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Evidence of a new susceptibility locus in Caucasian and Chinese patients","volume":"278","author":"LF Barcellos","year":"1997","journal-title":"JAMA"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/135245859900500211","article-title":"Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis","volume":"5","author":"H Zouali","year":"1999","journal-title":"Mult Scler"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/135245850000600412","article-title":"Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis","volume":"6","author":"CW Kirk","year":"2000","journal-title":"Mult Scler"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1074\/mcp.O116.064477","article-title":"CSF-PR 2.0: an interactive literature guide to quantitative cerebrospinal fluid mass spectrometry data from neurodegenerative disorders","volume":"16","author":"A Guldbrandsen","year":"2017","journal-title":"Mol Cell Proteomics"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1021\/acs.jproteome.6b00659","article-title":"In-depth cerebrospinal fluid quantitative proteome and deglycoproteome analysis: presenting a comprehensive picture of pathways and processes affected by multiple sclerosis","volume":"16","author":"AC Kroksveen","year":"2017","journal-title":"J Proteome Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/pmic.201500284","article-title":"Label-free analysis of human cerebrospinal fluid addressing various normalization strategies and revealing protein groups affected by multiple sclerosis","volume":"16","author":"JA Opsahl","year":"2016","journal-title":"Proteomics"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3892\/br.2016.668","article-title":"Proteomic analysis of cerebrospinal fluid for relapsing-remitting multiple sclerosis and clinically isolated syndrome","volume":"5","author":"Z Pavelek","year":"2016","journal-title":"Biomed Rep"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jprot.2012.09.037","article-title":"Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM","volume":"78","author":"AC Kroksveen","year":"2013","journal-title":"J Proteomics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:12:00Z","timestamp":1540339920000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202530"}},"subtitle":[],"editor":[{"given":"Joseph","family":"Najbauer","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,16]]},"references-count":69,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202530","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,16]]}}}