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Guideline CBO. 2003. http:\/\/www.mdl.nl\/uploads\/240\/117\/NSAID-gebruik_en_preventie_van_maagschade_-_CBO_2003.pdf<\/ext-link>"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2165\/11596000-000000000-00000","article-title":"Targeting outpatient drug safety: recommendations of the Dutch HARM-Wrestling Task Force","volume":"35","author":"MF Warle-van Herwaarden","year":"2012","journal-title":"Drug Saf"},{"key":"ref30","unstructured":"Pain. Guideline NHG. 2016. www.nhg.org<\/ext-link> Last accessed Januari 2017."},{"key":"ref31","unstructured":"Diagnostics and treatment of pain. Guideline oncoline. 2016. www.oncoline.nl<\/ext-link>"},{"key":"ref32","unstructured":"Dutch national G-standard. 2017. www.z-index.nl<\/ext-link>"},{"key":"ref33","year":"2017","unstructured":"SmPC. 2017<\/year>. http:\/\/db.cbg-meb.nl\/IB-teksten<\/ext-link>"},{"key":"ref34","unstructured":"Precautions for use of iodinated radio-contrast. Guideline NVR. 2007. http:\/\/www.mdl.nl\/uploads\/240\/356\/Richtlijn_Voorzorgsmaatregelen_bij_jodiumhoudende_contrastmiddelen.pdf<\/ext-link>"},{"key":"ref35","unstructured":"Diagnostics and treatment of rheumatoid arthritis. Guideline CBO. 2009. https:\/\/www.nvr.nl\/wp-content\/uploads\/2014\/11\/CBO-richtlijn-reumatode-artritis-2009.pdf<\/ext-link>"},{"key":"ref36","unstructured":"The art of dosing of vitamin K antagonists. Guideline FNT. 2016. https:\/\/www.fnt.nl\/kwaliteit\/de-kunst-van-het-doseren<\/ext-link>"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12913-016-1330-9","article-title":"Erratum to: The effectiveness of substitution of hospital ward care from medical doctors to physician assistants: a study protocol","volume":"16","author":"MJ Timmermans","year":"2016","journal-title":"BMC Health Serv Res"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/01.HCM.0000440621.39514.9f","article-title":"Implementation of the physician assistant in Dutch health care organizations: primary motives and outcomes","volume":"33","author":"AJ van Vught","year":"2014","journal-title":"The health care manager"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/jep.12499","article-title":"Physician assistants in medical ward care: a descriptive study of the situation in the Netherlands","volume":"22","author":"MJ Timmermans","year":"2016","journal-title":"J Eval Clin Pract"},{"issue":"8","key":"ref40","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/MEG.0000000000000634","article-title":"Noncompliance with guidelines on proton pump inhibitor prescription as gastroprotection in hospitalized surgical patients who are prescribed NSAIDs","volume":"28","author":"PM van den Bemt","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2369-15-2","article-title":"Guideline adherence for identification and hydration of high-risk hospital patients for contrast-induced nephropathy","volume":"15","author":"J Schilp","year":"2014","journal-title":"BMC Nephrol"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"e0128237","DOI":"10.1371\/journal.pone.0128237","article-title":"Adherence with Dosing Guideline in Patients with Impaired Renal Function at Hospital Discharge","volume":"10","author":"AC Drenth-van Maanen","year":"2015","journal-title":"PloS one"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1748-5908-8-35","article-title":"A checklist for identifying determinants of practice: a systematic review and synthesis of frameworks and taxonomies of factors that prevent or enable improvements in healthcare professional practice","volume":"8","author":"SA Flottorp","year":"2013","journal-title":"Implementation science: IS"},{"issue":"3S","key":"ref44","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1097\/JPA.0000000000000154","article-title":"Observations on the global spread of physician assistant education","volume":"28","author":"RM Ballweg","year":"2017","journal-title":"J Physician Assist Educ"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T17:22:02Z","timestamp":1571764922000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202626"}},"subtitle":[],"editor":[{"given":"Vineet","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":44,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202626","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]}}}