{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:42:25Z","timestamp":1790516545962,"version":"4.1.0"},"reference-count":93,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Wi945\/14-1; Wi945\/16-1; Wi945\/17-1"],"award-info":[{"award-number":["Wi945\/14-1; Wi945\/16-1; Wi945\/17-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["2012-305121 (NeurOmics)"],"award-info":[{"award-number":["2012-305121 (NeurOmics)"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CMMC","award":["C16"],"award-info":[{"award-number":["C16"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0203398","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T17:47:50Z","timestamp":1536256070000},"page":"e0203398","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of potential effects of Plastin 3 overexpression and low-dose SMN-antisense oligonucleotides on putative biomarkers in spinal muscular atrophy mice"],"prefix":"10.1371","volume":"13","author":[{"given":"Eike A.","family":"Strathmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyedmohsen","family":"Hosseinibarkooie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Frank","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip G.","family":"Zaworski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nothnagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-5191","authenticated-orcid":true,"given":"Brunhilde","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.nmd.2017.11.004","article-title":"Diagnosis and management of spinal muscular atrophy: Part 2: Pulmonary and acute care; medications, supplements and immunizations; other organ systems; and ethics","volume":"28","author":"RS Finkel","year":"2018","journal-title":"Neuromuscul Disord"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nmd.2017.11.005","article-title":"Diagnosis and management of spinal muscular atrophy: Part 1: Recommendations for diagnosis, rehabilitation, orthopedic and nutritional care","volume":"28","author":"E Mercuri","year":"2018","journal-title":"Neuromuscul Disord"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/nbdi.1996.0010","article-title":"The neurobiology of childhood spinal muscular atrophy","volume":"3","author":"TO Crawford","year":"1996","journal-title":"Neurobiol Dis"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1242\/dmm.007245","article-title":"The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy","volume":"4","author":"JN Sleigh","year":"2011","journal-title":"Dis Model Mech"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/ng1207","article-title":"A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy","volume":"34","author":"T Kashima","year":"2003","journal-title":"Nat Genet"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","article-title":"A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy","volume":"96","author":"CL Lorson","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng854","article-title":"Disruption of an SF2\/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1","volume":"30","author":"L Cartegni","year":"2002","journal-title":"Nat Genet"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ng0598-63","article-title":"SMN oligomerization defect correlates with spinal muscular atrophy severity","volume":"19","author":"CL Lorson","year":"1998","journal-title":"Nat Genet"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00439-003-1025-2","article-title":"Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1","volume":"114","author":"C Helmken","year":"2003","journal-title":"Hum Genet"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1086\/338627","article-title":"Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy","volume":"70","author":"M Feldkotter","year":"2002","journal-title":"Am J Hum Genet"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00439-006-0156-7","article-title":"Mildly affected patients with spinal muscular atrophy are partially protected by an increased SMN2 copy number","volume":"119","author":"B Wirth","year":"2006","journal-title":"Hum Genet"},{"issue":"9630","key":"ref12","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/S0140-6736(08)60921-6","article-title":"Spinal muscular atrophy","volume":"371","author":"MR Lunn","year":"2008","journal-title":"Lancet"},{"issue":"5875","key":"ref13","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1126\/science.1155085","article-title":"Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy","volume":"320","author":"GE Oprea","year":"2008","journal-title":"Science"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ajhg.2017.01.005","article-title":"Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis","volume":"100","author":"M Riessland","year":"2017","journal-title":"Am J Hum Genet"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s00018-015-2084-y","article-title":"Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals. Cellular and molecular life sciences","volume":"73","author":"L Heesen","year":"2016","journal-title":"CMLS"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1600-0854.2005.00276.x","article-title":"Molecular basis for dissimilar nuclear trafficking of the actin-bundling protein isoforms T- and L-plastin","volume":"6","author":"V Delanote","year":"2005","journal-title":"Traffic"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"e1001172","DOI":"10.1371\/journal.pgen.1001172","article-title":"Conserved genes act as modifiers of invertebrate SMN loss of function defects","volume":"6","author":"M Dimitriadi","year":"2010","journal-title":"PLoS Genet"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/hmg\/dds540","article-title":"Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality","volume":"22","author":"B Ackermann","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ajhg.2016.07.014","article-title":"The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype","volume":"99","author":"S Hosseinibarkooie","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"15","key":"ref20","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1523\/JNEUROSCI.5808-11.2012","article-title":"Survival motor neuron affects plastin 3 protein levels leading to motor defects","volume":"32","author":"T Hao le","year":"2012","journal-title":"J Neurosci"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"e89970","DOI":"10.1172\/jci.insight.89970","article-title":"Plastin-3 extends survival and reduces severity in mouse models of spinal muscular atrophy","volume":"2","author":"KA Kaifer","year":"2017","journal-title":"JCI Insight"},{"issue":"30","key":"ref22","doi-asserted-by":"crossref","first-page":"E4377","DOI":"10.1073\/pnas.1600015113","article-title":"Decreased function of survival motor neuron protein impairs endocytic pathways","volume":"113","author":"M Dimitriadi","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","article-title":"CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity and endocytosis","author":"E Janzen","year":"2018","journal-title":"Brain"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/gt.2017.45","article-title":"Therapeutic approaches for spinal muscular atrophy (SMA)","volume":"24","author":"M Scoto","year":"2017","journal-title":"Gene Ther"},{"key":"ref25","article-title":"Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and non-human primates","author":"F Rigo","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"issue":"18","key":"ref26","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa1702752","article-title":"Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy","volume":"377","author":"RS Finkel","year":"2017","journal-title":"N Engl J Med"},{"issue":"18","key":"ref27","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1706198","article-title":"Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy","volume":"377","author":"JR Mendell","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/acn3.23","article-title":"Electrophysiological Biomarkers in Spinal Muscular Atrophy: Preclinical Proof of Concept","volume":"1","author":"WD Arnold","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"e33572","DOI":"10.1371\/journal.pone.0033572","article-title":"Evaluation of SMN protein, transcript, and copy number in the biomarkers for spinal muscular atrophy (BforSMA) clinical study","volume":"7","author":"TO Crawford","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"e35462","DOI":"10.1371\/journal.pone.0035462","article-title":"Candidate proteins, metabolites and transcripts in the Biomarkers for Spinal Muscular Atrophy (BforSMA) clinical study","volume":"7","author":"RS Finkel","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/acn3.283","article-title":"Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study","volume":"3","author":"SJ Kolb","year":"2016","journal-title":"Ann Clin Transl Neurol"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"e0167077","DOI":"10.1371\/journal.pone.0167077","article-title":"Normalization of Patient-Identified Plasma Biomarkers in SMNDelta7 Mice following Postnatal SMN Restoration","volume":"11","author":"WD Arnold","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/acn3.406","article-title":"Longitudinal characterization of biomarkers for spinal muscular atrophy","volume":"4","author":"U Bonati","year":"2017","journal-title":"Ann Clin Transl Neurol"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"e0139950","DOI":"10.1371\/journal.pone.0139950","article-title":"Biomarker for Spinal Muscular Atrophy: Expression of SMN in Peripheral Blood of SMA Patients and Healthy Controls","volume":"10","author":"C Czech","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"e0167087","DOI":"10.1371\/journal.pone.0167087","article-title":"A Comparative Study of SMN Protein and mRNA in Blood and Fibroblasts in Patients with Spinal Muscular Atrophy and Healthy Controls","volume":"11","author":"RI Wadman","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2217\/bmm-2016-0242","article-title":"miRNAs as biomarkers of neurodegenerative disorders","volume":"11","author":"V Viswambharan","year":"2017","journal-title":"Biomark Med"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/JND-170209","article-title":"SMN Blood Levels in a Porcine Model of Spinal Muscular Atrophy","volume":"4","author":"CC Iyer","year":"2017","journal-title":"J Neuromuscul Dis"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"e60113","DOI":"10.1371\/journal.pone.0060113","article-title":"SMA-MAP: a plasma protein panel for spinal muscular atrophy","volume":"8","author":"DT Kobayashi","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132364","article-title":"Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the Delta 7 SMA Mouse","volume":"10","author":"VL McGovern","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/71709","article-title":"A mouse model for spinal muscular atrophy","volume":"24","author":"HM Hsieh-Li","year":"2000","journal-title":"Nat Genet"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/hmg\/ddq023","article-title":"SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy","volume":"19","author":"M Riessland","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"7367","key":"ref42","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature10485","article-title":"Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model","volume":"478","author":"Y Hua","year":"2011","journal-title":"Nature"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"e0150640","DOI":"10.1371\/journal.pone.0150640","article-title":"SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials","volume":"11","author":"P Zaworski","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref45","article-title":"Exploratory Data Analysis","author":"JW Tukey","year":"1977"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1214\/aoms\/1177706443","article-title":"Estimation of the Means of Dependent-Variables","volume":"29","author":"OJ Dunn","year":"1958","journal-title":"Annals of Mathematical Statistics"},{"issue":"293","key":"ref47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/01621459.1961.10482090","article-title":"Multiple Comparisons among Means","volume":"56","author":"OJ Dunn","year":"1961","journal-title":"Journal of the American Statistical Association"},{"issue":"2","key":"ref48","first-page":"65","article-title":"A Simple Sequentially Rejective Multiple Test Procedure","volume":"6","author":"S Holm","year":"1979","journal-title":"Scandinavian Journal of Statistics"},{"issue":"10","key":"ref49","doi-asserted-by":"crossref","first-page":"e0187030","DOI":"10.1371\/journal.pone.0187030","article-title":"Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice","volume":"12","author":"LJ Brylka","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1090-3798(03)00060-6","article-title":"The Hammersmith functional motor scale for children with spinal muscular atrophy: a scale to test ability and monitor progress in children with limited ambulation","volume":"7","author":"M Main","year":"2003","journal-title":"Eur J Paediatr Neurol"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/CIRCULATIONAHA.109.912568","article-title":"Assessing the role of circulating, genetic, and imaging biomarkers in cardiovascular risk prediction","volume":"123","author":"TJ Wang","year":"2011","journal-title":"Circulation"},{"issue":"17","key":"ref52","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.7150\/jca.19438","article-title":"High Intratumoral Expression of Tetranectin Associates with Poor Prognosis of Patients with Gastric Cancer after Gastrectomy","volume":"8","author":"H Chen","year":"2017","journal-title":"J Cancer"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.3390\/ijms11093106","article-title":"Identification of tetranectin as a potential biomarker for metastatic oral cancer","volume":"11","author":"ME Arellano-Garcia","year":"2010","journal-title":"Int J Mol Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.omtm.2018.01.007","article-title":"Plastin 3 Promotes Motor Neuron Axonal Growth and Extends Survival in a Mouse Model of Spinal Muscular Atrophy","volume":"9","author":"A Alrafiah","year":"2018","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1016\/S0021-9258(18)53842-4","article-title":"Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells","volume":"268","author":"CS Lin","year":"1993","journal-title":"The Journal of biological chemistry"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.gde.2013.03.003","article-title":"How genetic modifiers influence the phenotype of spinal muscular atrophy and suggest future therapeutic approaches","volume":"23","author":"B Wirth","year":"2013","journal-title":"Curr Opin Genet Dev"},{"issue":"8","key":"ref57","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/hmg\/6.8.1205","article-title":"The survival motor neuron protein in spinal muscular atrophy","volume":"6","author":"DD Coovert","year":"1997","journal-title":"Hum Mol Genet"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ng0797-265","article-title":"Correlation between severity and SMN protein level in spinal muscular atrophy","volume":"16","author":"S Lefebvre","year":"1997","journal-title":"Nat Genet"},{"issue":"5","key":"ref59","first-page":"383","article-title":"Antisense oligonucleotide inhibitors for the treatment of cancer: 1. Pharmacokinetic properties of phosphorothioate oligodeoxynucleotides","volume":"12","author":"RS Geary","year":"1997","journal-title":"Anticancer Drug Des"},{"issue":"11","key":"ref60","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1124\/dmd.31.11.1419","article-title":"Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species","volume":"31","author":"RS Geary","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"34635","DOI":"10.1038\/srep34635","article-title":"Survival Motor Neuron (SMN) protein is required for normal mouse liver development","volume":"6","author":"E Szunyogova","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/geno.1994.1649","article-title":"Characterization of human and mouse cartilage oligomeric matrix protein","volume":"24","author":"G Newton","year":"1994","journal-title":"Genomics"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/03008209809021499","article-title":"COMP (cartilage oligomeric matrix protein) is synthesized in ligament, tendon, meniscus, and articular cartilage","volume":"39","author":"G Muller","year":"1998","journal-title":"Connect Tissue Res"},{"issue":"3","key":"ref64","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/CIRCRESAHA.109.202762","article-title":"Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin","volume":"106","author":"L Wang","year":"2010","journal-title":"Circ Res"},{"issue":"27","key":"ref65","doi-asserted-by":"crossref","first-page":"22549","DOI":"10.1074\/jbc.M111.335935","article-title":"Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure","volume":"287","author":"P Agarwal","year":"2012","journal-title":"J Biol Chem"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ng0795-325","article-title":"Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia","volume":"10","author":"JT Hecht","year":"1995","journal-title":"Nat Genet"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ng0795-330","article-title":"Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene","volume":"10","author":"MD Briggs","year":"1995","journal-title":"Nat Genet"},{"issue":"11","key":"ref68","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1177\/2047487317703826","article-title":"Extracellular matrix markers and risk of myocardial infarction: The HUNT Study in Norway","volume":"24","author":"T Ueland","year":"2017","journal-title":"Eur J Prev Cardiol"},{"issue":"8","key":"ref69","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/1354750X.2015.1105498","article-title":"Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women","volume":"20","author":"S Kluzek","year":"2015","journal-title":"Biomarkers"},{"issue":"9","key":"ref70","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00393-015-1647-5","article-title":"Serum and synovial cartilage oligomeric matrix protein levels in early and established rheumatoid arthritis","volume":"75","author":"AO El Defrawy","year":"2016","journal-title":"Z Rheumatol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1016\/j.ejim.2017.05.003","article-title":"Cartilage oligomeric matrix protein on the spot for liver fibrosis evaluation: Too early or too late?","volume":"43","author":"K Zachou","year":"2017","journal-title":"Eur J Intern Med"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/1354750X.2015.1118547","article-title":"Cartilage oligomeric matrix protein and hyaluronic acid are sensitive serum biomarkers for early cartilage lesions in the knee joint","volume":"21","author":"Q Jiao","year":"2016","journal-title":"Biomarkers"},{"issue":"3","key":"ref73","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1172\/JCI117753","article-title":"Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism","volume":"95","author":"B Mansson","year":"1995","journal-title":"J Clin Invest"},{"issue":"2","key":"ref74","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s00586-014-3691-2","article-title":"Serum level of cartilage oligomeric matrix protein is lower in children with idiopathic scoliosis than in non-scoliotic controls","volume":"24","author":"P Gerdhem","year":"2015","journal-title":"Eur Spine J"},{"key":"ref75","article-title":"The Effects of Well-Rounded Exercise Program on Systemic Biomarkers Related to Cartilage Metabolism","author":"M Azukizawa","year":"2018","journal-title":"Cartilage"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/CND.0b013e318183e0fa","article-title":"Low bone mineral density in spinal muscular atrophy","volume":"10","author":"IA Khatri","year":"2008","journal-title":"J Clin Neuromuscul Dis"},{"issue":"4","key":"ref77","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.nmd.2017.01.019","article-title":"Low bone mineral density and fractures are highly prevalent in pediatric patients with spinal muscular atrophy regardless of disease severity","volume":"27","author":"HM Wasserman","year":"2017","journal-title":"Neuromuscul Disord"},{"issue":"5","key":"ref78","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2141.2006.06218.x","article-title":"Osteopontin: a bridge between bone and blood","volume":"134","author":"DN Haylock","year":"2006","journal-title":"Br J Haematol"},{"issue":"1","key":"ref79","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/path.2566","article-title":"Bone loss in survival motor neuron (Smn(-\/-) SMN2) genetic mouse model of spinal muscular atrophy","volume":"219","author":"S Shanmugarajan","year":"2009","journal-title":"J Pathol"},{"issue":"6","key":"ref80","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3892\/ijmm.2017.2964","article-title":"Human osteopontin: Potential clinical applications in cancer (Review)","volume":"39","author":"C Hao","year":"2017","journal-title":"Int J Mol Med"},{"issue":"6","key":"ref81","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.003048","article-title":"Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus","volume":"5","author":"J van der Leeuw","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"ref82","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.ajpath.2016.01.002","article-title":"Serum Osteopontin as a Novel Biomarker for Muscle Regeneration in Duchenne Muscular Dystrophy","volume":"186","author":"M Kuraoka","year":"2016","journal-title":"Am J Pathol"},{"issue":"6","key":"ref83","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1083\/jcb.127.6.1767","article-title":"A potential role for tetranectin in mineralization during osteogenesis","volume":"127","author":"UM Wewer","year":"1994","journal-title":"J Cell Biol"},{"issue":"D1","key":"ref84","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","article-title":"The Reactome Pathway Knowledgebase","volume":"46","author":"A Fabregat","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.metabol.2017.04.012","article-title":"Association of plasma dipeptidyl peptidase-4 activity with non-alcoholic fatty liver disease in nondiabetic Chinese population","volume":"73","author":"T Zheng","year":"2017","journal-title":"Metabolism"},{"issue":"1","key":"ref86","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.advms.2013.08.003","article-title":"Serum fetuin A concentration is elevated in children with non-alcoholic fatty liver disease","volume":"59","author":"DM Lebensztejn","year":"2014","journal-title":"Adv Med Sci"},{"issue":"11","key":"ref87","first-page":"1445","article-title":"Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level","volume":"7","author":"PR Srinivas","year":"1993","journal-title":"Mol Endocrinol"},{"issue":"3","key":"ref88","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/01616412.2017.1281195","article-title":"Plasma protein profiling for potential biomarkers in the early diagnosis of Alzheimer's disease","volume":"39","author":"Y Kitamura","year":"2017","journal-title":"Neurol Res"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jcrc.2017.05.004","article-title":"Kinetics of circulating fetuin-A may predict mortality independently from adiponectin, high molecular weight adiponectin and prognostic factors in critically ill patients with sepsis: A prospective study","volume":"41","author":"I Karampela","year":"2017","journal-title":"J Crit Care"},{"issue":"6","key":"ref90","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1111\/j.1523-1755.2005.00345.x","article-title":"Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin","volume":"67","author":"P Stenvinkel","year":"2005","journal-title":"Kidney Int"},{"issue":"4","key":"ref91","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/eci.12057","article-title":"Low serum fetuin A levels and incident stroke in patients with maintenance haemodialysis","volume":"43","author":"HY Chen","year":"2013","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"ref92","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/ejhg.2009.116","article-title":"SMN transcript levels in leukocytes of SMA patients determined by absolute real-time PCR","volume":"18","author":"FD Tiziano","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"ref93","article-title":"SMN mRNA and protein levels in peripheral blood. Biomarkers for SMA clinical trials","author":"CJ Sumner","year":"2006","journal-title":"Neurology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0203398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T21:24:18Z","timestamp":1661981058000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0203398"}},"subtitle":[],"editor":[{"given":"Ravindra N.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,6]]},"references-count":93,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0203398","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,6]]}}}