{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:56:48Z","timestamp":1780365408032,"version":"3.54.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0203479","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T13:53:13Z","timestamp":1538574793000},"page":"e0203479","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Efficacy and safety of 5 alpha-reductase inhibitor monotherapy in patients with benign prostatic hyperplasia: A meta-analysis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4490-3610","authenticated-orcid":true,"given":"Jae Heon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jung","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa Yeon","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yash","family":"Khandwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-5988","authenticated-orcid":true,"given":"Francesco","family":"Del Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"issue":"5","key":"ref1","first-page":"S122","article-title":"BPH: epidemiology and comorbidities","volume":"12","author":"KT McVary","year":"2006","journal-title":"Am J Manag Care"},{"issue":"27","key":"ref2","doi-asserted-by":"crossref","first-page":"e974","DOI":"10.1097\/MD.0000000000000974","article-title":"Comparative Effectiveness and Safety of Monodrug Therapies for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: A Network Meta-analysis","volume":"94","author":"JQ Yuan","year":"2015","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.eururo.2013.01.018","article-title":"Systematic review of combination drug therapy for non-neurogenic male lower urinary tract symptoms","volume":"64","author":"C Fullhase","year":"2013","journal-title":"Eur Urol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MOU.0000000000000126","article-title":"New concepts for the treatment of male lower urinary tract symptoms","volume":"25","author":"C Fullhase","year":"2015","journal-title":"Curr Opin Urol"},{"issue":"25","key":"ref5","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1056\/NEJMoa030656","article-title":"The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia","volume":"349","author":"JD McConnell","year":"2003","journal-title":"N Engl J Med"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.juro.2007.09.084","article-title":"The effects of dutasteride, tamsulosin and combination therapy on lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the CombAT study","volume":"179","author":"CG Roehrborn","year":"2008","journal-title":"J Urol"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.eururo.2004.05.008","article-title":"Efficacy and safety of long-term treatment with the dual 5 alpha-reductase inhibitor dutasteride in men with symptomatic benign prostatic hyperplasia","volume":"46","author":"F Debruyne","year":"2004","journal-title":"Eur Urol"},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJM199802263380901","article-title":"The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride Long-Term Efficacy and Safety Study Group","volume":"338","author":"JD McConnell","year":"1998","journal-title":"N Engl J Med"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0090-4295(02)01905-2","article-title":"Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia","volume":"60","author":"CG Roehrborn","year":"2002","journal-title":"Urology"},{"key":"ref10","article-title":"Alpha-1 adrenergic antagonists, 5-alpha reductase inhibitors, phosphodiesterase type 5 inhibitors, and phytotherapic compounds in men with lower urinary tract symptoms suggestive of benign prostatic obstruction: A systematic review and meta-analysis of urodynamic studies","author":"F Fusco","year":"2018","journal-title":"Neurourol Urodyn"},{"issue":"10","key":"ref11","first-page":"CD006015","article-title":"Finasteride for benign prostatic hyperplasia","author":"J Tacklind","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"ref12","first-page":"915","article-title":"Inhibitors of 5alpha-reductase-related side effects in patients seeking medical care for sexual dysfunction","volume":"35","author":"G Corona","year":"2012","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1517\/14740338.2013.742885","article-title":"Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation","volume":"12","author":"S Gur","year":"2013","journal-title":"Expert Opin Drug Saf"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1743-6109.2010.02157.x","article-title":"Adverse side effects of 5alpha-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients","volume":"8","author":"AM Traish","year":"2011","journal-title":"J Sex Med"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1001\/jamadermatol.2015.36","article-title":"Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia","volume":"151","author":"SM Belknap","year":"2015","journal-title":"A Meta-analysis. JAMA Dermatol"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/j.1743-6109.2011.02368.x","article-title":"An old problem with a new cause-5 alpha reductase inhibitors and persistent sexual dysfunction","volume":"8","author":"I. Goldstein","year":"2011","journal-title":"J Sex Med"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.4088\/JCP.12m07887","article-title":"Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects","volume":"73","author":"MS Irwig","year":"2012","journal-title":"J Clin Psychiatry"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/andr.12353","article-title":"Sexual dysfunction in subjects treated with inhibitors of 5alpha-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis","volume":"5","author":"G Corona","year":"2017","journal-title":"Andrology"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/smrj.3","article-title":"Side Effects of 5-Alpha Reductase Inhibitors: A Comprehensive Review","volume":"1","author":"L Trost","year":"2013","journal-title":"Sex Med Rev"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamainternmed.2017.0089","article-title":"Association of Suicidality and Depression With 5alpha-Reductase Inhibitors","volume":"177","author":"B Welk","year":"2017","journal-title":"JAMA Intern Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"SP Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"issue":"12","key":"ref22","first-page":"700","article-title":"Interpreting estimates of treatment effects: implications for managed care","volume":"33","author":"SV Faraone","year":"2008","journal-title":"P T"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2288-8-32","article-title":"The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation study","volume":"8","author":"JO Friedrich","year":"2008","journal-title":"BMC Med Res Methodol"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"R DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"JP Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"7414","key":"ref26","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JP Higgins","year":"2003","journal-title":"BMJ"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1001\/jama.2016.21043","article-title":"Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone","volume":"317","author":"MJ Budoff","year":"2017","journal-title":"JAMA"},{"issue":"13","key":"ref28","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1056\/NEJMoa0908127","article-title":"Effect of dutasteride on the risk of prostate cancer","volume":"362","author":"GL Andriole","year":"2010","journal-title":"N Engl J Med"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.juro.2008.06.033","article-title":"Does prostate growth confound prostate specific antigen velocity? Data from the Baltimore longitudinal study of aging","volume":"180","author":"S Loeb","year":"2008","journal-title":"J Urol"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.juro.2009.06.047","article-title":"Prostate volume changes over time: results from the Baltimore Longitudinal Study of Aging","volume":"182","author":"S Loeb","year":"2009","journal-title":"J Urol"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0022-5347(01)66461-9","article-title":"Natural history of prostatism: longitudinal changes in voiding symptoms in community dwelling men","volume":"155","author":"SJ Jacobsen","year":"1996","journal-title":"J Urol"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00345-014-1460-9","article-title":"Demographic and comorbidity profile of patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a real-life clinical setting: Are 5-alpha-reductase inhibitor consumers different?","volume":"33","author":"F Fusco","year":"2015","journal-title":"World J Urol"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pbb.2004.04.016","article-title":"Interaction of chronic ethanol exposure and finasteride: sex and strain differences","volume":"78","author":"DA Finn","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1006\/hbeh.2002.1763","article-title":"Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats","volume":"41","author":"CA Frye","year":"2002","journal-title":"Horm Behav"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3758\/CABN.1.3.287","article-title":"Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrus decreases anxiolytic behaviors and enhances exploratory and antinociceptive behaviors","volume":"1","author":"ME Rhodes","year":"2001","journal-title":"Cogn Affect Behav Neurosci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0203479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T13:07:14Z","timestamp":1540213634000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0203479"}},"subtitle":[],"editor":[{"given":"Peter F.W.M.","family":"Rosier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,3]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0203479","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,3]]}}}