{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:14:04Z","timestamp":1757700844453,"version":"3.37.3"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Support Foundation of Sao Paulo (FAPESP)","award":["2016\/18850-9"],"award-info":[{"award-number":["2016\/18850-9"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202401","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T13:36:48Z","timestamp":1534945008000},"page":"e0202401","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Vaginal lipidomics of women with vulvovaginal candidiasis and cytolytic vaginosis: A non-targeted LC-MS pilot study"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-7421","authenticated-orcid":true,"given":"Jos\u00e9 Marcos","family":"Sanches","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo C\u00e9sar","family":"Giraldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Nogueira","family":"Eberlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lygia Azevedo","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Migliorini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Nakahira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Jan Marinus","family":"Bieleveld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Garcia","family":"Discacciati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"issue":"5","key":"ref1","first-page":"257","article-title":"Influence of frequency of vaginal intercourses and the use of doushing on vaginal microbiota","volume":"27","author":"P Giraldo","year":"2005"},{"issue":"2","key":"ref2","first-page":"152","article-title":"Identification of cytolytic vaginosis versus vulvovaginal candidiasis","volume":"19","author":"Z Hu","year":"2015"},{"issue":"9577","key":"ref3","first-page":"1961","article-title":"Vulvovaginal candidosis","volume":"369","author":"J Sobel","year":"2007"},{"issue":"1","key":"ref4","first-page":"13","article-title":"Cytolytic vaginosis: misdiagnosed as candidal vaginitis","volume":"12","author":"N Cerikcioglu","year":"2004"},{"issue":"4","key":"ref5","first-page":"1245","article-title":"Cytolytic vaginosis","volume":"165","author":"L Cibley","year":"1991"},{"issue":"6","key":"ref6","first-page":"1993","article-title":"Comprehensive two-dimensional gas chromatography in metabolomics","volume":"402","author":"M Almstetter","year":"2012"},{"issue":"1","key":"ref7","first-page":"9","article-title":"Current metabolomics: technological advances","volume":"116","author":"S Putri","year":"2013"},{"issue":"6","key":"ref8","first-page":"1071","article-title":"Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics","volume":"44","author":"X Han","year":"2003"},{"issue":"3","key":"ref9","first-page":"61","article-title":"Lipidomics is emerging","volume":"1634","author":"M Lagarde","year":"2003"},{"issue":"19","key":"ref10","first-page":"1812","article-title":"The human plasma lipidome","volume":"365","author":"O Quehenberger","year":"2011"},{"key":"ref11","first-page":"593","article-title":"Lipidomics: coming to grips with lipid diversity","volume":"11","author":"A Shevchenko","year":"2010"},{"issue":"1","key":"ref12","first-page":"14","article-title":"Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations","volume":"74","author":"R Amsel","year":"1983"},{"issue":"2","key":"ref13","first-page":"297","article-title":"Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation","volume":"29","author":"R Nugent","year":"1991"},{"issue":"11","key":"ref14","first-page":"5035","article-title":"XCMS Online: a web-based platform to process untargeted metabolomic data","volume":"84","author":"R Tautenhahn","year":"2012"},{"issue":"W1","key":"ref15","first-page":"W251","article-title":"MetaboAnalyst 3.0\u2014making metabolomics more meaningful","volume":"43","author":"J Xia","year":"2015"},{"key":"ref16"},{"key":"ref17"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF03261931","article-title":"Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects","volume":"51","author":"S Reuter","year":"2012","journal-title":"Clin Pharmacokinet"},{"key":"ref19","first-page":"477","article-title":"Fatty acid oxidation disorders","volume":"64","author":"P Rinaldo","year":"2002"},{"issue":"11","key":"ref20","first-page":"E990","article-title":"Long-chain acylcarnitines activate cell stress and myokine release in C2C12 myotubes: calcium-dependent and -independent effects","volume":"308","author":"C McCoin","year":"2015"},{"issue":"1","key":"ref21","first-page":"94","article-title":"Inhibitory effects of palmitoylcarnitine and lysophosphatidylcholine on the sodium current of cardiac ventricular cells","volume":"420","author":"T Sato","year":"1992"},{"issue":"12","key":"ref22","first-page":"E1378","article-title":"Acylcarnitines activate proinflammatory signaling pathways","volume":"306","author":"J Rutkowsky","year":"2014"},{"issue":"4","key":"ref23","first-page":"347","article-title":"Chemistry of lipid peroxidation products and their use as biomarkers in early detection of diseases","volume":"64","author":"Y Yoshida","year":"2015"},{"issue":"4\u20135","key":"ref24","first-page":"135","article-title":"Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans","volume":"87","author":"C Ramsden","year":"2012"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/srep01349","article-title":"Linoleic acid metabolite drives severe asthma by causing airway epithelial injury","volume":"3","author":"U Mabalirajan","year":"2013","journal-title":"Sci Rep"},{"issue":"39","key":"ref26","first-page":"24055","article-title":"Disruption of 12\/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein","volume":"271","author":"D Sun","year":"1996"},{"issue":"3","key":"ref27","first-page":"1454","article-title":"Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells","volume":"265","author":"H Kuhn","year":"1990"},{"issue":"2","key":"ref28","first-page":"323","article-title":"Effect of quercetin 7-rhamnoside on glycochenodeoxycholic acid-induced L-02 human normal liver cell apoptosis","volume":"32","author":"S Liang","year":"2013"},{"issue":"1","key":"ref29","first-page":"122","article-title":"Glycochenodeoxycholate induces rat alveolar epithelial type II cell death and inhibits surfactant secretion in vitro","volume":"53","author":"H Zhangxue","year":"2012"},{"issue":"8","key":"ref30","first-page":"1656","article-title":"Resolution of subchorionic hematoma and symptoms of threatened miscarriage using vaginal alpha lipoic acid or progesterone: clinical evidences","volume":"20","author":"M Costantino","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"18","key":"ref31","first-page":"4219","article-title":"Safety of oral alpha-lipoic acid treatment in pregnant women: a retrospective observational study","volume":"21","author":"E Parente","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"11\u201312","key":"ref32","first-page":"1418","article-title":"Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue","volume":"26","author":"O Tirosh","year":"1999"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1002\/mnfr.201500338","article-title":"Treatment of oxidative stress in brain of ovariectomized rats with omega-3 and lipoic acid","volume":"59","author":"C Behling","year":"2015","journal-title":"Mol. Nutr. Food Res"},{"key":"ref34","first-page":"1096","article-title":"N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease","author":"E Polyak","year":"2018","journal-title":"Molecular Genetics and Metabolism"},{"article-title":"Princ\u00edpios de Bioqu\u00edmica de Lehninger Porto Alegre","year":"2011","author":"D NELSON","key":"ref35"},{"issue":"50","key":"ref36","first-page":"14946","article-title":"Bestowing antifungal and antibacterial activities by lipophilic acid conjugation to D,L-amino acid-containing antimicrobial peptides: a plausible mode of action","volume":"42","author":"D Avrahami","year":"2003"},{"issue":"10","key":"ref37","first-page":"2873","article-title":"Undecylenic acid inhibits morphogenesis of Candida albicans","volume":"44","author":"N McLain","year":"2000"},{"issue":"12","key":"ref38","first-page":"3209","article-title":"Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells","volume":"53","author":"H Staiger","year":"2004"},{"issue":"2","key":"ref39","first-page":"232","article-title":"Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment","volume":"33","author":"X Li","year":"2013"},{"issue":"1","key":"ref40","first-page":"1","article-title":"Endoplasmic reticulum stress involved in high-fat diet and palmitic acid-induced vascular damages and fenofibrate intervention","volume":"458","author":"Y Lu","year":"2015"},{"issue":"3","key":"ref41","first-page":"796","article-title":"Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells","volume":"216","author":"R Lambertucci","year":"2008"},{"issue":"6","key":"ref42","first-page":"1288","article-title":"Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia","volume":"54","author":"R Watters","year":"2013"},{"issue":"5","key":"ref43","first-page":"884","article-title":"Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons","volume":"129","author":"W Shen","year":"2014"},{"issue":"9","key":"ref44","first-page":"2527","article-title":"Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia","volume":"51","author":"S Stefanic","year":"2010"},{"issue":"9","key":"ref45","first-page":"1033","article-title":"Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis","volume":"21","author":"Q Zhu","year":"2016"},{"article-title":"Molecular Biology of the Cell","year":"2010","author":"B. Alberts","key":"ref46"},{"issue":"1","key":"ref47","first-page":"139","article-title":"Catabolism of L-lysine by Pseudomonas aeruginosa","volume":"99","author":"J Fothergill","year":"1977"},{"issue":"9","key":"ref48","first-page":"607","article-title":"Free amino-acid content of wax-stimulated human whole saliva as related to periodontal disease","volume":"32","author":"S Syrjanen","year":"1987"},{"article-title":"Excess Omega-6 Fatty Acids Influx in Aging Drives Metabolic Dysregulation, Electrocardiographic Alterations and Low-grade Chronic Inflammation","year":"2017","author":"V Kain","key":"ref49"},{"key":"ref50","first-page":"673","article-title":"The antibacterial activity of various saturated and unsaturated fatty acids against several oral pathogens","volume":"34","author":"J Choi","year":"2013"},{"issue":"5","key":"ref51","first-page":"293","article-title":"Essential fatty acids are antagonists of the leukotriene B4 receptor","volume":"52","author":"K Yagaloff","year":"1995"},{"issue":"2","key":"ref52","first-page":"F181","article-title":"Prostanoid biosynthesis and mechanisms of action","volume":"263","author":"W Smith","year":"1992"},{"issue":"5","key":"ref53","first-page":"349","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"C Serhan","year":"2008"},{"issue":"11","key":"ref54","first-page":"571","article-title":"Lipid mediators of sensitivity in sensory neurons","volume":"26","author":"K Park","year":"2005"},{"issue":"4","key":"ref55","first-page":"283","article-title":"Effects of alpha- tocopherol on bacterial translocation and lipid peroxidation in rats with intestinal obstruction","volume":"18","author":"A Schanaider","year":"2003"},{"key":"ref56","first-page":"297","article-title":"Antioxidant effects of extra virgin olive oil enriched by myrtle phenolic extracts on iron-mediated lipid peroxidation under intestinal conditions model","volume":"237","author":"S Dairi","year":"2017"},{"issue":"1","key":"ref57","first-page":"213","article-title":"Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals","volume":"4","author":"S Denniss","year":"2008"},{"issue":"1","key":"ref58","first-page":"8","article-title":"Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, alpha-tocopherol and gamma-tocopherol in preeclampsia and normal pregnancy","volume":"58","author":"P Palan","year":"2004"},{"issue":"6","key":"ref59","first-page":"e0179292","article-title":"Effect of three edible oils on the intestinal absorption of caffeic acid: An in vivo and in vitro study","volume":"12","author":"W Prasadani","year":"2017"},{"issue":"15","key":"ref60","first-page":"3370","article-title":"Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides","volume":"27","author":"S Vudhgiri","year":"2017"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T12:27:35Z","timestamp":1540297655000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202401"}},"subtitle":[],"editor":[{"given":"Manuel","family":"Portero-Otin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,22]]},"references-count":60,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202401","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,8,22]]}}}