{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:56:12Z","timestamp":1779126972570,"version":"3.51.4"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202838","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T13:43:47Z","timestamp":1544017427000},"page":"e0202838","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["The administration of high-mobility group box 1 fragment prevents deterioration of cardiac performance by enhancement of bone marrow mesenchymal stem cell homing in the delta-sarcoglycan-deficient hamster"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-8513","authenticated-orcid":true,"given":"Takashi","family":"Kido","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takasumi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuto","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Toda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kuratani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0140-6736(16)31713-5","article-title":"Dilated cardiomyopathy","volume":"390","author":"RG Weintraub","year":"2017","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.amjcard.2010.11.033","article-title":"Effect of Left Ventricular Reverse Remodeling on Long-Term Prognosis After Therapy With Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers and \u03b2 blockers in Patients With Idiopathic Dilated Cardiomyopathy","volume":"107","author":"E Hoshikawa","year":"2011","journal-title":"Am J Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMoa1608029","article-title":"Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure","volume":"375","author":"L Kober","year":"2016","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/europace\/euu361","article-title":"Reduction in coronary microvascular resistance thorough cardiac resynchronization and its impact on chronic reverse remodeling of left ventricle in patients with non-ischemic cardiomyopathy","volume":"17","author":"M Ito","year":"2015","journal-title":"Europace"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJM199412083312307","article-title":"Idiopathic Dilated Cardiomyopathy","volume":"331","author":"GW Dec","year":"1994","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/CIRCHEARTFAILURE.109.855023","article-title":"A Pilot Trial to Assess Potential Effects of Selective Intracoronary Bone Marrow-Derived Progenitor Cell Infusion in Patients With Nonischemic Dilated Cardiomyopathy","volume":"2","author":"U Fischer-Rasokat","year":"2009","journal-title":"Circ Heart Fail"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.jacc.2009.11.070","article-title":"The ABCD (Autologous Bone Marrow Cells in Dilated Cardiomyopathy) Trial A Long-Term Follow-Up Study","volume":"55","author":"B Bhargava","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.112.276519","article-title":"Effects of Intracoronary CD34<sup>+<\/sup> Stem Cell Transplantation in Nonischemic Dilated Cardiomyopathy Patients","volume":"112","author":"B Vrtovec","year":"2013","journal-title":"Circ Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/j.1582-4934.2009.00912.x","article-title":"Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver","volume":"14","author":"Y Chen","year":"2010","journal-title":"J Cell Mol Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.biocel.2008.01.007","article-title":"Mesenchymal stem cells: A promising candidate in regenerative medicine","volume":"40","author":"Y Chen","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.4049\/jimmunol.180.4.2581","article-title":"Mesencymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type","volume":"15","author":"M Sasaki","year":"2008","journal-title":"J Immnol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbrc.2013.02.008","article-title":"The chaperone like function of the nonhistone protein HMGB1","volume":"8","author":"T Osmanov","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1073\/pnas.1016753108","article-title":"PDGFR\u03b1-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia","volume":"108","author":"K Tamai","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ref14","first-page":"11008","article-title":"Systemic high-mobility group box 1 administration suppresses sikin inflammation by inducing an accumulation of","volume":"5","author":"E Aikawa","year":"2015","journal-title":"PDGFR"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/jcp.2008.060731","article-title":"Dilated Cardiomyopathy: a review","volume":"62","author":"A Luk","year":"2009","journal-title":"J Clin Pathol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/jb\/mvg140","article-title":"Defect of Delta-Sarcoglycan Gene Is Responsible for Development of Dilated Cardiomyopathy of a Novel Hamster Strain, J2N-k: Calcineurin\/PP2B Activity in the Heart of J2N-k Hamster","volume":"134","author":"S Mitsuhashi","year":"2003","journal-title":"J Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yjmcc.2013.02.008","article-title":"Global metabolic analysis of heart tissue in a hamster model for dilated cardiomyopathy","volume":"59","author":"K Maekawa","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","article-title":"Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing","volume":"25","author":"G Chamberlain","year":"2007","journal-title":"Stem Cells"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1242\/dev.155879","article-title":"Tracing the destiny of mesenchymal stem cells from embryo to adult bone marrow and white adipose tissue via Pdgfr\u03b1 expression","volume":"145","author":"H Miwa","year":"2018","journal-title":"Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1161\/01.CIR.0000018605.14470.DD","article-title":"Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium","volume":"105","author":"K Nakamura","year":"2002","journal-title":"Circulation"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"23041","DOI":"10.1074\/jbc.M409397200","article-title":"Galpha12\/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts","volume":"280","author":"T Fujii","year":"2005","journal-title":"J Bio Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1089\/scd.2007.0276","article-title":"High Mobility Group Box 1 Protein Inhibits the Proliferetion of Human Mesenchymal Stem Cells and Promotes Their Migration and Differentiation along Osteoblastic Pathway","volume":"17","author":"E Meng","year":"2008","journal-title":"Stem Cells Dev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1093\/eurheartj\/ehm011","article-title":"Circulation of CD34<sup>+<\/sup> progenitor cell populations in patients with idiopathic dilated and ischemic cardiomyopathy (DCM and ICM)","volume":"28","author":"HD Theiss","year":"2007","journal-title":"Eur Heart J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1161\/01.CIR.0000147780.30124.CF","article-title":"Stromal Cell-Derived Factor-1\u03b1 Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infaction but Is Not Sufficient to Induce Homing in the Absence of Injury","volume":"110","author":"JD Abbott","year":"2004","journal-title":"Circulation"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0140-6736(03)14232-8","article-title":"Effect of stromal\u2013cell-derived factor 1 on stem-cell homing and tissue regeneration in ischemic cardiomyopathy","volume":"362","author":"AT Askari","year":"2003","journal-title":"Lancet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/CIRCULATIONAHA.106.672451","article-title":"Stromal cell derived factor-1 alpha confers protection against myocardial ischemia\/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis","volume":"116","author":"X Hu","year":"2007","journal-title":"Circulation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluriotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Y Jiang","year":"2002","journal-title":"Nature"},{"key":"ref28","first-page":"441","article-title":"J Cell Biol","volume":"164","author":"R Palumbo","year":"2004","journal-title":"J Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/01.RES.0000225952.61196.39","article-title":"Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling","volume":"98","author":"R Uemura","year":"2006","journal-title":"Circ Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"H2308","DOI":"10.1152\/ajpheart.00565.2008","article-title":"VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function","volume":"295","author":"TA Markel","year":"2008","journal-title":"Am J Physiol Hear Circ Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1089\/ten.tea.2014.0036","article-title":"Xenotransplantation of Bone Marrow-Derived Human Mesechymal Stem Cell Sheets Attenuates Left Ventricular Remodeling in a Porcine Ischemic Cardiomyopahty Model","volume":"21","author":"M Kawamura","year":"2015","journal-title":"Tissue Eng Part A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"16766","DOI":"10.1073\/pnas.1416121111","article-title":"TSG-6 as a biomarker to predict efficacy of human mesenchymal stem\/progenitor celss in modulating sterile inflammation in vivo","volume":"111","author":"RH Lee","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1182\/blood-2010-12-327353","article-title":"Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2\/NF-\u03baB singnaling in resident acrophages","volume":"118","author":"H Choi","year":"2011","journal-title":"Blood"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","article-title":"Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6","volume":"5","author":"RH Lee","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.2337\/db12-0931","article-title":"TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity","volume":"62","author":"DJ Kota","year":"2013","journal-title":"Diabetes"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"38438","DOI":"10.1038\/srep38438","article-title":"Intravenous hMSCs Ameliorate Acute Pancreatitis in Mice via Secretion of Tumor Necrosis Factor-\u03b1 Stimulated Gene\/Protein 6","volume":"6","author":"Z He","year":"2016","journal-title":"Sci Rep"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular endothelial growth factor (VEGF) and its receptors","volume":"13","author":"G Neufeld","year":"1999","journal-title":"FASEB J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"R1503","DOI":"10.1152\/ajpregu.00227.2009","article-title":"Intramuscular VEGF repairs the failing heart: role of host-derived growth factors and mobilization of progenitor cells","volume":"297","author":"D Zisa","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.ejheart.2007.07.008","article-title":"Idiopathic dilated cardiomyopathy exhibits defective vascularization and vessel formation","volume":"9","author":"S Roura","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0002-9149(99)00074-0","article-title":"Coronary arterial dimension-to-left ventricular mass ratio in idiopathic dilated cardiomyopathy","volume":"83","author":"T Mela","year":"1999","journal-title":"Am J Cardiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1002\/jcb.26637","article-title":"Mechanistic effects of mesenchymal and hematopoietic stem cells: New therapeutic targets in myocardial infarction","volume":"119","author":"AE Shafei","year":"2018","journal-title":"J Cell Biochem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"H2131","DOI":"10.1152\/ajpheart.01239.2003","article-title":"Hepatocyte growth factor prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts","volume":"288","author":"T Nakamura","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref43","first-page":"2556","article-title":"Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty","volume":"105","author":"S Miyagawa","year":"2002"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jtcvs.2004.11.001","article-title":"Reorganization of cytoskeletal proteins and prolonged life expectancy caused by hepatocyte growth factor in a hamster model of late-phase dilated cardiomyopathy","volume":"130","author":"H Kondoh","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1083\/jcb.142.5.1279","article-title":"Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin","volume":"142","author":"AA Hack","year":"1998","journal-title":"J Cell Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1073\/pnas.96.1.220","article-title":"Severe cardiomyopathy in mice lacking dystrophin and MyoD","volume":"96","author":"LA Megeney","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13287-018-0773-9","article-title":"Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications","volume":"9","author":"X Guo","year":"2018","journal-title":"Stem Cell Res Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T11:07:58Z","timestamp":1589195278000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202838"}},"subtitle":[],"editor":[{"given":"Meijing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202838","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/390864","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,5]]}}}