{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:15:57Z","timestamp":1763727357746,"version":"3.37.3"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish National Science Center","award":["UMO-2011\/01\/N\/NZ6\/01762"],"award-info":[{"award-number":["UMO-2011\/01\/N\/NZ6\/01762"]}]},{"DOI":"10.13039\/501100010621","name":"Medical University of Lublin","doi-asserted-by":"crossref","award":["DS 168"],"award-info":[{"award-number":["DS 168"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010621","name":"Medical University of Lublin","doi-asserted-by":"crossref","award":["DS 460\/2016"],"award-info":[{"award-number":["DS 460\/2016"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0201589","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T14:03:58Z","timestamp":1533823438000},"page":"e0201589","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9814-5061","authenticated-orcid":true,"given":"Daniel","family":"Pietrzak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-6160","authenticated-orcid":true,"given":"Aldona","family":"Pietrzak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Grywalska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Kici\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Roli\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Donica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-0104","authenticated-orcid":true,"given":"Kinga","family":"Franciszkiewicz-Pietrzak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Borz\u0119cki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Socha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaros\u0142aw","family":"Niedzia\u0142ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Krasowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: a systematic review of incidence and prevalence","volume":"133","author":"R Parisi","year":"2013","journal-title":"J Invest Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1468-3083.2012.04451.x","article-title":"Perceived relationships between severity of psoriasis symptoms, gender, stigmatization and quality of life","volume":"27","author":"D Bohm","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref3","first-page":"16","article-title":"Depression and anxiety disorders among patients with psoriasis: a hospital-based case-control study","volume":"381905","author":"M Golpour","year":"2012","journal-title":"Dermatol Res Pract"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/jdv.12350","article-title":"Psoriasis beyond the skin: an expert group consensus on the management of psoriatic arthritis and common co-morbidities in patients with moderate-to-severe psoriasis","volume":"28","author":"R Strohal","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1517\/14656566.2016.1128894","article-title":"Impact and management of depression in psoriasis patients","volume":"17","author":"AM Korman","year":"2016","journal-title":"Expert Opin Pharmacother"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4103\/0253-7176.168587","article-title":"A cross-sectional study of prevalence and implications of depression and anxiety in psoriasis","volume":"37","author":"S Lakshmy","year":"2015","journal-title":"Indian J Psychol Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"409637","DOI":"10.1155\/2015\/409637","article-title":"Exploring the physiological link between psoriasis and mood disorders","volume":"2015","author":"CJ Connor","year":"2015","journal-title":"Dermatol Res Pract"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jid.2016.11.032","article-title":"Depression Is Associated with an Increased Risk of Psoriatic Arthritis among Patients with Psoriasis: A Population-Based Study","volume":"137","author":"RT Lewinson","year":"2017","journal-title":"J Invest Dermatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2340\/00015555-2183","article-title":"Psoriasis and new-onset depression: a Danish Nationwide Cohort Study","volume":"96","author":"P Jensen","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/pde.12416","article-title":"Effect of age at diagnosis on chronic quality of life and long-term outcomes of individuals with psoriasis","volume":"32","author":"GE Kim","year":"2015","journal-title":"Pediatr Dermatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jad.2016.11.045","article-title":"Depressiveness, measured with Beck Depression Inventory, in patients with psoriasis","volume":"209","author":"D Pietrzak","year":"2017","journal-title":"J Affect Disord"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.ad.2013.04.014","article-title":"Mental health self-assessment in patients with moderate to severe psoriasis: an observational, multicenter study of 1164 patients in Spain (the VACAP Study)","volume":"104","author":"RM Pujol","year":"2013","journal-title":"Actas Dermosifiliogr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/bjd.12371","article-title":"Psychological differences between early- and late-onset psoriasis: a study of personality traits, anxiety and depression in psoriasis","volume":"169","author":"C Remrod","year":"2013","journal-title":"Br J Dermatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/jdv.13615","article-title":"A prospective cross-sectional study of anxiety and depression in patients with psoriasis in Singapore","volume":"30","author":"SI Tee","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1046\/j.1468-3083.2002.00467.x","article-title":"Assessment of depression in subjects with psoriasis vulgaris and lichen planus","volume":"16","author":"A Akay","year":"2002","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/jamadermatol.2015.3605","article-title":"Psoriasis and the risk of depression in the US population: National Health and Nutrition Examination Survey 2009\u20132012","volume":"152","author":"BE Cohen","year":"2016","journal-title":"JAMA Dermatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jad.2015.04.044","article-title":"IL-6, IL-18, sIL-2R, and TNFalpha proinflammatory markers in depression and schizophrenia patients who are free of overt inflammation","volume":"182","author":"HK Al-Hakeim","year":"2015","journal-title":"J Affect Disord"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000447777","article-title":"Obesity, type 1 diabetes, and psoriasis: an autoimmune triple flip","volume":"84","author":"M Granata","year":"2017","journal-title":"Pathobiology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033291709005558","article-title":"Not fade away: the HPA axis and depression","volume":"40","author":"PJ Cowen","year":"2010","journal-title":"Psychol Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/j.1365-2133.2010.09984.x","article-title":"How stress gets under the skin: cortisol and stress reactivity in psoriasis","volume":"163","author":"AW Evers","year":"2010","journal-title":"Br J Dermatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.pnpbp.2010.04.011","article-title":"Glucocorticoids, cytokines and brain abnormalities in depression","volume":"35","author":"PA Zunszain","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref22","first-page":"133","article-title":"Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases","volume":"28","author":"AD Hock","year":"2014","journal-title":"In Vivo"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2016.03.022","article-title":"The role of vitamin D in the prevention of late-life depression","volume":"198","author":"OI Okereke","year":"2016","journal-title":"J Affect Disord"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4103\/0378-6323.159928","article-title":"Vitamin D and skin diseases: A review","volume":"81","author":"B Wadhwa","year":"2015","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1073\/pnas.86.16.6367","article-title":"Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes","volume":"86","author":"RM Grossman","year":"1989","journal-title":"Proc Natl Acad Sci. USA"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.4049\/jimmunol.0803721","article-title":"IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells","volume":"183","author":"WA Goodman","year":"2009","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cca.2008.04.005","article-title":"Cytokines and anticytokines in psoriasis","volume":"394","author":"A Pietrzak","year":"2008","journal-title":"Clin Chim Acta"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/13547500600565735","article-title":"Plasma and scales levels of interleukin 18 in comparison with other possible clinical and laboratory biomarkers of psoriasis activity","volume":"11","author":"I Flisiak","year":"2006","journal-title":"Biomarkers"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/ijd.12790","article-title":"The role of vitamin D in psoriasis: a review","volume":"54","author":"T Soleymani","year":"2015","journal-title":"Int J Dermatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/oby.2011.404","article-title":"Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity","volume":"20","author":"AT Drincic","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","article-title":"Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors","volume":"35","author":"M Berk","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Y Dowlati","year":"2010","journal-title":"Biol Psychiatry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.psyneuen.2016.07.001","article-title":"Effects of interleukin-6, interleukin-18, and statin use, evaluated at acute stroke, on post-stroke depression during 1-year follow-up","volume":"72","author":"HJ Kang","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2147\/NDT.S124630","article-title":"Long-term bicycle riding ameliorates the depression of the patients undergoing hemodialysis by affecting the levels of interleukin-6 and interleukin-18","volume":"13","author":"C Zhao","year":"2016","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11011-008-9118-1","article-title":"The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression","volume":"24","author":"M Maes","year":"2009","journal-title":"Metab Brain Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1017\/S0033291708003723","article-title":"Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study","volume":"39","author":"D Gimeno","year":"2009","journal-title":"Psychol Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis","volume":"71","author":"MB Howren","year":"2009","journal-title":"Psychosom Med"},{"key":"ref38","article-title":"Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions","author":"N Kappelmann","year":"2016","journal-title":"Mol Psychiatry"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1756-185X.2011.01673.x","article-title":"The role of interleukin (IL)-17 in anxiety and depression of patients with rheumatoid arthritis","volume":"15","author":"Y Liu","year":"2012","journal-title":"Int J Rheum Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1017\/S1092852915000449","article-title":"Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut\u2013brain pathways","volume":"21","author":"M Martin-Subero","year":"2016","journal-title":"CNS Spectr"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.pnpbp.2010.06.014","article-title":"Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression","volume":"35","author":"M Maes","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.biopsych.2012.09.021","article-title":"Inflammatory T helper 17 cells promote depression-like behavior in mice","volume":"73","author":"E Beurel","year":"2013","journal-title":"Biol Psychiatry"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1111\/jdv.14460","article-title":"Depression and Suicidality in Psoriasis: Review of the Literature Including the Cytokine Theory of Depression","volume":"31","author":"J Koo","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.bbi.2011.05.002","article-title":"Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder","volume":"25","author":"ME Sublette","year":"2011","journal-title":"Brain Behav Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.biopsych.2010.10.014","article-title":"Association of plasma interleukin-18 levels with emotion regulation and \u03bc-opioid neurotransmitter function in major depression and healthy volunteers","volume":"69","author":"AR Prossin","year":"2011","journal-title":"Biol Psychiatry"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1523\/JNEUROSCI.17-24-09473.1997","article-title":"Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice","volume":"17","author":"J Raber","year":"1997","journal-title":"J Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: classical theories and new developments","volume":"31","author":"CM Pariante","year":"2008","journal-title":"Trends Neurosci SL"},{"key":"ref48","first-page":"1675","article-title":"Peripheral blood regulatory T cell measurements correlate with serum vitamin D level in patients with psoriasis","volume":"20","author":"C Mattozzi","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jphotobiol.2010.05.008","article-title":"Vitamin D status in psoriasis patients during different treatments with phototherapy","volume":"101","author":"A Osmancevic","year":"2010","journal-title":"J Photochem Photobiol B"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2340\/00015555-1685","article-title":"Narrow-band ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation","volume":"94","author":"MJ Ala-Houhala","year":"2014","journal-title":"Acta Derm Venereol"},{"key":"ref51","article-title":"How ultraviolet light touches the brain and endocrine system through skin, and why","author":"AT Slominski","year":"2018","journal-title":"Endocrinology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1096\/fj.07-9326rev","article-title":"Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?","volume":"22","author":"JC McCann","year":"2008","journal-title":"FASEB J"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jad.2016.08.082","article-title":"Vitamin D and depression","volume":"208","author":"GB Parker","year":"2017","journal-title":"J Affect Disord"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"AH Miller","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchemneu.2004.08.006","article-title":"Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain","volume":"29","author":"DW Eyles","year":"2005","journal-title":"J Chem Neuroanat"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1043-2760(01)00547-1","article-title":"New clues about vitamin D functions in the nervous system","volume":"13","author":"E Garcion","year":"2002","journal-title":"Trends Endocrinol Metab"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0306-4522(01)00049-5","article-title":"Evidence of functional vitamin D receptors in rat hippocampus","volume":"104","author":"MC Langub","year":"2001","journal-title":"Neuroscience"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1096\/fj.14-268342","article-title":"Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior","volume":"29","author":"RP Patrick","year":"2015","journal-title":"FASEB J"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"14875","DOI":"10.1038\/srep14875","article-title":"Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland","volume":"5","author":"AT Slominski","year":"2015","journal-title":"Sci Rep"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jsbmb.2013.10.012","article-title":"The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions","volume":"144","author":"AT Slominski","year":"2014","journal-title":"J Steroid Biochem Mol Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0201589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T12:42:17Z","timestamp":1540212137000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0201589"}},"subtitle":[],"editor":[{"given":"Sinan","family":"Guloksuz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":60,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0201589","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,8,9]]}}}