{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:56:28Z","timestamp":1791950188708,"version":"4.3.4"},"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21 AA0022396"],"award-info":[{"award-number":["R21 AA0022396"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0201659","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T17:44:23Z","timestamp":1533145463000},"page":"e0201659","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Retinal Wnt signaling defect in a zebrafish fetal alcohol spectrum disorder model"],"prefix":"10.1371","volume":"13","author":[{"given":"Pooja","family":"Muralidharan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapnalee","family":"Sarmah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3449-7126","authenticated-orcid":true,"given":"James A.","family":"Marrs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrn3767","article-title":"Intrinsically different retinal progenitor cells produce specific types of progeny","volume":"15","author":"C Cepko","year":"2014","journal-title":"Nature reviews Neuroscience"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0959-4388(99)80005-1","article-title":"The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates","volume":"9","author":"CL Cepko","year":"1999","journal-title":"Current opinion in neurobiology"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0959-437X(97)80013-5","article-title":"Cellular diversification in the vertebrate retina","volume":"7","author":"WA Harris","year":"1997","journal-title":"Current opinion in genetics & development"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.stem.2011.11.004","article-title":"Fate restriction and multipotency in retinal stem cells","volume":"9","author":"L Centanin","year":"2011","journal-title":"Cell stem cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0074-7696(06)59005-9","article-title":"Neurogenesis in the fish retina","volume":"259","author":"DL Stenkamp","year":"2007","journal-title":"International review of cytology"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1002\/dvdy.21721","article-title":"The developmental sequence of gene expression within the rod photoreceptor lineage in embryonic zebrafish","volume":"237","author":"SM Nelson","year":"2008","journal-title":"Developmental dynamics: an official publication of the American Association of Anatomists"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/cne.903590403","article-title":"Developmental patterning of rod and cone photoreceptors in embryonic zebrafish","volume":"359","author":"PA Raymond","year":"1995","journal-title":"The Journal of comparative neurology"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0012-1606(87)90338-1","article-title":"Germinal cells in the goldfish retina that produce rod photoreceptors","volume":"122","author":"PA Raymond","year":"1987","journal-title":"Developmental biology"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0092-8674(00)81538-X","article-title":"p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina","volume":"99","author":"S Ohnuma","year":"1999","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-213X-6-36","article-title":"Molecular characterization of retinal stem cells and their niches in adult zebrafish","volume":"6","author":"PA Raymond","year":"2006","journal-title":"BMC developmental biology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.042308.113259","article-title":"From progenitors to differentiated cells in the vertebrate retina","volume":"25","author":"M Agathocleous","year":"2009","journal-title":"Annual review of cell and developmental biology"},{"issue":"19","key":"ref12","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1242\/dev.040451","article-title":"A directional Wnt\/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina","volume":"136","author":"M Agathocleous","year":"2009","journal-title":"Development (Cambridge, England)"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1634\/stemcells.2007-0900","article-title":"Canonical Wnt signaling controls proliferation of retinal stem\/progenitor cells in postembryonic Xenopus eyes","volume":"26","author":"T Denayer","year":"2008","journal-title":"Stem cells (Dayton, Ohio)"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1242\/dev.00244","article-title":"Wnt2b controls retinal cell differentiation at the ciliary marginal zone","volume":"130","author":"F Kubo","year":"2003","journal-title":"Development (Cambridge, England)"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1242\/dev.01856","article-title":"Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes","volume":"132","author":"F Kubo","year":"2005","journal-title":"Development (Cambridge, England)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1749-8104-7-30","article-title":"beta-catenin\/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina","volume":"7","author":"JR Meyers","year":"2012","journal-title":"Neural development"},{"issue":"36","key":"ref17","doi-asserted-by":"crossref","first-page":"13409","DOI":"10.1073\/pnas.0601634103","article-title":"Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development","volume":"103","author":"LD Nadauld","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/dvdy.22325","article-title":"Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebrafish eye","volume":"239","author":"WZ Stephens","year":"2010","journal-title":"Developmental dynamics: an official publication of the American Association of Anatomists"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuron.2005.02.023","article-title":"Frizzled 5 signaling governs the neural potential of progenitors in the developing Xenopus retina","volume":"46","author":"TJ Van Raay","year":"2005","journal-title":"Neuron"},{"issue":"13","key":"ref20","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1242\/dev.01881","article-title":"Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways","volume":"132","author":"M Yamaguchi","year":"2005","journal-title":"Development (Cambridge, England)"},{"issue":"23","key":"ref21","doi-asserted-by":"crossref","first-page":"13298","DOI":"10.1073\/pnas.93.23.13298","article-title":"Retinoic acid alters photoreceptor development in vivo","volume":"93","author":"GA Hyatt","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1242\/dev.122.1.195","article-title":"Retinoic acid establishes ventral retinal characteristics","volume":"122","author":"GA Hyatt","year":"1996","journal-title":"Development (Cambridge, England)"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0896-6273(00)00034-9","article-title":"Midline signals regulate retinal neurogenesis in zebrafish","volume":"27","author":"I Masai","year":"2000","journal-title":"Neuron"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ydbio.2005.08.045","article-title":"Targeted effects of retinoic acid signaling upon photoreceptor development in zebrafish","volume":"287","author":"SN Prabhudesai","year":"2005","journal-title":"Developmental biology"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1242\/dev.130922","article-title":"Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish","volume":"143","author":"LE Valdivia","year":"2016","journal-title":"Development (Cambridge, England)"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.preteyeres.2011.06.004","article-title":"The rod photoreceptor lineage of teleost fish","volume":"30","author":"DL Stenkamp","year":"2011","journal-title":"Progress in retinal and eye research"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ydbio.2004.11.018","article-title":"Notch-Delta signaling is required for spatial patterning and Muller glia differentiation in the zebrafish retina","volume":"278","author":"RL Bernardos","year":"2005","journal-title":"Developmental biology"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/eye.2009.30","article-title":"Ocular teratogens: old acquaintances and new dangers","volume":"23","author":"A Tandon","year":"2009","journal-title":"Eye (London, England)"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ntt.2004.06.011","article-title":"Ethanol exposure alters zebrafish development: a novel model of fetal alcohol syndrome","volume":"26","author":"J Bilotta","year":"2004","journal-title":"Neurotoxicology and teratology"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0892-0362(02)00319-7","article-title":"Effects of embryonic exposure to ethanol on zebrafish visual function","volume":"24","author":"J Bilotta","year":"2002","journal-title":"Neurotoxicology and teratology"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.alcohol.2014.11.001","article-title":"Zebrafish retinal defects induced by ethanol exposure are rescued by retinoic acid and folic acid supplement","volume":"49","author":"P Muralidharan","year":"2015","journal-title":"Alcohol (Fayetteville, NY)"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1017\/S0952523807070423","article-title":"Mechanisms for persistent microphthalmia following ethanol exposure during retinal neurogenesis in zebrafish embryos","volume":"24","author":"B Kashyap","year":"2007","journal-title":"Visual neuroscience"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1017\/S095252389916303X","article-title":"Neurogenesis in the visual system of embryonic and adult zebrafish (Danio rerio). off","volume":"16","author":"RC Marcus","year":"1999","journal-title":"Visual neuroscience"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ntt.2013.05.006","article-title":"Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway","volume":"38","author":"HY Chung","year":"2013","journal-title":"Neurotoxicology and teratology"},{"issue":"1\u20132","key":"ref35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.brainresrev.2011.02.001","article-title":"The role of oxidative stress in fetal alcohol spectrum disorders","volume":"67","author":"PS Brocardo","year":"2011","journal-title":"Brain research reviews"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3390\/brainsci3020964","article-title":"Fetal Alcohol Spectrum Disorder (FASD) Associated Neural Defects: Complex Mechanisms and Potential Therapeutic Targets","volume":"3","author":"P Muralidharan","year":"2013","journal-title":"Brain sciences"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1242\/bio.20135546","article-title":"Ethanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects","volume":"2","author":"S Sarmah","year":"2013","journal-title":"Biology open"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3727\/096368909X12483162197204","article-title":"Cellular epigenetic modifications of neural stem cell differentiation","volume":"18","author":"RP Singh","year":"2009","journal-title":"Cell transplantation"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1530-0277.2010.01391.x","article-title":"Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation","volume":"35","author":"FC Zhou","year":"2011","journal-title":"Alcoholism, clinical and experimental research"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1111\/j.1530-0277.2011.01445.x","article-title":"Ethanol influences on Bax translocation, mitochondrial membrane potential, and reactive oxygen species generation are modulated by vitamin E and brain-derived neurotrophic factor","volume":"35","author":"MB Heaton","year":"2011","journal-title":"Alcoholism, clinical and experimental research"},{"issue":"5\u20136","key":"ref41","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1242\/dmm.001420","article-title":"Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation","volume":"2","author":"H Kot-Leibovich","year":"2009","journal-title":"Disease models & mechanisms"},{"issue":"7\u20138","key":"ref42","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.alcohol.2009.03.004","article-title":"Zebrafish fetal alcohol syndrome model: effects of ethanol are rescued by retinoic acid supplement","volume":"44","author":"JA Marrs","year":"2010","journal-title":"Alcohol (Fayetteville, NY)"},{"issue":"2\u20133","key":"ref43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0304-3940(99)00144-5","article-title":"Vitamin E and beta-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome","volume":"263","author":"JJ Mitchell","year":"1999","journal-title":"Neuroscience letters"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/dvdy.24015","article-title":"Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid","volume":"242","author":"S Sarmah","year":"2013","journal-title":"Developmental dynamics: an official publication of the American Association of Anatomists"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"75.e7","DOI":"10.1016\/j.ajog.2010.03.017","article-title":"Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate","volume":"203","author":"M Serrano","year":"2010","journal-title":"American journal of obstetrics and gynecology"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ydbio.2004.12.014","article-title":"Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels","volume":"279","author":"R Yelin","year":"2005","journal-title":"Developmental biology"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1530-0277.1991.tb00562.x","article-title":"A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step","volume":"15","author":"G Duester","year":"1991","journal-title":"Alcoholism, clinical and experimental research"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0014-4800(71)90095-5","article-title":"The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina","volume":"15","author":"E Mezey","year":"1971","journal-title":"Experimental and molecular pathology"},{"issue":"5","key":"ref49","first-page":"S18-30","article-title":"Folate and antifolate pharmacology","volume":"24","author":"B Kamen","year":"1997","journal-title":"Seminars in oncology"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"e38057","DOI":"10.1371\/journal.pone.0038057","article-title":"Folic acid transport to the human fetus is decreased in pregnancies with chronic alcohol exposure","volume":"7","author":"JR Hutson","year":"2012","journal-title":"PloS one"},{"issue":"9","key":"ref51","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1523\/JNEUROSCI.5230-07.2008","article-title":"Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells","volume":"28","author":"N Obholzer","year":"2008","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.mod.2009.07.002","article-title":"Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas","volume":"126","author":"MJ Parsons","year":"2009","journal-title":"Mechanisms of development"},{"issue":"8","key":"ref53","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.modgep.2006.04.006","article-title":"GFAP transgenic zebrafish","volume":"6","author":"RL Bernardos","year":"2006","journal-title":"Gene expression patterns: GEP"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ydbio.2012.07.016","article-title":"Visualization and exploration of Tcf\/Lef function using a highly responsive Wnt\/beta-catenin signaling-reporter transgenic zebrafish","volume":"370","author":"N Shimizu","year":"2012","journal-title":"Developmental biology"},{"key":"ref55","article-title":"The zebrafish book","author":"M Westerfield","year":"2000"},{"issue":"8","key":"ref56","doi-asserted-by":"crossref","first-page":"e22991","DOI":"10.1371\/journal.pone.0022991","article-title":"Phenothiourea sensitizes zebrafish cranial neural crest and extraocular muscle development to changes in retinoic acid and IGF signaling","volume":"6","author":"BL Bohnsack","year":"2011","journal-title":"PloS one"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/dvdy.23729","article-title":"Zebrafish cadherin-11 participates in retinal differentiation and retinotectal axon projection during visual system development","volume":"241","author":"SG Clendenon","year":"2012","journal-title":"Developmental dynamics: an official publication of the American Association of Anatomists"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"e10367","DOI":"10.1371\/journal.pone.0010367","article-title":"Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis","volume":"5","author":"S Sarmah","year":"2010","journal-title":"PloS one"},{"issue":"25","key":"ref59","doi-asserted-by":"crossref","DOI":"10.3791\/1229","article-title":"Zebrafish whole mount high-resolution double fluorescent in situ hybridization","author":"T Brend","year":"2009","journal-title":"Journal of visualized experiments: JoVE"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"6","key":"ref61","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.alcohol.2014.06.003","article-title":"Developmental age strengthens barriers to ethanol accumulation in zebrafish","volume":"48","author":"CB Lovely","year":"2014","journal-title":"Alcohol (Fayetteville, NY)"},{"issue":"3\u20134","key":"ref62","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mod.2008.11.009","article-title":"NeuroD regulates proliferation of photoreceptor progenitors in the retina of the zebrafish","volume":"126","author":"MJ Ochocinska","year":"2009","journal-title":"Mechanisms of development"},{"issue":"6","key":"ref63","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities","volume":"169","author":"R Nusse","year":"2017","journal-title":"Cell"},{"issue":"5","key":"ref64","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1001\/jama.2017.21896","article-title":"Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities","volume":"319","author":"PA May","year":"2018","journal-title":"Jama"},{"issue":"3","key":"ref65","first-page":"159","article-title":"Estimating the prevalence of fetal alcohol syndrome","volume":"25","author":"PA May","year":"2001","journal-title":"A summary. Alcohol research & health: the journal of the National Institute on Alcohol Abuse and Alcoholism"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/ddrr.68","article-title":"Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies","volume":"15","author":"PA May","year":"2009","journal-title":"Developmental disabilities research reviews"},{"issue":"4","key":"ref67","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0039-6257(87)90028-2","article-title":"Ocular involvement in the fetal alcohol syndrome","volume":"31","author":"K Stromland","year":"1987","journal-title":"Survey of ophthalmology"},{"issue":"9","key":"ref68","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/bdra.20385","article-title":"Perturbation of retinoic acid (RA)-mediated limb development suggests a role for diminished RA signaling in the teratogenesis of ethanol","volume":"79","author":"CS Johnson","year":"2007","journal-title":"Birth defects research Part A, Clinical and molecular teratology"},{"issue":"9","key":"ref69","first-page":"1644","article-title":"Ethanol-induced microphthalmia is not mediated by changes in retinoic acid or sonic hedgehog signaling during retinal neurogenesis","volume":"35","author":"B Kashyap","year":"2011","journal-title":"Alcoholism, clinical and experimental research"},{"issue":"5","key":"ref70","doi-asserted-by":"crossref","first-page":"e98080","DOI":"10.1371\/journal.pone.0098080","article-title":"Ethanol-induced transcriptional activation of programmed cell death 4 (Pdcd4) is mediated by GSK-3beta signaling in rat cortical neuroblasts","volume":"9","author":"AK Riar","year":"2014","journal-title":"PloS one"},{"issue":"3","key":"ref71","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/humrep\/den439","article-title":"Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation","volume":"24","author":"LL Wang","year":"2009","journal-title":"Human reproduction (Oxford, England)"},{"issue":"22","key":"ref72","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1242\/dev.090738","article-title":"A self-renewing division of zebrafish Muller glial cells generates neuronal progenitors that require N-cadherin to regenerate retinal neurons","volume":"140","author":"M Nagashima","year":"2013","journal-title":"Development (Cambridge, England)"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"340296","DOI":"10.1155\/2012\/340296","article-title":"The role of immunoglobulin superfamily cell adhesion molecules in cancer metastasis","volume":"2012","author":"C Wai Wong","year":"2012","journal-title":"International journal of cell biology"},{"issue":"26","key":"ref74","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1523\/JNEUROSCI.1624-07.2007","article-title":"Late-stage neuronal progenitors in the retina are radial Muller glia that function as retinal stem cells","volume":"27","author":"RL Bernardos","year":"2007","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"3","key":"ref75","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ntt.2006.02.001","article-title":"Teratogenic effects of ethanol exposure on zebrafish visual system development","volume":"28","author":"FJ Arenzana","year":"2006","journal-title":"Neurotoxicology and teratology"},{"issue":"4","key":"ref76","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1067\/mpa.2000.105278","article-title":"Clinical and electroretinographic findings in fetal alcohol syndrome","volume":"4","author":"TE Hug","year":"2000","journal-title":"Journal of AAPOS: the official publication of the American Association for Pediatric Ophthalmology and Strabismus"},{"issue":"11","key":"ref77","first-page":"2861","article-title":"Prenatal ethanol exposure alters scotopic and photopic components of adult rat electroretinograms","volume":"32","author":"LM Katz","year":"1991","journal-title":"Investigative ophthalmology & visual science"},{"issue":"10","key":"ref78","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1167\/iovs.05-0971","article-title":"Effects of ethanol on photoreceptors and visual function in developing zebrafish","volume":"47","author":"JI Matsui","year":"2006","journal-title":"Investigative ophthalmology & visual science"},{"issue":"1","key":"ref79","first-page":"238","article-title":"Motor Function Deficits Following Chronic Prenatal Ethanol Exposure are Linked to Impairments in Insulin\/IGF, Notch and Wnt Signaling in the Cerebellum","volume":"4","author":"M Tong","year":"2013","journal-title":"Journal of diabetes & metabolism"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1471-4159.2011.07273.x","article-title":"CaMKII activation is a novel effector of alcohol's neurotoxicity in neural crest stem\/progenitor cells","volume":"118","author":"A Garic","year":"2011","journal-title":"Journal of neurochemistry"},{"key":"ref81","first-page":"41","article-title":"Lithium-mediated protection against ethanol neurotoxicity","volume":"4","author":"J Luo","year":"2010","journal-title":"Frontiers in neuroscience"},{"issue":"4","key":"ref82","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.mehy.2012.01.014","article-title":"Vitamin A, folate, and choline as a possible preventive intervention to fetal alcohol syndrome","volume":"78","author":"MS Ballard","year":"2012","journal-title":"Medical hypotheses"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ntt.2013.06.001","article-title":"Effects of retinoic acid exposure during zebrafish retinogenesis","volume":"40","author":"H Carreno","year":"2013","journal-title":"Neurotoxicology and teratology"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/ncb2586","article-title":"Insm1a-mediated gene repression is essential for the formation and differentiation of Muller glia-derived progenitors in the injured retina","volume":"14","author":"R Ramachandran","year":"2012","journal-title":"Nat Cell Biol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1242\/dev.104380","article-title":"Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation","volume":"141","author":"R Laranjeiro","year":"2014","journal-title":"Development"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"e18431","DOI":"10.1371\/journal.pone.0018431","article-title":"Wnt signaling is required for early development of zebrafish swimbladder","volume":"6","author":"A Yin","year":"2011","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0201659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T16:26:56Z","timestamp":1661704016000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0201659"}},"subtitle":[],"editor":[{"given":"Robert L.","family":"Tanguay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":86,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0201659","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]}}}