{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:15:12Z","timestamp":1775592912342,"version":"3.50.1"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K16964"],"award-info":[{"award-number":["17K16964"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K11337"],"award-info":[{"award-number":["16K11337"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202585","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T13:45:19Z","timestamp":1535031919000},"page":"e0202585","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Age-related differences in the clinical features of ocular sarcoidosis"],"prefix":"10.1371","volume":"13","author":[{"given":"Kei","family":"Takayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozo","family":"Harimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohito","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manzo","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-7089","authenticated-orcid":true,"given":"Masaru","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"issue":"17","key":"ref1","first-page":"1224","article-title":"Sarcoidosis","volume":"336","author":"LS Newman","year":"1997"},{"issue":"8","key":"ref2","first-page":"429","article-title":"Pulmonary sarcoidosis","volume":"305","author":"GW Hunninghake","year":"1981"},{"issue":"7","key":"ref3","first-page":"461","article-title":"The eye in sarcoidosis","volume":"45","author":"RP Crick","year":"1961"},{"issue":"4","key":"ref4","first-page":"452","article-title":"Intraocular manifestations of systemic sarcoidosis","volume":"36","author":"K Ohara","year":"1992"},{"issue":"3\u20134","key":"ref5","first-page":"287","article-title":"Risk factors for ocular sarcoidosis","volume":"72","author":"A Rothova","year":"1989"},{"issue":"2","key":"ref6","first-page":"112","article-title":"An epidemiological perspective of the pathology and etiology of sarcoidosis","volume":"33","author":"M Sawahata","year":"2016"},{"issue":"2","key":"ref7","first-page":"272","article-title":"Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan","volume":"109","author":"M Sawahata","year":"2015"},{"issue":"4","key":"ref8","first-page":"585","article-title":"The diagnosis of sarcoidosis","volume":"36","author":"P Govender","year":"2015"},{"issue":"7","key":"ref9","first-page":"1296","article-title":"Surgical excision of iris nodules in the management of sarcoid uveitis","volume":"108","author":"VV Ocampo Jr.","year":"2001"},{"issue":"1","key":"ref10","first-page":"8","article-title":"Directed conjunctival biopsy and impact of histologic sectioning methodology on the diagnosis of ocular sarcoidosis","volume":"4","author":"KM Bui","year":"2014"},{"key":"ref11","first-page":"599","article-title":"Immunohistochemical examination of lacrimal gland tissue from patients with ocular sarcoidosis","volume":"438","author":"JA Smith","year":"1998"},{"issue":"3","key":"ref12","first-page":"160","article-title":"International criteria for the diagnosis of ocular sarcoidosis: results of the first International Workshop On Ocular Sarcoidosis (IWOS)","volume":"17","author":"CP Herbort","year":"2009"},{"issue":"7","key":"ref13","first-page":"856","article-title":"Long-term visual and systemic prognoses of 83 cases of biopsy-proven sarcoid uveitis","volume":"101","author":"C Rochepeau","year":"2017"},{"issue":"1","key":"ref14","first-page":"119","article-title":"Distinguishing features of ocular sarcoidosis in an international cohort of uveitis patients","volume":"125","author":"NR Acharya","year":"2018"},{"issue":"2\u20133","key":"ref15","first-page":"213","article-title":"Valpha24+ NKT cells are decreased in elderly humans","volume":"37","author":"O DelaRosa","year":"2002"},{"issue":"4","key":"ref16","first-page":"416","article-title":"NK and NKT cells in aging and longevity: role of zinc and metallothioneins","volume":"29","author":"E Mocchegiani","year":"2009"},{"issue":"8","key":"ref17","first-page":"2194","article-title":"Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis","volume":"43","author":"JE Snyder-Cappione","year":"2013"},{"issue":"4","key":"ref18","first-page":"1069","article-title":"The impact of ageing on natural killer cell function and potential consequences for health in older adults","volume":"12","author":"J Hazeldine","year":"2013"},{"key":"ref19","first-page":"337","article-title":"Peripheral blood natural killer cell percentages in granulomatosis with polyangiitis correlate with disease inactivity and stage","volume":"17","author":"W Merkt","year":"2015"},{"issue":"4","key":"ref20","first-page":"316","article-title":"Activated CD8+ T cells and natural killer T cells in bronchoalveolar lavage fluid in hypersensitivity pneumonitis and sarcoidosis","volume":"31","author":"A Tondell","year":"2015"},{"issue":"7","key":"ref21","first-page":"635","article-title":"Reproductive and hormonal factors in relation to incidence of sarcoidosis in US Black women: The Black Women\u2019s Health Study","volume":"176","author":"YC Cozier","year":"2012"},{"issue":"6","key":"ref22","first-page":"491","article-title":"Sex hormones alter Th1 responses and enhance granuloma formation in the lung","volume":"81","author":"K Tajima","year":"2011"},{"issue":"2","key":"ref23","first-page":"272","article-title":"The influence of ovarian hormones on the granulomatous inflammatory process in the rat lung","volume":"8","author":"M Shirai","year":"1995"},{"issue":"12","key":"ref24","first-page":"1324","article-title":"A case control etiologic study of sarcoidosis: environmental and occupational risk factors","volume":"170","author":"LS Newman","year":"2004"},{"issue":"3","key":"ref25","first-page":"226","article-title":"Job and industry classifications associated with sarcoidosis in A Case-Control Etiologic Study of Sarcoidosis (ACCESS)","volume":"47","author":"J Barnard","year":"2005"},{"issue":"4","key":"ref26","first-page":"683","article-title":"Efficacy and safety of conventional transbronchial needle aspiration in sarcoidosis: a systematic review and meta-analysis","volume":"58","author":"R Agarwal","year":"2013"},{"key":"ref27","first-page":"331","article-title":"Efficacy and safety of transbronchial lung biopsy for the diagnosis of lymphangioleiomyomatosis: A report of 24 consecutive patients","volume":"23","author":"T Koba","year":"2017"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T13:09:50Z","timestamp":1540300190000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202585"}},"subtitle":[],"editor":[{"given":"James T.","family":"Rosenbaum","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202585","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]}}}