{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:30:59Z","timestamp":1790634659540,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202615","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T13:30:21Z","timestamp":1543411821000},"page":"e0202615","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tracking a serial killer: Integrating phylogenetic relationships, epidemiology, and geography for two invasive meningococcal disease outbreaks"],"prefix":"10.1371","volume":"13","author":[{"given":"Ifeoma","family":"Ezeoke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline R.","family":"Galac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin T.","family":"Liem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierce A.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kilianski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry S.","family":"Gibbons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kornblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Del Rosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Janies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5898-4565","authenticated-orcid":true,"given":"Don","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"ref1","first-page":"116","article-title":"Summary of Notifiable Infectious Diseases and Conditions, 2015","volume":"64","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1086\/597257","article-title":"Epidemiologic Investigation and Targeted Vaccination Initiative in Response to an Outbreak of Meningococcal Disease among Illicit Drug Users in Brooklyn, New York","volume":"48","author":"D Weiss","year":"2009","journal-title":"Clin Inf Dis"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3201\/eid2108.141837","article-title":"Community-Based Outbreak of Neisseria meningitidis Serogroup C Infection in Men who Have Sex with Men, New York City, New York, USA, 2010\u20132013","volume":"21","author":"MM Kratz","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1128\/JCM.41.9.4411-4414.2003","article-title":"Outbreak of Serogroup C Meningococcal Disease Caused by a Variant of Neisseria meningitidis Serotype 2a ET-15 in a Community of Men Who Have Sex with Men","volume":"41","author":"RSW Tsang","year":"2003","journal-title":"J Clin Microbiol"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1128\/JCM.01190-07","article-title":"Molecular Epidemiology of Neisseria meningitidis Isolates from an Outbreak of Meningococcal Disease among Men Who Have Sex with Men, Chicago, Illinois, 2003","volume":"45","author":"S Schmink","year":"2007","journal-title":"J Clin Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"939","DOI":"10.15585\/mmwr.mm6535e1","article-title":"Outbreak of Serogroup C Meningococcal Disease Primarily Affecting Men Who Have Sex with Men-Southern California, 2016","volume":"65","author":"S Nanduri","year":"2016","journal-title":"Morb Mortal Weekly Rep"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/cid\/cix438","article-title":"Increased Risk for Meningococcal Disease Among Men Who Have Sex With Men in the United States, 2012\u20132015","volume":"65","author":"TA Folaranmi","year":"2017","journal-title":"Clin Inf Dis"},{"issue":"28","key":"ref8","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2013.18.28.20523","article-title":"A cluster of invasive meningococcal disease in young men who have sex with men in Berlin, October 2012 to May 2013","volume":"18","author":"U Marcus","year":"2013","journal-title":"Eurosurveillance"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2015.20.3.21016","article-title":"Serogroup C invasive meningococcal disease among men who have sex with men and in gay-oriented social venues in the Paris region: July 2013 to December 2014","volume":"20","author":"L Aubert","year":"2015","journal-title":"Eurosurveillance"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3201\/eid2303.161039","article-title":"Two Cases of Neisseria meningitidis Proctitis in HIV-positive Men Who Have Sex With Men","volume":"23","author":"J Gutierrez-Fernandez","year":"2017","journal-title":"Emerg Inf Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/1469-0691.12647","article-title":"<italic>Neisseria meningitidis<\/italic>; clones, carriage and disease","volume":"20","author":"RC Read","year":"2014","journal-title":"Clin Microbiol Infect"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1155\/2007\/295973","article-title":"Usefulness of pulsed-field gel electrophoresis in tracking two outbreaks of invasive meningococcal disease serogroup C in British Columbia","volume":"18","author":"G Quan","year":"2007","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/1471-2334-13-554","article-title":"Genomic comparative analysis and gene function prediction in infectious diseases: application to the investigation of a meningitis outbreak","volume":"13","author":"E Lavezzo","year":"2013","journal-title":"BMC Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1473-3099(12)70277-3","article-title":"Whole-genome sequencing to delineate <italic>Mycobacterium tuberculosis<\/italic> outbreaks: a retrospective observational study","volume":"13","author":"TM Walker","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1012928","article-title":"The Origin of the Haitian Cholera Outbreak Strain","volume":"364","author":"CS Chin","year":"2011","journal-title":"N Eng J Med"},{"issue":"148","key":"ref16","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004129","article-title":"Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing","volume":"4","author":"ES Snitkin","year":"2012","journal-title":"Sci Transl Med"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","DOI":"10.3201\/eid2311.170308","article-title":"Legionnaires\u2019 Disease Outbreak Caused by Endemic Strain of Legionella pneumophila, New York, USA, 2015","volume":"23","author":"P Lapierre","year":"2017","journal-title":"Emerg Inf Dis"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.3201\/eid2310.161623","article-title":"Molecular Tracing to Find Source of a Protracted Invasive Listeriosis Outbreak, Southern Germany, 2012\u20132016","volume":"23","author":"S Kleta","year":"2017","journal-title":"Emerg Inf Dis"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2016.21.45.30395","article-title":"An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August, 2015","volume":"21","author":"J Lucidarme","year":"2016","journal-title":"Eurosurveillance"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"e0154047","DOI":"10.1371\/journal.pone.0154047","article-title":"Evolutionary Events Associated with an Outbreak of Meningococcal Disease in Men Who Have Sex with Men","volume":"11","author":"MK Taha","year":"2017","journal-title":"PLOS ONE"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/cid\/cix215","article-title":"Large Cluster of Neisseria meningitidis Urethritis in Columbus, Ohio, 2015","volume":"65","author":"JA Bazan","year":"2017","journal-title":"Clin Infec Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1073\/pnas.1620971114","article-title":"Emergence of a new Neisseria meningitidis clonal complex 11 lineage 11.2 clade as an effective urogenital pathogen","volume":"114","author":"YL Tzeng","year":"2017","journal-title":"PNAS"},{"key":"ref23","unstructured":"Council of State and Territorial Epidemiologists. Position statement 14-ID-06. Revision of the National Surveillance Case Definition for Meningococcal Disease. 2014; 2017 (May 26)."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/B978-0-7020-4088-7.00093-6","article-title":"Bacterial meningitis","volume":"121","author":"S Heckenberg","year":"2014","journal-title":"Handb Clin Neuro"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1309\/3489075U03LMK9AE","article-title":"Pathogenesis and diagnosis of human meningococcal disease using immunohistochemical and PCR assays","volume":"122","author":"J Guarner","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1101\/gr.074492.107","article-title":"Velvet: algorithms for de novo short read assembly using de Bruijn graphs","volume":"18","author":"DR Zerbino","year":"2008","journal-title":"Genome Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-2164-9-75","article-title":"The RAST Server: rapid annotations using subsystems technology","volume":"9","author":"RK Aziz","year":"2008","journal-title":"BMC Genomics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.1038\/srep08365","article-title":"RASTtk: A modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes","volume":"5","author":"T Brettin","year":"2015","journal-title":"Sci. Rep"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1101\/gr.1224503","article-title":"OrthoMCL: identification of ortholog groups for eukaryotic genomes","volume":"13","author":"L Li","year":"2003","journal-title":"Genome Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"D363","DOI":"10.1093\/nar\/gkj123","article-title":"OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups","volume":"34","author":"F Chen","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref31","first-page":"1972","article-title":"BLAST+: architecture and applications. BMC Bioinformatics. 2009; 421. Capella-Guti\u00e9rrez S, Silla-Mart\u00ednez JM, Gabald\u00f3n T. trimAl: A tool for automated alignment trimming in large-scale phylogenetic analyses","volume":"25","author":"C Camacho","year":"2009","journal-title":"Bioinformatics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"20522","DOI":"10.1128\/genomeA.00795-13","article-title":"Draft Genome Sequence of a Neisseria meningitidis Serogroup C Isolate of Sequence Type 11 Linked to an Outbreak among Men Who Have Sex with Men","volume":"1","author":"FJ Veyrier","year":"2013","journal-title":"Genome Announc"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1186\/1471-2105-11-595","article-title":"BIGSdb: Scalable analysis of bacterial genome variation at the population level","volume":"11","author":"KA Jolley","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"K Katoh","year":"2013","journal-title":"Mol. Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1093\/bioinformatics\/btp348","article-title":"trimAl: A tool for automated alignment trimming in large-scale phylogenetic analyses","volume":"25","author":"S Capella-Guti\u00e9rrez","year":"2009","journal-title":"Bioinformatics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.ympev.2010.04.024","article-title":"FASconCAT: Convenient handling of data matrices","volume":"56","author":"P K\u00fcck","year":"2010","journal-title":"Mol. Phylogenet. Evol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1093\/bioinformatics\/btl446","article-title":"RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models","volume":"22","author":"A Stamatakis","year":"2006","journal-title":"Bioinformatics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am. J. Hum. Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"A Conesa","year":"2005","journal-title":"Bioinformatics"},{"key":"ref40","first-page":"1","article-title":"Phylogenetic visualization of the spread of H7 influenza A viruses","author":"DA Janies","year":"2015","journal-title":"Cladistics"},{"key":"ref41","article-title":"PAUP*: Phylogenetic Analysis Using Parsimony (*and Other Methods)","author":"DL Swofford","year":"2002"},{"key":"ref42","first-page":"1","article-title":"The igraph software package for complex network research","volume":"1695","author":"G Cs\u00e1rdi","year":"2006","journal-title":"InterJournal Complex Syst"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v048.i04","article-title":"qgraph: Network Visualizations of Relationships in Psychometric Data","volume":"48","author":"S Epskamp","year":"2012","journal-title":"J. Stat. Softw"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1186\/1471-2164-15-1138","article-title":"A gene-by-gene population genomics platform: de novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes","volume":"15","author":"HB Bratcher","year":"2014","journal-title":"BMC Genomics"},{"issue":"Suppl 2","key":"ref45","doi-asserted-by":"crossref","first-page":"B103","DOI":"10.1016\/j.vaccine.2009.04.064","article-title":"Genome flexibility in Neisseria meningitidis","volume":"27","author":"C Schoen","year":"2009","journal-title":"Vaccine"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1073\/pnas.0800151105","article-title":"Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis","volume":"105","author":"C Schoen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nrmicro.2015.13","article-title":"Within-host evolution of bacterial pathogens","volume":"14","author":"X Didelot","year":"2016","journal-title":"Nat. Rev. Microbiol"},{"key":"ref48","unstructured":"Wa\u015bko I, Hryniewicz W, Skoczy\u0144ska A. Significance of Meningococcal Hyperinvasive Clonal Complexes and their Influence on Vaccine Development."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tmaid.2018.05.003","article-title":"The threat of meningococcal disease during Hajj and Umrah mass gatherings: A comprehensive review","volume":"24","author":"S Yezli","year":"2018","journal-title":"Travel Med Infect. Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.vaccine.2016.02.014","article-title":"Global epidemiology of Group W meningococcal disease (1970\u20132015): Multifocal emergence and persistence of hypervirulent sequence type (ST)-11 clonal complex","volume":"34","author":"MM Mustapha","year":"2016","journal-title":"Vaccine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:54:02Z","timestamp":1588960442000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202615"}},"subtitle":[],"editor":[{"given":"Baochuan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,28]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202615","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/387597","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,28]]}}}