title":"Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial","volume":"116","author":"S Ishigami","year":"2015","journal-title":"Circ Res"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1161\/CIRCRESAHA.117.312311","article-title":"Impact of Cardiac Progenitor Cells on Heart Failure and Survival in Single Ventricle Congenital Heart Disease","volume":"122","author":"T Sano","year":"2018","journal-title":"Circ Res"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/CIRCULATIONAHA.110.971622","article-title":"Characterization and functionality of cardiac progenitor cells in congenital heart patients","volume":"123","author":"R Mishra","year":"2011","journal-title":"Circulation"},{"key":"ref6","article-title":"Gata4-Dependent Differentiation of c-Kit(+) Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart","author":"BD Maliken","year":"2018","journal-title":"Circulation"},{"issue":"7500","key":"ref7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature13309","article-title":"c-kit+ cells minimally contribute cardiomyocytes to the heart","volume":"509","author":"JH van Berlo","year":"2014","journal-title":"Nature"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cell.2013.07.039","article-title":"Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair","volume":"154","author":"GM Ellison","year":"2013","journal-title":"Cell"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/CIRCRESAHA.117.310702","article-title":"Clinical Progress in Cell Therapy for Single Ventricle Congenital Heart Disease","volume":"120","author":"GJ Bittle","year":"2017","journal-title":"Circ Res"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.echo.2009.03.026","article-title":"Right ventricular function in infants, children and adolescents: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 640 healthy patients and calculation of z score values","volume":"22","author":"M Koestenberger","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"issue":"18","key":"ref11","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1161\/CIRCULATIONAHA.114.012975","article-title":"Molecular Mechanisms of Right Ventricular Failure","volume":"132","author":"S Reddy","year":"2015","journal-title":"Circulation"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/CIRCRESAHA.116.310494","article-title":"Concurrent Isolation of 3 Distinct Cardiac Stem Cell Populations From a Single Human Heart Biopsy","volume":"121","author":"MM Monsanto","year":"2017","journal-title":"Circ Res"},{"issue":"19","key":"ref13","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.116.024145","article-title":"Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair","volume":"135","author":"M Tiburcy","year":"2017","journal-title":"Circulation"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCULATIONAHA.106.655209","article-title":"Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens","volume":"115","author":"RR Smith","year":"2007","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.biopha.2016.01.020","article-title":"Overexpressing NKx2.5 increases the differentiation of human umbilical cord drived mesenchymal stem cells into cardiomyocyte-like cells","volume":"78","author":"Z Ruan","year":"2016","journal-title":"Biomed Pharmacother"},{"issue":"1\u20132","key":"ref16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-014-2188-y","article-title":"Mesenchymal stem cells overexpressing integrin-linked kinase attenuate left ventricular remodeling and improve cardiac function after myocardial infarction","volume":"397","author":"Q Mao","year":"2014","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"e37802","DOI":"10.1371\/journal.pone.0037802","article-title":"ILK induces cardiomyogenesis in the human heart","volume":"7","author":"A Traister","year":"2012","journal-title":"PLoS One"},{"key":"ref18","first-page":"1","article-title":"The Genetic Landscape of Hypoplastic Left Heart Syndrome","year":"2018","journal-title":"Pediatr Cardiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fped.2014.00125","article-title":"Hypoplastic left heart syndrome\u2014unresolved issues","volume":"2","author":"RR Arnold","year":"2014","journal-title":"Front Pediatr"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.athoracsur.2015.10.077","article-title":"Vulnerability of Coronary Circulation After Norwood Operation","volume":"101","author":"H Saiki","year":"2016","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"H1189","DOI":"10.1152\/ajpheart.00904.2015","article-title":"TNF receptor signaling inhibits cardiomyogenic differentiation of cardiac stem cells and promotes a neuroadrenergic-like fate","volume":"311","author":"T Hamid","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12015-017-9728-2","article-title":"Prolonged Growth Hormone\/Insulin\/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging","volume":"13","author":"MZ Ratajczak","year":"2017","journal-title":"Stem Cell Rev"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/CIRCRESAHA.116.309362","article-title":"A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells","volume":"120","author":"MZ Ratajczak","year":"2017","journal-title":"Circ Res"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.116.309710","article-title":"The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away","volume":"120","author":"CL Cai","year":"2017","journal-title":"Circ Res"},{"key":"ref25","article-title":"The Genetic Landscape of Hypoplastic Left Heart Syndrome","author":"H Yagi","year":"2018","journal-title":"Pediatr Cardiol"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.cell.2015.05.026","article-title":"Dynamics of Cell Generation and Turnover in the Human Heart","volume":"161","author":"O Bergmann","year":"2015","journal-title":"Cell"},{"issue":"30","key":"ref27","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1093\/eurheartj\/ehx343","article-title":"Cardiomyocyte renewal in the human heart: insights from the fall-out","volume":"38","author":"E Lazar","year":"2017","journal-title":"Eur Heart J"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIRCRESAHA.118.312420","article-title":"Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility","volume":"122","author":"J Mayourian","year":"2018","journal-title":"Circ Res"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/CIRCRESAHA.117.310796","article-title":"Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity","volume":"121","author":"J Mayourian","year":"2017","journal-title":"Circ Res"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00395-013-0334-4","article-title":"Doxorubicin induces senescence and impairs function of human cardiac progenitor cells","volume":"108","author":"E Piegari","year":"2013","journal-title":"Basic Res Cardiol"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0245808","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0200342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T20:23:29Z","timestamp":1540239809000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0200342"}},"subtitle":[],"editor":[{"given":"Federico","family":"Quaini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,25]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0200342","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0245808","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,25]]}}}