{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:01:41Z","timestamp":1778526101342,"version":"3.51.4"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Science and Technology Major Project","award":["2008ZX10005008, 2017A020213016"],"award-info":[{"award-number":["2008ZX10005008, 2017A020213016"]}]},{"name":"Shenzhen Basic Research Program","award":["JCYJ20160229173844278"],"award-info":[{"award-number":["JCYJ20160229173844278"]}]},{"name":"Guangdong Province Science and Technology Project","award":["2017A020213016"],"award-info":[{"award-number":["2017A020213016"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0203220","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T17:31:30Z","timestamp":1536082290000},"page":"e0203220","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical and histopathological features of chronic hepatitis B virus infected patients with high HBV-DNA viral load and normal alanine aminotransferase level: A multicentre-based study in China"],"prefix":"10.1371","volume":"13","author":[{"given":"Yu-Feng","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Qiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Song","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Shan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yi","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Ti","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu-Min","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung-Ting","family":"Sham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Kam-Wah","family":"Mok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5166-4814","authenticated-orcid":true,"given":"Chi-On","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Dong","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,9,4]]},"reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1056\/NEJMra0801644","article-title":"Hepatitis B Virus Infection","volume":"359","author":"JL Dienstag","year":"2008","journal-title":"New England Journal of Medicine"},{"issue":"9663","key":"ref2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0140-6736(09)60207-5","article-title":"Hepatitis B virus infection","volume":"373","author":"YF Liaw","year":"2009","journal-title":"The Lancet"},{"issue":"S5","key":"ref3","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.22898","article-title":"The natural history of chronic hepatitis B virus infection","volume":"49","author":"BJ McMahon","year":"2009","journal-title":"Hepatology"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S1473-3099(15)00218-2","article-title":"Seroepidemiology of hepatitis B virus infection in 2 million men aged 21\u201349 years in rural China: a population-based, cross-sectional study","volume":"16","author":"J Liu","year":"2015","journal-title":"The Lancet Infectious Diseases"},{"issue":"s1","key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2893.2010.01266.x","article-title":"Epidemiology and prevention of hepatitis B virus infection in China","volume":"17","author":"FM Lu","year":"2010","journal-title":"Journal of Viral Hepatitis"},{"issue":"Supplement 3","key":"ref6","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1111\/j.1524-4733.2009.00636.x","article-title":"Assessment of total economic burden of chronic hepatitis B (CHB)-related diseases in Beijing and Guangzhou, China","volume":"12","author":"M Hu","year":"2009","journal-title":"Value in Health"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"e78672","DOI":"10.1371\/journal.pone.0078672","article-title":"Significant fibrosis is not rare in Chinese chronic hepatitis B patients with persistent normal ALT","volume":"8","author":"B Liao","year":"2013","journal-title":"PLOS ONE"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2893.2010.01270.x","article-title":"Significant histopathology in Chinese chronic hepatitis B patients with persistently high\u2013normal alanine aminotransferase","volume":"17","author":"HL Gui","year":"2010","journal-title":"Journal of Viral Hepatitis"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.295.1.65","article-title":"Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis b virus dna level","volume":"295","author":"C Chen","year":"2006","journal-title":"JAMA"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.28156","article-title":"AASLD guidelines for treatment of chronic hepatitis B","volume":"63","author":"NA Terrault","year":"2016","journal-title":"Hepatology"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/atm.2017.01.28","article-title":"Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection","volume":"5","author":"P Parikh","year":"2017","journal-title":"Annals of Translational Medicine"},{"issue":"9204","key":"ref12","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(99)00219-6","article-title":"Serum aminotransferase concentration as evidence of hepatocellular damage","volume":"355","author":"MC Kew","year":"2000","journal-title":"The Lancet"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jhep.2012.02.010","article-title":"EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection","volume":"57","journal-title":"Journal of Hepatology"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0168-8278(02)00004-1","article-title":"Serum hepatitis B virus DNA levels and liver histology in inactive HBsAg carriers","volume":"36","author":"M Martinot-Peignoux","year":"2002","journal-title":"Journal of Hepatology"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jhep.2007.07.022","article-title":"The clinical significance of persistently normal ALT in chronic hepatitis B infection","volume":"47","author":"M Lai","year":"2007","journal-title":"Journal of Hepatology"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/hep.510270505","article-title":"Factors associated with serum alanine transaminase activity in healthy subjects: Consequences for the definition of normal values, for selection of blood donors, and for patients with chronic hepatitis C","volume":"27","author":"A Piton","year":"1998","journal-title":"Hepatology"},{"issue":"7446","key":"ref17","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/bmj.38050.593634.63","article-title":"Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study","volume":"328","author":"CK Hyeon","year":"2004","journal-title":"BMJ"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/jvh.12563","article-title":"The gamma-glutamyl transpeptidase-to-platelet ratio predicts liver fibrosis and cirrhosis in HBeAg-positive chronic HBV infection patients with high HBV DNA and normal or mildly elevated alanine transaminase levels in China","volume":"23","author":"Q Li","year":"2016","journal-title":"Journal of Viral Hepatitis"},{"issue":"15","key":"ref19","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.3748\/wjg.v23.i15.2802","article-title":"Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients","volume":"23","author":"JL Cheng","year":"2017","journal-title":"World journal of gastroenterology"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"e0123452","DOI":"10.1371\/journal.pone.0123452","article-title":"Age as a predictor of significant fibrosis features in HBeAg-negative chronic hepatitis B virus infection with persistently normal alanine aminotransferase","volume":"10","author":"Y Tan","year":"2015","journal-title":"PLOS ONE"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1097\/MCG.0000000000000544","article-title":"Histologic disease in Chinese chronic hepatitis B patients with low viral loads and persistently normal alanine aminotransferase levels","volume":"50","author":"H Wang","year":"2016","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"e0134532","DOI":"10.1371\/journal.pone.0134532","article-title":"A mechanistic assessment of the discordance between normal serum alanine aminotransferase levels and altered liver histology in chronic hepatitis B","volume":"10","author":"X Gong","year":"2015","journal-title":"PLOS ONE"},{"issue":"Part B","key":"ref23","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.cca.2015.10.002","article-title":"Serum MiRNA panel as potential biomarkers for chronic hepatitis B with persistently normal alanine aminotransferase","volume":"451","author":"Y Tan","year":"2015","journal-title":"Clinica Chimica Acta"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1053\/j.gastro.2008.02.075","article-title":"Virologic and Histologic Features of Chronic Hepatitis B Virus-Infected Asymptomatic Patients With Persistently Normal ALT","volume":"134","author":"M Kumar","year":"2008","journal-title":"Gastroenterology"},{"issue":"13","key":"ref25","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/hepr.12693","article-title":"Alanine aminotransferase course, serum hepatitis B virus DNA, and liver stiffness measurement for therapeutic decisions in hepatitis B e antigen-negative chronic hepatitis B","volume":"46","author":"P Charatcharoenwitthaya","year":"2016","journal-title":"Hepatology Research"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijid.2016.09.007","article-title":"Predictors of treatment requirement in HBeAg-negative chronic hepatitis B patients with persistently normal alanine aminotransferase and high serum HBV DNA levels","volume":"52","author":"A Ormeci","year":"2016","journal-title":"International Journal of Infectious Diseases"},{"issue":"8","key":"ref27","first-page":"1369","article-title":"The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa","volume":"65","author":"M Lemoine","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12072-015-9675-4","article-title":"Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update","volume":"10","author":"SK Sarin","year":"2016","journal-title":"Hepatology International"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0203220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T22:53:52Z","timestamp":1720565632000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0203220"}},"subtitle":[],"editor":[{"given":"Isabelle","family":"Chemin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,4]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0203220","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,4]]}}}