{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:00:30Z","timestamp":1790686830437,"version":"4.1.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202119","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T14:18:44Z","timestamp":1535552324000},"page":"e0202119","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Phenotypic screening and molecular characterization of carbapenemase-producing Gram-negative bacilli recovered from febrile neutropenic pediatric cancer patients in Egypt"],"prefix":"10.1371","volume":"13","author":[{"given":"Noha A.","family":"Kamel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa N.","family":"El-tayeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona R.","family":"El-Ansary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed T.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7608-850X","authenticated-orcid":true,"given":"Khaled M.","family":"Aboshanab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/cid\/cir492","article-title":"Infections in patients with hematologic neoplasms and hematopoietic stem cell transplantation: neutropenia, humoral, and splenic defects","volume":"53","author":"A Safdar","year":"2011","journal-title":"Clinical infectious diseases"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s15010-017-0988-1","article-title":"Non-fermentative Gram-negative rods bacteremia in children with cancer: a 14-year single-center experience","volume":"45","author":"D Averbuch","year":"2017","journal-title":"Infection"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijid.2018.03.022","article-title":"Bloodstream infections in cancer patients. Risk factors associated with mortality","volume":"71","author":"B Islas-Mu\u00f1oz","year":"2018","journal-title":"International Journal of Infectious Diseases"},{"key":"ref4","first-page":"1","article-title":"Bloodstream infections in haematological cancer patients colonized by multidrug-resistant bacteria","author":"C Cattaneo","year":"2018","journal-title":"Annals of hematology"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1469-0691.2012.03815.x","article-title":"Identification and screening of carbapenemase-producing Enterobacteriaceae","volume":"18","author":"P Nordmann","year":"2012","journal-title":"Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1469-0691.2012.03821.x","article-title":"Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe","volume":"18","author":"R Canton","year":"2012","journal-title":"Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/CMR.00001-07","article-title":"Carbapenemases: the versatile beta-lactamases","volume":"20","author":"AM Queenan","year":"2007","journal-title":"Clinical microbiology reviews"},{"key":"ref8","first-page":"1","article-title":"Emerging Gram negative resistance to last-line antimicrobial agents fosfomycin, colistin and ceftazidime-avibactam\u2013epidemiology, laboratory detection and treatment implications","author":"N Sherry","year":"2018","journal-title":"Expert Review of Anti-infective Therapy"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2017.22.6.30461","article-title":"Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014","volume":"22","author":"L Dortet","year":"2017","journal-title":"Eurosurveillance"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/jac\/dkx521","article-title":"A multiplex lateral flow immunoassay for the rapid identification of NDM-, KPC-, IMP-and VIM-type and OXA-48-like carbapenemase-producing Enterobacteriaceae","volume":"73","author":"H Boutal","year":"2018","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"ref11","author":"J Holt","year":"1994"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug\u2010resistant, extensively drug\u2010resistant and pandrug\u2010resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"AP Magiorakos","year":"2012","journal-title":"Clinical microbiology and infection"},{"key":"ref13","unstructured":"CLSI. CLSI. Performance standards for antimicrobial susceptibility testing: 25th informational supplement. CLSI document M100-S25. Clinical and Laboratory Standards Institute,2015, Wayne, PA. 2015."},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"346","DOI":"10.4103\/0976-9668.117009","article-title":"Modified Hodge test: A useful and the low-cost phenotypic method for detection of carbapenemase producers in Enterobacteriaceae members","volume":"4","author":"KV Ramana","year":"2013","journal-title":"Journal of Natural Science, Biology, and Medicine"},{"key":"ref15","unstructured":"CLSI. Performance Standards for Antimicrobial Susceptibility Testing\u2013Twenty-Seventh Informational Supplement. CLSI Document M100S (ISBN 156238-923-8). CLSI, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087\u20131898 USA. 2017."},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1128\/JCM.01634-13","article-title":"Blue-Carba, an Easy Biochemical Test for Detection of Diverse Carbapenemase Producers Directly from Bacterial Cultures","volume":"51","author":"J Pires","year":"2013","journal-title":"Journal of Clinical Microbiology"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1128\/JCM.03026-14","article-title":"Evaluation of the Blue-Carba test for rapid detection of carbapenemases in gram-negative bacilli","volume":"53","author":"F Pasteran","year":"2015","journal-title":"Journal of clinical microbiology"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/1120009X.2016.1201272","article-title":"Rapid Blue-Carba test: reduction in the detection time of carbapenemases performed from a 4-hour bacterial lawn","volume":"29","author":"M Nastro","year":"2017","journal-title":"Journal of Chemotherapy"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1128\/JCM.00901-13","article-title":"A Combined Disk Test for Direct Differentiation of Carbapenemase-Producing Enterobacteriaceae in Surveillance Rectal Swabs","volume":"51","author":"S Pournaras","year":"2013","journal-title":"Journal of Clinical Microbiology"},{"key":"ref20","article-title":"Molecular Cloning: a laboratory manual","author":"J Sambrook","year":"2001"},{"key":"ref21","first-page":"1250","article-title":"In Manual of Clinical Microbiology","author":"PR Murray","year":"2007"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3201\/eid1710.110655","article-title":"Global spread of carbapenemase-producing Enterobacteriaceae","volume":"17","author":"P Nordmann","year":"2011","journal-title":"Emerging infectious diseases"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.diagmicrobio.2010.12.002","article-title":"Multiplex PCR for detection of acquired carbapenemase genes","volume":"70","author":"L Poirel","year":"2011","journal-title":"Diagnostic microbiology and infectious disease"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"e382","DOI":"10.1038\/bcj.2015.110","article-title":"Infectious complications in children with acute myeloid leukemia: decreased mortality in multicenter trial AML-BFM 2004","volume":"6","author":"K Bochennek","year":"2017","journal-title":"Blood cancer journal"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jmii.2015.08.013","article-title":"Bloodstream infections in pediatric patients with acute leukemia: Emphasis on gram-negative bacteria infections","volume":"50","author":"F-C Kuo","year":"2017","journal-title":"Journal of Microbiology, Immunology and Infection"},{"issue":"17","key":"ref26","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.4103\/0366-6999.213411","article-title":"Clinical Characteristics of Bloodstream Infections in Pediatric Acute Leukemia: A Single-center Experience with 231 Patients","volume":"130","author":"J-F Yao","year":"2017","journal-title":"Chinese medical journal"},{"key":"ref27","first-page":"1","article-title":"Spread of carbapenem resistant Enterobacteriaceae at tertiary care cancer hospital in Egypt","author":"HA ElMahallawy","year":"2018","journal-title":"Infectious Diseases"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.sjbs.2016.07.004","article-title":"Comparison of phenotypic and PCR methods for detection of carbapenemases production by Enterobacteriaceae","volume":"24","author":"M AlTamimi","year":"2017","journal-title":"Saudi journal of biological sciences"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijantimicag.2012.08.015","article-title":"Occurrence of OXA-48 and VIM-1 carbapenemase-producing Enterobacteriaceae in Egypt","volume":"41","author":"L Poirel","year":"2013","journal-title":"International journal of antimicrobial agents"},{"issue":"3","key":"ref30","article-title":"Evaluation of Chromogenic Medium chromID OXA-48 for Detection of OXA-48 Producing Enterobacteriaceae","volume":"26","author":"I Shehata","year":"2017","journal-title":"The Egyptian Journal of Medical Microbiology (EJMM)"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/0974-777X.176149","article-title":"Laboratory Detection and Clinical Implication of Oxacillinase-48 like Carbapenemase: The Hidden Threat","volume":"8","author":"YD Bakthavatchalam","year":"2016","journal-title":"Journal of Global Infectious Diseases"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"e1130","DOI":"10.1016\/j.ijid.2013.06.016","article-title":"The emergence of OXA-48-and NDM-1-positive Klebsiella pneumoniae in Riyadh","volume":"17","author":"A Shibl","year":"2013","journal-title":"Saudi Arabia. International Journal of Infectious Diseases"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1128\/JCM.01929-16","article-title":"Comparison of phenotypic tests and an immunochromatographic assay and development of a new algorithm for detection of OXA-48-like carbapenemases","volume":"55","author":"F Koroska","year":"2017","journal-title":"Journal of clinical microbiology"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/CMR.00117-13","article-title":"OXA \u03b2-lactamases","volume":"27","author":"BA Evans","year":"2014","journal-title":"Clinical microbiology reviews"},{"issue":"31","key":"ref35","doi-asserted-by":"crossref","first-page":"20549","DOI":"10.2807\/1560-7917.ES2013.18.31.20549","article-title":"Intercontinental spread of OXA-48 beta-lactamase-producing Enterobacteriaceae over a 11-year period, 2001 to 2011","volume":"18","author":"A Potron","year":"2013","journal-title":"Eurosurveillance"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"e0170769","DOI":"10.1371\/journal.pone.0170769","article-title":"Retrospective and prospective evaluation of the Carbapenem inactivation method for the detection of carbapenemase-producing Enterobacteriaceae","volume":"12","author":"L Gauthier","year":"2017","journal-title":"PloS one"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1128\/AAC.01458-16","article-title":"Evaluation of a multiplex PCR assay to rapidly detect Enterobacteriaceae with a broad range of \u03b2-lactamases directly from perianal swabs","volume":"60","author":"KD Chavda","year":"2016","journal-title":"Antimicrobial agents and chemotherapy"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:25:41Z","timestamp":1588973141000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202119"}},"subtitle":[],"editor":[{"given":"Ashraf B.","family":"Abdel-Naim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202119","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]}}}