{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:11:51Z","timestamp":1790712711417,"version":"4.1.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA041750"],"award-info":[{"award-number":["DA041750"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA043268"],"award-info":[{"award-number":["DA043268"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0203566","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T19:02:55Z","timestamp":1547751775000},"page":"e0203566","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Epitranscriptomics: Correlation of N6-methyladenosine RNA methylation and pathway dysregulation in the hippocampus of HIV transgenic rats"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-6273","authenticated-orcid":true,"given":"Yu","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Zorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Sumazin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-2151","authenticated-orcid":true,"given":"Pietro Paolo","family":"Sanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vez","family":"Repunte-Canonigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"issue":"7397","key":"ref1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"D Dominissini","year":"2012","journal-title":"Nature"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3&apos; UTRs and near stop codons","volume":"149","author":"KD Meyer","year":"2012","journal-title":"Cell"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1073\/pnas.72.6.2012","article-title":"Methylated simian virus 40-specific RNA from nuclei and cytoplasm of infected BSC-1 cells","volume":"72","author":"S Lavi","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7544","key":"ref4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature14281","article-title":"N6-methyladenosine marks primary microRNAs for processing","volume":"519","author":"CR Alarcon","year":"2015","journal-title":"Nature"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1261\/rna.041178.113","article-title":"Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA","volume":"19","author":"N Liu","year":"2013","journal-title":"RNA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-genom-090413-025405","article-title":"The pivotal regulatory landscape of RNA modifications","volume":"15","author":"S Li","year":"2014","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02263-16","article-title":"Viral Epitranscriptomics","volume":"91","author":"EM Kennedy","year":"2017","journal-title":"J Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13059-016-0874-7","article-title":"Expanding the diversity of DNA base modifications with N(6)-methyldeoxyadenosine","volume":"17","author":"KD Meyer","year":"2016","journal-title":"Genome Biol"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA Modifications in Gene Expression Regulation","volume":"169","author":"IA Roundtree","year":"2017","journal-title":"Cell"},{"issue":"13","key":"ref10","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1101\/gad.262766.115","article-title":"RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation","volume":"29","author":"Y Yue","year":"2015","journal-title":"Genes Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0092-8674(74)90153-6","article-title":"Existence of methylated messenger RNA in mouse L cells","volume":"1","author":"R Perry","year":"1974","journal-title":"Cell"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells","volume":"71","author":"R Desrosiers","year":"1974","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"46","key":"ref13","doi-asserted-by":"crossref","first-page":"15170","DOI":"10.1523\/JNEUROSCI.3236-14.2014","article-title":"Novel RNA modifications in the nervous system: form and function","volume":"34","author":"JS Satterlee","year":"2014","journal-title":"J Neurosci"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrg3724","article-title":"Gene expression regulation mediated through reversible m(6)A RNA methylation","volume":"15","author":"Y Fu","year":"2014","journal-title":"Nat Rev Genet"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"160003","DOI":"10.1098\/rsob.160003","article-title":"Recent advances in dynamic m6A RNA modification","volume":"6","author":"G Cao","year":"2016","journal-title":"Open Biol"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1101\/gad.301036.117","article-title":"m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover","volume":"31","author":"S Ke","year":"2017","journal-title":"Genes Dev"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1021\/bi00627a023","article-title":"Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid","volume":"16","author":"CM Wei","year":"1977","journal-title":"Biochemistry"},{"issue":"7540","key":"ref18","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature14234","article-title":"N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions","volume":"518","author":"N Liu","year":"2015","journal-title":"Nature"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1002\/jcb.25967","article-title":"Regulatory Role of N6 -methyladenosine (m6 A) Methylation in RNA Processing and Human Diseases","volume":"118","author":"W Wei","year":"2017","journal-title":"J Cell Biochem"},{"issue":"7481","key":"ref20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"X Wang","year":"2014","journal-title":"Nature"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency","volume":"161","author":"X Wang","year":"2015","journal-title":"Cell"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing","volume":"61","author":"W Xiao","year":"2016","journal-title":"Mol Cell"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nchembio.1654","article-title":"Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain","volume":"10","author":"C Xu","year":"2014","journal-title":"Nat Chem Biol"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nn.3449","article-title":"The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry","volume":"16","author":"ME Hess","year":"2013","journal-title":"Nat Neurosci"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"E738","DOI":"10.1002\/oby.20444","article-title":"Association between obesity-related gene FTO and ADHD","volume":"21","author":"Z Choudhry","year":"2013","journal-title":"Obesity (Silver Spring)"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ng.2561","article-title":"Genome-wide association studies identify four ER negative-specific breast cancer risk loci","volume":"45","author":"M Garcia-Closas","year":"2013","journal-title":"Nat Genet"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/ng.2571","article-title":"A variant in FTO shows association with melanoma risk not due to BMI","volume":"45","author":"MM Iles","year":"2013","journal-title":"Nat Genet"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.4049\/jimmunol.136.7.2526","article-title":"Induction and regulation by monokines of hepatic synthesis of the mouse serum amyloid P-component (SAP)","volume":"136","author":"PT Le","year":"1986","journal-title":"J Immunol"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"e50354","DOI":"10.1371\/journal.pone.0050354","article-title":"Group N-LNFS, Alzheimer&apos;s Disease Neuroimaging I. Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer&apos;s disease","volume":"7","author":"C Reitz","year":"2012","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1749-6632.2010.05903.x","article-title":"From GWAS to biology: lessons from FTO","volume":"1220","author":"YC Tung","year":"2011","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"E148","DOI":"10.1210\/jc.2014-1893","article-title":"Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5","volume":"100","author":"F Shen","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"24345","DOI":"10.1038\/srep24345","article-title":"Increased N6-methyladenosine in Human Sperm RNA as a Risk Factor for Asthenozoospermia","volume":"6","author":"Y Yang","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1128\/JVI.20.1.45-53.1976","article-title":"Influenza viral mRNA contains internal N6-methyladenosine and 5&apos;-terminal 7-methylguanosine in cap structures","volume":"20","author":"RM Krug","year":"1976","journal-title":"J Virol"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/nar\/3.3.749","article-title":"The methylation of adenovirus-specific nuclear and cytoplasmic RNA","volume":"3","author":"S Sommer","year":"1976","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.chom.2016.09.015","article-title":"N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection","volume":"20","author":"NS Gokhale","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1021\/bi00622a021","article-title":"Sequence specificity of internal methylation in B77 avian sarcoma virus RNA subunits","volume":"16","author":"K Dimock","year":"1977","journal-title":"Biochemistry"},{"issue":"Pt 10","key":"ref37","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1099\/0022-1317-64-10-2191","article-title":"Stabilities of avian sarcoma virus RNAs: comparison of subgenomic and genomic species with cellular mRNAs","volume":"64","author":"CM Stoltzfus","year":"1983","journal-title":"J Gen Virol"},{"key":"ref38","article-title":"Unravelling HIV-1 Latency, One Cell at a Time","author":"YL Kok","year":"2017","journal-title":"Trends Microbiol"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.bbagrm.2017.02.002","article-title":"Epitranscriptomic regulation of viral replication","volume":"1860","author":"C Pereira-Montecinos","year":"2017","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/JVI.42.3.918-931.1982","article-title":"Accumulation of spliced avian retrovirus mRNA is inhibited in S-adenosylmethionine-depleted chicken embryo fibroblasts","volume":"42","author":"CM Stoltzfus","year":"1982","journal-title":"J Virol"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0042-6822(83)90508-1","article-title":"Methylations of adenosine residues (m6A) in pre-mRNA are important for formation of late simian virus 40 mRNAs","volume":"131","author":"D Finkel","year":"1983","journal-title":"Virology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"16011","DOI":"10.1038\/nmicrobiol.2016.11","article-title":"Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells","volume":"1","author":"G Lichinchi","year":"2016","journal-title":"Nat Microbiol"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.chom.2016.04.002","article-title":"Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression","volume":"19","author":"EM Kennedy","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref44","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.15528","article-title":"N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression","volume":"5","author":"N Tirumuru","year":"2016","journal-title":"Elife"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.immuni.2005.06.008","article-title":"Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA","volume":"23","author":"K Kariko","year":"2005","journal-title":"Immunity"},{"issue":"16","key":"ref46","doi-asserted-by":"crossref","first-page":"9271","DOI":"10.1073\/pnas.161290298","article-title":"An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction","volume":"98","author":"W Reid","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1750-1326-9-26","article-title":"Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats","volume":"9","author":"V Repunte-Canonigo","year":"2014","journal-title":"Molecular neurodegeneration"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11481-007-9078-y","article-title":"Spatial learning and memory in HIV-1 transgenic rats","volume":"2","author":"M Vigorito","year":"2007","journal-title":"J Neuroimmune Pharmacol"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/13550280802232996","article-title":"Further characterization of the spatial learning deficit in the human immunodeficiency virus-1 transgenic rat","volume":"15","author":"AL Lashomb","year":"2009","journal-title":"J Neurovirol"},{"issue":"29","key":"ref50","doi-asserted-by":"crossref","first-page":"10550","DOI":"10.1523\/JNEUROSCI.4403-14.2015","article-title":"Induction of Interleukin-1beta by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention","volume":"35","author":"L Festa","year":"2015","journal-title":"J Neurosci"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/COH.0000000000000102","article-title":"Evolving clinical phenotypes in HIV-associated neurocognitive disorders","volume":"9","author":"N Sacktor","year":"2014","journal-title":"Curr Opin HIV AIDS"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1750-1326-9-26","article-title":"Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats","volume":"9","author":"V Repunte-Canonigo","year":"2014","journal-title":"Mol Neurodegener"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"e0175316","DOI":"10.1371\/journal.pone.0175316","article-title":"Gene expression patterns associated with neurological disease in human HIV infection","volume":"12","author":"PP Sanna","year":"2017","journal-title":"PLoS One"},{"issue":"1\u20132","key":"ref54","first-page":"16","article-title":"Immune activation, viral gene product expression and neurotoxicity in the HIV-1 transgenic rat","volume":"247","author":"W Royal 3rd","year":"2012","journal-title":"J Neuroimmunol"},{"issue":"11","key":"ref55","doi-asserted-by":"crossref","first-page":"6365","DOI":"10.1128\/JVI.67.11.6365-6378.1993","article-title":"Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity","volume":"67","author":"DF Purcell","year":"1993","journal-title":"J Virol"},{"issue":"43","key":"ref56","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrn2040","article-title":"HIV and antiretroviral therapy in the brain: neuronal injury and repair","volume":"8","author":"R Ellis","year":"2007","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"ref58","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ana.410420618","article-title":"Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center","volume":"42","author":"E Masliah","year":"1997","journal-title":"Ann Neurol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13550280903131915","article-title":"Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy","author":"I Everall","year":"2009","journal-title":"J Neurovirol"},{"key":"ref60","article-title":"Understanding Frailty, Aging, and Inflammation in HIV Infection","author":"SX Leng","year":"2015","journal-title":"Curr HIV\/AIDS Rep"},{"issue":"19","key":"ref61","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1101\/gad.269415.115","article-title":"A majority of m6A residues are in the last exons, allowing the potential for 3&apos; UTR regulation","volume":"29","author":"S Ke","year":"2015","journal-title":"Genes Dev"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tig.2015.03.002","article-title":"The alternative role of DNA methylation in splicing regulation","volume":"31","author":"G Lev Maor","year":"2015","journal-title":"Trends Genet"},{"issue":"5","key":"ref63","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrm3785","article-title":"The dynamic epitranscriptome: N6-methyladenosine and gene expression control","volume":"15","author":"KD Meyer","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5523","key":"ref64","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/257251a0","article-title":"N6, O2&apos;-dimethyladenosine a novel methylated ribonucleoside next to the 5&apos; terminal of animal cell and virus mRNAs","volume":"257","author":"C Wei","year":"1975","journal-title":"Nature"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0203566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:35:44Z","timestamp":1694565344000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0203566"}},"subtitle":[],"editor":[{"given":"Massimo","family":"Caputi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0203566","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,17]]}}}