{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:00:29Z","timestamp":1787022029356,"version":"build-2736575974"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 106-003468"],"award-info":[{"award-number":["NTUH 106-003468"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC 106-2314-B-002-201"],"award-info":[{"award-number":["NSC 106-2314-B-002-201"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 105-003054"],"award-info":[{"award-number":["NTUH 105-003054"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202020","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T14:35:12Z","timestamp":1533825312000},"page":"e0202020","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["New ultrasound grading system for cesarean scar pregnancy and its implications for management strategies: An observational cohort study"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0753-2793","authenticated-orcid":true,"given":"Shin-Yu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jung","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-An","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1144-2117","authenticated-orcid":true,"given":"Yi-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Nan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Chung","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/01.AOG.0000218690.24494.ce","article-title":"Cesarean scar ectopic pregnancies: etiology, diagnosis, and management","volume":"107","author":"MA Rotas","year":"2006","journal-title":"Obstet Gynecol"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/uog.56","article-title":"First-trimester diagnosis and management of pregnancies implanted into the lower uterine segment Cesarean section scar","volume":"21","author":"D Jurkovic","year":"2003","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/uog.55","article-title":"Cesarean scar pregnancy","volume":"21","author":"D Jurkovic","year":"2003","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/uog.999","article-title":"Cesarean section scar evaluation by saline contrast sonohysterography","volume":"23","author":"C Regnard","year":"2004","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"3","key":"ref5","first-page":"168","article-title":"Cesarean Scar Pregnancy and Morbidly Adherent Placenta: Different or Similar?","volume":"19","author":"M Pekar-Zlotin","year":"2017","journal-title":"Isr Med Assoc J"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/uog.14775","article-title":"Natural history of early first-trimester pregnancies implanted in Cesarean scars","volume":"46","author":"N Zosmer","year":"2015","journal-title":"Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.7863\/ultra.34.4.595","article-title":"Outcome of cesarean scar pregnancies diagnosed sonographically in the first trimester","volume":"34","author":"AY Michaels","year":"2015","journal-title":"J Ultrasound Med"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejogrb.2011.11.026","article-title":"Caesarean scar pregnancy: comparative efficacy and safety of treatment by uterine artery chemoembolization and systemic methotrexate injection","volume":"161","author":"X Wu","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.fertnstert.2015.12.130","article-title":"Cesarean scar pregnancy: a systematic review of treatment studies","volume":"105","author":"K Birch Petersen","year":"2016","journal-title":"Fertil Steril"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00404-015-3952-2","article-title":"Uterine artery embolization combined with curettage vs. methotrexate plus curettage for cesarean scar pregnancy","volume":"294","author":"W Liu","year":"2016","journal-title":"Arch Gynecol Obstet"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s40477-015-0162-5","article-title":"Cesarean section scar ectopic pregnancy: a clinical case series","volume":"18","author":"M Rheinboldt","year":"2015","journal-title":"J Ultrasound"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1471-0528.2006.01237.x","article-title":"Caesarean scar pregnancy","volume":"114","author":"A Ash","year":"2007","journal-title":"BJOG"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/humupd\/dmh042","article-title":"Ectopic pregnancies in a Caesarean scar: review of the medical approach to an iatrogenic complication","volume":"10","author":"R Maymon","year":"2004","journal-title":"Hum Reprod Update"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1046\/j.1469-0705.2000.00300-2.x","article-title":"Pregnancy in a cesarean scar","volume":"16","author":"Y Vial","year":"2000","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1007\/s00261-015-0472-2","article-title":"Cesarean scar ectopic pregnancy: imaging features, current treatment options, and clinical outcomes","volume":"40","author":"RM Riaz","year":"2015","journal-title":"Abdom Imaging"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4293\/108680813X13654754535197","article-title":"Laparoscopic management or laparoscopy combined with transvaginal management of type II cesarean scar pregnancy","volume":"17","author":"HY Wang","year":"2013","journal-title":"JSLS"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/uog.15857","article-title":"Surgical treatment of Cesarean scar ectopic pregnancy: efficacy and safety of ultrasound-guided suction curettage","volume":"47","author":"D Jurkovic","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00270-011-0097-y","article-title":"Uterine artery embolization combined with local methotrexate and systemic methotrexate for treatment of cesarean scar pregnancy with different ultrasonographic pattern","volume":"35","author":"F Lian","year":"2012","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"351 e1","DOI":"10.1016\/j.ajog.2016.03.010","article-title":"A new minimally invasive treatment for cesarean scar pregnancy and cervical pregnancy","volume":"215","author":"IE Timor-Tritsch","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"ref20","article-title":"Risk factors associated with failure of treatment for cesarean scar pregnancy","author":"YC Chiang","year":"2017","journal-title":"Int J Gynaecol Obstet"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.7863\/ultra.34.4.601","article-title":"Cesarean scar pregnancies: experience of 60 cases","volume":"34","author":"IE Timor-Tritsch","year":"2015","journal-title":"J Ultrasound Med"},{"issue":"11\u201312","key":"ref22","first-page":"469","article-title":"Classification and management of cervical ectopic pregnancies: experience at a single institution","volume":"55","author":"JH Hwang","year":"2010","journal-title":"J Reprod Med"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/jog.13267","article-title":"Clinical classification and treatment of cesarean scar pregnancy","volume":"43","author":"H Zhang","year":"2017","journal-title":"J Obstet Gynaecol Res"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jmig.2015.04.008","article-title":"Local Methotrexate Injection as the First-line Treatment for Cesarean Scar Pregnancy: Review of the Literature","volume":"22","author":"VY Cheung","year":"2015","journal-title":"J Minim Invasive Gynecol"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00404-013-2982-x","article-title":"Low-dose methotrexate treatment in ectopic pregnancy: a retrospective analysis of 164 ectopic pregnancies treated between 2000 and 2008","volume":"289","author":"J Lermann","year":"2014","journal-title":"Arch Gynecol Obstet"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.11152\/mu.2013.2066.153.jej1eaj2","article-title":"Uterine artery embolization with methotrexate infusion as treatment for cesarean scar pregnancy. Case report","volume":"15","author":"Junior J Elito","year":"2013","journal-title":"Med Ultrason"},{"key":"ref27","article-title":"A large intrauterine vascular lesion developing after the successful treatment of a cesarean scar pregnancy with methotrexate injection","author":"JW Song","year":"2017","journal-title":"J Clin Ultrasound"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"126 e1","DOI":"10.1016\/j.ajog.2015.08.052","article-title":"Large intrauterine mass associated with cesarean scar pregnancy","volume":"214","author":"G Liu","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"ref29","first-page":"268","article-title":"Successful Management of Cesarean Scar Pregnancy Complicated by an Arteriovenous Malformation","volume":"15","author":"ES Smith","year":"2015","journal-title":"Ochsner J"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.tjog.2013.10.026","article-title":"Acquired uterine arteriovenous malformation in a cesarean scar pregnancy","volume":"52","author":"D Kim","year":"2013","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/uog.5149","article-title":"The management of Cesarean scar ectopic pregnancy following treatment with methotrexate\u2014a clinical challenge","volume":"30","author":"S Deb","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref32","first-page":"137","article-title":"Comparative efficacy and safety of local and systemic methotrexate injection in cesarean scar pregnancy","volume":"11","author":"P Peng","year":"2015","journal-title":"Ther Clin Risk Manag"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00404-015-3881-0","article-title":"Therapeutic effects of uterine artery embolisation (UAE) and methotrexate (MTX) conservative therapy used in treatment of cesarean scar pregnancy","volume":"293","author":"H Yang","year":"2016","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/jog.12051","article-title":"Bilateral uterine artery chemoembolization combined with dilation and curettage for treatment of cesarean scar pregnancy: A method for preserving the uterus","volume":"39","author":"W Lan","year":"2013","journal-title":"J Obstet Gynaecol Res"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10397-014-0863-3","article-title":"Transvaginal hysterotomy for cesarean scar pregnancy in 40 consecutive cases","volume":"12","author":"Z Huanxiao","year":"2015","journal-title":"Gynecol Surg"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejogrb.2014.09.017","article-title":"Transvaginal surgical management of cesarean scar pregnancy: analysis of 49 cases from one tertiary care center","volume":"182","author":"JB Li","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:05:05Z","timestamp":1540339505000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202020"}},"subtitle":[],"editor":[{"given":"Xing","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":36,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202020","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]}}}