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inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells","volume":"23","author":"A Yamamoto","year":"1998","journal-title":"Cell Struct Funct"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e43418","DOI":"10.1371\/journal.pone.0043418","article-title":"Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion","volume":"7","author":"YJ Choi","year":"2012","journal-title":"PLoS ONE"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1128\/EC.00110-08","article-title":"Evidence for the Role of Calcineurin in Morphogenesis and Calcium Homeostasis during Mycelium-to-Yeast Dimorphism of <italic>Paracoccidioides brasiliensis<\/italic>","volume":"7","author":"CBL Campos","year":"2008","journal-title":"Eukaryot Cell"},{"key":"ref42","unstructured":"Stanford University, Stanford. Saccharomyces Genome Database. In: Saccharomyces Genome Database (SGD) [Internet]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.yeastgenome.org\/\" xlink:type=\"simple\">https:\/\/www.yeastgenome.org\/<\/ext-link>"},{"key":"ref43","unstructured":"NCBI. Basic Local Alignment Search Tool (BLAST). In: Basic Local Alignment Search Tool [Internet]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/blast.ncbi.nlm.nih.gov\/Blast.cgi\" xlink:type=\"simple\">https:\/\/blast.ncbi.nlm.nih.gov\/Blast.cgi<\/ext-link>"},{"article-title":"The NCBI Handbook","year":"2002","author":"T Madden","key":"ref44"},{"key":"ref45","first-page":"165","article-title":"Experimental murine paracoccidiodomycosis induced by the inhalation of conidia","volume":"25","author":"JG McEwen","year":"1987","journal-title":"J Med Vet Mycol Bi-Mon Publ Int Soc Hum Anim Mycol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1055\/s-0031-1295724","article-title":"Pulmonary paracoccidioidomycosis","volume":"32","author":"F Queiroz-Telles","year":"2011","journal-title":"Semin Respir Crit Care Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.fgb.2014.01.008","article-title":"Transcriptomic reprogramming of genus 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