{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:55:50Z","timestamp":1776095750813,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007381","name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional","doi-asserted-by":"publisher","award":["CNPq 465549\/2014-4"],"award-info":[{"award-number":["CNPq 465549\/2014-4"]}],"id":[{"id":"10.13039\/501100007381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0200885","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T13:33:23Z","timestamp":1532093603000},"page":"e0200885","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Twin Peaks: A spatial and temporal study of twinning rates in Brazil"],"prefix":"10.1371","volume":"13","author":[{"given":"Augusto C\u00e9sar","family":"Cardoso-dos-Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliano","family":"Boquett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Zagonel de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidia Maria","family":"Callegari-Jacques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia Helena","family":"Barbian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa Vieira","family":"Sanseverino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Matte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-0460","authenticated-orcid":true,"given":"Lav\u00ednia","family":"Schuler-Faccini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"ref1","unstructured":"Frost M, Lynch D. Twin Peaks (Television Series). CBS Telev Distrib. United States; 1990; 50 minutes."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1017\/S0021932006001337","article-title":"Secular Trends in Twinning Rates","volume":"39","author":"A V D\u2019addato","year":"2007","journal-title":"J Biosoc Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1728-4457.2015.00088.x","article-title":"Twinning Rates in Developed Countries: Trends and Explanations","volume":"41","author":"G Pison","year":"2015","journal-title":"Popul Dev Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/14767058.2010.508218","article-title":"The world of twins: an update","volume":"23","author":"G Corsello","year":"2010","journal-title":"J Matern Neonatal Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(03)14237-7","article-title":"Twinning","volume":"362","author":"JG Hall","year":"2003","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1136\/jech-2015-206302","article-title":"Twinning and major birth defects, National Birth Defects Prevention Study, 1997\u20132007","volume":"70","author":"AL Dawson","year":"2016","journal-title":"J Epidemiol Community Health"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.rbmo.2012.11.008","article-title":"Do assisted-reproduction twin pregnancies require additional antenatal care?","volume":"26","author":"E Jauniaux","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/humrep\/den134","article-title":"Perinatal outcome of twin pregnancies in women of advanced age","volume":"23","author":"I Delbaere","year":"2008","journal-title":"Hum Reprod"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3109\/14767058.2012.746298","article-title":"Outcome of Twin pregnancy in women \u226545 years old: a retrospective cohort study","volume":"26","author":"I Laskov","year":"2013","journal-title":"J Matern Neonatal Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1053\/j.semperi.2012.02.001","article-title":"Epidemiology of Twinning in Developed Countries","volume":"36","author":"C V Ananth","year":"2012","journal-title":"Semin Perinatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.fertnstert.2009.09.009","article-title":"International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009","volume":"92","author":"F Zegers-Hochschild","year":"2009","journal-title":"Fertil Steril"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14767058.2017.1382469","article-title":"Twins and socioeconomic factors: changes in the last 20 years","author":"A Malamitsi-Puchner","year":"2017","journal-title":"J Matern neonatal Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1017\/thg.2016.75","article-title":"Twinning and Multiple Birth Rates According to Maternal Age in the City of S\u00e3o Paulo, Brazil: 2003\u20132014","volume":"19","author":"E Otta","year":"2016","journal-title":"Twin Res Hum Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1590\/S1519-38292008000400006","article-title":"Prevalence of twin births in Pelotas, in the State of Rio Grande do Sul, Brazil","volume":"8","author":"CF Geraldo","year":"2008","journal-title":"Rev Bras Sa\u00fade Matern Infant, Recife"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1590\/S1415-47572003000300005","article-title":"Twinning rate trend in a population sample from the city of S\u00e3o Paulo, Brazil","volume":"26","author":"GMDD Colletto","year":"2003","journal-title":"Genet Mol Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1590\/S1516-31802001000600007","article-title":"Twinning rate in a sample from a Brazilian hospital with a high standard of reproductive care","volume":"119","author":"SCAM Colletto","year":"2001","journal-title":"Sao Paulo Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e25239","DOI":"10.1371\/journal.pone.0025239","article-title":"Twinning across the Developing World","volume":"6","author":"J Smits","year":"2011","journal-title":"PLoS One"},{"key":"ref18","year":"2013"},{"key":"ref19","unstructured":"Brazilian Institute of Geography and Statistics. Mapas\u2014bases e referenciais. In: Malhas digitais\u2014Municipal [Internet]. 2015 [cited 14 Apr 2017]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/mapas.ibge.gov.br\/bases-e-referenciais\/bases-cartograficas\/malhas-digitais\" xlink:type=\"simple\">https:\/\/mapas.ibge.gov.br\/bases-e-referenciais\/bases-cartograficas\/malhas-digitais<\/ext-link>"},{"key":"ref20","unstructured":"Brasil. Banco de Dados do Sistema \u00danico de Sa\u00fade (DATASUS). In: Minist\u00e9rio da Sa\u00fade [Internet]. 2017 [cited 14 Apr 2017]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www2.datasus.gov.br\/DATASUS\/index.php\" xlink:type=\"simple\">http:\/\/www2.datasus.gov.br\/DATASUS\/index.php<\/ext-link>"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1590\/0102-311X00196113","article-title":"Avalia\u00e7\u00e3o dos sistemas de informa\u00e7\u00f5es sobre nascidos vivos e \u00f3bitos no Brasil na d\u00e9cada de 2000","volume":"30","author":"PG de Frias","year":"2014","journal-title":"Cad Saude Publica"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1353\/hub.2006.0044","article-title":"Weinberg\u2019s differential rule reconsidered","volume":"78","author":"J Fellman","year":"2006","journal-title":"Hum Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1017\/thg.2016.49","article-title":"Temporal and Spatial Variations in the Twinning Rate in Norway","volume":"19","author":"J Fellman","year":"2016","journal-title":"Twin Res Hum Genet"},{"key":"ref24","article-title":"High incidence of monozygotic twinning in infertility treatment","author":"A Sobek","year":"2016","journal-title":"Biomed Pap"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.5935\/1518-0557.20160026","article-title":"Socioeconomic profile of couples seeking the public healthcare system (SUS) for infertility treatment","volume":"20","author":"R Tavares","year":"2016","journal-title":"JBRA Assist Reprod"},{"key":"ref26","first-page":"221","article-title":"Barriers to access to infertility care and assisted reproductive technology within the public health sector in Brazil","volume":"4","author":"MY Makuch","year":"2012","journal-title":"Facts, views Vis ObGyn"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1590\/S0103-73312015000300005","article-title":"Tecnologias de reprodu\u00e7\u00e3o assistida no Brasil: op\u00e7\u00f5es para ampliar o acesso","volume":"25","author":"MCD V Corr\u00eaa","year":"2015","journal-title":"Physis Rev Sa\u00fade Coletiva"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1477-7827-12-87","article-title":"Infertility care and the introduction of new reproductive technologies in poor resource settings","volume":"12","author":"L Bahamondes","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"ref29","year":"2000"},{"key":"ref30","unstructured":"United Nations Development Programme. O \u00cdndice de Desenvolvimento Humano Municipal Brasileiro [Internet]. Bras\u00edlia; 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.atlasbrasil.org.br\/2013\/pt\/consulta\/\" xlink:type=\"simple\">http:\/\/www.atlasbrasil.org.br\/2013\/pt\/consulta\/<\/ext-link>"},{"key":"ref31","year":"2016"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1538-4632.1995.tb00338.x","article-title":"Local Indicators of Spatial Association-LISA","volume":"27","author":"L Anselin","year":"2010","journal-title":"Geogr Anal"},{"key":"ref33","year":"2017"},{"key":"ref34","year":"2014"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/humupd\/dmm036","article-title":"Dizygotic twinning","volume":"14","author":"C Hoekstra","year":"2007","journal-title":"Hum Reprod Update"},{"key":"ref36","first-page":"1","volume":"1","author":"MG Bulmer","year":"1970"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1530\/REP-08-0206","article-title":"Monozygotic twinning associated with assisted reproductive technologies: a review","volume":"136","author":"KI Aston","year":"2008","journal-title":"Reproduction"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10815-015-0616-x","article-title":"Clustering of monozygotic twinning in IVF","volume":"33","author":"DA Vaughan","year":"2016","journal-title":"J Assist Reprod Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/S0140-6736(11)60054-8","article-title":"The Brazilian health system: history, advances, and challenges","volume":"377","author":"J Paim","year":"2011","journal-title":"Lancet"},{"key":"ref40","unstructured":"Anvisa. SisEmbrio - 7o Relat\u00f3rio do Sistema Nacional de Produ\u00e7\u00e3o de Embri\u00f5es [Internet]. Bras\u00edlia.; 2014. Report No.: 7. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/portal.anvisa.gov.br\/\" xlink:type=\"simple\">http:\/\/portal.anvisa.gov.br\/<\/ext-link>"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e0171888","DOI":"10.1371\/journal.pone.0171888","article-title":"The sociodemographic, behavioral, reproductive, and health factors associated with fertility in Brazil","volume":"12","author":"CAO Tejada","year":"2017","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e40756","DOI":"10.1371\/journal.pone.0040756","article-title":"Transitions in Fertility for Brazilian Women: An Analysis of Impact Factors","volume":"7","author":"R Madalozzo","year":"2012","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1093\/humrep\/der158","article-title":"Inequitable access to assisted reproductive technology for the low-income Brazilian population: a qualitative study","volume":"26","author":"MY Makuch","year":"2011","journal-title":"Hum Reprod"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1093\/humrep\/deh304","article-title":"Can assisted reproduction technology compensate for the natural decline in fertility with age? A model assessment","volume":"19","author":"H Leridon","year":"2004","journal-title":"Hum Reprod"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijgo.2009.03.033","article-title":"Reproductive healthcare systems should include accessible infertility diagnosis and treatment: An important challenge for resource-poor countries","volume":"106","author":"W Ombelet","year":"2009","journal-title":"Int J Gynecol Obstet"},{"key":"ref46","unstructured":"United Nations. The Millennium Development Goals Report 2015 [Internet]. New York; 2015. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.un.org\/millenniumgoals\/\" xlink:type=\"simple\">http:\/\/www.un.org\/millenniumgoals\/<\/ext-link>"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000096872","article-title":"Color and Genomic Ancestry in Brazilians: A Study with Forensic Microsatellites","volume":"62","author":"JR Pimenta","year":"2006","journal-title":"Hum Hered"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e1004572","DOI":"10.1371\/journal.pgen.1004572","article-title":"Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals","volume":"10","author":"A Ruiz-Linares","year":"2014","journal-title":"PLoS Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/humrep\/des217","article-title":"High twinning rate in C\u00e2ndido God\u00f3i: a new role for p53 in human fertility","volume":"27","author":"A Tagliani-Ribeiro","year":"2012","journal-title":"Hum Reprod"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0200885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T01:24:23Z","timestamp":1540344263000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0200885"}},"subtitle":[],"editor":[{"given":"Ariadne","family":"Malamitsi-Puchner","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,20]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0200885","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,20]]}}}