{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T12:28:05Z","timestamp":1769344085224,"version":"3.49.0"},"reference-count":90,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0203957","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T17:30:28Z","timestamp":1537896628000},"page":"e0203957","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Systematic review update of observational studies further supports aspirin role in cancer treatment: Time to share evidence and decision-making with patients?"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4352-1570","authenticated-orcid":true,"given":"Peter C.","family":"Elwood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet E.","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julieta","family":"Galante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison L.","family":"Weightman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delyth","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Longley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Dolwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Chia W. K.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Lanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(09)60503-1","article-title":"Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials","volume":"373","year":"2009","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/clc.22394","article-title":"Reducing cardiovascular and cancer risk: how to address global primary prevention in clinical practice","volume":"38","author":"A Battistoni","year":"2015","journal-title":"Clin Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1470-2045(12)70112-2","article-title":"Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials","volume":"13","author":"AM Algra","year":"2012","journal-title":"Lancet Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.amjmed.2012.01.017","article-title":"Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials","volume":"125","author":"EJ Mills","year":"2012","journal-title":"The Amer J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0140-6736(11)61049-0","article-title":"Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial","volume":"378","author":"J Burn","year":"2013","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/S0140-6736(11)61720-0","article-title":"Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials","volume":"379","author":"PM Rothwell","year":"2012","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1073\/pnas.61.1.46","article-title":"Antimetastatic effects associated with platelet reduction","volume":"61","author":"GJ Gasic","year":"1968","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/jama.2009.1112","article-title":"Aspirin use and survival after diagnosis of colorectal cancer","volume":"302","author":"AT Chan","year":"2009","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/bjc.2011.289","article-title":"Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?","volume":"105","author":"RE Langley","year":"2011","journal-title":"Brit J Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(09)60243-9","article-title":"Aspirin, salicylates, and cancer","volume":"373","author":"PC Elwood","year":"2009","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(12)60209-8","article-title":"Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials","volume":"379","author":"PM Rothwell","year":"2012","journal-title":"Lancet"},{"key":"ref12","first-page":"419","article-title":"Adjuvant antiplatelet therapy with aspirin in colo-rectal cancer","volume":"13","author":"A Lipton","year":"1982","journal-title":"J Medicine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/1097-0142(19930301)71:5<1741::AID-CNCR2820710507>3.0.CO;2-Q","article-title":"No effect of an antiaggregant treatment with aspirin in small cell lung cancer treated with CCAVP16 chemotherapy. Results from a randomized clinical trial of 303 patients. The &quot;Petites Cellules&quot; Group","volume":"71","author":"B Lebeau","year":"1993","journal-title":"Cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1200\/JCO.1991.9.12.2104","article-title":"A randomized prospective assessment of recombinant leukocyte A human interferon with or without aspirin in advanced renal adenocarcinoma","volume":"9","author":"ET Creagan","year":"1991","journal-title":"Journal of Clin Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1245\/s10434-009-0382-z","article-title":"A preliminary study on the postoperative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia","volume":"16","author":"JF Liu","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cct.2016.10.004","article-title":"Add-aspirin: a phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours","volume":"51","author":"C Coyle","year":"2016","journal-title":"Contemporary Clin Trials"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"846","DOI":"10.7326\/M16-0576","article-title":"Aspirin for disease prevention: public policy or personal choice?","volume":"164","author":"C Baigent","year":"2016","journal-title":"Ann Int Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e0152402","DOI":"10.1371\/journal.pone.0152402","article-title":"Aspirin in the treatment of cancer: reductions in metastatic spread and in mortality: a systematic review and meta-analyses of published studies","volume":"11","author":"PC Elwood","year":"2016","journal-title":"PLoS One"},{"key":"ref19","first-page":"e1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS One"},{"key":"ref20","article-title":"The Newcastle-Ottaway Scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis","author":"G Wells","year":"2011"},{"key":"ref21","author":"M Egger","year":"2001"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1200\/JCO.2015.65.3519","article-title":"Aspirin as secondary prevention in patients with colorectal cancer: an unselected population-based study","volume":"34","author":"SJ Bains","year":"2016","journal-title":"J Clin Oncol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/bjc.2016.425","article-title":"Effect of low-dose aspirin use on survival of patients with gastrointestinal malignancies; an observational study","volume":"116","author":"MA Frouws","year":"2017","journal-title":"British J Cancer"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.clcc.2016.07.011","article-title":"The role of aspirin as antitumoral agent for heavily pretreated patients with metastatic colorectal cancer receiving capecitabine monotherapy","volume":"16","author":"R Giampieri","year":"2017","journal-title":"Clin Colorectal Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.17554\/j.issn.2224-3992.2016.05.605","article-title":"Does antiplatelet therapy affect short-term and long-term outcomes of patients undergoing surgery for colorectal cancer?\u2014Surgical radicality versus perioperative antiplatelet-related morbidity risks","volume":"5","author":"N Shimoike","year":"2016","journal-title":"Journal of Gastroenterol and Hepatol Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/bjc.2015.336","article-title":"Aspirin as a neoadjuvant agent during preoperative chemoradiation for rectal cancer","volume":"113","author":"A Restivo","year":"2015","journal-title":"Brit J Cancer"},{"key":"ref27","article-title":"Does low-dose aspirin use for cardiovascular disease prevention reduce colorectal cancer deaths? A comparison of two cohorts in the Florence district, Italy","author":"L Ventura","year":"2016","journal-title":"In: Eur J Cancer Prev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1038\/ctg.2017.18","article-title":"Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study","volume":"8","author":"RT Gray","year":"2017","journal-title":"Clin and Translat Gastroenterol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1200\/JCO.2017.72.3569","article-title":"Timing of aspirin and other nonsteroidal anti-inflammatory drug use among patients with colorectal cancer in relation to tumor markers and survival","volume":"35","author":"X Hua","year":"2017","journal-title":"J Clin Oncol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e0153413","DOI":"10.1371\/journal.pone.0153413","article-title":"Non-steroidal anti-inflammatory drugs and cancer death in the Finnish Prostate Cancer Screening Trial","volume":"11","author":"T Veitonmaki","year":"2016","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/imj.13312","article-title":"Examining the impact of regular aspirin use and PIK3CA mutations on survival in stage 2 colon cancer","volume":"47","author":"C Murphy","year":"2017","journal-title":"Intern Med J"},{"key":"ref32","first-page":"3177","article-title":"Aspirin use and mortality from cancer in a prospective cohort study","volume":"24","author":"LD Ratnasinghe","year":"2004","journal-title":"Anticancer Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1136\/bmj.j2497","article-title":"Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study","volume":"357","author":"J Hippisley-Cox","year":"2017","journal-title":"Brit Med J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1200\/JCO.2016.70.7547","article-title":"Aspirin use and colorectal cancer survival according to tumor CD274 (Programmed Cell Death 1 Ligand 1) expression status","volume":"35","author":"T Hamada","year":"2017","journal-title":"J Clin Oncol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.canep.2016.12.008","article-title":"Low-dose aspirin use and survival in breast cancer patients: a nationwide cohort study","volume":"47","author":"UC Mc Menamin","year":"2017","journal-title":"Cancer Epidemiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10549-016-4081-8","article-title":"Aspirin\/antiplatelet agent use improves disease-free survival and reduces the risk of distant metastases in Stage II and III triple-negative breast cancer patients","volume":"161","author":"J Shiao","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1200\/JCO.2017.35.15_suppl.1521","article-title":"Impact of PIK3CA tumor mutation on the association of aspirin or NSAID use and time to breast cancer recurrence","volume":"35","author":"AM McCarthy","year":"2017","journal-title":"J Clin Oncol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5301\/tj.5000424","article-title":"Impact of aspirin on clinical outcomes for African American men with prostate cancer undergoing radiation","volume":"102","author":"VW Osborn","year":"2016","journal-title":"Tumori"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/pros.23020","article-title":"Use of non-steroidal anti-inflammatory drugs and prostate cancer survival in the Finnish prostate cancer screening trial","volume":"75","author":"T Veitonmaki","year":"2015","journal-title":"Prostate"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1158\/1940-6207.CAPR-17-0033","article-title":"Do aspirin and other NSAIDs confer a survival benefit in men diagnosed with prostate cancer? A pooled analysis of NIH-AARP and PLCO cohorts","volume":"10","author":"CK Zhou","year":"2017","journal-title":"Cancer Prev Research"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10552-013-0306-x","article-title":"Low-dose aspirin and survival in men with prostate cancer: a study using the UK Clinical Practice Research Datalink","volume":"25","author":"CR Cardwell","year":"2014","journal-title":"Cancer Causes Control"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.eururo.2017.01.044","article-title":"Regular aspirin use and the risk of lethal prostate cancer in the Physicians&apos; Health Study","volume":"72","author":"MK Downer","year":"2017","journal-title":"Eur Urol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ejogrb.2016.09.005","article-title":"The effect of metabolic comorbidities and commonly used drugs on the prognosis of patients with ovarian cancer","volume":"207","author":"D Bar","year":"2016","journal-title":"Eur J of Obs Gynec and Repr Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/AOG.0000000000001491","article-title":"Association of low-dose aspirin and survival of women with endometrial cancer","volume":"128","author":"K Matsuo","year":"2016","journal-title":"Obs Gyne"},{"key":"ref45","first-page":"2109","article-title":"Aspirin in combination with TACE in treatment of unresectable HCC: a matched-pairs analysis","volume":"6","author":"JH Li","year":"2016","journal-title":"American Journal of Cancer Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.lungcan.2017.01.018","article-title":"Effects of aspirin on small-cell lung cancer mortality and metastatic presentation","volume":"106","author":"P Maddison","year":"2017","journal-title":"Lung Cancer"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s10147-017-1165-3","article-title":"Aspirin use and head and neck cancer survival: an observational study of 11,623 person-years follow-up","volume":"23","author":"S-A Kim","year":"2018","journal-title":"Int J Clin Oncol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1002\/(SICI)1097-0142(19980615)82:12<2326::AID-CNCR5>3.0.CO;2-Q","article-title":"Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma","volume":"82","author":"L Rosenberg","year":"1998","journal-title":"Cancer"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/aje\/kwi248","article-title":"Use of nonsteroidal antiinflammatory drugs and risk of colon cancer in a population-based, case-control study of African Americans and Whites","volume":"162","author":"LB Sansbury","year":"2005","journal-title":"Amer J Epidemiol"},{"key":"ref50","first-page":"1108","article-title":"Aspirin use in relation to risk of prostate cancer","volume":"11","author":"MF Leitzmann","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/bjc.2014.264","article-title":"Aspirin use and survival after the diagnosis of breast cancer: a population-based cohort study","volume":"111","author":"DM Fraser","year":"2014","journal-title":"Brit J Cancer"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1158\/1055-9965.EPI-14-1415","article-title":"De novo post-diagnosis aspirin use and mortality in women with stage I-III breast cancer","volume":"24","author":"TI Barron","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/ijc.28671","article-title":"Anticoagulant medication at time of needle biopsy for breast cancer in relation to risk of lymph node metastasis","volume":"135","author":"R Ljung","year":"2014","journal-title":"Int J Cancer"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10549-006-9277-x","article-title":"NSAID use and survival after breast cancer diagnosis in post-menopausal women","volume":"101","author":"CK Blair","year":"2007","journal-title":"Breast Cancer Res Treat"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.juro.2014.11.018","article-title":"The use of aspirin and the risk of mortality in patients with prostate cancer","volume":"193","author":"J Assayag","year":"2015","journal-title":"J Urol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.canep.2014.12.010","article-title":"Aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, acetaminophen and ovarian cancer survival","volume":"39","author":"CM Nagle","year":"2015","journal-title":"Cancer Epidemiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejcts.2010.01.015","article-title":"Aspirin and non-small cell lung cancer resections: effect on long-term survival","volume":"38","author":"E Fontaine","year":"2010","journal-title":"Eur J Cardio-Thoracic Surg"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12885-015-1152-x","article-title":"Can daily intake of aspirin and\/or statins influence the behavior of non-muscle invasive bladder cancer? A retrospective study on a cohort of patients undergoing transurethral bladder resection","volume":"15","author":"AL Pastore","year":"2015","journal-title":"BMC Cancer"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1182\/blood-2013-07-517102","article-title":"Statin and aspirin use is associated with improved outcome of FCR therapy in relapsed\/refractory chronic lymphocytic leukemia","volume":"123","author":"YK Chae","year":"2014","journal-title":"Blood"},{"key":"ref60","article-title":"PIK3CA mutations, aspirin use and mortality in patients with women\u2019s cancers or colorectal cancers treated in early-phase clinical trials. POSTER Epidemiology, Primary and Secondary Prevention","author":"Y Chae","year":"2013"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.canep.2015.10.030","article-title":"Aspirin and other non-steroidal anti-inflammatory drug prescriptions and survival after the diagnosis of head and neck and oesophageal cancer","volume":"39","author":"TV Macfarlane","year":"2015","journal-title":"Cancer Epidemiol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/ijc.2910110322","article-title":"Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease","volume":"11","author":"GJ Gasic","year":"1973","journal-title":"Internat J Cancer"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00047657","article-title":"Role of plasma, platelets, and endothelial cells in tumor metastasis","volume":"3","author":"GJ Gasic","year":"1984","journal-title":"Cancer Metastasis Rev"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrc3004","article-title":"Contribution of platelets to tumour metastasis","volume":"11","author":"LJ Gay","year":"2011","journal-title":"Nature Reviews Cancer"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ctrv.2016.12.008","article-title":"The mortality reducing effect of aspirin in colorectal cancer patients: Interpreting the evidence","volume":"55","author":"MA Frouws","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0140-6736(16)30468-8","article-title":"Effects of aspirin on risk and severity of early recurrent stroke after transient aschaemic attack and aschaemic stroke: time-course analysis of randomised trials","volume":"388","author":"PM Rothwell","year":"2016","journal-title":"Lancet"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1093\/eurheartj\/ehl334","article-title":"A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50,279 patients at risk for coronary artery disease","volume":"27","author":"GG Biondi-Zoccai","year":"2006","journal-title":"Eur Heart J"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1001\/archneur.62.8.1217","article-title":"Effect of discontinuing aspirin therapy on the risk of brain ischemic stroke","volume":"62","author":"AB Maulaz","year":"2005","journal-title":"Archives of Neurology"},{"key":"ref69","article-title":"Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials","author":"PM Rothwell","year":"2018","journal-title":"Lancet"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/1745-6215-12-261","article-title":"The ASCOLT trial investigators. (2011) The utility of Aspirin in dukes C and high risk dukes B colorectal cancer\u2014The ASCOLT study: study protocol for a randomized controlled trial","volume":"12","author":"R Ali","year":"2011","journal-title":"Trials"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S2468-1253(17)30402-8","article-title":"FOCUS4: a new trial design for evaluation of targeted drugs in colorectal cancer?","volume":"3","author":"HJ Schmoll","year":"2018","journal-title":"Lancet Gastroenterology and Hepatology"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10689-013-9650-y","article-title":"Chemoprevention in Lynch syndrome","volume":"12","author":"J Burn","year":"2013","journal-title":"Fam Cancer"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.ejso.2018.01.501","article-title":"The PROVENT study, a multicentre double blind placebo controlled randomised trial to evaluate the effects of Vitamin D and aspirin on progression of low risk prostate cancer during active surveillance","volume":"44","author":"G Shaw","year":"2018","journal-title":"European J Surgical Oncology"},{"key":"ref74","first-page":"61","article-title":"Critical views in Gastroenterology &amp; Hepatology: aspirin prophylaxis: putting gut bleeds into perspective","volume":"10","author":"PC Elwood","year":"2014","journal-title":"Gastroenterol Hepatol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"e0166166","DOI":"10.1371\/journal.pone.0166166","article-title":"Systematic review and meta-analysis of randomised trials to ascertain fatal gastrointestinal bleeding events attributable to preventive low-dose aspirin: no evidence of increased risk","volume":"11","author":"PC Elwood","year":"2016","journal-title":"PLoS One"},{"key":"ref76","article-title":"Incidence of Upper and Lower Gastrointestinal Bleeding in New Users of Low-dose Aspirin","author":"L Cea Soriano","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.jacc.2010.09.010","article-title":"ACCF\/ACG\/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF\/ACG\/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents","volume":"56","author":"NS Abraham","year":"2010","journal-title":"J Amer Coll Cardiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.3748\/wjg.v21.i17.5382","article-title":"Proton pump inhibitors in prevention of low-dose aspirin-associated upper gastrointestinal injuries","volume":"21","author":"C Mo","year":"2015","journal-title":"World J Gastroenterol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ajgsup.2016.2","article-title":"Prevention of gastrointestinal bleeding in patients receiving direct oral anticoagulants","volume":"3","author":"NS Abraham","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/gut.44.3.331","article-title":"of the Rockall risk scoring system in upper gastrointestinal bleeding","volume":"44","author":"EM Vreeburg","year":"1999","journal-title":"Gut"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(00)02110-3","article-title":"Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial","volume":"355","year":"2000","journal-title":"Lancet"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1056\/NEJMoa1210384","article-title":"Low-Dose Aspirin for Preventing Recurrent Venous thromboembolism","volume":"367","author":"TA Brighton","year":"2012","journal-title":"New Engl J Med"},{"issue":"6","key":"ref83","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/sj.neo.7900263","article-title":"The hypercoagulable state of malignancy pathogenesis and current debate","volume":"4","author":"GJ Caine","year":"2002","journal-title":"Neoplasia"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S1470-2045(07)70409-6","article-title":"Venous thromboembolism in cervical cancer","volume":"9","author":"L Barbara","year":"2009","journal-title":"Lancet Oncol"},{"issue":"Suppl 1","key":"ref85","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/S0049-3848(16)30093-7","article-title":"Incidental venous thromboembolismevents in cancer patients: what do we know in 2016?","volume":"140","author":"HA Liebman","year":"2016","journal-title":"Thromb Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1200\/JCO.2007.14.1283","article-title":"American Society of Clinical Oncology guideline: recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer","volume":"25","author":"GH Lyman","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/jech.2009.087767","article-title":"My health: whose responsibility? A jury decides","volume":"64","author":"P Elwood","year":"2010","journal-title":"J Epidemiol and Comm Health"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"h1481","DOI":"10.1136\/bmj.h1481","article-title":"Update on the UK law on consent","volume":"350","author":"DK Sokol","year":"2015","journal-title":"Brit Med J"},{"issue":"4","key":"ref89","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10689-017-9986-9","article-title":"General practitioner attitudes towards prescribing aspirin to carriers of Lynch Syndrome: findings from a national survey","volume":"16","author":"SG Smith","year":"2017","journal-title":"Fam Cancer"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1056\/NEJM199406303302611","article-title":"Incorporating patients&apos; preferences into medical decisions","volume":"330","author":"JP Kassirer","year":"1994","journal-title":"N Engl J Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0203957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:06:54Z","timestamp":1588990014000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0203957"}},"subtitle":[],"editor":[{"given":"Daotai","family":"Nie","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":90,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0203957","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,25]]}}}