{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:32:55Z","timestamp":1784637175525,"version":"3.55.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SALUD-2014-1-233760"],"award-info":[{"award-number":["SALUD-2014-1-233760"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0201676","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T18:10:20Z","timestamp":1533838220000},"page":"e0201676","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["An original Eurasian haplotype, HLA-DRB1*14:54-DQB1*05:03, influences the susceptibility to idiopathic achalasia"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-7221","authenticated-orcid":true,"given":"Janette","family":"Furuzawa-Carballeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Zu\u00f1iga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana I.","family":"Hern\u00e1ndez-Zaragoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0518-4518","authenticated-orcid":true,"given":"Rodrigo","family":"Barquera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Marques-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Jim\u00e9nez-Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Cruz-Lagunas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5311-9633","authenticated-orcid":true,"given":"Nora E.","family":"Regino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7821-3589","authenticated-orcid":true,"given":"Ram\u00f3n","family":"Espinosa-Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond J.","family":"Yunis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Romero-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Azamar-Llamas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Coss-Adame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Valdovinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Torres-Landa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Palacios-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Bre\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Alejandro-Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Hern\u00e1ndez-\u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Granados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Torres-Villalobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/nyas.13176","article-title":"Achalasia: from diagnosis to management","volume":"1381","author":"MF Vaezi","year":"2016","journal-title":"Ann NY Acad Sci"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ajg.2013.196","article-title":"ACG clinical guideline: diagnosis and management of achalasia","volume":"108","author":"MF Vaezi","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"729217","DOI":"10.1155\/2015\/729217","article-title":"Achalasia\u2014An Autoimmune Inflammatory Disease: A Cross-Sectional Study","volume":"2015","author":"J Furuzawa-Carballeda","year":"2015","journal-title":"J Immunol Res"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/BF01297220","article-title":"Achalasia in monozygotic twins","volume":"27","author":"DT Stein","year":"1982","journal-title":"Dig Dis Sci"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF01536254","article-title":"Significant DQw1 association in achalasia","volume":"34","author":"RK Wong","year":"1989","journal-title":"Dig Dis Sci"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1399-0039.1998.tb03059.x","article-title":"Contribution of HLA class II genes to susceptibility in achalasia","volume":"52","author":"EG De la Concha","year":"1998","journal-title":"Tissue Antigens"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1034\/j.1399-0039.2000.560206.x","article-title":"Presence of a protective allele for achalasia on the central region of the major histocompatibility complex","volume":"56","author":"EG de la Concha","year":"2000","journal-title":"Tissue Antigens"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/ng.3029","article-title":"Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia","volume":"46","author":"I Gockel","year":"2014","journal-title":"Nat Genet"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ejhg.2015.262","article-title":"The HLA-DQ\u03b21 insertion is a strong achalasia risk factor and displays a geospatial north-south gradient among Europeans","volume":"24","author":"J Becker","year":"2016","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1399-0039.2003.00098.x","article-title":"Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks","volume":"62","author":"EJ Yunis","year":"2003","journal-title":"Tissue Antigens"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"e74442","DOI":"10.1371\/journal.pone.0074442","article-title":"HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations","volume":"8","author":"J Z\u00fa\u00f1iga","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"ref12","first-page":"791","article-title":"Gene frequencies and admixture estimates in four Mexican urban centers","volume":"62","author":"R Lisker","year":"1990","journal-title":"Hum Biol"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.molimm.2007.07.042","article-title":"HLA class I and class II haplotypes in admixed families from several regions of Mexico","volume":"45","author":"R Barquera","year":"2008","journal-title":"Mol Immunol"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.fsigen.2007.08.017","article-title":"Genetic admixture and diversity estimations in the Mexican Mestizo population from Mexico City using 15 STR polymorphic markers","volume":"2","author":"T Ju\u00e1rez-Cedillo","year":"2008","journal-title":"Forensic Sci Int. Genet"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/nmo.12477","article-title":"The Chicago classification of esophageal motility disorders, v3.0","volume":"27","author":"PJ Kahrilas","year":"2015","journal-title":"Neurogastroenterol Motil"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1399-0039.2010.01616.x","article-title":"Resolution of HLA class I sequence-based typing ambiguities by group-specific sequencing primers","volume":"77","author":"TV Lebedeva","year":"2011","journal-title":"Tissue Antigens"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/nar\/29.1.210","article-title":"IMGT\/HLA Database\u2014a sequence database for the human major histocompatibility complex","volume":"29","author":"J Robinson","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref18","first-page":"47","article-title":"Arlequin (version 3.0): an integrated software package for population genetics data analysis","volume":"1","author":"L Excoffier","year":"2007","journal-title":"Evol Bioinform Online"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF01066731","article-title":"The investigation of linkage between a quantitative trait and a marker locus","volume":"2","author":"JK Haseman","year":"1972","journal-title":"Behav Genet"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/genetics\/164.2.747","article-title":"Maximum Likelihood estimation of admixture proportions from genetic data","volume":"164","author":"J Wang","year":"2003","journal-title":"Genetics"},{"issue":"Pt4","key":"ref21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1046\/j.1469-1809.2002.00118.x","article-title":"Distribution of HLA alleles in Portugal and Cabo Verde. Relationships with the slave trade route","volume":"66","author":"H Sp\u00ednola","year":"2002","journal-title":"Ann Hum Genet"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0198-8859(01)00298-1","article-title":"Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations","volume":"62","author":"K Cao","year":"2001","journal-title":"Hum Immunol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.0001-2815.2004.00192.x","article-title":"Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci","volume":"63","author":"K Cao","year":"2004","journal-title":"Tissue Antigens"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0198-8859(01)00212-9","article-title":"HLA diversity, differentiation, and haplotype evolution in Mesoamerican Natives","volume":"62","author":"JA Hollenbach","year":"2001","journal-title":"Hum Immunol"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1399-0039.2006.00636.x","article-title":"High-resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population","volume":"68","author":"JE Garc\u00eda-Ort\u00edz","year":"2006","journal-title":"Tissue Antigens"},{"key":"ref26","unstructured":"Tratchenberg E, Vinson M, Hayes E, Hsu YM, Houtchens K, Erlich H,et al. Southern Han Chinese from People\u2019s Republic of China. Anthropology\/human genetic diversity population reports. In: Hansen JA (ed.). Immunobiology of the Human MHC: Proceedings of the 13th International Histocompatibility Workshop and Conference. Seattle: IHWG Press. 2006; pp. 616\u2013617."},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/genetics\/164.4.1567","article-title":"Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies","volume":"164","author":"D Falush","year":"2003","journal-title":"Genetics"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0379-0738(00)00422-9","article-title":"Population data of 13 STRS in Southern Spain (Andalusia)","volume":"119","author":"P Sanz","year":"2001","journal-title":"Forensic Sci Int"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00414-004-0505-9","article-title":"The Fang population of Equatorial Guinea characterized by 15 STR-PCR polymorphisms","volume":"119","author":"P Calzada","year":"2005","journal-title":"Int J Legal Med"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00414-004-0488-6","article-title":"Characterisation of three Amerindian populations from Hidalgo State (Mexico) by 15 STR-PCR polymorphisms","volume":"119","author":"C Barrot","year":"2005","journal-title":"Int J Legal Med"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/ajhb.20787","article-title":"Analyzing the genetic structure of the Tepehua in relation to other neighbouring Mesoamerican populations. A study based on allele frequencies of STR markers","volume":"20","author":"A Gonz\u00e1lez-Mart\u00edn","year":"2008","journal-title":"Am J Hum Biol"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ibd.20852","article-title":"Antinuclear antibodies: a marker associated with steroid dependence in patients with ulcerative colitis","volume":"15","author":"J Barahona-Garrido","year":"2009","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/jgh.13839","article-title":"Autoimmune comorbidity in achalasia patients","volume":"33","author":"F Romero-Hern\u00e1ndez","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1013242831900","article-title":"Myenteric antiplexus antibodies and class II HLA in achalasia","volume":"47","author":"A Ruiz-de-Leon","year":"2002","journal-title":"Dig Dis Sci"},{"issue":"7","key":"ref35","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2982.2006.00772.x","article-title":"HLA and enteric antineuronal antibodies in patients with achalasia","volume":"18","author":"A Latiano","year":"2006","journal-title":"Neurogastroenterol motil"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0016-5085(99)70546-9","article-title":"Association of HLA-DR and\u2013DQ alleles with idiopathic achalasia","volume":"117","author":"GN Verne","year":"1999","journal-title":"Gastroenterology"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/jid.2009.241","article-title":"Pemphigus vulgaris in White Europeans is linked with HLA Class II allele HLA DRB1*1454 but not DRB1*1401","volume":"130","author":"M Saha","year":"2010","journal-title":"J Invest Dermatol"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/tan.12796","article-title":"Human leukocyte antigen class II (DRB1 and DQB1) alleles and haplotypes frequencies in patients with pemphigus vulgaris among the Serbian population","volume":"87","author":"D Zivanovic","year":"2016","journal-title":"HLA"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/iji.12052","article-title":"High susceptibility to pemphigus vulgaris due to HLA-DRB1*14:54 in the Slovak population","volume":"40","author":"Z P\u00e1rnick\u00e1","year":"2013","journal-title":"Int J Immunogenet"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1073\/pnas.88.11.5056","article-title":"Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris","volume":"88","author":"AR Ahmed","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1399-0039.1994.tb02390.x","article-title":"HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method","volume":"44","author":"H Niizeki","year":"1994","journal-title":"Tissue Antigens"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/gbe\/evw046","article-title":"Localizing Ashkenazic Jews to Primeval Villages in the Ancient Iranian Lands of Ashkenaz","volume":"8","author":"R Das","year":"2016","journal-title":"Genome Biol Evol"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0198-8859(97)00182-1","article-title":"Identical MHC markers in non-Jewish Iranian and Ashkenazi Jewish patients with pemphigus vulgaris: possible common central Asian ancestral origin","volume":"57","author":"N Mobini","year":"1997","journal-title":"Hum Immunol"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2307\/27502710","article-title":"Small numbers, great impact: Mexico and its migrants, 1821\u20131973","volume":"20","author":"J Buchenau","year":"2001","journal-title":"J Am Ethn His"},{"issue":"4\u20135","key":"ref45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1744-313X.2008.00779.x","article-title":"HLA-A, B, Cw, DRB1, DQB1 and DPB1 alleles and haplotypes in the genetically homogenous Irish population","volume":"35","author":"C Dunne","year":"2008","journal-title":"Int J Immunogenet"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.humimm.2012.01.005","article-title":"Estimation of human leukocyte antigen class I and class II high-resolution allele and haplotype frequencies in the Italian population and comparison with other European populations","volume":"73","author":"S Rendine","year":"2012","journal-title":"Hum Immunol"},{"key":"ref47","first-page":"220","article-title":"The Cambridge survey of world migration","author":"E Hu-Dehart","year":"1995"},{"issue":"12","key":"ref48","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.humimm.2016.10.005","article-title":"HLA-A, -B, -C, and -DRB1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 7595 individuals","volume":"77","author":"J Kwok","year":"2016","journal-title":"Hum Immunol"},{"issue":"9","key":"ref49","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.humimm.2013.06.011","article-title":"HLA and MICA polymorphism in Polynesians and New Zealand Maori: implications for ancestry and health","volume":"74","author":"HA Edinur","year":"2013","journal-title":"Hum Immunol"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1034\/j.1399-0039.2000.550501.x","article-title":"Evolution of Pacific\/Asian populations inferred from HLA class II allele frequency distributions","volume":"55","author":"SJ Mack","year":"2000","journal-title":"Tissue Antigens"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1399-0039.2008.01016.x","article-title":"Multiple sclerosis in Gypsies from southern Spain: prevalence, mitochondrial DNA haplogroups and HLA class II association","volume":"71","author":"O Fern\u00e1ndez","year":"2008","journal-title":"Tissue Antigens"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1399-0039.1992.tb01919.x","article-title":"Comparison of HLA class II alleles in Gypsy and Czech populations by DNA typing with oligonucleotide probes","volume":"39","author":"M Cern\u00e1","year":"1992","journal-title":"Tissue Antigens"},{"key":"ref53","article-title":"Ame sam e rromane d\u017eene [We are the Romani People]","author":"IF Hancock","year":"2001"},{"issue":"24","key":"ref54","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.cub.2012.10.039","article-title":"Reconstructing the population history of European Romani from genome-wide data","volume":"22","author":"I Mendizabal","year":"2012","journal-title":"Curr Biol"},{"issue":"1590","key":"ref55","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1098\/rstb.2011.0312","article-title":"Distinct evolutionary strategies of human leucocyte antigen loci in pathogen-rich environments","volume":"367","author":"A Sanchez-Mazas","year":"2012","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"17","key":"ref56","doi-asserted-by":"crossref","first-page":"11260","DOI":"10.1073\/pnas.162006499","article-title":"MHC heterozygosity confers a selective advantage against multiple-strain infections","volume":"99","author":"DJ Penn","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2004.11.002","article-title":"Tumor necrosis factor-alpha -308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans","volume":"24","author":"AA Rodr\u00edguez-Carre\u00f3n","year":"2005","journal-title":"J Autoimmun"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/096120339600500304","article-title":"The role of HLA-DR alleles and complotypes through the ethnic barrier in systemic lupus erythematosus in Mexicans","volume":"5","author":"J Granados","year":"1996","journal-title":"Lupus"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"e0126727","DOI":"10.1371\/journal.pone.0126727","article-title":"HLA Class I and II Blocks Are Associated to Susceptibility, Clinical Subtypes and Autoantibodies in Mexican Systemic Sclerosis (SSc) Patients","volume":"10","author":"TS Rodriguez-Reyna","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"ref60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1442-2050.2011.01249.x","article-title":"The prevalence of autoimmune disease in patients with esophageal achalasia","volume":"25","author":"JD Booy","year":"2012","journal-title":"Dis Esophagus"},{"issue":"7","key":"ref61","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1111\/j.1572-0241.2008.01967.x","article-title":"Achalasia: virus-induced euthanasia of neurons?","volume":"103","author":"GE Boeckxstaens","year":"2008","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"ref62","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1111\/j.1572-0241.2008.01956.x","article-title":"T cells in the myenteric plexus of achalasia patients show a skewed TCR repertoire and react to HSV-1 antigens","volume":"103","author":"M Facco","year":"2008","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1046\/j.1365-2567.2002.01472.x","article-title":"Glycoprotein B from strain 17 of herpes simplex virus type I contains an invariant chain homologous sequence that binds to MHC class II molecules","volume":"107","author":"E Sievers","year":"2002","journal-title":"Immunology"},{"issue":"6","key":"ref64","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-2982.2009.01284.x","article-title":"Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene","volume":"21","author":"F Paladini","year":"2009","journal-title":"Neurogastroenterol Motil"},{"issue":"35","key":"ref65","doi-asserted-by":"crossref","first-page":"7892","DOI":"10.3748\/wjg.v22.i35.7892","article-title":"New insights into the pathophysiology of achalasia and implications for future treatment","volume":"22","author":"J Furuzawa-Carballeda","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"2","key":"ref66","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/2050640616648870","article-title":"Allele-specific transcriptional activity of the variable number of tandem repeats of the inducible nitric oxide synthase gene is associated with idiopathic achalasia","volume":"5","author":"G Sarnelli","year":"2017","journal-title":"United European Gastroenterol J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0201676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:50:25Z","timestamp":1693813825000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0201676"}},"subtitle":[],"editor":[{"given":"Farook","family":"Thameem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":66,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0201676","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]}}}