{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:24:16Z","timestamp":1792607056838,"version":"4.5.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY15H150001"],"award-info":[{"award-number":["LY15H150001"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202620","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T13:47:25Z","timestamp":1537364845000},"page":"e0202620","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":62,"title":["The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4824-3904","authenticated-orcid":true,"given":"Guobin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-6404","authenticated-orcid":true,"given":"Zhitao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-8328","authenticated-orcid":true,"given":"Hongliu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000353134","article-title":"Cardiac surgery-associated acute kidney injury","volume":"3","author":"H Mao","year":"2013","journal-title":"Cardiorenal Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.4103\/0971-9784.191570","article-title":"The myocardial protective effect of dexmedetomidine in high-risk patients undergoing aortic vascular surgery","volume":"19","author":"R Soliman","year":"2016","journal-title":"Ann Card Anaesth"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e4646","DOI":"10.1590\/1414-431X20154646","article-title":"Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass","volume":"49","author":"NM Bulow","year":"2016","journal-title":"Braz J Med Biol Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/anae.12636","article-title":"The effects of dexmedetomidine on inflammatory mediators after cardiopulmonary bypass","volume":"69","author":"M Ueki","year":"2014","journal-title":"Anaesthesia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/0267659115615207","article-title":"A review of the peri-operative risk stratification assessment tools used for the prediction of cardiovascular complications in non-cardiac surgery","volume":"31","author":"P Magapu","year":"2016","journal-title":"Perfusion"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/heartasia-2013-010471","article-title":"Risk factors for cardiovascular events and bleeding complications following non-cardiac surgery or procedure in patients with drug eluting stent placement","volume":"6","author":"D Tiwari","year":"2014","journal-title":"Heart Asia"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.soard.2009.06.009","article-title":"Cardiovascular complications of obesity surgery in patients with increased preoperative cardiac risk","volume":"5","author":"BA Afolabi","year":"2009","journal-title":"Surg Obes Relat Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/S0735-1097(03)00191-8","article-title":"Calcium antagonists reduce cardiovascular complications after cardiac surgery: a meta-analysis","volume":"41","author":"DN Wijeysundera","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"ref9","first-page":"207","article-title":"Cardiovascular complications of cardiac and noncardiac surgery","volume":"17","author":"HK Hellerstein","year":"1949","journal-title":"J Am Assoc Nurse Anesth"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1053\/j.jvca.2017.04.013","article-title":"Gastrointestinal Complications After Cardiac Surgery: A Nationwide Population-Based Analysis of Morbidity and Mortality Predictors","volume":"31","author":"R Chaudhry","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref11","article-title":"Can dexmedetomidine be a safe and efficacious sedative agent in post-cardiac surgery patients? A meta-analysis","volume":"16","author":"YY Lin","year":"2012","journal-title":"Critical Care"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/CIRCULATIONAHA.113.007253","article-title":"Troponin T and B-type natriuretic peptide after on-pump cardiac surgery: prognostic impact on 12-month mortality and major cardiac events after adjustment for postoperative complications","volume":"130","author":"GA Lurati Buse","year":"2014","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1053\/j.jvca.2013.05.005","article-title":"Detailed insight into the impact of postoperative neuropsychiatric complications on mortality in a cohort of cardiac surgery subjects: a 23,000-patient-year analysis","volume":"28","author":"LJ Krzych","year":"2014","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.5761\/atcs.oa.13-02268","article-title":"Impact of severe postoperative complications after cardiac surgery on mortality in patients aged over 80 years","volume":"20","author":"H Kamiya","year":"2014","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jcrc.2012.12.011","article-title":"Mortality and complications in elderly patients undergoing cardiac surgery","volume":"28","author":"E Curiel-Balsera","year":"2013","journal-title":"J Crit Care"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/0310057X0903700409","article-title":"Cardiac complications and mortality rates in diabetic patients following non-cardiac surgery in an Australian teaching hospital","volume":"37","author":"SN Bolsin","year":"2009","journal-title":"Anaesth Intensive Care"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e0152829","DOI":"10.1371\/journal.pone.0152829","article-title":"The Influence of Perioperative Dexmedetomidine on Patients Undergoing Cardiac Surgery: A Meta-Analysis","volume":"11","author":"J Geng","year":"2016","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1213\/ANE.0000000000000869","article-title":"Dexmedetomidine Pharmacology in Neonates and Infants After Open Heart Surgery","volume":"122","author":"F Su","year":"2016","journal-title":"Anesth Analg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jclinane.2017.05.002","article-title":"Dexmedetomidine and Renal Protection after Cardiac Surgery","volume":"40","author":"SK Mahboobi","year":"2017","journal-title":"Journal of Clinical Anesthesia"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jclinane.2016.03.014","article-title":"A comparative study between propofol and dexmedetomidine as sedative agents during performing transcatheter aortic valve implantation","volume":"32","author":"M Khalil","year":"2016","journal-title":"J Clin Anesth"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1053\/j.jvca.2016.05.038","article-title":"Dexmedetomidine Versus Propofol Sedation Improves Sublingual Microcirculation After Cardiac Surgery: A Randomized Controlled Trial","volume":"30","author":"X Liu","year":"2016","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/j.jvca.2015.06.026","article-title":"Dexmedetomidine Attenuates Myocardial Injury in Off-Pump Coronary Artery Bypass Graft Surgery","volume":"30","author":"X Chi","year":"2016","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/0259-1162.156299","article-title":"A study to compare the overall effectiveness between midazolam and dexmedetomidine during monitored anesthesia care: A randomized prospective study","volume":"9","author":"MA Rasheed","year":"2015","journal-title":"Anesth Essays Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4103\/1658-354X.154715","article-title":"Dexmedetomidine as an adjunct in postoperative analgesia following cardiac surgery: A randomized, double-blind study","volume":"9","author":"S Priye","year":"2015","journal-title":"Saudi Journal of Anaesthesia"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1329","DOI":"10.1097\/MD.0000000000001329","article-title":"Effect of Intraoperative and Postoperative Infusion of Dexmedetomidine on the Quality of Postoperative Analgesia in Highly Nicotine-Dependent Patients After Thoracic Surgery: A CONSORT-Prospective, Randomized, Controlled Trial","volume":"94","author":"C Ren","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4103\/0971-9784.159801","article-title":"Effect of dexmeditomidine on postoperative junctional ectopic tachycardia after complete surgical repair of tetralogy of Fallot: A prospective randomized controlled study","volume":"18","author":"SV Kadam","year":"2015","journal-title":"Ann Card Anaesth"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2146\/ajhp050508","article-title":"Sedation and analgesia in the intensive care unit: evaluating the role of dexmedetomidine","volume":"64","author":"PM Szumita","year":"2007","journal-title":"Am J Health Syst Pharm"},{"key":"ref28","first-page":"S38","article-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","volume":"5","author":"GS Higgins Jpt","year":"2011","journal-title":"Naunyn-Schmiedebergs Archiv f\u00fcr experimentelle Pathologie und Pharmakologie"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s00540-015-1975-2","article-title":"Effects of dexmedetomidine and propofol on sedation in patients after coronary artery bypass graft surgery in a fast-track recovery room setting","volume":"29","author":"Y Karaman","year":"2015","journal-title":"J Anesth"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/icvts\/ivu367","article-title":"The dose-related effects of dexmedetomidine on renal functions and serum neutrophil gelatinase-associated lipocalin values after coronary artery bypass grafting: a randomized, triple-blind, placebo-controlled study","volume":"20","author":"OO Balkanay","year":"2015","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"ref31","first-page":"37","article-title":"Comparison of dexmedetomidine and propofol for short-term sedation in early postoperative period after cardiac surgery","author":"AA Eremenko","year":"2014","journal-title":"Anesteziol Reanimatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1053\/j.jvca.2012.12.013","article-title":"Does dexmedetomidine provide cardioprotection in coronary artery bypass grafting with cardiopulmonary bypass? A pilot study","volume":"27","author":"Z Tosun","year":"2013","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3892\/etm.2013.1183","article-title":"Protective effect of dexmedetomidine in coronary artery bypass grafting surgery","volume":"6","author":"J Ren","year":"2013","journal-title":"Exp Ther Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/0971-9784.91480","article-title":"The effects of dexmedetomidine on attenuation of stress response to endotracheal intubation in patients undergoing elective off-pump coronary artery bypass grafting","volume":"15","author":"S Sulaiman","year":"2012","journal-title":"Annals of Cardiac Anaesthesia"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s11096-011-9480-7","article-title":"Efficacy and safety of dexmedetomidine versus morphine in post-operative cardiac surgery patients","volume":"33","author":"N Abd Aziz","year":"2011","journal-title":"Int J Clin Pharm"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/0971-9784.58829","article-title":"Dexmedetomidine as an adjunct to anesthetic induction to attenuate hemodynamic response to endotracheal intubation in patients undergoing fast-track CABG","volume":"13","author":"F Menda","year":"2010","journal-title":"Ann Card Anaesth"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00000542-199702000-00009","article-title":"Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting","volume":"86","author":"J Jalonen","year":"1997","journal-title":"Anesthesiology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S1053-0770(03)00200-3","article-title":"ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens","volume":"17","author":"DL Herr","year":"2003","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/0971-9784.58829","article-title":"Dexmedetomidine as an adjunct to anesthetic induction to attenuate hemodynamic response to endotracheal intubation in patients undergoing fast-track CABG","volume":"13","author":"F Menda","year":"2010","journal-title":"Annals of Cardiac Anaesthesia"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1097\/ALN.0b013e3181b6a783","article-title":"Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study)","volume":"111","author":"Y Shehabi","year":"2009","journal-title":"Anesthesiology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/01.CCM.0000162565.18193.E5","article-title":"Dexmedetomidine does not improve patient satisfaction when compared with propofol during mechanical ventilation","volume":"33","author":"SM Corbett","year":"2005","journal-title":"Crit Care Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1176\/appi.psy.50.3.206","article-title":"Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery","volume":"50","author":"JR Maldonado","year":"2009","journal-title":"Psychosomatics"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004780","article-title":"Efficacy of prophylactic dexmedetomidine in preventing postoperative junctional ectopic tachycardia after pediatric cardiac surgery","volume":"6","author":"DM El Amrousy","year":"2017","journal-title":"Journal of the American Heart Association"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13643-017-0500-0","article-title":"Effects of perioperative statin use on cardiovascular complications in patients submitted to non-cardiac surgery: protocol for a systematic review, meta-analysis, and trial sequential analysis","volume":"6","author":"EA Suzumura","year":"2017","journal-title":"Syst Rev"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.3892\/etm.2017.4227","article-title":"Myocardial protective effects of dexmedetomidine in patients undergoing cardiac surgery: A meta-analysis and systematic review","volume":"13","author":"Z Gong","year":"2017","journal-title":"Exp Ther Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T07:55:03Z","timestamp":1571903703000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202620"}},"subtitle":[],"editor":[{"given":"Shane","family":"Patman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":45,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202620","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]}}}