{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:59:06Z","timestamp":1778752746947,"version":"3.51.4"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2012\/21087-4"],"award-info":[{"award-number":["2012\/21087-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0201843","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T13:32:16Z","timestamp":1534944736000},"page":"e0201843","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Resistance training and caloric restriction prevent systolic blood pressure rise by improving the nitric oxide effect on smooth muscle and morphological changes in the aorta of ovariectomized rats"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-7098","authenticated-orcid":true,"given":"Anderson Diogo de Souza","family":"Lino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiana","family":"Vianna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Camargo","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus Vinicius Campos","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Dias","family":"Ruffoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia Tardivo","family":"Marin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucimar Retto da Silva","family":"de Av\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio Eduardo de Andrade","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerson Jhonatan","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio","family":"Tirapegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto Eiji","family":"Shiguemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s12265-012-9349-8","article-title":"Elastin in large artery stiffness and hypertension","volume":"5","author":"JE Wagenseil","year":"2012","journal-title":"Journal of cardiovascular translational research"},{"key":"ref2","first-page":"112","article-title":"Age-related vascular stiffening: causes and consequences","volume":"6","author":"JC Kohn","year":"2015","journal-title":"Frontiers in genetics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3634948","DOI":"10.1155\/2016\/3634948","article-title":"Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders","volume":"2016","author":"A Janus","year":"2016","journal-title":"Mediators of inflammation"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/heart.89.9.1104","article-title":"Cardiac and vascular pathophysiology in hypertension","volume":"89","author":"J Mayet","year":"2003","journal-title":"Heart"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"R Visse","year":"2003","journal-title":"Circ Res"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ajh.2008.306","article-title":"Estrogen deficiency- induced alterations of vascular MMP-2, MT1-MMP, and TIMP-2 in ovariectomized rats","volume":"22","author":"KK Lam","year":"2009","journal-title":"Am J Hypertens"},{"issue":"2","key":"ref7","first-page":"76","article-title":"Matrix metalloproteinases and cardiovascular diseases","volume":"13","author":"A Papazafiropoulou","year":"2009","journal-title":"Hippokratia"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.amjhyper.2003.11.007","article-title":"The effect of Ca2+ channel antagonists on plasma concentrations of matrix metalloproteinase- 2 and -9 in essential hypertension","volume":"17","author":"A Zervoudaki","year":"2004","journal-title":"Am J Hypertens"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/CIRCRESAHA.116.303596","article-title":"The structural factor of hypertension: large and small artery alterations","volume":"116","author":"S Laurent","year":"2015","journal-title":"Circ Res"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1210\/en.2012-1340","article-title":"Minireview: Translational Animal Models of Human Menopause: Challenges and Emerging Opportunities","volume":"153","author":"RD Brinton","year":"2012","journal-title":"Endocrinology"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.maturitas.2009.11.007","article-title":"Exercise training associated with estrogen therapy induced cardiovascular benefits after ovarian hormones deprivation","volume":"65","author":"K Flues","year":"2010","journal-title":"Maturitas"},{"issue":"26","key":"ref12","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1016\/j.lfs.2005.05.044","article-title":"Exercise training attenuates blood pressure elevation and adverse remodeling in the aorta of spontaneously hypertensive rats","volume":"77","author":"PP Horta","year":"2005","journal-title":"Life sciences"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.exger.2010.07.002","article-title":"Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta","volume":"45","author":"M Zanetti","year":"2010","journal-title":"Experimental gerontology"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.cjca.2014.03.020","article-title":"Arterial stiffness and its clinical implications in women","volume":"30","author":"T Coutinho","year":"2014","journal-title":"Can J Cardiol"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"H491","DOI":"10.1152\/ajpheart.00589.2001","article-title":"Influence of estrogen on aortic stiffness and endothelial function in female rats","volume":"282","author":"R Tatchum-Talom","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1600-0838.2010.01284.x","article-title":"Effects of resistance training on matrix metalloproteinase-2 activity and biomechanical and physical properties of bone in ovariectomized and intact rats","volume":"22","author":"GE Shiguemoto","year":"2012","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1139\/h04-002","article-title":"Physiological hypertrophy of the FHL muscle following 8 weeks of progressive resistance exercise in the rat","volume":"29","author":"TA Hornberger Jr","year":"2004","journal-title":"Can J Appl Physiol"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1139\/H09-059","article-title":"Effects of ovariectomy and resistance training on MMP-2 activity in skeletal muscle","volume":"34","author":"J Prestes","year":"2009","journal-title":"Appl Physiol Nutr Metab"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0197-4580(99)00043-3","article-title":"Controlling caloric consumption: protocols for rodents and rhesus monkeys","volume":"20","author":"TD Pugh","year":"1999","journal-title":"Neurobiology of aging"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/cbf.3017","article-title":"Leucine improves protein nutritional status and regulates hepatic lipid metabolism in calorie- restricted rats","volume":"32","author":"JA Pedroso","year":"2014","journal-title":"Cell biochemistry and function"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"PG Reeves","year":"1993","journal-title":"J Nutr"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.niox.2012.01.009","article-title":"Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability","volume":"26","author":"MM Castro","year":"2012","journal-title":"Nitric oxide: biology and chemistry \/ official journal of the Nitric Oxide Society"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1210\/jcem-68-2-374","article-title":"Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies","volume":"68","author":"E Bonora","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"MJ Mulvany","year":"1977","journal-title":"Circ Res"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1097\/00004872-200111000-00006","article-title":"Norepinephrine-induced aortic hyperplasia and extracellular matrix deposition are endothelin-dependent","volume":"19","author":"HH Dao","year":"2001","journal-title":"Journal of hypertension"},{"key":"ref26","first-page":"105","article-title":"Small artery remodeling and significance in the development of hypertension","volume":"17","author":"MJ Mulvany","year":"2002","journal-title":"News in physiological sciences: an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1746-6148-10-162","article-title":"Hepatic inflammation scores correlate with common carotid intima-media thickness in rats with NAFLD induced by a high-fat diet","volume":"10","author":"J Wu","year":"2014","journal-title":"BMC veterinary research"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pharmthera.2004.02.003","article-title":"Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients","volume":"102","author":"Y Higashi","year":"2004","journal-title":"Pharmacology & therapeutics"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1463-1326.2008.00863.x","article-title":"Effect of caloric restriction with and without exercise training on oxidative stress and endothelial function in obese subjects with type 2 diabetes","volume":"10","author":"TP Wycherley","year":"2008","journal-title":"Diabetes, obesity & metabolism"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1055\/s-0030-1263117","article-title":"Menopause: Highlighting the Effects of Resistance Training","volume":"31","author":"RD Leite","year":"2010","journal-title":"Int J Sports Med"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2165\/00007256-200434110-00004","article-title":"Exercise for health for early postmenopausal women: a systematic review of randomised controlled trials","volume":"34","author":"TM Asikainen","year":"2004","journal-title":"Sports medicine"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.febslet.2011.03.015","article-title":"Calorie restriction and prevention of age-associated chronic disease","volume":"585","author":"D Omodei","year":"2011","journal-title":"FEBS letters"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/10623320600780942","article-title":"Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension","volume":"13","author":"G Derosa","year":"2006","journal-title":"Endothelium"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2741\/3228","article-title":"Discovery of the nitric oxide signaling pathway and targets for drug development","volume":"14","author":"NS Bryan","year":"2009","journal-title":"Frontiers in bioscience"},{"issue":"6474","key":"ref35","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/368850a0","article-title":"Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle","volume":"368","author":"VM Bolotina","year":"1994","journal-title":"Nature"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/sj.bjp.0703613","article-title":"Cyclic GMP-independent relaxation of rat pulmonary artery by spermine NONOate, a diazeniumdiolate nitric oxide donor","volume":"131","author":"KL Homer","year":"2000","journal-title":"Br J Pharmacol"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.steroids.2004.05.016","article-title":"Estrogen induced changes in Akt-dependent activation of endothelial nitric oxide synthase and vasodilation","volume":"69","author":"M Florian","year":"2004","journal-title":"Steroids"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.CIR.103.1.e1","article-title":"Exercise training in coronary artery disease and coronary vasomotion","volume":"103","author":"S Gielen","year":"2001","journal-title":"Circulation"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1161\/01.RES.0000155332.17783.26","article-title":"Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle","volume":"96","author":"A Huang","year":"2005","journal-title":"Circ Res"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/bja\/aeh163","article-title":"Physiology of the endothelium","volume":"93","author":"HF Galley","year":"2004","journal-title":"British journal of anaesthesia"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/01.CIR.0000109141.48980.37","article-title":"Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis","volume":"109","author":"U Laufs","year":"2004","journal-title":"Circulation"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/CIRCRESAHA.116.309326","article-title":"Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis","volume":"120","author":"U Forstermann","year":"2017","journal-title":"Circ Res"},{"issue":"37","key":"ref43","doi-asserted-by":"crossref","first-page":"14855","DOI":"10.1073\/pnas.0704329104","article-title":"SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase","volume":"104","author":"I Mattagajasingh","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11154-012-9229-1","article-title":"Role of insulin resistance in endothelial dysfunction","volume":"14","author":"R Muniyappa","year":"2013","journal-title":"Rev Endocr Metab Disord"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"787063","DOI":"10.1155\/2015\/787063","article-title":"Exercise training and calorie restriction influence the metabolic parameters in ovariectomized female rats","volume":"2015","author":"A Posa","year":"2015","journal-title":"Oxidative medicine and cellular longevity"},{"key":"ref46","article-title":"Exercise training ameliorates glucosamine-induced insulin resistance in ovariectomized rats","author":"CH Chen","year":"2016","journal-title":"Menopause"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.bbadis.2012.02.018","article-title":"Calorie restriction prevents the development of insulin resistance and impaired insulin signaling in skeletal muscle of ovariectomized rats","volume":"1822","author":"M Prasannarong","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11357-009-9103-6","article-title":"Tissue elasticity and the ageing elastic fibre","volume":"31","author":"MJ Sherratt","year":"2009","journal-title":"AGE"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/01.HYP.36.6.970","article-title":"Estrogen replacement reduces age-associated remodeling in rat mesenteric arteries","volume":"36","author":"Y Zhang","year":"2000","journal-title":"Hypertension"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/sj.jhh.1001518","article-title":"Plasma levels of active extracellular matrix metalloproteinases 2 and 9 in patients with essential hypertension before and after antihypertensive treatment","volume":"17","author":"A Zervoudaki","year":"2003","journal-title":"J Hum Hypertens"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/HYPERTENSIONAHA.110.154732","article-title":"Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat","volume":"56","author":"VW Dolinsky","year":"2010","journal-title":"Hypertension"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/01.gme.0000191209.13115.46","article-title":"Exercise training attenuates cardiovascular adverse remodeling in adult ovariectomized spontaneously hypertensive rats","volume":"13","author":"CM Marques","year":"2006","journal-title":"Menopause"},{"issue":"6","key":"ref53","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1096\/fj.05-5263com","article-title":"Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats","volume":"20","author":"DE Mager","year":"2006","journal-title":"FASEB J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0201843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T02:56:38Z","timestamp":1540263398000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0201843"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,22]]},"references-count":53,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0201843","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,22]]}}}