{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:51:05Z","timestamp":1790679065648,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI13C1232"],"award-info":[{"award-number":["HI13C1232"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0204204","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T13:54:02Z","timestamp":1537278842000},"page":"e0204204","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":87,"title":["Novel urinary exosomal biomarkers of acute T cell-mediated rejection in kidney transplant recipients: A cross-sectional study"],"prefix":"10.1371","volume":"13","author":[{"given":"Jeong-Hoon","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Hyeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Yeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Yeon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang-Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Lim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Chang","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-2278","authenticated-orcid":true,"given":"Jae Berm","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ha","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4648-0324","authenticated-orcid":true,"given":"Chan-Duck","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,9,18]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM199408113310606","article-title":"Renal transplantation","volume":"331","author":"M Suthanthiran","year":"1994","journal-title":"The New England journal of medicine"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1681\/ASN.V9112135","article-title":"Impact of renal cadaveric transplantation on survival in end-stage renal failure: evidence for reduced mortality risk compared with hemodialysis during long-term follow-up","volume":"9","author":"P Schnuelle","year":"1998","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1600-6143.2004.00332.x","article-title":"Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era","volume":"4","author":"HU Meier-Kriesche","year":"2004","journal-title":"American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1600-6143.2004.00515.x","article-title":"Long-term renal allograft survival: have we made significant progress or is it time to rethink our analytic and therapeutic strategies?","volume":"4","author":"HU Meier-Kriesche","year":"2004","journal-title":"American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nephro.2011.07.409","article-title":"Serum and urinary biomarkers in acute kidney transplant rejection","volume":"8","author":"N Alachkar","year":"2012","journal-title":"N\u00e9phrologie & Th\u00e9rapeutique"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/ndt\/gfv044","article-title":"Con: Kidney biopsy: an irreplaceable tool for patient management in nephrology","volume":"30","author":"RJ Glassock","year":"2015","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.trre.2013.10.004","article-title":"Urine proteomics in kidney transplantation","volume":"28","author":"SC Kim","journal-title":"Transplantation Reviews"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1021\/pr5001048","article-title":"Serum Metabolomics Study of the Acute Graft Rejection in Human Renal Transplantation Based on Liquid Chromatography\u2013Mass Spectrometry","volume":"13","author":"X Zhao","year":"2014","journal-title":"Journal of Proteome Research"},{"issue":"4","key":"ref9","first-page":"259","article-title":"Proteomic profiling of renal allograft rejection in serum using magnetic bead-based sample fractionation and MALDI-TOF MS","volume":"10","author":"W Sui","year":"2010","journal-title":"Clinical and"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.kint.2015.12.049","article-title":"Mining the human urine proteome for monitoring renal transplant injury","volume":"89","author":"TK Sigdel","year":"2016","journal-title":"Kidney international"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"AS Levey","year":"2009","journal-title":"Ann Intern Med"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1074\/mcp.M113.030577","article-title":"The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics","volume":"13","author":"TK Sigdel","year":"2014","journal-title":"Molecular & cellular proteomics: MCP"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1600-6143.2008.02159.x","article-title":"Banff 07 classification of renal allograft pathology: updates and future directions","volume":"8","author":"K Solez","year":"2008","journal-title":"American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1002\/pmic.201000443","article-title":"Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy","volume":"11","author":"PG Moon","year":"2011","journal-title":"Proteomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jprot.2015.10.005","article-title":"Identification of EDIL3 on extracellular vesicles involved in breast cancer cell invasion","volume":"131","author":"JE Lee","year":"2016","journal-title":"Journal of proteomics"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12882-016-0373-9","article-title":"Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients","volume":"17","author":"J Smedbr\u00e5ten","year":"2016","journal-title":"BMC Nephrology"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1158\/1078-0432.CCR-15-0654","article-title":"Identification of Developmental Endothelial Locus-1 on Circulating Extracellular Vesicles as a Novel Biomarker for Early Breast Cancer Detection","volume":"22","author":"PG Moon","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"26","key":"ref18","doi-asserted-by":"crossref","first-page":"40189","DOI":"10.18632\/oncotarget.9561","article-title":"Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer","volume":"7","author":"PG Moon","year":"2016","journal-title":"Oncotarget"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein\u2013protein association networks, made broadly accessible","volume":"45","author":"D Szklarczyk","year":"2017","journal-title":"Nucleic Acids Research"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/00007890-200010150-00018","article-title":"Increased impact of acute rejection on chronic allograft failure in recent era","volume":"70","author":"HU Meier-Kriesche","year":"2000","journal-title":"Transplantation"},{"key":"ref21","article-title":"USRDS Annual Data Report: Atlas of chronic kidney disease and end-stage renal disease in the United States2014","author":"AJ Collins","year":"2013"},{"issue":"Suppl 1","key":"ref22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/ajt.12579","article-title":"OPTN\/SRTR 2012 Annual Data Report: kidney","volume":"14","author":"AJ Matas","year":"2014","journal-title":"American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"782798","DOI":"10.1155\/2015\/782798","article-title":"Human Urine Proteomics: Analytical Techniques and Clinical Applications in Renal Diseases","volume":"2015","author":"S Kalantari","year":"2015","journal-title":"International Journal of Proteomics"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1681\/ASN.2008040406","article-title":"Large-scale proteomics and phosphoproteomics of urinary exosomes","volume":"20","author":"PA Gonzales","year":"2009","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1440-1797.2005.00387.x","article-title":"Prospects for urinary proteomics: exosomes as a source of urinary biomarkers","volume":"10","author":"EJ Hoorn","year":"2005","journal-title":"Nephrology (Carlton, Vic)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-61779-319-6_9","article-title":"Nano LC-MS\/MS: a robust setup for proteomic analysis","volume":"790","author":"M Gaspari","year":"2011","journal-title":"Methods in molecular biology (Clifton, NJ)"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/chromsci\/bmt023","article-title":"Nano-Liquid Chromatography in Pharmaceutical and Biomedical Research","volume":"51","author":"MR Gama","year":"2013","journal-title":"Journal of Chromatographic Science"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrm1736","article-title":"Tetraspanin functions and associated microdomains","volume":"6","author":"ME Hemler","year":"2005","journal-title":"Nature reviews Molecular cell biology"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.canlet.2008.10.014","article-title":"Tspan-1 is a tetraspanin preferentially expressed by mucinous and endometrioid subtypes of human ovarian carcinomas","volume":"275","author":"CJ Scholz","year":"2009","journal-title":"Cancer letters"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0065-2776(08)60024-3","article-title":"Integrins in the immune system","volume":"72","author":"Y Shimizu","year":"1999","journal-title":"Advances in immunology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.immunol.22.012703.104649","article-title":"Integrins and T cell-mediated immunity","volume":"22","author":"JT Pribila","year":"2004","journal-title":"Annual review of immunology"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"C Gabay","year":"1999","journal-title":"The New England journal of medicine"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1523-1755.2005.00438.x","article-title":"Protease activity of plasma hemopexin","volume":"68","author":"WW Bakker","year":"2005","journal-title":"Kidney international"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1046\/j.1523-1755.2003.00907.x","article-title":"Production of hemopexin by TNF-alpha stimulated human mesangial cells","volume":"63","author":"JJ Kapojos","year":"2003","journal-title":"Kidney international"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"e0165083","DOI":"10.1371\/journal.pone.0165083","article-title":"Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function","volume":"11","author":"MS Zhang","year":"2016","journal-title":"PloS one"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00024382-200115030-00004","article-title":"Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan","volume":"15","author":"M Ombrellino","year":"2001","journal-title":"Shock (Augusta, Ga)"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1189\/jlb.0607338","article-title":"Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation","volume":"82","author":"P Van Lint","year":"2007","journal-title":"Journal of leukocyte biology"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nri1418","article-title":"Matrix metalloproteinases as modulators of inflammation and innate immunity","volume":"4","author":"WC Parks","year":"2004","journal-title":"Nature reviews Immunology"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/sj.jid.5701184","article-title":"The epidermal growth factor receptor system in skin repair and inflammation","volume":"128","author":"S Pastore","year":"2008","journal-title":"The Journal of investigative dermatology"},{"issue":"Suppl 7","key":"ref40","doi-asserted-by":"crossref","first-page":"vii109","DOI":"10.1093\/annonc\/mdl962","article-title":"Interaction between the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor (VEGF) pathways: a rational approach for multi-target anticancer therapy","volume":"17","author":"F Ciardiello","year":"2006","journal-title":"Annals of oncology: official journal of the European Society for Medical Oncology"},{"key":"ref41","first-page":"57","article-title":"Perturbations in the Urinary Exosome in Transplant Rejection","volume":"1","author":"TK Sigdel","year":"2014","journal-title":"Frontiers in Medicine"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5500\/wjt.v5.i4.251","article-title":"Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney","volume":"5","author":"B Merhi","year":"2015","journal-title":"World Journal of Transplantation"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/phar.1591","article-title":"African-American Race Modifies the Influence of Tacrolimus Concentrations on Acute Rejection and Toxicity in Kidney Transplant Recipients","volume":"35","author":"DJ Taber","year":"2015","journal-title":"Pharmacotherapy"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"524","DOI":"10.2215\/CJN.03100906","article-title":"Racial differences in graft survival: a report from the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS)","volume":"2","author":"A Omoloja","year":"2007","journal-title":"Clinical journal of the American Society of Nephrology: CJASN"},{"key":"ref45","first-page":"447","article-title":"Effect of race on kidney transplants","volume":"1990","author":"YC Zhou","journal-title":"Clinical transplants"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0204204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T17:30:08Z","timestamp":1662053408000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0204204"}},"subtitle":[],"editor":[{"given":"Giovanni","family":"Camussi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,18]]},"references-count":45,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0204204","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,18]]}}}