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The importance of the F4 receptor in post-weaned pigs In eliciting F4 specific immune responses in the intestine [Doctoral dissertation]. University of Saskatchewan: Saskatoon; 2006."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e81473","DOI":"10.1371\/journal.pone.0081473","article-title":"Age-related expression of the polymeric immunoglobulin receptor (pIgR) in the gastric mucosa of young pigs","volume":"8","author":"P Trevisi","year":"2013","journal-title":"PLoS one"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-2199-8-67","article-title":"Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR","volume":"8","author":"AB Nygard","year":"2007","journal-title":"BMC Mol Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.vetmic.2015.03.014","article-title":"The pig gut microbial diversity: Understanding the pig gut microbial ecology through the next generation high throughput sequencing","volume":"177","author":"HB Kim","year":"2015","journal-title":"Vet 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Effects of neonatal microbial association and early life diet composition on systemic immunology and on in-situ gut functionality of caesarean derived piglets in later life. In The 41th Animal Nutrition Research Forum, Wageningen UR Livestock Research, Wageningen, the Netherlands, April 15, 2016. p. 16."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.vetimm.2005.02.010","article-title":"Development of a porcine small intestinal cDNA micro-array: characterization and functional analysis of the response to enterotoxigenic E. coli","volume":"105","author":"TA Niewold","year":"2005","journal-title":"Vet Imunol Immunop"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.vetmic.2009.08.014","article-title":"Transcriptomics of enterotoxigenic Escherichia coli infection. 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