{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:19:58Z","timestamp":1787062798316,"version":"build-2736575974"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H21-11-1"],"award-info":[{"award-number":["H21-11-1"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06277"],"award-info":[{"award-number":["16H06277"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K09095"],"award-info":[{"award-number":["17K09095"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26253041"],"award-info":[{"award-number":["26253041"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17015018"],"award-info":[{"award-number":["17015018"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0203386","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T13:42:03Z","timestamp":1536327723000},"page":"e0203386","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Prediction model for pancreatic cancer risk in the general Japanese population"],"prefix":"10.1371","volume":"13","author":[{"given":"Masahiro","family":"Nakatochi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0214-3649","authenticated-orcid":true,"given":"Yingsong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumie","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5666-1970","authenticated-orcid":true,"given":"Masato","family":"Ozaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Sasahira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Ohkawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Egawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawako","family":"Kuruma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhisa","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaochen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.cgh.2016.05.034","article-title":"Global Trends in Pancreatic Cancer Mortality From 1980 Through 2013 and Predictions for 2017","volume":"14","author":"AL Lucas","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/jjco\/hyr141","article-title":"Cigarette smoking and pancreas cancer risk: an evaluation based on a systematic review of epidemiologic evidence in the Japanese population","volume":"41","author":"K Matsuo","year":"2011","journal-title":"Jpn J Clin Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1056\/NEJM200007133430201","article-title":"Environmental and heritable factors in the causation of cancer\u2014analyses of cohorts of twins from Sweden, Denmark, and Finland","volume":"343","author":"P Lichtenstein","year":"2000","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"66328","DOI":"10.18632\/oncotarget.11041","article-title":"Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21","volume":"7","author":"M Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41467-018-02942-5","article-title":"Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer","volume":"9","author":"AP Klein","year":"2018","journal-title":"Nat Commun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ng.429","article-title":"Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer","volume":"41","author":"L Amundadottir","year":"2009","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ng.522","article-title":"A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33","volume":"42","author":"GM Petersen","year":"2010","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/ng.3052","article-title":"Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer","volume":"46","author":"BM Wolpin","year":"2014","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/ng.3341","article-title":"Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer","volume":"47","author":"EJ Childs","year":"2015","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1158\/1055-9965.EPI-12-1182","article-title":"Lack of replication of seven pancreatic cancer susceptibility loci identified in two Asian populations","volume":"22","author":"D Campa","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng.1020","article-title":"Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations","volume":"44","author":"C Wu","year":"2012","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e11824","DOI":"10.1371\/journal.pone.0011824","article-title":"Genome-wide association study of pancreatic cancer in Japanese population","volume":"5","author":"SK Low","year":"2010","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e72311","DOI":"10.1371\/journal.pone.0072311","article-title":"An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population","volume":"8","author":"AP Klein","year":"2013","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1007\/s00432-017-2505-4","article-title":"The more from East-Asian, the better: risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese","volume":"143","author":"M Abe","year":"2017","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13058-016-0786-1","article-title":"Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry","volume":"18","author":"W Wen","year":"2016","journal-title":"Breast Cancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/jnci\/djn180","article-title":"Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk","volume":"100","author":"MH Gail","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10549-011-1904-5","article-title":"A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population","volume":"132","author":"A Sueta","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1056\/NEJMoa0907727","article-title":"Performance of common genetic variants in breast-cancer risk models","volume":"362","author":"S Wacholder","year":"2010","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/1471-2407-13-337","article-title":"Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case-control study in Japan","volume":"13","author":"Y Lin","year":"2013","journal-title":"BMC Cancer"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0895-4356(96)00297-1","article-title":"Epidemiological features of first-visit outpatients in Japan: comparison with general population and variation by sex, age, and season","volume":"50","author":"M Inoue","year":"1997","journal-title":"J Clin Epidemiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"CC Chang","year":"2015","journal-title":"Gigascience"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","article-title":"Population structure and eigenanalysis","volume":"2","author":"N Patterson","year":"2006","journal-title":"PLoS Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"C Genomes Project","year":"2015","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nmeth.2307","article-title":"Improved whole-chromosome phasing for disease and population genetic studies","volume":"10","author":"O Delaneau","year":"2013","journal-title":"Nat Methods"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"S Das","year":"2016","journal-title":"Nat Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"D1001","DOI":"10.1093\/nar\/gkt1229","article-title":"The NHGRI GWAS Catalog, a curated resource of SNP-trait associations","volume":"42","author":"D Welter","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"X Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajhg.2011.02.002","article-title":"Estimating missing heritability for disease from genome-wide association studies","volume":"88","author":"SH Lee","year":"2011","journal-title":"Am J Hum Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"J Ferlay","year":"2015","journal-title":"Int J Cancer"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/jnci\/dji128","article-title":"Cancer risk prediction models: a workshop on development, evaluation, and application","volume":"97","author":"AN Freedman","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/aje\/kwv026","article-title":"Detectable Symptomatology Preceding the Diagnosis of Pancreatic Cancer and Absolute Risk of Pancreatic Cancer Diagnosis","volume":"182","author":"HA Risch","year":"2015","journal-title":"Am J Epidemiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e0146473","DOI":"10.1371\/journal.pone.0146473","article-title":"Development and Validation of a Prediction Model to Estimate Individual Risk of Pancreatic Cancer","volume":"11","author":"A Yu","year":"2016","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrg.2016.27","article-title":"Developing and evaluating polygenic risk prediction models for stratified disease prevention","volume":"17","author":"N Chatterjee","year":"2016","journal-title":"Nat Rev Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.1093\/hmg\/ddu312","article-title":"Most common \u2018sporadic\u2019 cancers have a significant germline genetic component","volume":"23","author":"Y Lu","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref35","first-page":"506","article-title":"Evaluation of polygenic risk scores for predicting breast and prostate cancer risk","volume":"35","author":"MJ Machiela","year":"2011","journal-title":"Genet Epidemiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0203386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:56:42Z","timestamp":1604883402000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0203386"}},"subtitle":[],"editor":[{"given":"Amanda Ewart","family":"Toland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0203386","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]}}}