{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:35:14Z","timestamp":1787060114371,"version":"build-2736575974"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["261101792014"],"award-info":[{"award-number":["261101792014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202481","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T19:35:48Z","timestamp":1535398548000},"page":"e0202481","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Application of Venn's diagram in the diagnosis of pleural tuberculosis using IFN-\u03b3, IP-10 and adenosine deaminase"],"prefix":"10.1371","volume":"13","author":[{"given":"Ana Paula","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3112-2559","authenticated-orcid":true,"given":"Raquel da Silva","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Ribeiro-Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Oliveira","family":"Soares da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Thomaz","family":"Mafort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana\u00edna","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-5376","authenticated-orcid":true,"given":"Geraldo Moura Batista","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Silva","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio","family":"Rufino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. Global Tuberculosis Report 2016. Available in: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int.tb\" xlink:type=\"simple\">http:\/\/www.who.int.tb<\/ext-link>. Accessed on June 15, 2017"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1038\/emi.2016.80","article-title":"A combination of the QuantiFERON-TB Gold In-Tube assay and the detection of adenosine deaminase improves the diagnosis of tuberculous pleural effusion","volume":"5","author":"Y Liu","year":"2016","journal-title":"Emerg Microb & Infec"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2334-14-9","article-title":"Epidemiology of extrapulmonary tuberculosis in Brazil: a hierarchical model","volume":"14","author":"T Gomes","year":"2014","journal-title":"BMC Infectious Diseases"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1183\/09031936.00147507","article-title":"Novel tests for diagnosing tuberculous pleural effusion: what Works and what does not?","volume":"31","author":"A Trajman","year":"2008","journal-title":"Eur Respir J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1469-0691.2008.02655.x","article-title":"Enzyme-linked immunospot assay for interferon-gamma in the diagnosis of tuberculosis pleurisy","volume":"15","author":"LN Lee","year":"2009","journal-title":"Clin Microbiol Infect"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"83857","DOI":"10.1371\/journal.pone.0083857","article-title":"Interferon-Gamma Release Assay Performance of Pleural Fluid and Peripheral Blood in Pleural Tuberculosis","volume":"8","author":"F Liu","year":"2013","journal-title":"PlosOne"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1471-2466-14-58","article-title":"Comparison of same day diagnostic tools including Gene Xpert and unistimulated IFN-\u03b3 for the evaluation of pleural tuberculosis: a prospective cohort study","volume":"14","author":"R Meldau","year":"2014","journal-title":"BMC Pulm Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1378\/chest.99.5.1103","article-title":"Cytokine content in pleural effusion","volume":"99","author":"K Shimokata","year":"1991","journal-title":"Chest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2796.2008.02012.x","article-title":"Recruitment of Mycobacterium tuberculosis specific CD4<sup>+<\/sup> T cells to the site of infection for diagnosis of active tuberculosis","volume":"265","author":"J Nemeth","year":"2009","journal-title":"J Int Med"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"e30324","DOI":"10.1371\/journal.pone.0030324","article-title":"Highly Accurate Diagnosis of Pleural Tuberculosis by Immunological Analysis of the Pleural Effusion","volume":"7","author":"JS Sutherland","year":"2012","journal-title":"PLoS ONE"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1378\/chest.06-2063","article-title":"Diagnosis and treatment of tuberculosis pleural effusion in 2006","volume":"131","author":"A Gopi","year":"2007","journal-title":"Chest"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1440-1843.2010.01723.x","article-title":"Update on tuberculous pleural effusion","volume":"15","author":"RW Light","year":"2010","journal-title":"Respirology"},{"key":"ref13","article-title":"Implementing tuberculosis diagnosis","year":"2015","journal-title":"Policy framework"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1183\/09031936.00067307","article-title":"Use of a T-cell interferon-\u03b3 release assay for the diagnosis of tuberculosis pleurisy","volume":"30","author":"M Losi","year":"2007","journal-title":"Eur Respir J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1183\/09031936.00005309","article-title":"Utility of quantitative T-cell responses <italic>versus<\/italic> unstimulated interferon-\u03b3 for the diagnosis of pleural tuberculosis","volume":"34","author":"K Dheda","year":"2009","journal-title":"Eur Respir J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1128\/JCM.00823-15","article-title":"Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis: a Systematic Review and Meta-Analysis","volume":"53","author":"AN Aggarwal","year":"2015","journal-title":"J Clin Microbiol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"11672","DOI":"10.4238\/2015.September.28.19","article-title":"Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis","volume":"14","author":"ZZ Li","year":"2015","journal-title":"Gen and Mol Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e951","DOI":"10.7717\/peerj.951","article-title":"Accuracy of the interferon-gamma release assay for the diagnosis of tuberculous pleurisy: an updated meta-analysis","volume":"3","author":"CS Pang","year":"2015","journal-title":"Peer J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.lab.2004.11.013","article-title":"Evaluation of interferon-\u03b3, interferon-\u03b3-inducing cytokines, and interferon-\u03b3-inducible chemokines in tuberculous pleural effusions","volume":"145","author":"M Okamoto","year":"2005","journal-title":"J Lab Clin Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tube.2010.12.005","article-title":"Polyfunctional Mycobacterium tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB","volume":"91","author":"L El Fenniri","year":"2011","journal-title":"Tuberculosis"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jinf.2012.02.013","article-title":"Interferon gamma and interferon gamma inducible protein-10 in detecting tuberculosis infection","volume":"64","author":"BSA Kabeer","year":"2012","journal-title":"J Infec"},{"key":"ref22","first-page":"1092","article-title":"Methods of enzymatic analysis","author":"G Giusti","year":"1974"},{"key":"ref23","first-page":"1172","article-title":"Simultaneous measurement of T-helper 1 cytokines in tuberculous pleural effusion","volume":"7","author":"A Hiraki","year":"2003","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.tube.2006.07.005","article-title":"Modern approaches to a rapid diagnosis of tuberculosis: promises and challenges ahead","volume":"87","author":"RP Tiwari","year":"2007","journal-title":"Tuberculosis"},{"key":"ref25","first-page":"338","article-title":"Markers for differentiation of tubercular pleural effusion from non-tubercular effusion","volume":"67","author":"V Ambade","year":"2011","journal-title":"MJAFI"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1086\/426139","article-title":"Ex vivo Characterization of Early Secretory Antigenic Target 6 \u2013Specific T Cells at Sites of Active Disease in Pleural Tuberculosis","volume":"40","author":"KA Wilkinson","year":"2005","journal-title":"Clin Infec Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1378\/chest.123.3.740","article-title":"Diagnostic significance of interferon-\u03b3 in tuberculous pleural effusions","volume":"123","author":"K Aoe","year":"2003","journal-title":"Chest"},{"issue":"8","key":"ref28","first-page":"777","article-title":"Adenosine deaminase and interferon gamma measurements for the diagnosis of tuberculous pleurisy: a meta-analysis","volume":"7","author":"S Greco","year":"2003","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1378\/chest.06-2273","article-title":"Diagnostic value of interferon-\u03b3 in tuberculous pleurisy","volume":"131","author":"J Jiang","year":"2007","journal-title":"Chest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jmii.2010.04.001","article-title":"Differential diagnosis of tuberculous and malignant pleurisy using pleural fluid adenosine deaminase and interferon gamma in Taiwan","volume":"44","author":"YC Liu","year":"2011","journal-title":"J Microbiol Immunol Infect"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cyto.2007.12.009","article-title":"Expression of CXC and CC type of chemokines and its receptors in tuberculous and non-tuberculous effusions","volume":"41","author":"S Pokkali","year":"2008","journal-title":"Cytokine"},{"issue":"15","key":"ref32","doi-asserted-by":"crossref","first-page":"282","DOI":"10.21037\/atm.2016.07.23","article-title":"Advances in the diagnosis of tuberculous pleuritis","volume":"4","author":"JM Porcel","year":"2016","journal-title":"Ann Transl Med"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"e4689","DOI":"10.1371\/journal.pone.0004689","article-title":"Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting","volume":"4","author":"K Dheda","year":"2009","journal-title":"PLoS ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2147\/IJGM.S100237","article-title":"Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion","volume":"9","author":"KY Chen","year":"2016","journal-title":"Int J Gen Med"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ejcdt.2012.08.004","article-title":"Diagnostic value of adenosine deaminase in tuberculous and malignant pleural effusion","volume":"61","author":"NA Helmy","year":"2012","journal-title":"Egypt J Chest Dis Tubercl"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"e0113047","DOI":"10.1371\/journal.pone.0113047","article-title":"Pleural Fluid Adenosine Deaminase (PFADA) in the Diagnosis of Tuberculous Effusions in a Low Incidence Population","volume":"10","author":"DT Arnold","year":"2015","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1378\/chest.87.3.351","article-title":"Carcinomatous and tuberculous pleural effusions","volume":"87","author":"Y Niwa","year":"1985","journal-title":"Chest"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1378\/chest.97.3.605","article-title":"Serum and pleural adenosine deaminase. Correlation with lymphocytic population","volume":"97","author":"MF Baganha","year":"1990","journal-title":"Chest"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1186\/1471-2334-13-546","article-title":"Factors affecting pleural fluid adenosine deaminase level and the implication on the diagnosis of tuberculous pleural effusion: a retrospective cohort study","volume":"13","author":"TR Tay","year":"2013","journal-title":"BMC Infectious Diseases"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.5588\/ijtld.14.0257","article-title":"Role of adenosine deaminase and the influence of age on the diagnosis of pleural tuberculosis","volume":"18","author":"FC Abrao","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/MAJ.0000000000000260","article-title":"Factors influencing pleural adenosine deaminase level in patients with tuberculous pleurisy","volume":"348","author":"SJ Lee","year":"2014","journal-title":"Am J Med Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/1574-695X.12006","article-title":"Improved diagnostic power by combined interferon-gamma release assay and nested-PCR in tuberculous pleurisy in high tuberculosis prevalence area","volume":"66","author":"Y Gao","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e38729","DOI":"10.1371\/journal.pone.0038729","article-title":"Diagnostic accuracy of adenosine deaminase and lymphocyte proportion in pleural fluid for tuberculous pleurisy in different prevalence scenarios","volume":"7","author":"A Garcia-Zamalloa","year":"2012","journal-title":"PLoS ONE"},{"key":"ref44","first-page":"47","article-title":"Diagnosis of tuberculous pleurisy with combination of adenosine deaminase and interferon-\u03b3 immunospot assay in a tuberculosis-endemic population","volume":"96","author":"HY Xu","year":"2017","journal-title":"Medicine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jinf.2013.05.009","article-title":"Evaluating pleural ADA, ADA2, IFN-\u03b3 and IGRA for diagnosing tuberculous pleurisy","volume":"67","author":"LT Keng","year":"2013","journal-title":"J Infect"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e102702","DOI":"10.1371\/journal.pone.0102702","article-title":"Evaluation of Cepheid\u2019s Xpert MTB\/RIF test on pleural fluid in the diagnosis of pleural tuberculosis in a high prevalence HIV\/TB setting","volume":"9","author":"JK Lusiba","year":"2014","journal-title":"PLoS ONE"},{"key":"ref47","first-page":"709","article-title":"BMC Infec Dis","volume":"14","author":"L Maynard-Smith","year":"2014","journal-title":"BMC Infec Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1128\/JCM.03205-15","article-title":"Diagnostic performance of Xpert MTB\/RIF in tuberculous pleural effusion: systematic review and meta-analysis","volume":"54","author":"IS Sehgal","year":"2016","journal-title":"J Clin Microbiol"},{"issue":"10","key":"ref49","doi-asserted-by":"crossref","first-page":"e0165428","DOI":"10.1371\/journal.pone.0165428","article-title":"Clinical and laboratory differences between lymphocyte and neutrophil-predominant pleural tuberculosis","volume":"11","author":"H Choi","year":"2016","journal-title":"PLoS ONE"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5588\/ijtld.12.0236","article-title":"Comparison of polymorphonuclear and lymphocyte rich tuberculous pleural effusions","volume":"17","author":"S Bielsa","year":"2013","journal-title":"Int J Tuberc Lung Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:10:56Z","timestamp":1540339856000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202481"}},"subtitle":[],"editor":[{"given":"Katalin Andrea","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,27]]},"references-count":50,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202481","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.17504\/protocols.io.saseaee","asserted-by":"object"},{"id-type":"doi","id":"10.17504\/protocols.io.saceaaw","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,27]]}}}