{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:00:29Z","timestamp":1787022029522,"version":"build-2736575974"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["CNPq\/MS\/DECIT n. 37\/2014. Projeto 470298\/2014-6"],"award-info":[{"award-number":["CNPq\/MS\/DECIT n. 37\/2014. Projeto 470298\/2014-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0203340","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T13:36:45Z","timestamp":1546263405000},"page":"e0203340","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["In silico repositioning of approved drugs against Schistosoma mansoni energy metabolism targets"],"prefix":"10.1371","volume":"13","author":[{"given":"Nicole Melo","family":"Calixto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Braz","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Clecildo Barreto","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-0960","authenticated-orcid":true,"given":"Lourival de Almeida","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"ref1","first-page":"749","article-title":"Schistosomiasis and soil- transmitted helminthiases: number of people treated in 2016","volume":"92","year":"2017","journal-title":"Wkly Epidemiol Rec"},{"key":"ref2","first-page":"89","article-title":"Preventive chemotherapy for helminth diseases: progress report, 2014","year":"2016","journal-title":"Wkly Epidemiol Rec"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3947\/ic.2013.45.1.32","article-title":"Praziquantel Treatment in Trematode and Cestode Infections: An Update","volume":"45","author":"J. Chai","year":"2013","journal-title":"Infect Chemother"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/QCO.0b013e328318978f","article-title":"Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis","volume":"21","author":"MJ Doenhoff","year":"2008","journal-title":"Curr Opin Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1590\/0074-0276108052013011","article-title":"Antischistosomal activity of a calcium channel antagonist on schistosomula and adult Schistosoma mansoni worms","volume":"108","author":"V Silva-Moraes","year":"2013","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4155\/fmc.15.11","article-title":"What is the mechanism of action of praziquantel and how might resistance strike?","volume":"7","author":"PM Cupit","year":"2015","journal-title":"Future Med Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1017\/S0031182013000231","article-title":"New approaches for understanding mechanisms of drug resistance in schistosomes","volume":"140","author":"RM Greenberg","year":"2013","journal-title":"Parasitology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.molbiopara.2010.05.003","article-title":"Schistosoma mansoni express higher levels of multidrug resistance-associated protein 1 (SmMRP1) in juvenile worms and in response to praziquantel","volume":"173","author":"RS Kasinathan","year":"2010","journal-title":"Mol Biochem Parasitol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e0003962","DOI":"10.1371\/journal.pntd.0003962","article-title":"Activity profile of an FDA-approved compound library against Schistosoma mansoni","volume":"9","author":"G Panic","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijpddr.2014.07.002","article-title":"Repurposing drugs for the treatment and control of helminth infections","volume":"4","author":"G Panic","year":"2014","journal-title":"Int J Parasitol Drugs drug Resist"},{"key":"ref11","first-page":"1","article-title":"Revisiting glucose uptake and metabolism in schistosomes: New molecular insights for improved schistosomiasis therapies","volume":"5","author":"H You","year":"2014","journal-title":"Front Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S0031182011002204","article-title":"Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase","author":"T Manneck","year":"2012","journal-title":"Parasitology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1021\/ci2001764","article-title":"Identification of the Schistosoma mansoni molecular target for the antimalarial drug artemether","author":"R Lepore","year":"2011","journal-title":"J Chem Inf Model"},{"key":"ref14","first-page":"1","article-title":"Deconstructing the drug development process: the new face of innovation","volume":"3","author":"K. Kaitin","year":"2010","journal-title":"Clin Pharmacol Ther"},{"key":"ref15","article-title":"Drug discovery in pharmaceutical industry: Productivity challenges and trends","author":"I. Khanna","year":"2012","journal-title":"Drug Discovery Today"},{"key":"ref16","article-title":"Drugs for Neglected Diseases initiative model of drug development for neglected diseases: Current status and future challenges","author":"JR Ioset","year":"2011","journal-title":"Future Med Chem"},{"key":"ref17","first-page":"151","article-title":"Repurposing Strategies for Therapeutics","volume":"24","author":"SH Sleigh","year":"2010","journal-title":"Pharmaceut Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.drudis.2011.02.016","article-title":"In silico repositioning of approved drugs for rare and neglected diseases","volume":"16","author":"S Ekins","year":"2011","journal-title":"Drug Discov Today"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1752-0509-6-80","article-title":"Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug","volume":"6","author":"H Lee","year":"2012","journal-title":"BMC Syst Biol."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpddr.2014.02.002","article-title":"Drug repurposing and human parasitic protozoan diseases","volume":"4","author":"KT Andrews","year":"2014","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"ref21","first-page":"1","article-title":"Computational and Practical Aspects of Drug Repositioning","volume":"0","author":"TI Oprea","year":"2015","journal-title":"Drug repurposing, rescue, repositioning"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/0022-3859.81870","article-title":"Drug repositioning: Re-investigating existing drugs for new therapeutic indications","volume":"57","author":"BM Padhy","year":"2011","journal-title":"J Postgrad Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"D668","DOI":"10.1093\/nar\/gkj067","article-title":"DrugBank: a comprehensive resource for in silico drug discovery and exploration","volume":"34","author":"DS Wishart","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"D901","DOI":"10.1093\/nar\/gkm958","article-title":"DrugBank: a knowledgebase for drugs, drug actions and drug targets","volume":"36","author":"DS Wishart","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1039\/c2cs35357a","article-title":"Drug repositioning by structure-based virtual screening","volume":"42","author":"DL Ma","year":"2013","journal-title":"Chem Soc Rev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.drudis.2012.08.005","article-title":"In silico drug repositioning-what we need to know","volume":"18","author":"Z Liu","year":"2013","journal-title":"Drug Discov Today. Elsevier Ltd"},{"key":"ref27","first-page":"483","article-title":"In Vivo-In Vitro-In Silico Pharmacokinetic Modelling in Drug Development","volume":"50","author":"O Pelkonen","year":"2011"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e59288","DOI":"10.1371\/journal.pone.0059288","article-title":"A Systematic In Silico Search for Target Similarity Identifies Several Approved Drugs with Potential Activity against the Plasmodium falciparum Apicoplast","volume":"8","author":"NANA Bispo","year":"2013","journal-title":"PLoS One"},{"key":"ref29","article-title":"In silico search of energy metabolism inhibitors for alternative leishmaniasis treatments","author":"LA Silva","year":"2015","journal-title":"Biomed Res Int"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000804","article-title":"Identification of attractive drug targets in neglected- disease pathogens using an in Silico approach","volume":"4","author":"GJ Crowther","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"D98","DOI":"10.1093\/nar\/gkr1032","article-title":"GeneDB-an annotation database for pathogens","volume":"40","author":"FJ Logan-Klumpler","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"D1091","DOI":"10.1093\/nar\/gkt1068","article-title":"DrugBank 4.0: shedding new light on drug metabolism","volume":"42","author":"V Law","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref33","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv1230","article-title":"Therapeutic target database update 2016: Enriched resource for bench to clinical drug target and targeted pathway information","volume":"44","author":"H Yang","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"D1060","DOI":"10.1093\/nar\/gkq1037","article-title":"PROMISCUOUS: a database for network-based drug-repositioning","volume":"39","author":"J von Eichborn","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"S Kim","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","author":"P Shannon","year":"2003","journal-title":"Genome Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/S0036-46651997000300007","article-title":"Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice","volume":"39","author":"CF PANCERA","year":"1997","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"638057","DOI":"10.1155\/2013\/638057","article-title":"A systematic review of ethanol and fomepizole use in toxic alcohol ingestions","volume":"2013","author":"L Beatty","year":"2013","journal-title":"Emerg Med Int"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1475-2867-14-12","article-title":"Single nucleotide polymorphism at alcohol dehydrogenase-1B is associated with risk of esophageal squamous cell carcinoma","volume":"14","author":"B Ye","year":"2014","journal-title":"Cancer Cell Int"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejphar.2012.07.003","article-title":"Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria","volume":"690","author":"D Pravdic","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1046\/j.1365-2044.2003.03076.x","article-title":"The effects of sevoflurane and desflurane in vitro on platelet-leukocyte adhesion in whole blood","volume":"58","author":"NA Horn","year":"2003","journal-title":"Anaesthesia"},{"key":"ref42","first-page":"1","article-title":"Isoflurane produces antidepressant effects and induces TrkB signaling in rodents.","author":"H Antila","year":"2017","journal-title":"Sci Rep"},{"key":"ref43","first-page":"1033","article-title":"Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5. ChemMedChem.","volume":"12","author":"H Wang","year":"2017","journal-title":"NIH Public Access"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pestbp.2018.05.004","article-title":"Effects of a novel SDHI fungicide pyraziflumid on the biology of the plant pathogenic fungi Bipolaris maydis","volume":"149","author":"YP Hou","year":"2018","journal-title":"Pestic Biochem Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pestbp.2018.06.002","article-title":"Baseline sensitivity of Bipolaris maydis to the novel succinate dehydrogenase inhibitor benzovindiflupyr and its efficacy","volume":"149","author":"YP Hou","year":"2018","journal-title":"Pestic Biochem Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1021\/acs.jafc.7b00249","article-title":"Discovery of Novel Succinate Dehydrogenase Inhibitors by the Integration of in Silico Library Design and Pharmacophore Mapping","volume":"65","author":"TT Yao","year":"2017","journal-title":"J Agric Food Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/ps.4488","article-title":"Design, synthesis and biological evaluation of novel nicotinamide derivatives bearing a substituted pyrazole moiety as potential SDH inhibitors","volume":"73","author":"XH Lv","year":"2017","journal-title":"Pest Manag Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0203340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T16:27:09Z","timestamp":1588955229000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0203340"}},"subtitle":[],"editor":[{"given":"Josu\u00e9 de","family":"Moraes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,31]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0203340","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/397059","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,31]]}}}