{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:31:19Z","timestamp":1784194279707,"version":"3.55.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202804","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T18:55:38Z","timestamp":1535568938000},"page":"e0202804","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serological proteomic biomarkers to identify Paracoccidioides species and risk of relapse"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-964X","authenticated-orcid":true,"given":"Tatiane Fernanda","family":"Sylvestre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo de Souza","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julhiany de F\u00e1tima","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamaria Mello Miranda","family":"Paniago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Schneider","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Alves","family":"Pauletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0575-2263","authenticated-orcid":true,"given":"L\u00eddia Raquel de","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilene Delazari","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinaldo Poncio","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ympev.2009.04.005","article-title":"Phylogenetic analysis reveals a high level of speciation in the <italic>Paracoccidioides<\/italic> genus","volume":"52","author":"MM Teixeira","year":"2009","journal-title":"Mol Phylo Evol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/00362178585380481","article-title":"The ecology of <italic>Paracoccidioides brasiliensis<\/italic>: a puzzle still unsolved. Sabouraudia","volume":"23","author":"A Restrepo","year":"1985","journal-title":"J Med Vet Mycol"},{"key":"ref3","first-page":"87","article-title":"Aspectos epidemiol\u00f3gicos da paracoccidioidomicose na \u00e1rea end\u00eamica de Botucatu (S\u00e3o Paulo-Brasil)","volume":"25","author":"SA Marques","year":"1983","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1439-0507.2008.01687.x","article-title":"Is the geographical origin of a <italic>Paracoccidioides brasiliensis<\/italic> isolate important for antigen production for regional diagnosis of paracoccidioidomycosis?","volume":"53","author":"J Batista Jr","year":"2008","journal-title":"Mycoses"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e3174","DOI":"10.1371\/journal.pntd.0003174","article-title":"Serological diagnosis of paracoccidioidomycosis: high rate of inter-laboratorial variability among Medical Mycology Reference Centers","volume":"8","author":"MSM Vidal","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e2986","DOI":"10.1371\/journal.pntd.0002986","article-title":"Serology of paracoccidioidomycosis due to <italic>Paracoccidioides lutzii<\/italic>","volume":"8","author":"G Gegembauer","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e2834","DOI":"10.1371\/journal.pntd.0002834","article-title":"Prevalence and serological diagnosis of relapse in paracoccidioidomycosis patients","volume":"8","author":"TF Sylvestre","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1021\/pr5002274","article-title":"Exploring potential virulence regulators in <italic>Paracoccidioides brasiliensis<\/italic> isolates of varying virulence through quantitative proteomics","volume":"13","author":"DG Castilho","year":"2014","journal-title":"J Proteome Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jprot.2011.08.020","article-title":"A quantitative view of the morphological phases of <italic>Paracoccidioides brasiliensis<\/italic> using proteomics","volume":"75","author":"TC Rezende","year":"2011","journal-title":"J Proteomics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e22810","DOI":"10.1371\/journal.pone.0022810","article-title":"Proteomic analysis reveals that iron availability alters the metabolic status of the pathogenic fungus <italic>Paracoccidioides brasiliensis<\/italic>","volume":"6","author":"AFA Parente","year":"2011","journal-title":"PLoS ONE"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/yea.3225","article-title":"Analysis of <italic>Paracoccidioideslutzii<\/italic> mitochondria: a proteomic approach","volume":"34","author":"L Casaletti","year":"2017","journal-title":"Yeast"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2174\/1874285801711010224","article-title":"Paracoccidioidomycosis: Current Perspectives from Brazil","volume":"11","author":"RP Mendes","year":"2017","journal-title":"Open Microbiol J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/13693780310001615358","article-title":"Simplified method for producing <italic>Paracoccidioides brasiliensis<\/italic> exoantigens for use in immunodiffusion tests","volume":"41","author":"ZP Camargo","year":"2003","journal-title":"Med Mycol"},{"key":"ref14","first-page":"233","article-title":"Paracoccidioidomycosis","author":"RP Mendes","year":"1994"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"MM Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e43521","DOI":"10.1371\/journal.pone.0043521","article-title":"Novel processed form of Syndecan-1 shed from SCC-9 cells plays a role in cell migration","volume":"7","author":"AZB Arag\u00e3o","year":"2012","journal-title":"PLoS ONE"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijmm.2013.11.007","article-title":"The <italic>Staphylococcus aureus<\/italic> proteome","volume":"304","author":"A Otto","year":"2014","journal-title":"Int J Med Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jprot.2016.10.017","article-title":"MALDI-TOF mass spectrometry for rapid diagnosis of postoperative endophthalmitis","volume":"30","author":"A Mailhac","year":"2017","journal-title":"J Proteomics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.exppara.2016.09.007","article-title":"Identification and typing of free-living <italic>Acanthamoeba<\/italic> spp. by MALDI-TOF MS Biotyper","volume":"170","author":"F Del Chierico","year":"2016","journal-title":"Exp Parasitol"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1007\/s11274-015-1936-9","article-title":"Identification of invasion proteins of <italic>Cryptosporidium parvum<\/italic>","volume":"31","author":"P Singh","year":"2015","journal-title":"World J Microbiol Biotechnol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1002\/pmic.200400903","article-title":"Proteomics-based identification of novel <italic>Candida albicans<\/italic> antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies","volume":"4","author":"A Pitarch","year":"2004","journal-title":"Proteomics"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2217\/fmb.13.22","article-title":"Immunoproteomic and immunoinformatics analysis of <italic>Cryptococcus gatti<\/italic>: novel candidate antigens for diagnosis","volume":"8","author":"LMS Martins","year":"2013","journal-title":"Future Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"14505","DOI":"10.3390\/ijms150814505","article-title":"Immunoproteome of <italic>Aspergillus fumigatus<\/italic> using sera of patients with invasive aspergillosis","volume":"15","author":"ED Virginio","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2217\/fmb.14.49","article-title":"Immunoreactivity of synthetic peptides derived from proteins of <italic>Cryptococcus gattii<\/italic>","volume":"9","author":"MSS Brand\u00e3o","year":"2014","journal-title":"Future Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.180.7.4697","article-title":"Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function","volume":"180","author":"J Jantsch","year":"2008","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/cdd.2008.12","article-title":"Biology of HIF-1alpha","volume":"15","author":"A Weidemann","year":"2008","journal-title":"Cell Death Differ"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1074\/mcp.R200007-MCP200","article-title":"The human plasma proteome: history, character, and diagnostic prospects","volume":"1","author":"NL Anderson","year":"2002","journal-title":"Mol Cell Proteomics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1074\/mcp.M300127-MCP200","article-title":"The human plasma proteome: a nonredundant list developed by combination of four separate sources","volume":"3","author":"NL Anderson","year":"2004","journal-title":"Mol Cell Proteomics"},{"key":"ref29","first-page":"45","article-title":"The plasma proteins: structure, function and genetic control","volume":"2","author":"FR Putnam","year":"1984"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/pmic.200390057","article-title":"Multi-component immunoaffinity subtraction chromatography: an innovative step towards a comprehensive survey of the human plasma proteome","volume":"3","author":"R Pieper","year":"2003","journal-title":"Proteomics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/1357-2725(96)00032-5","article-title":"Alpha 1-antichymotrypsin","volume":"28","author":"N Kalsheker","year":"1996","journal-title":"Int J Biochem Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1006806615226","article-title":"Monocyte adherence to <italic>Paracoccidioides brasiliensis<\/italic>, zymosan-C3b and erythrocyte-hemolysin in patients with paracoccidioidomycosis","volume":"138","author":"MA Shikanai-Yasuda","year":"1997","journal-title":"Mycopathologia"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/02681219880000641","article-title":"Involvement of the major glycoprotein (gp43) of <italic>Paracoccidioidesbrasiliensis<\/italic> in attachment to macrophages","volume":"36","author":"SR Almeida","year":"1998","journal-title":"Med Mycol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.4238\/vol7-4gmr472","article-title":"Regula\u00e7\u00e3o da express\u00e3o do gene da alfa-globina humana e alfa-talassemia","volume":"7","author":"DM Ribeiro","year":"2008","journal-title":"Genet Mol Res"},{"key":"ref35","first-page":"185","article-title":"The structure and function of human IgA","volume":"271","author":"MA Kerr","year":"1990","journal-title":"Biochem J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7192","DOI":"10.1016\/S0021-9258(19)66954-1","article-title":"Immunoglobulin structure and genetics. Identity between variable regions of a mu and a gamma2 chain","volume":"252","author":"AC Wang","year":"1977","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1128\/AAC.01620-09","article-title":"Antimicrobial mechanism of action of transferrins: selective inhibition of H+-ATPase","volume":"54","author":"MT Andr\u00e9s","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1348-0421.2006.tb03798.x","article-title":"Chloroquine inhibits <italic>Paracoccidioides brasiliensis<\/italic> survival within human monocytes by limiting the availability of intracellular iron","volume":"50","author":"LA Dias-Melicio","year":"2006","journal-title":"Microbiol Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/02681218880000161","article-title":"Growth and production of iron chelants by <italic>Paracoccidioides brasiliensis<\/italic> mycelial and yeast forms","volume":"26","author":"R Arango","year":"1988","journal-title":"J Med Vet Mycol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T20:26:01Z","timestamp":1661891161000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202804"}},"subtitle":[],"editor":[{"given":"Kirsten","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":39,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202804","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]}}}