{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:47Z","timestamp":1792788527364,"version":"4.5.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010289","name":"Princess Margaret Hospital Foundation","doi-asserted-by":"publisher","award":["9324"],"award-info":[{"award-number":["9324"]}],"id":[{"id":"10.13039\/100010289","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Telethon New Children's Hospital Research Fund","award":["4749600"],"award-info":[{"award-number":["4749600"]}]},{"name":"Perron Family Foundation"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1072593"],"award-info":[{"award-number":["1072593"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cancer Council of Western Australia Research Fellowship"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0201449","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T13:57:50Z","timestamp":1533823070000},"page":"e0201449","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Exercise training improves vascular function and secondary health measures in survivors of pediatric oncology related cerebral insult"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0950-6019","authenticated-orcid":true,"given":"Treya M.","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana R.","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Wallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin K.","family":"Howie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon M.","family":"Straker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bullock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Walwyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Gottardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine H.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine S.","family":"Choong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise H.","family":"Naylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1200\/JCO.2013.51.1055","article-title":"Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor study","volume":"32","author":"GT Armstrong","year":"2014","journal-title":"J Clin Oncol"},{"key":"ref2","year":"2014"},{"key":"ref3","year":"2012"},{"issue":"15","key":"ref4","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"KC Oeffinger","year":"2006","journal-title":"N Engl J Med"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1043454204272531","article-title":"Cardiovascular late effects (childhood cancer survivorship)","volume":"22","author":"D Greving","year":"2005","journal-title":"J Pediatr Oncol Nurs"},{"issue":"19","key":"ref6","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/jnci\/djn310","article-title":"Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study","volume":"100","author":"AC Mertens","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"13","key":"ref7","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1200\/JCO.2001.19.13.3163","article-title":"Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study","volume":"19","author":"AC Mertens","year":"2001","journal-title":"J Clin Oncol"},{"issue":"17","key":"ref8","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1200\/JCO.2003.01.202","article-title":"Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study","volume":"21","author":"RJ Packer","year":"2003","journal-title":"J Clin Oncol"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2265.2004.02196.x","article-title":"High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma","volume":"62","author":"AM Pereira","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"36","key":"ref10","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1200\/JCO.2011.38.9833","article-title":"Therapy for pediatric brain tumors and the risk of growth hormone deficiency","volume":"29","author":"C Sklar","year":"2011","journal-title":"J Clin Oncol"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/leu.2010.54","article-title":"Exercise in adult and pediatric hematological cancer survivors: an intervention review","volume":"24","author":"KY Wolin","year":"2010","journal-title":"Leukemia"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1002\/pbc.24565","article-title":"Endothelial function in long\u2010term survivors of childhood acute lymphoblastic leukemia: Effects of a home\u2010based exercise program","volume":"60","author":"LS J\u00e4rvel\u00e4","year":"2013","journal-title":"Pediatr Blood Cancer"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cjca.2015.12.023","article-title":"Vascular complications of cancer chemotherapy","volume":"32","author":"AC Cameron","year":"2016","journal-title":"Can J Cardiol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s12012-015-9324-0","article-title":"Endothelial function in patients with hematologic malignancies undergoing high-dose chemotherapy followed by hematopoietic stem cell transplantation","volume":"16","author":"M Por\u0119ba","year":"2016","journal-title":"Cardiovasc Toxicol"},{"key":"ref15","article-title":"Dexrazoxane Significantly Reduces Anthracycline-induced Cardiotoxicity in Pediatric Solid Tumor Patients: A Systematic Review","author":"K Liesse","year":"2018","journal-title":"J Pediatr Hematol Oncol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rpor.2013.07.007","article-title":"Opportunities for rehabilitation of patients with radiation fibrosis syndrome","volume":"19","author":"K Hojan","year":"2014","journal-title":"Reports of Practical Oncology & Radiotherapy"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2307\/3579788","article-title":"Radiation-induced muscle damage in rats after fractionated high-dose irradiation","volume":"149","author":"H-Y Hsu","year":"1998","journal-title":"Radiat Res"},{"issue":"9701","key":"ref18","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0140-6736(09)61299-X","article-title":"CNS complications of radiotherapy and chemotherapy","volume":"374","author":"C Soussain","year":"2009","journal-title":"The Lancet"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ijrobp.2013.03.034","article-title":"Radiation, atherosclerotic risk factors, and stroke risk in survivors of pediatric cancer: a report from the Childhood Cancer Survivor Study","volume":"86","author":"S Mueller","year":"2013","journal-title":"International Journal of Radiation Oncology* Biology* Physics"},{"key":"ref20","article-title":"Fitness, body composition and vascular health in adolescent and young adult survivors of paediatric brain cancer and cranial radiotherapy","author":"TM Long","year":"2017","journal-title":"Int J Adolesc Med Health"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2265.2007.02753.x","article-title":"Metabolic effects of growth hormone (GH) replacement in children and adolescents with severe isolated GH deficiency due to a GHRH receptor mutation","volume":"66","author":"H Gleeson","year":"2007","journal-title":"Clin Endocrinol (Oxf"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1158\/1055-9965.EPI-07-0048","article-title":"Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study","volume":"16","author":"TA Florin","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/cncr.29211","article-title":"Frailty in childhood cancer survivors","volume":"121","author":"KK Ness","year":"2015","journal-title":"Cancer"},{"key":"ref24","year":"2014"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jsams.2009.09.008","article-title":"Position statement on physical activity and exercise intensity terminology","volume":"13","author":"K Norton","year":"2010","journal-title":"Science and Medicine in Sport"},{"key":"ref26","unstructured":"The American College of Sports Medicine. ACSM&apos;s Guidelines for Exercise Testing and Prescription. Ninth Edition ed2014. 480 p."},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12170-008-0054-8","article-title":"Too little exercise and too much sitting: inactivity physiology and the need for new recommendations on sedentary behavior","volume":"2","author":"MT Hamilton","year":"2008","journal-title":"Curr Cardiovasc Risk Rep"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2337\/dc07-2046","article-title":"Breaks in sedentary time","volume":"31","author":"GN Healy","year":"2008","journal-title":"Diabetes Care"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1249\/MSS.0000000000001094","article-title":"Exercise Intervention in Pediatric Patients with Solid Tumors: The Physical Activity in Pediatric Cancer Trial","volume":"49","author":"C Fiuza-Luces","year":"2017","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1249\/01.mss.0000240326.54147.fc","article-title":"Effects of an intrahospital exercise program intervention for children with leukemia","volume":"39","author":"AF San Juan","year":"2007","journal-title":"Med Sci Sports Exerc"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"461512","DOI":"10.1155\/2011\/461512","article-title":"Exercise interventions in children with cancer: a review","volume":"2011","author":"TT Huang","year":"2011","journal-title":"Int J Pediatr"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1200\/JCO.2005.06.085","article-title":"Review of exercise intervention studies in cancer patients","volume":"23","author":"DA Galv\u00e3o","year":"2005","journal-title":"J Clin Oncol"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10554-010-9616-1","article-title":"Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis","volume":"26","author":"Y Inaba","year":"2010","journal-title":"The international journal of cardiovascular imaging"},{"issue":"8828","key":"ref34","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0140-6736(92)93147-F","article-title":"Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis","volume":"340","author":"DS Celermajer","year":"1992","journal-title":"The Lancet"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"H2","DOI":"10.1152\/ajpheart.00471.2010","article-title":"Assessment of flow-mediated dilation in humans: a methodological and physiological guideline","volume":"300","author":"DH Thijssen","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2288-12-54","article-title":"Translation equations to compare ActiGraph GT3X and Actical accelerometers activity counts","volume":"12","author":"L Straker","year":"2012","journal-title":"BMC Med Res Methodol"},{"key":"ref37","unstructured":"Respironics. Actical Physical Activity Monitoring System, Actical Software Version 2.12 and ActiReader Instruction Manual. In: Philips, editor. 2008."},{"key":"ref38","unstructured":"Global Database on Body Mass Index [Internet]. 2017. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/bmi\/index.jsp?introPage=intro_3.html\" xlink:type=\"simple\">http:\/\/apps.who.int\/bmi\/index.jsp?introPage=intro_3.html<\/ext-link>"},{"key":"ref39","first-page":"395","article-title":"Essentials of strength training and conditioning Champaign","author":"TR Baechle","year":"2008"},{"issue":"5","key":"ref40","first-page":"377","article-title":"Psychophysical bases of perceived exertion","volume":"14","author":"GA Borg","year":"1982","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00005768-199705001-00256","article-title":"Calibration of the computer science and applications, inc.(CSA) Accelerometer 256","volume":"29","author":"P Freedson","year":"1997","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"J Cohen","year":"1992","journal-title":"Psychol Bull"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/HYPERTENSIONAHA.110.167015","article-title":"Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?","volume":"57","author":"DJ Green","year":"2011","journal-title":"Hypertension"},{"issue":"12","key":"ref44","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0002-9149(98)00702-4","article-title":"Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease","volume":"82","author":"B Takase","year":"1998","journal-title":"The American journal of cardiology"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"e12713","DOI":"10.14814\/phy2.12713","article-title":"Exercise training improves vascular function in adolescents with type 2 diabetes","volume":"4","author":"LH Naylor","year":"2016","journal-title":"Physiological reports"},{"issue":"8","key":"ref46","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/ptj\/80.8.782","article-title":"Submaximal exercise testing: clinical application and interpretation","volume":"80","author":"V Noonan","year":"2000","journal-title":"Phys Ther"},{"issue":"8","key":"ref47","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/clc.4960130809","article-title":"Metabolic equivalents (METS) in exercise testing, exercise prescription, and evaluation of functional capacity","volume":"13","author":"M Jette","year":"1990","journal-title":"Clin Cardiol"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/MPH.0b013e318162c476","article-title":"A community-based physical activity program for adolescents with cancer (project TREK): program feasibility and preliminary findings","volume":"30","author":"MR Keats","year":"2008","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejca.2017.04.020","article-title":"Exercise training improves physical function and fitness in long-term paediatric brain tumour survivors treated with cranial irradiation","volume":"80","author":"P Piscione","year":"2017","journal-title":"Eur J Cancer"},{"issue":"05","key":"ref50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1055\/s-2007-965571","article-title":"Benefits of intrahospital exercise training after pediatric bone marrow transplantation","volume":"29","author":"AF San Juan","year":"2008","journal-title":"Int J Sports Med"},{"issue":"9","key":"ref51","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1210\/jc.2004-0160","article-title":"Factors that affect final height and change in height standard deviation scores in survivors of childhood cancer treated with growth hormone: a report from the childhood cancer survivor study","volume":"89","author":"CM Brownstein","year":"2004","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1210\/jc.2003-030784","article-title":"Final height and body mass index among adult survivors of childhood brain cancer: childhood cancer survivor study","volume":"88","author":"JG Gurney","year":"2003","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0959-8049(00)00438-X","article-title":"Group ftDLES. Adult height and age at menarche in childhood cancer survivors","volume":"37","author":"E Noorda","year":"2001","journal-title":"Eur J Cancer"},{"issue":"1","key":"ref54","first-page":"15","article-title":"Physical activity of Canadian children and youth: accelerometer results from the 2007 to 2009 Canadian Health Measures Survey","volume":"22","author":"RC Colley","year":"2011","journal-title":"Health Rep"},{"issue":"1","key":"ref55","first-page":"7","article-title":"Physical activity of Canadian adults: accelerometer results from the 2007 to 2009 Canadian Health Measures Survey","volume":"22","author":"RC Colley","year":"2011","journal-title":"Health Rep"},{"issue":"7","key":"ref56","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/pbc.21091","article-title":"Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemia","volume":"49","author":"KK Ness","year":"2007","journal-title":"Pediatr Blood Cancer"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0201449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T22:49:05Z","timestamp":1720478945000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0201449"}},"subtitle":[],"editor":[{"given":"Alejandro","family":"Luc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":56,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0201449","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]}}}