{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:32:27Z","timestamp":1790170347741,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2015\/12485-4"],"award-info":[{"award-number":["2015\/12485-4"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2016\/25255-0"],"award-info":[{"award-number":["2016\/25255-0"]}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/51904-9"],"award-info":[{"award-number":["2010\/51904-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202515","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T13:30:21Z","timestamp":1534771821000},"page":"e0202515","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Circulating catecholamines are associated with biobehavioral factors and anxiety symptoms in head and neck cancer patients"],"prefix":"10.1371","volume":"13","author":[{"given":"Daniela B.","family":"Bastos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna A. M.","family":"Sarafim-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L\u00facia M. M.","family":"Sundefeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda A.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana D. P.","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9der R.","family":"Biasoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauco I.","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce E.","family":"Casarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-7749","authenticated-orcid":true,"given":"Daniel G.","family":"Bernab\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S1470-2045(04)01597-9","article-title":"Stress, depression, the immune system, and cancer","volume":"5","author":"EM Reiche","year":"2004","journal-title":"Lancet Oncol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/00006842-200111000-00014","article-title":"Endocrine levels at the start of treatment are associated with subsequent psychological adjustment in cancer patients with metastatic disease","volume":"63","author":"L Cohen","year":"2001","journal-title":"Psychosom Med"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1037\/a0035730","article-title":"Biobehavioral Approaches to cancer progression and survival: mechanisms and interventions","volume":"70","author":"SK Lutgendorf","year":"2015","journal-title":"Am Psychol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/s40064-016-2136-2","article-title":"Assessment of psychosocial factors and distress in women having adjuvant endocrine therapy for breast cancer: the relationship among emotional distress and patient and treatment-related factors","volume":"5","author":"O Ates","year":"2016","journal-title":"SpringerPlus"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1186\/1471-2407-14-731","article-title":"Distress, anxiety and depression in patients with brain metastases before and after radiotherapy.","volume":"14","author":"M-C Cordes","year":"2014","journal-title":"BMC Cancer"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/pon.3439","article-title":"Psychological distress in women with breast and gynecological cancer treated with radical surgery","volume":"23","author":"P G\u00f3mez-Campelo","year":"2014","journal-title":"Psychooncology"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/pon.3381","article-title":"Assessing multidimensional worry in cancer survivors","volume":"23","author":"J Moye","year":"2014","journal-title":"Psychooncology"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nrc1820","article-title":"The influence of bio-behavioural factors on tumour biology: pathways and mechanisms","volume":"6","author":"MH Antoni","year":"2006","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2008.06.007","article-title":"Neuroendocrine modulation of cancer progression","volume":"23","author":"GN Armaiz-Pena","year":"2009","journal-title":"Brain Behav Immun"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.iac.2010.09.001","article-title":"Biobehavioral influences on cancer progression","volume":"31","author":"ES Costanzo","year":"2011","journal-title":"Immunol Allergy Clin North Ame"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbi.2010.10.012","article-title":"Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients","volume":"25","author":"SK Lutgendorf","year":"2011","journal-title":"Brain Behav Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/S0889-1591(02)00059-4","article-title":"Catcholamines, sympathetic innervation, and immunity","volume":"17","author":"KS Madden","year":"2003","journal-title":"Brain Behav Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2147\/CLEP.S33695","article-title":"Beta blockers, norepinephrine, and cancer: an epidemiological viewpoint.","volume":"4","author":"PJ Fitzgerald","year":"2012","journal-title":"Clin Epidemiol"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri1571","article-title":"Stress-induced immune dysfunction: implications for health","volume":"5","author":"R Glaser","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"28","key":"ref15","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1200\/JCO.2005.10.015","article-title":"Social support, psychological distress, and natural killer cell activity in ovarian cancer","volume":"23","author":"SK Lutgendorf","year":"2005","journal-title":"J Clin Oncol"},{"issue":"12","key":"ref16","first-page":"4514","article-title":"Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines","volume":"9","author":"SK Lutgendorf","year":"2003","journal-title":"Clin Cancer Res"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bbi.2008.10.005","article-title":"Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression","volume":"23","author":"EV Yang","year":"2009","journal-title":"Brain Behav Immun"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bbi.2010.12.012","article-title":"Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells","volume":"25","author":"DG Bernab\u00e9","year":"2011","journal-title":"Brain Behav Immun"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.pan.2016.03.005","article-title":"Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade","volume":"16","author":"LI Partecke","year":"2016","journal-title":"Pancreatology"},{"issue":"21","key":"ref20","doi-asserted-by":"crossref","first-page":"10357","DOI":"10.1158\/0008-5472.CAN-06-2496","article-title":"Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase MMP-2, and MMP-9 in nasopharyngeal carcinoma tumor cells","volume":"66","author":"EV Yang","year":"2006","journal-title":"Cancer Res"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1172\/JCI40802","article-title":"Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis","volume":"120","author":"AK Sood","year":"2010","journal-title":"J Clin Invest."},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/pon.4305","article-title":"Anxiety and serum catecholamines as predictors of survival and recurrence in hepatocellular carcinoma","volume":"26","author":"J Liu","year":"2017","journal-title":"Psychooncology"},{"issue":"4\u20135","key":"ref23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","article-title":"Global epidemiology of oral and oropharyngeal cancer","volume":"45","author":"S. Warnakulasuriya","year":"2009","journal-title":"Oral Oncol"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.bjoms.2014.03.019","article-title":"Quality of life, psychological wellbeing and treatment needs of trauma and head and neck cancer patients","volume":"52","author":"F Shiraz","year":"2014","journal-title":"Br J Oral & Maxillofac Surg"},{"key":"ref25","first-page":"1029","article-title":"Anxiety and depression in patients with head and neck cancer: 6-month follow-up study","volume":"12","author":"YS Wu","year":"2016","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"e99179","DOI":"10.1371\/journal.pone.0099179","article-title":"Association of increased circulating catecholamine and glucocorticoid levels with risk of psychological problems in oral neoplasm patients","volume":"9","author":"H Xie","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0030-4220(78)90383-3","article-title":"Definition of leukoplakia and related lesions: an aid to studies on oral precancer","volume":"46","author":"IR Kramer","year":"1978","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"11 Pt 1","key":"ref28","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1097\/00005537-199711000-00009","article-title":"Validation of the Charlson Comorbidity Index in patients with head and neck cancer: A multi- institutional study","volume":"107","author":"B Singh","year":"1997","journal-title":"Laryngoscope"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/(SICI)1097-4679(199701)53:1<7::AID-JCLP2>3.0.CO;2-S","article-title":"The Beck Anxiety Inventory: reexamination of factor structure and psychometric properties","volume":"53","author":"A Osman","year":"1997","journal-title":"J Clin Psychol"},{"key":"ref30","first-page":"119","article-title":"Serum catecholamine levels determined by high performance liquid chromatography coupled with electrochemical detection","volume":"36","author":"Casarini DE Naffah-Mazzacoratti","year":"1992","journal-title":"Arquivos Brasileiros de Endocrinologia e Metabologia"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jcb.10485","article-title":"Mesangial cells are able to produce catecholamines in vitro","volume":"89","author":"GS Di Marco","year":"2003","journal-title":"J Cell Biochem"},{"issue":"46","key":"ref32","doi-asserted-by":"crossref","first-page":"35462","DOI":"10.1074\/jbc.M110.109579","article-title":"Stress effects on FosB- and Interleukin-8 (IL8)-driven ovarian cancer growth and metastasis","volume":"285","author":"MM Shahzad","year":"2010","journal-title":"J Biol Chem"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/00000658-198811000-00017","article-title":"Increased urinary excretion of cortisol and catecholamines in malnourished cancer patients","volume":"208","author":"C Drott","year":"1988","journal-title":"Ann Surg"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10865-006-9082-3","article-title":"Associations among salivary cortisol, melatonin, catecholamines, sleep quality and stress in women with breast cancer and healthy controls","volume":"30","author":"LE Carlson","year":"2007","journal-title":"J Behav Med"},{"issue":"1\u20132","key":"ref35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.autneu.2011.09.006","article-title":"Exploring autonomic nervous system dysfunction in patients with cancer cachexia: a pilot study","volume":"166","author":"A Chauhan","year":"2012","journal-title":"Auton Neurosci"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/00365520310007738","article-title":"Reversibility of increased formation of catecholamines in patients with alcoholic liver disease","volume":"39","author":"A Parlesak","year":"2004","journal-title":"Scand J Gastroenterol"},{"issue":"2\u20133","key":"ref37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0014-2999(02)01939-8","article-title":"Plasma catecholamines in ethanol tolerance and withdrawal in mice","volume":"448","author":"GL Kov\u00e1cs","year":"2002","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1530-0277.1997.tb04450.x","article-title":"Endocrine and hemodynamic effects of stress versus systemic CRF in alcoholics during early and medium term abstinence","volume":"21","author":"H Ehrenreich","year":"1997","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-1781(99)00099-2","article-title":"Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations","volume":"89","author":"A Heinz","year":"1999","journal-title":"Psychiatry Res"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/00365529309098254","article-title":"Acute effects of smoking during modified sham feeding in duodenal ulcer patients. An analysis of nicotine, acid secretion, gastrin, catecholamines, epidermal growth factor, prostaglandin E2, and bile acids","volume":"28","author":"G Lindell","year":"1993","journal-title":"Scand J Gastroenterol."},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/1097-4679(197807)34:3<759::AID-JCLP2270340338>3.0.CO;2-Y","article-title":"Psychological and physiological changes during tobacco-abstinence in habitual smokers","volume":"34","author":"A. Elgerot","year":"1978","journal-title":"J Clin Psychol"},{"issue":"8","key":"ref42","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/0002-9378(79)90727-0","article-title":"The effect of smoking and oral contraceptives on the urinary excretion of epinephrine and norepinephrine","volume":"135","author":"FP Zuspan","year":"1979","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0091-3057(91)90109-F","article-title":"Changes in urinary catecholamine excretion after smoking cessation","volume":"40","author":"KD Ward","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1136\/jclinpath-2012-200695","article-title":"Increased plasma and salivary cortisol levels in patients with oral cancer and their association with clinical stage","volume":"65","author":"DG Bernab\u00e9","year":"2012","journal-title":"J Clin Pathol"},{"issue":"19","key":"ref45","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1002\/cncr.29516","article-title":"Eudaimonic well-being and tumor norepinephrine in epithelial ovarian cancer patients","volume":"121","author":"LZ Davis","year":"2015","journal-title":"Cancer"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1037\/a0018836","article-title":"The pain, depression, and fatigue symptom cluster in advanced breast cancer: covariation with the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system.","volume":"29","author":"LM Thornton","year":"2010","journal-title":"Health psychol"},{"issue":"4","key":"ref47","first-page":"448","article-title":"Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption","volume":"34","author":"HC Becker","year":"2012","journal-title":"Alcohol Res"},{"key":"ref48","first-page":"650707","article-title":"Screening for depression, sleep-related disturbances, and anxiety in patients with adenocarcinoma of the pancreas: A preliminary study","volume":"2012","author":"AD Boyd","year":"2012","journal-title":"ScientificWorldJournal"},{"issue":"17","key":"ref49","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1002\/cncr.28188","article-title":"Sleep disturbance, distress, and quality of life in ovarian cancer patients during the first year post diagnosis.","volume":"119","author":"L Clevenger","year":"2013","journal-title":"Cancer"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0022-3999(97)00302-4","article-title":"Chronic insomnia and activity of the stress system: a preliminary study","volume":"45","author":"AN Vgontzas","year":"1998","journal-title":"J Psychosom Res"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/sleep\/29.10.1347","article-title":"Sleep disturbance, norepinephrine, and D-dimer are all related in elderly caregivers of people with Alzheimer disease","volume":"29","author":"BT Mausbach","year":"2006","journal-title":"Sleep"},{"issue":"9","key":"ref52","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.psyneuen.2009.04.005","article-title":"Intra-Individual variability in sleep duration and fragmentation: associations with stress","volume":"34","author":"EJ Mezick","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.psyneuen.2017.11.001","article-title":"Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats","volume":"89","author":"VB Valente","year":"2018","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1600-0714.2008.00691.x","article-title":"Expression of beta2-adrenergic receptor in oral squamous cell carcinoma","volume":"38","author":"ZJ Shang","year":"2009","journal-title":"J Oral Pathol Med."},{"issue":"11","key":"ref55","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.oraloncology.2015.08.007","article-title":"Chronic stress promotes oral cancer growth and angiogenesis with increased circulating catecholamine and glucocorticoid levels in a mouse model","volume":"51","author":"H Xie","year":"2015","journal-title":"Oral Oncol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T10:42:01Z","timestamp":1540204921000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202515"}},"subtitle":[],"editor":[{"given":"Gabriele","family":"Multhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,20]]},"references-count":55,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202515","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,20]]}}}