{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:00:30Z","timestamp":1787022030565,"version":"build-2736575974"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013398","name":"Innlandet Hospital Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013398","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008568","name":"Norske Kvinners Sanitetsforening","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008568","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012266","name":"Norwegian Rheumatism Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012266","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Norwegian Heart and Lung Association"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202346","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T13:39:45Z","timestamp":1535031585000},"page":"e0202346","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Differential expression of vitamin D associated genes in the aorta of coronary artery disease patients with and without rheumatoid arthritis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-9753","authenticated-orcid":true,"given":"Ingvild","family":"Oma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Kristoffer","family":"Olstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline Kirsti","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torstein","family":"Lyberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"Molberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Fostad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Wang Fagerland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven Martin","family":"Almdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein Erik","family":"Rynning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Yndestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon Elling","family":"Whist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Hollan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/annrheumdis-2011-200726","article-title":"Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies","volume":"71","author":"JA Avina-Zubieta","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref2","article-title":"Rheumatoid arthritis and mortality among women during 36 years of prospective follow-up: Results from the Nurses' Health Study","author":"JA Sparks","year":"2015","journal-title":"Arthritis Care & Research"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrrheum.2015.40","article-title":"Atherosclerosis in rheumatoid arthritis: is it all about inflammation?","volume":"11","author":"S Skeoch","year":"2015","journal-title":"Nat Rev Rheumatol"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.autrev.2015.06.004","article-title":"Prevention of cardiovascular disease in rheumatoid arthritis","volume":"14","author":"I Hollan","year":"2015","journal-title":"Autoimmun Rev"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/rheumatology\/ken394","article-title":"Vitamin D and autoimmune rheumatic diseases","volume":"48","author":"M Cutolo","year":"2009","journal-title":"Rheumatology"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/CIRCRESAHA.113.301241","article-title":"Vitamin D and cardiovascular disease","volume":"114","author":"PE Norman","year":"2014","journal-title":"Circ Res"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/abbi.1999.1605","article-title":"Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system","volume":"374","author":"CM Veldman","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13075-015-0704-4","article-title":"Vitamin D deficiency in chronic inflammatory rheumatic diseases: results of the cardiovascular in rheumatology [CARMA] study","volume":"17","author":"A Urruticoechea-Arana","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"ref9","article-title":"Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study","author":"B Schottker","year":"2013","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"ref10","first-page":"702","article-title":"Circannual vitamin d serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe","volume":"24","author":"M Cutolo","year":"2006","journal-title":"Clin Exp Rheumatol"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/HCO.0000000000000108","article-title":"Vitamin D and atherosclerosis","volume":"29","author":"AR Menezes","year":"2014","journal-title":"Current opinion in cardiology"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/art.39574","article-title":"Brief Report: Proatherogenic Cytokine Microenvironment in the Aortic Adventitia of Patients With Rheumatoid Arthritis","volume":"68","author":"A Ahmed","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1002\/art.22690","article-title":"Inflammatory rheumatic disease and smoking are predictors of aortic inflammation: a controlled study of biopsy specimens obtained at coronary artery surgery","volume":"56","author":"I Hollan","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/03009742.2016.1172664","article-title":"Plasma vitamin D levels and inflammation in the aortic wall of patients with coronary artery disease with and without inflammatory rheumatic disease","volume":"46","author":"I Oma","year":"2017","journal-title":"Scand J Rheumatol"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"FC Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gr.107920.110","article-title":"A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution","volume":"20","author":"SV Ramagopalan","year":"2010","journal-title":"Genome Res"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"TD Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.biocel.2008.06.018","article-title":"Growth arrest and DNA damage-45 alpha (GADD45alpha)","volume":"41","author":"A Rosemary Siafakas","year":"2009","journal-title":"The international journal of biochemistry & cell biology"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/tpj.2010.55","article-title":"Changes in the gene expression profile of gastric cancer cells in response to ibuprofen: a gene pathway analysis","volume":"11","author":"P Bonelli","year":"2011","journal-title":"Pharmacogenomics J"},{"issue":"1","key":"ref20","first-page":"341","article-title":"Expression and function of the vitamin D receptor in malignant germ cell tumour of the testis","volume":"32","author":"F Bremmer","year":"2012","journal-title":"Anticancer Res"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/art.27363","article-title":"Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells","volume":"62","author":"Y Li","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1074-7613(02)00302-3","article-title":"Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome","volume":"16","author":"JM Salvador","year":"2002","journal-title":"Immunity"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s13075-015-0748-5","article-title":"Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate","volume":"17","author":"MC de Andres","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1101\/gad.214023.113","article-title":"Emerging roles of the corepressors NCoR1 and SMRT in homeostasis","volume":"27","author":"A Mottis","year":"2013","journal-title":"Genes Dev"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nri2748","article-title":"Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells","volume":"10","author":"CK Glass","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jsbmb.2012.08.006","article-title":"Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1alpha,25-dihydroxyvitamin D3-responsive genes","volume":"136","author":"MB Meyer","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref27","article-title":"Paraoxonases-1, -2 and -3: What are their functions?","author":"CE Furlong","year":"2016","journal-title":"Chem Biol Interact"},{"issue":"40","key":"ref28","doi-asserted-by":"crossref","first-page":"29491","DOI":"10.1074\/jbc.M605379200","article-title":"Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2","volume":"281","author":"CJ Ng","year":"2006","journal-title":"J Biol Chem"},{"issue":"48","key":"ref29","doi-asserted-by":"crossref","first-page":"44444","DOI":"10.1074\/jbc.M105660200","article-title":"Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein","volume":"276","author":"CJ Ng","year":"2001","journal-title":"J Biol Chem"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2004.09.035","article-title":"The paraoxonase gene family and atherosclerosis","volume":"38","author":"CJ Ng","year":"2005","journal-title":"Free Radic Biol Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T21:00:16Z","timestamp":1589922016000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202346"}},"subtitle":[],"editor":[{"given":"Aamir","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202346","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]}}}