{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:33:04Z","timestamp":1792801984063,"version":"4.5.0"},"reference-count":110,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union 6th Framework Program for Research and Technological Development","award":["VALAPODYN, contract # LSHG-CT-2006-037277"],"award-info":[{"award-number":["VALAPODYN, contract # LSHG-CT-2006-037277"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0201742","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T13:33:14Z","timestamp":1534426394000},"page":"e0201742","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-2255","authenticated-orcid":true,"given":"Georgia","family":"Kalozoumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kel-Margoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Vafiadaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermona","family":"Soreq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Depaulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Sanoudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,16]]},"reference":[{"key":"ref1","article-title":"Advancing research diagnostic criteria for Alzheimer&apos;s disease: the IWG-2 criteria","author":"B Dubois","year":"2014"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1212\/01.wnl.0000398451.98153.85","article-title":"Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy: An MRI volumetric study","volume":"76","author":"F Cendes","year":"2011","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1474-4422(10)70310-0","article-title":"Mechanisms of epileptogenesis and potential treatment targets","volume":"10","author":"A Pitk\u00e4nen","year":"2011","journal-title":"The Lancet Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3171\/jns.1995.82.2.0220","article-title":"Influence of the type of initial precipitating injury and at what age it occurs on course and outcome in patients with temporal lobe seizures","volume":"82","author":"GW Mathern","year":"1995","journal-title":"J Neurosurg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0920-1211(96)00052-6","article-title":"The pathogenic and progressive features of chronic human hippocampal epilepsy","volume":"26","author":"GW Mathern","year":"1996","journal-title":"Epilepsy Research"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/107385840100700410","article-title":"Mesial temporal lobe epilepsy: what have we learned?","volume":"7","author":"J. Engel","year":"2001","journal-title":"The Neuroscientist"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.yebeh.2015.08.037","article-title":"The enigma of the latent period in the development of symptomatic acquired epilepsy\u2014Traditional view versus new concepts","volume":"52","author":"W L\u00f6scher","year":"2015","journal-title":"Epilepsy Behav"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molbrainres.2005.08.005","article-title":"Gene profiling the response to kainic acid induced seizures","volume":"141","author":"JG Hunsberger","year":"2005","journal-title":"Molecular Brain Research"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1177\/0192623309344202","article-title":"Kainic Acid-induced F-344 Rat model of Mesial Temporal Lobe Epilepsy: Gene Expression and Canonical Pathways","volume":"37","author":"AK Sharma","year":"2009","journal-title":"Toxicologic Pathology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e10733","DOI":"10.1371\/journal.pone.0010733","article-title":"Transcriptome Analysis of the Hippocampal CA1 Pyramidal Cell Region after Kainic Acid-Induced Status Epilepticus in Juvenile Rats","volume":"5","author":"HB Laur\u00e9n","year":"2010","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1471-2164-11-230","article-title":"Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis","volume":"11","author":"OK Okamoto","year":"2010","journal-title":"BMC Genomics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"11083","DOI":"10.1523\/JNEUROSCI.2766-06.2006","article-title":"Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy","volume":"26","author":"JA Gorter","year":"2006","journal-title":"The Journal of Neuroscience"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/j.1460-9568.2010.07403.x","article-title":"Gene expression analysis of the emergence of epileptiform activity after focal injection of kainic acid into mouse hippocampus","volume":"32","author":"D Motti","year":"2010","journal-title":"European Journal of Neuroscience"},{"key":"ref14","first-page":"1","article-title":"RNA sequencing reveals region- specific molecular mechanisms associated with epileptogenesis in a model of classical hippocampal sclerosis","author":"AS Vieira","year":"2016","journal-title":"Nature Publishing Group"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1750-3639.2008.00254.x","article-title":"Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion?","volume":"20","author":"YY Wang","year":"2010","journal-title":"Brain Pathology"},{"key":"ref16","first-page":"515","article-title":"Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy","volume":"5","author":"Y Ben-Ari","year":"1980","journal-title":"NSC"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1684\/epd.2012.0528","article-title":"Animal models to study aetiopathology of epilepsy: what are the features to model?","volume":"14","author":"I Guillemain","year":"2012","journal-title":"Epileptic Disord"},{"key":"ref18","first-page":"717","article-title":"Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy","volume":"89","author":"V Bouilleret","year":"1999","journal-title":"NSC"},{"key":"ref19","first-page":"101","article-title":"Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy","volume":"112","author":"V Riban","year":"2002","journal-title":"NSC"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroimage.2007.07.016","article-title":"Short-term changes in bilateral hippocampal coherence precede epileptiform events","volume":"38","author":"R Meier","year":"2007","journal-title":"NeuroImage"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2011.01.001","article-title":"Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy","volume":"42","author":"C Heinrich","year":"2011","journal-title":"Neurobiology of Disease"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neurol.2015.01.558","article-title":"Animal models for mesiotemporal lobe epilepsy: The end of a misunderstanding?","volume":"171","author":"A Depaulis","year":"2015","journal-title":"Revue Neurologique"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1111\/j.1460-9568.2005.04386.x","article-title":"Disruption of the neurogenic potential of the dentate gyrus in a mouse model of temporal lobe epilepsy with focal seizures","volume":"22","author":"JE Kralic","year":"2005","journal-title":"European Journal of Neuroscience"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1523\/JNEUROSCI.5516-05.2006","article-title":"Reelin Deficiency and Displacement of Mature Neurons, But Not Neurogenesis, Underlie the Formation of Granule Cell Dispersion in the Epileptic Hippocampus","volume":"26","author":"C Heinrich","year":"2006","journal-title":"The Journal of Neuroscience"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"17530","DOI":"10.1073\/pnas.0708301104","article-title":"Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy","volume":"104","author":"T Dugladze","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1528-1167.2008.01595.x","article-title":"Granule cell dispersion develops without neurogenesis and does not fully depend on astroglial cell generation in a mouse model of temporal lobe epilepsy","volume":"49","author":"N Nitta","year":"2008","journal-title":"Epilepsia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.expneurol.2007.11.012","article-title":"Botulinum neurotoxin E (BoNT\/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy","volume":"210","author":"F Antonucci","year":"2008","journal-title":"Experimental Neurology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nm.2127","article-title":"Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures","volume":"16","author":"M Maroso","year":"2010","journal-title":"Nature Medicine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/cns.12523","article-title":"Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy","volume":"22","author":"V Duveau","year":"2016","journal-title":"CNS Neurosci Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1111\/j.1528-1167.2011.03273.x","article-title":"Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy","volume":"52","author":"F Pernot","year":"2011","journal-title":"Epilepsia"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1073\/pnas.0330960100","article-title":"Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle","volume":"100","author":"D Sanoudou","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.metabol.2016.03.005","article-title":"Ciliary neurotrophic factor upregulates follistatin and Pak1, causes overexpression of muscle differentiation related genes and downregulation of established atrophy mediators in skeletal muscle","volume":"65","author":"A Tsompanidis","year":"2016","journal-title":"Metabolism\u2014Clinical and Experimental"},{"key":"ref33","first-page":"835","volume":"466","author":"H Guo","year":"2010"},{"key":"ref34","article-title":"MicroRNA mir-346 targets the 5\u2032-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression","author":"NP Tsai","year":"2009","journal-title":"Biochemical Journal"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.0013-9580.2005.35504.x","article-title":"Glutamate receptor antagonists and benzodiazepine inhibit the progression of granule cell dispersion in a mouse model of mesial temporal lobe epilepsy","volume":"46","author":"F Suzuki","year":"2005","journal-title":"Epilepsia"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/epi.12297","article-title":"Issues related to development of antiepileptogenic therapies","volume":"54","author":"A Pitk\u00e4nen","year":"2013","journal-title":"Epilepsia"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.1460-9568.1999.00401.x","article-title":"Prolonged expression of zinc finger immediate-early gene mRNAs and decreased protein synthesis following kainic acid induced seizures","volume":"11","author":"J Honkaniemi","year":"1999","journal-title":"Eur J Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2202-11-9","article-title":"Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats","volume":"11","author":"KV Christensen","year":"2010","journal-title":"BMC Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.brainres.2007.10.102","article-title":"mRNA expression of activity-regulated cytoskeleton-associated protein (arc) in the amygdala-kindled rats","volume":"1189","author":"K Akiyama","year":"2008","journal-title":"Brain Research"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"9245","DOI":"10.1523\/JNEUROSCI.18-22-09245.1998","article-title":"Nonobligate role of early or sustained expression of immediate-early gene proteins c-fos, c-jun, and Zif\/268 in hippocampal mossy fiber sprouting","volume":"18","author":"WK Nahm","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuroscience.2011.03.072","article-title":"Induction of c-Fos, Zif268, and Arc from acute bouts of voluntary wheel running in new and pre-existing adult mouse hippocampal granule neurons","volume":"184","author":"PJ Clark","year":"2011","journal-title":"Neuroscience"},{"key":"ref42","first-page":"302","volume":"13","author":"Y Ji","year":"2010"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.nlm.2011.08.009","article-title":"Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c","volume":"97","author":"H Gerstein","year":"2012","journal-title":"Neurobiology of Learning and Memory"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1021\/acs.jproteome.6b00003","article-title":"High-Throughput LC-MS\/MS Proteomic Analysis of a Mouse Model of Mesiotemporal Lobe Epilepsy Predicts Microglial Activation Underlying Disease Development","volume":"15","author":"V Bitsika","year":"2016","journal-title":"J Proteome Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/glia.21091","article-title":"Translocator protein (18 kDa)\/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state","volume":"59","author":"J Choi","year":"2011","journal-title":"Glia"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2967\/jnumed.110.086629","article-title":"The translocator protein","volume":"52","author":"AM Scarf","year":"2011","journal-title":"Journal of Nuclear Medicine"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1007\/s11064-011-0576-1","article-title":"Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy","volume":"36","author":"Z Xu","year":"2011","journal-title":"Neurochemical Research"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","article-title":"GFAP in health and disease","volume":"93","author":"J Middeldorp","year":"2011","journal-title":"Prog Neurobiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1046\/j.1460-9568.2000.00131.x","article-title":"Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy","volume":"12","author":"E Aronica","year":"2000","journal-title":"Eur J Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0006-8993(97)01552-7","article-title":"A light and electron microscopic study of cytoplasmic phospholipase A2 and cyclooxygenase-2 in the hippocampus after kainate lesions","volume":"788","author":"TL Sandhya","year":"1998","journal-title":"Brain Research"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2174\/1568006043481239","article-title":"Neuroprotection abilities of cytosolic phospholipase A2 inhibitors in kainic acid-induced neurodegeneration","volume":"4","author":"AA Farooqui","year":"2004","journal-title":"Curr Drug Targets Cardiovasc Haematol Disord"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1523\/JNEUROSCI.5177-11.2012","article-title":"Cdk5\/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration","volume":"32","author":"JR Sundaram","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1742-2094-7-68","article-title":"Kr\u00fcppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation","volume":"7","author":"DK Kaushik","year":"2010","journal-title":"Journal of Neuroinflammation"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1742-2094-9-57","article-title":"Therapeutic targeting of Kr\u00fcppel-like factor 4 abrogates microglial activation","volume":"9","author":"DK Kaushik","year":"2012","journal-title":"Journal of Neuroinflammation"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"12174","DOI":"10.1523\/JNEUROSCI.2289-06.2006","article-title":"Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation","volume":"26","author":"Y Zhang","year":"2006","journal-title":"The Journal of Neuroscience"},{"key":"ref56","article-title":"Cold pre\u2010conditioning neuroprotection depends on TNF\u2010\u03b1 and is enhanced by blockade of interleukin\u201011","author":"HM Mitchell","year":"2011","journal-title":"Journal of \u2026"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.expneurol.2006.08.023","article-title":"Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients","volume":"203","author":"A Fahrner","year":"2007","journal-title":"Experimental Neurology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0304-3940(02)00718-8","article-title":"Immature-like astrocytes are associated with dentate granule cell migration in human temporal lobe epilepsy","volume":"330","author":"A Crespel","year":"2002","journal-title":"Neuroscience Letters"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF02815150","article-title":"Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus","volume":"30","author":"GW Mathern","year":"1997","journal-title":"Molecular and Chemical Neuropathology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.yebeh.2005.06.003","article-title":"New facets of the neuropathology and molecular profile of human temporal lobe epilepsy","volume":"7","author":"NC de Lanerolle","year":"2005","journal-title":"Epilepsy Behav"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1111\/j.1528-1167.2005.00298.x","article-title":"Brain inflammation in epilepsy: experimental and clinical evidence","volume":"46","author":"A Vezzani","year":"2005","journal-title":"Epilepsia"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neulet.2011.02.040","article-title":"Inflammation and prevention of epileptogenesis","volume":"497","author":"T Ravizza","year":"2011","journal-title":"Neuroscience Letters"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"A Vezzani","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fnmol.2012.00066","article-title":"Acetylcholinesterase loosens the brain&apos;s cholinergic anti-inflammatory response and promotes epileptogenesis","volume":"5","author":"Y Gnatek","year":"2012","journal-title":"Front Mol Neurosci"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.nbd.2007.08.012","article-title":"Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy","volume":"29","author":"T Ravizza","year":"2008","journal-title":"Neurobiology of Disease"},{"key":"ref66","first-page":"00086","author":"K Borges","year":"2003"},{"issue":"Suppl 2","key":"ref67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1528-1167.2008.01491.x","article-title":"Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats","volume":"49","author":"LA Shapiro","year":"2008","journal-title":"Epilepsia"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"9133","DOI":"10.1523\/JNEUROSCI.1820-08.2008","article-title":"Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling","volume":"28","author":"E Avignone","year":"2008","journal-title":"The Journal of Neuroscience"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/glia.22516","article-title":"Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus","volume":"61","author":"L Ulmann","year":"2013","journal-title":"Glia"},{"key":"ref70","first-page":"301","article-title":"Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system","volume":"137","author":"T Ravizza","year":"2006","journal-title":"NSC"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1742-2094-6-40","article-title":"Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus","volume":"6","author":"ML Foresti","year":"2009","journal-title":"Journal of Neuroinflammation"},{"key":"ref72","first-page":"425","article-title":"Neurobiology of Disease","volume":"46","author":"J Abraham","year":"2012","journal-title":"Neurobiology of Disease"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroscience.2014.12.021","article-title":"Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus","volume":"287","author":"N Wang","year":"2015","journal-title":"Neuroscience"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1471-4159.2012.07823.x","article-title":"Vimentin participates in microglia activation and neurotoxicity in cerebral ischemia","volume":"122","author":"SX Jiang","year":"2012","journal-title":"Journal of Neurochemistry"},{"key":"ref75","article-title":"microRNAs in the pathophysiology of epilepsy","author":"GP Brennan","year":"2017","journal-title":"Neuroscience Letters"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.nbd.2013.10.026","article-title":"Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy","volume":"62","author":"JA Gorter","year":"2014","journal-title":"Neurobiology of Disease"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jneuroim.2012.07.009","article-title":"Tubby regulates microglial phagocytosis through MerTK","volume":"252","author":"NB Caberoy","year":"2012","journal-title":"Journal of Neuroimmunology"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.expneurol.2017.06.009","article-title":"Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy","volume":"295","author":"SK Wyatt","year":"2017","journal-title":"Experimental Neurology"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1038\/s41598-017-02969-6","article-title":"Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus","volume":"7","author":"R Raoof","year":"2017","journal-title":"Sci Rep"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"e25068","DOI":"10.1371\/journal.pone.0025068","article-title":"Neuronal activity regulates hippocampal miRNA expression","volume":"6","author":"SM Eacker","year":"2011","journal-title":"PLoS One"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbrc.2011.05.004","article-title":"miRNA profiling of bilateral rat hippocampal CA3 by deep sequencing","volume":"409","author":"Y Shinohara","year":"2011","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.nbd.2014.09.011","article-title":"Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis","volume":"73","author":"NM Sosanya","year":"2015","journal-title":"Neurobiology of Disease"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"JD Lambeth","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1471-4159.2011.07572.x","article-title":"Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation","volume":"120","author":"S-H Choi","year":"2012","journal-title":"Journal of Neurochemistry"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"12039","DOI":"10.1523\/JNEUROSCI.3568-08.2008","article-title":"Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase","volume":"28","author":"C Ch\u00e9ret","year":"2008","journal-title":"The Journal of Neuroscience"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/brain\/aws012","article-title":"NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury","volume":"135","author":"MT Fischer","year":"2012","journal-title":"Brain"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1097\/NEN.0b013e3182358e4e","article-title":"Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation","volume":"70","author":"A Guemez-Gamboa","year":"2011","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2202-12-49","article-title":"Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia","volume":"12","author":"Y Huo","year":"2011","journal-title":"BMC Neurosci"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"40151","DOI":"10.1074\/jbc.M111.279711","article-title":"Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity","volume":"286","author":"Q Li","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1742-2094-9-5","article-title":"NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration","volume":"9","author":"L Qin","year":"2012","journal-title":"Journal of Neuroinflammation"},{"key":"ref91","first-page":"654","article-title":"Reactive oxygen species are related to ionic fluxes and volume decrease in apoptotic cerebellar granule neurons: role of NOX enzymes","volume":"117","author":"B Hern\u00e1ndez-Enr\u00edquez","year":"2011","journal-title":"Journal of Neurochemistry"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.biocel.2011.06.001","article-title":"Reactive oxygen species participate in the p38-mediated apoptosis induced by potassium deprivation and staurosporine in cerebellar granule neurons","volume":"43","author":"Y Ramiro-Cort\u00e9s","year":"2011","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"ref93","first-page":"819","volume":"12","author":"N Demaurex","year":"2009"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.nbd.2011.02.012","article-title":"Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1\/2 mechanisms","volume":"42","author":"R Di Maio","year":"2011","journal-title":"Neurobiology of Disease"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.nbd.2012.07.013","article-title":"Thiol oxidation and altered NR2B\/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis","volume":"49","author":"R Di Maio","year":"2013","journal-title":"Neurobiology of Disease"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neulet.2010.08.049","article-title":"Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy","volume":"484","author":"RRF Pestana","year":"2010","journal-title":"Neuroscience Letters"},{"key":"ref97","first-page":"1","article-title":"Post-treatment of an NADPH oxidase inhibitor prevents","author":"JH Kim","year":"2013","journal-title":"Brain Research"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.brainres.2010.08.086","article-title":"Extracellular hydrogen peroxide contributes to oxidative glutamate toxicity","volume":"1359","author":"JS Ha","year":"2010","journal-title":"Brain Research"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1471-4159.2012.07659.x","article-title":"Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial-neuronal interactions","volume":"121","author":"EL Mead","year":"2012","journal-title":"Journal of Neurochemistry"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1471-4159.2004.02838.x","article-title":"Activation of NADPH oxidase and extracellular superoxide production in seizure-induced hippocampal damage","volume":"92","author":"M Patel","year":"2005","journal-title":"Journal of Neurochemistry"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuroscience.2015.07.005","article-title":"Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective","volume":"303","author":"S Williams","year":"2015","journal-title":"Neuroscience"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bbadis.2014.11.016","article-title":"NADPH oxidase activation and 4-hydroxy-2-nonenal\/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy","volume":"1852","author":"A Pecorelli","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"ref103","unstructured":"Paxinos G, Franklin K. The mouse brain in stereotaxic coordinates (Academic, San Diego). 2001."},{"key":"ref104","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/j.1460-9568.2008.06443.x","article-title":"Opening of the blood-brain barrier during isoflurane anaesthesia","volume":"28","author":"S T\u00e9trault","year":"2008","journal-title":"Eur J Neurosci"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/ana.24804","article-title":"Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy","volume":"80","author":"G Bar-Klein","year":"2016","journal-title":"Ann Neurol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1093\/hmg\/ddl186","article-title":"Skeletal muscle repair in a mouse model of nemaline myopathy","volume":"15","author":"D Sanoudou","year":"2006","journal-title":"Human Molecular Genetics"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"VG Tusher","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/tpj.2009.51","article-title":"Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice","volume":"10","author":"D Sanoudou","year":"2010","journal-title":"Pharmacogenomics J"},{"issue":"Suppl 2","key":"ref109","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1186\/1471-2105-7-S2-S13","article-title":"Beyond microarrays: find key transcription factors controlling signal transduction pathways","volume":"7","author":"A Kel","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/microarrays4020270","article-title":"\u201cUpstream Analysis\u201d: An Integrated Promoter-Pathway Analysis Approach to Causal Interpretation of Microarray Data","volume":"4","author":"J Koschmann","year":"2015","journal-title":"Microarrays (Basel)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0201742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T09:29:48Z","timestamp":1661765388000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0201742"}},"subtitle":[],"editor":[{"given":"Stephen D.","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,16]]},"references-count":110,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0201742","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,16]]}}}