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Assessment of the economic impact of porcine reproductive and respira-tory syndrome virus on U.S. pork producers. Proceeding of the 20th international pig veterinary society congress; 2008. pp 86."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2460\/javma.2005.227.385","article-title":"Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States","volume":"227","author":"EJ Neumann","year":"2005","journal-title":"J. Am. Vet. Med. Assoc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e88807","DOI":"10.1371\/journal.pone.0088807","article-title":"Genomic evolution of porcine reproductive and respiratory syndrome virus (PRRSV) isolates revealed by deep sequencing","volume":"9","author":"MS Brar","year":"2014","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"E2172","DOI":"10.1073\/pnas.1321930111","article-title":"Transactivation of programmed ribosomal frameshifting by a viral protein","volume":"111","author":"Y Li","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1099\/vir.0.000104","article-title":"Evolutionary Diversification of Type 2 Porcine Reproductive and Respiratory Syndrome Virus","volume":"96","author":"MS Brar","year":"2015","journal-title":"J. Gen. 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Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"11837","DOI":"10.1128\/JVI.76.23.11837-11844.2002","article-title":"Comparison of molecular and biological characteristics of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (ingelvac PRRS MLV), the parent strain of the vaccine (ATCC VR2332), ATCC VR2385, and two recent field isolates of PRRSV","volume":"76","author":"T Opriessnig","year":"2002","journal-title":"J. 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Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2012.09.013","article-title":"Comparative analysis of immune responses following experimental infection of pigs with European porcine reproductive and respiratory syndrome virus strains of differing virulence","volume":"163","author":"E Weesendorp","year":"2013","journal-title":"Vet. Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.vetmic.2012.11.024","article-title":"Increased pathogenicity of European porcine reproductive and respiratory syndrome virus is associated with enhanced adaptive responses and viral clearance","volume":"163","author":"SB Morgan","year":"2013","journal-title":"Vet. 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Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/CVI.00304-06","article-title":"Protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection through passive transfer of PRRSV-neutralizing antibodies is dose dependent","volume":"14","author":"OJ Lopez","year":"2007","journal-title":"Clin. Vaccine Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1128\/JVI.74.22.10834-10837.2000","article-title":"Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection","volume":"74","author":"R Allende","year":"2000","journal-title":"J. Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2460\/ajvr.1991.53.04.485","article-title":"Experimental reproduction of swine infertility and respiratory syndrome in pregnant sows","volume":"53","author":"WT Christianson","year":"1992","journal-title":"Am. J. Vet. Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0165-2427(95)05494-4","article-title":"Changes of lymphocyte subpopulations in pigs infected with porcine reproductive and respiratory syndrome (PRRS) virus","volume":"50","author":"M Shimizu","year":"1996","journal-title":"Vet. Immunol. Immunopathol"},{"key":"ref29","first-page":"267","article-title":"Virological and immunological responses to porcine reproductive and respiratory syndrome virus in a large population of gilts","volume":"68","author":"L Batista","year":"2004","journal-title":"Can. J. Vet. Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0378-1135(00)00196-6","article-title":"Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development","volume":"74","author":"XJ Meng","year":"2000","journal-title":"Vet. 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Vaccine Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.virol.2012.08.026","article-title":"Dissociation of porcine reproductive and respiratory syndrome virus neutralization from antibodies specific to major envelope protein surface epitopes","volume":"433","author":"J Li","year":"2012","journal-title":"Virology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.vetmic.2007.02.009","article-title":"Assessment of the efficacy of commercial porcine reproductive and respiratory syndrome virus (PRRSV) vaccines based on measurement of serologic response, frequency of gamma-IFN-producing cells and virological parameters of protection upon challenge","volume":"123","author":"FA Zuckermann","year":"2007","journal-title":"Vet. 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Vaccine Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.1016\/j.vaccine.2014.04.054","article-title":"Proteome-wide screening of the European porcine reproductive and respiratory syndrome virus reveals a broad range of T cell antigen reactivity","volume":"32","author":"H Mokhtar","year":"2014","journal-title":"Vaccine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.virusres.2011.03.018","article-title":"Identification of immunodominant T-cell epitopes in membrane protein of highly pathogenic porcine reproductive and respiratory syndrome virus","volume":"158","author":"YX Wang","year":"2011","journal-title":"Virus Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1016\/j.vaccine.2009.07.029","article-title":"In silico prediction and ex vivo evaluation of potential T-cell epitopes in glycoproteins 4 and 5 and nucleocapsid protein of genotype-I (European) of porcine reproductive and respiratory syndrome virus","volume":"27","author":"I Diaz","year":"2009","journal-title":"Vaccine"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1016\/j.vaccine.2008.06.047","article-title":"Identification of immunodominant T-cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus","volume":"26","author":"K Vashisht","year":"2008","journal-title":"Vaccine"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.virusres.2012.06.024","article-title":"Location of T-cell epitopes in nonstructural proteins 9 and 10 of type-II porcine reproductive and respiratory syndrome virus","volume":"169","author":"R Parida","year":"2012","journal-title":"Virus Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3390\/v5020663","article-title":"Predicted peptides from non-structural proteins of porcine reproductive and respiratory syndrome virus are able to induce IFN-gamma and IL-10","volume":"5","author":"A Burgara-Estrella","year":"2013","journal-title":"Viruses"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"14986","DOI":"10.1128\/JVI.79.23.14986-14991.2005","article-title":"Tat(28\u201335)SL8-specific CD8+ T lymphocytes are more effective than Gag(181\u2013189)CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay","volume":"79","author":"JT Loffredo","year":"2005","journal-title":"J. Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1128\/JVI.01780-06","article-title":"Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication","volume":"81","author":"C Chung","year":"2007","journal-title":"J. Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"11640","DOI":"10.1073\/pnas.93.21.11640","article-title":"Profluorescent protease substrates: intramolecular dimers described by the exciton model","volume":"93","author":"BZ Packard","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.4049\/jimmunol.179.6.3812","article-title":"Granzyme B activity in target cells detects attack by cytotoxic lymphocytes","volume":"179","author":"BZ Packard","year":"2007","journal-title":"J. Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-1135(96)01347-8","article-title":"Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV)","volume":"56","author":"X Duan","year":"1997","journal-title":"Vet. Microbiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1099\/vir.0.020503-0","article-title":"Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage","volume":"91","author":"BW Van","year":"2010","journal-title":"J. Gen. Virol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1099\/vir.0.2008\/005009-0","article-title":"Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus","volume":"89","author":"GH Van","year":"2008","journal-title":"J. Gen. Virol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.virusres.2010.07.018","article-title":"A brief review of CD163 and its role in PRRSV infection","volume":"154","author":"SK Welch","year":"2010","journal-title":"Virus Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0168-1702(99)00073-8","article-title":"Analysis of cellular immune response in pigs recovered from porcine respiratory and reproductive syndrome infection","volume":"64","author":"FL Lopez","year":"1999","journal-title":"Virus Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0042-6822(03)00009-6","article-title":"Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination","volume":"309","author":"WA Meier","year":"2003","journal-title":"Virology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1099\/vir.0.039289-0","article-title":"Identification of porcine reproductive and respiratory syndrome virus ORF1a-encoded non-structural proteins in virus-infected cells","volume":"93","author":"Y Li","year":"2012","journal-title":"J. Gen. Virol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1089\/vim.2004.17.594","article-title":"Temporary CD8+ T-cell depletion in pigs does not exacerbate infection with porcine reproductive and respiratory syndrome virus (PRRSV)","volume":"17","author":"L Lohse","year":"2004","journal-title":"Viral Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.2190315","article-title":"Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine","volume":"248","author":"RJ Orentas","year":"1990","journal-title":"Science"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.1128\/JVI.00513-09","article-title":"Strong ability of Nef-specific CD4+ cytotoxic T cells to suppress human immunodeficiency virus type 1 (HIV-1) replication in HIV-1-infected CD4+ T cells and macrophages","volume":"83","author":"N Zheng","year":"2009","journal-title":"J. Virol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.dci.2013.01.003","article-title":"Phenotypic maturation of porcine NK- and T-cell subsets","volume":"40","author":"SC Talker","year":"2013","journal-title":"Dev. Comp. Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molimm.2014.10.025","article-title":"Phenotypic and functional differentiation of porcine alphabeta T cells: current knowledge and available tools","volume":"66","author":"W Gerner","year":"2015","journal-title":"Mol. Immunol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1128\/JVI.75.10.4889-4895.2001","article-title":"In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II","volume":"75","author":"W Feng","year":"2001","journal-title":"J. Virol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1099\/0022-1317-76-12-3039","article-title":"Classical swine fever virus-specific cytotoxic T lymphocytes and identification of a T cell epitope","volume":"76","author":"T Pauly","year":"1995","journal-title":"J. Gen. Virol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/vim.2013.0011","article-title":"Characterization of cytotoxic T lymphocyte function after foot-and-mouth disease virus infection and vaccination","volume":"26","author":"JR Patch","year":"2013","journal-title":"Viral. Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1128\/CVI.00415-13","article-title":"Assessment of the phenotype and functionality of porcine CD8 T cell responses following vaccination with live attenuated classical swine fever virus (CSFV) and virulent CSFV challenge","volume":"20","author":"G Franzoni","year":"2013","journal-title":"Clin. Vaccine Immunol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"e0165450","DOI":"10.1371\/journal.pone.0165450","article-title":"Recognition of Highly Diverse Type-1 and -2 Porcine Reproductive and Respiratory Syndrome Viruses (PRRSVs) by T-Lymphocytes Induced in Pigs after Experimental Infection with a Type-2 PRRSV Strain","volume":"11","author":"CJ Chung","year":"2016","journal-title":"PLoS One"},{"key":"ref65","unstructured":"OIE (World Organization for Animal Health). Porcine Reproductive and Respiratory Syndrome. In: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2015, 8th edn. 2015. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.oie.int\/fileadmin\/Home\/eng\/Health_standards\/tahm\/2.08.06_PRRS.pdf\" xlink:type=\"simple\">http:\/\/www.oie.int\/fileadmin\/Home\/eng\/Health_standards\/tahm\/2.08.06_PRRS.pdf<\/ext-link>"},{"key":"ref66","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"LJ Reed","year":"1938","journal-title":"Am. J. Hygiene"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2052.2010.02019.x","article-title":"Molecular characterization of swine leucocyte antigen class II genes in outbred pig populations","volume":"41","author":"CS Ho","year":"2010","journal-title":"Anim. Genet"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1365-2052.2009.01860.x","article-title":"Molecular characterization of swine leucocyte antigen class I genes in outbred pig populations","volume":"40","author":"CS Ho","year":"2009","journal-title":"Anim. Genet"},{"key":"ref69","unstructured":"Chung C, Grimm AL, Rzepka J, Stanton J, Choi E, Song J. PRRSV replication in porcine alveolar macrophages causes late and minor down-regulations of MHC class I and II molecules that are epitope presentation structures for CD8+ CTL and CD4+ helper T cells. Proceeding of the 23rd international pig veterinary society congress. 2014. pp 286."},{"key":"ref70","doi-asserted-by":"crossref","first-page":"6916","DOI":"10.1074\/jbc.273.12.6916","article-title":"Granzyme release and caspase activation in activated human T-lymphocytes","volume":"273","author":"JM Zapata","year":"1998","journal-title":"J. Biol. 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