{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:49:35Z","timestamp":1792198175178,"version":"4.4.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-105-2314-B-273-001-MY3"],"award-info":[{"award-number":["MOST-105-2314-B-273-001-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST- 106-2320-B-006-074"],"award-info":[{"award-number":["MOST- 106-2320-B-006-074"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0204603","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T17:30:30Z","timestamp":1539019830000},"page":"e0204603","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Estrogen and mechanical loading-related regulation of estrogen receptor-\u03b2 and apoptosis in tendinopathy"],"prefix":"10.1371","volume":"13","author":[{"given":"Jeng-Long","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Ming","family":"Jou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Liang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Ting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Li","family":"Shiau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Earn","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-855X","authenticated-orcid":true,"given":"Shih-Yao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e0117993","DOI":"10.1371\/journal.pone.0117993","article-title":"Identification of genetic determinants of the sexual dimorphism in CNS autoimmunity","volume":"10","author":"F Bearoff","year":"2011","journal-title":"PLoS ONE"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrrheum.2010.231","article-title":"Sexual dimorphism of RA manifestations: genes, hormones and behavior","volume":"7","author":"WJ Kovacs","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.5271\/sjweh.3160","article-title":"Risk factors for de Quervain's disease in a French working population","volume":"37","author":"A Petit Le Manac'h","year":"2011","journal-title":"Scand J Work Environ Health"},{"key":"ref4","first-page":"4","article-title":"Women are more likely than men to develop these painful conditions","volume":"17","year":"2010","journal-title":"Harv Womens Health Watch"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/rheumatology\/30.1.60","article-title":"Higher incidence of carpal tunnel syndrome in ovariectomized women","volume":"30","author":"E Pascual","year":"1991","journal-title":"Br J Rheumatol"},{"key":"ref6","first-page":"323","article-title":"Risk factors associated with trigger finger. Case-control study","volume":"76","author":"ML De la Parra-M\u00e1rquez","year":"2008","journal-title":"Cir cir"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jdiacomp.2016.02.017","article-title":"Achilles or biceps tendon rupture in women and men with type 2 diabetes: A population-based case-control study","volume":"30","author":"J Spoendlin","year":"2016","journal-title":"J Diabetes Complications"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1228.e23","DOI":"10.1016\/j.amjmed.2012.05.027","article-title":"Impact of age, sex, obesity, and steroid use on quinolone-associated tendon disorders","volume":"125","author":"BL Wise","year":"2012","journal-title":"Am J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/jor.21160","article-title":"The expression of estrogen receptors in the tenosynovium of postmenopausal women with idiopathic carpal tunnel syndrome","volume":"28","author":"JK Kim","year":"2010","journal-title":"J Orthop Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0039-128X(00)00143-4","article-title":"Estrogen receptor antibodies: specificity and utility in detection, localization and analyses of estrogen receptor alpha and beta","volume":"66","author":"M Pavao","year":"2001","journal-title":"Steroids"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1210\/me.2012-1284","article-title":"Minireview: the year in review of estrogen regulation of metabolism","volume":"26","author":"DJ Clegg","year":"2012","journal-title":"Mol Endocrinol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1007\/s00018-013-1317-1","article-title":"The role of estrogen receptor \u03b1 in the regulation of bone and growth plate cartilage","volume":"70","author":"AE B\u00f6rjesson","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1359\/jbmr.0301203","article-title":"Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice","volume":"19","author":"AS Chagin","year":"2004","journal-title":"J Bone Miner Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.joca.2010.03.008","article-title":"GRIP1 enhances estrogen receptor alpha-dependent extracellular matrix gene expression in chondrogenic cells","volume":"18","author":"M Kato","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1038\/onc.2013.384","article-title":"Estrogen receptor \u03b2 upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer","volume":"33","author":"P Dey","year":"2014","journal-title":"Oncogene"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/S0736-0266(02)00075-X","article-title":"Apoptosis in rotator cuff tendonopathy","volume":"20","author":"J Yuan","year":"2012","journal-title":"J Orthop Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1177\/0363546509340264","article-title":"Is apoptosis the cause of noninsertional achilles tendinopathy?","volume":"37","author":"CJ Pearce","year":"2009","journal-title":"Am J Sports Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1177\/0363546506295702","article-title":"Excessive apoptosis in patellar tendinopathy in athletes","volume":"35","author":"\u00d8 Lian","year":"2007","journal-title":"Am J Sports Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1136\/bjsm.2004.015164","article-title":"High strain mechanical loading rapidly induces tendon apoptosis: an ex vivo rat tibialis anterior model","volume":"39","author":"A Scott","year":"2005","journal-title":"Br J Sports Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"26452","DOI":"10.3390\/ijms161125968","article-title":"The Estrogen Receptor-\u03b2 Expression in De Quervain's Disease","volume":"16","author":"PC Shen","year":"2015","journal-title":"Int J Mol Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1038\/s41598-017-05466-y","article-title":"Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics","volume":"7","author":"SY Lee","year":"2017","journal-title":"Sci Rep"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jse.2013.11.013","article-title":"The severity of the long head biceps tendinopathy in patients with chronic rotator cuff tears: macroscopic versus microscopic results","volume":"23","author":"PT Wu","year":"2014","journal-title":"J Shoulder Elbow Surg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"40840","DOI":"10.1038\/srep40840","article-title":"High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expressionvia CD44 in tendinopathy","volume":"7","author":"PT Wu","year":"2017","journal-title":"Sci Rep"},{"key":"ref24","first-page":"187","article-title":"Tendon injury and tendinopathy: healing and repair","volume":"87","author":"P Sharma","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0363-5023(03)00366-6","article-title":"Flexor tendon healing in the rat: a histologic and gene expression study","volume":"28","author":"W Oshiro","year":"2003","journal-title":"J Hand Surg Am"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"14427","DOI":"10.3390\/ijms150814427","article-title":"Low-frequency high-magnitude mechanical strain of articular chondrocytes activates p38 MAPK and induces phenotypic changes associated with osteoarthritis and pain","volume":"15","author":"DH Rosenzweig","year":"2014","journal-title":"Int J Mol Sci"},{"key":"ref27","first-page":"1173","article-title":"Anti-inflammatory and anti-catabolic effects of tendoactive on human tenocytes in vitro","volume":"26","author":"M Shakibaei","year":"2011","journal-title":"Histol Histopathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1016\/j.bbamcr.2013.06.019","article-title":"Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGF\u03b2","volume":"1833","author":"ER Jones","year":"2013","journal-title":"Biochim Biophys Acta."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bbrc.2015.05.122","article-title":"IL-1\u03b2 irreversibly inhibits tenogenic differentiation and alters metabolism in injured tendon-derived progenitor cells in vitro","volume":"463","author":"K Zhang","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.joca.2014.07.003","article-title":"Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth","volume":"22","author":"J Chen","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"ref31","first-page":"7021862","article-title":"The Risk of Achilles Tendon Rupture in the Patients with Achilles Tendinopathy: Healthcare Database Analysis in the United States","author":"Y Yasui","year":"2017","journal-title":"Biomed Res Int"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1177\/0363546514540599","article-title":"Acute achilles tendon ruptures: incidence of injury and surgery in Sweden between 2001 and 2012","volume":"42","author":"TT Huttunen","year":"2014","journal-title":"Am J Sports Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1142\/S0218810412500207","article-title":"The study of work behaviours and risks for occupational overuse syndrome","volume":"17","author":"N Laoopugsin","year":"2012","journal-title":"Hand Surg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/aje\/kwu286","article-title":"General population job exposure matrix applied to a pooled study of prevalent carpal tunnel syndrome","volume":"181","author":"AM Dale","year":"2015","journal-title":"Am J Epidemiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/oemed-2015-103298","article-title":"Exposure-response relationships between movements and postures of the wrist and carpal tunnel syndrome among male and female house painters: a retrospective cohort study","volume":"73","author":"T Heilskov-Hansen","year":"2016","journal-title":"Occup Environ Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0204603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T16:10:44Z","timestamp":1662221444000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0204603"}},"subtitle":[],"editor":[{"given":"Hazel RC","family":"Screen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0204603","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,8]]}}}