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Situaci\u00f3n de la leptospirosis en el Per\u00fa 1994\u20132004. Rev Peru Med Exp Salud P\u00fablica. 2006;23. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/1036\" xlink:type=\"simple\">http:\/\/www.rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/1036<\/ext-link>"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijid.2008.04.002","article-title":"Bartonella: emerging pathogen or emerging awareness?","volume":"13","author":"E Mogollon-Pasapera","year":"2009","journal-title":"Int J Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijantimicag.2014.04.006","article-title":"Pathogenicity and treatment of <italic>Bartonella<\/italic> infections","volume":"44","author":"E Angelakis","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.medmal.2012.11.005","article-title":"Diagnosis and 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Evol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.diagmicrobio.2009.03.014","article-title":"Detection of pathogenic <italic>Leptospira<\/italic> spp. through TaqMan polymerase chain reaction targeting the LipL32 gene","volume":"64","author":"RA Stoddard","year":"2009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref36","unstructured":"Babraham Bioinformatics. FastQC: A Quality Control Tool for High Throughput Sequence Data. [cited 2 Apr 2018] [Internet]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/\" xlink:type=\"simple\">https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/<\/ext-link>"},{"key":"ref37","unstructured":"FelixKrueger. TrimGalore; 2017 [cited 2 Apr 2018] [Internet]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/github.com\/FelixKrueger\/TrimGalore\" xlink:type=\"simple\">https:\/\/github.com\/FelixKrueger\/TrimGalore<\/ext-link>"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"R46","DOI":"10.1186\/gb-2014-15-3-r46","article-title":"Kraken: ultrafast metagenomic sequence classification using exact alignments","volume":"15","author":"DE Wood","year":"2014","journal-title":"Genome Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e00032","DOI":"10.1128\/mSystems.00032-16","article-title":"16S rRNA amplicon sequencing for epidemiological surveys of bacteria in wildlife","volume":"1","author":"M Galan","year":"2016","journal-title":"mSystems"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e0003929","DOI":"10.1371\/journal.pntd.0003929","article-title":"A comparison between transcriptome sequencing and 16S metagenomics for detection of bacterial pathogens in wildlife","volume":"9","author":"M Razzauti","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref41","first-page":"27663","article-title":"Analysis of composition of microbiomes: a novel method for studying microbial composition","volume":"26","author":"S Mandal","year":"2015","journal-title":"Microb Ecol Health Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4269\/ajtmh.13-0334","article-title":"Household characteristics associated with rodent presence and <italic>Leptospira<\/italic> infection in rural and urban communities from southern Chile","volume":"90","author":"C Mu\u00f1oz-Zanzi","year":"2014","journal-title":"Am J Trop Med Hyg"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3201\/eid2006.131194","article-title":"<italic>Bartonella<\/italic> spp. and <italic>Yersinia pestis<\/italic> reservoirs, Cusco, Peru","volume":"20","author":"A Martin-Alonso","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e0003843","DOI":"10.1371\/journal.pntd.0003843","article-title":"Environmental and behavioural determinants of leptospirosis transmission: a systematic review","volume":"9","author":"MA Mwachui","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1128\/AEM.02728-12","article-title":"Comparative analysis of <italic>Leptospira<\/italic> strains isolated from environmental soil and water in the Philippines and Japan","volume":"79","author":"M Saito","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e0004895","DOI":"10.1371\/journal.pntd.0004895","article-title":"Distribution and diversity of pathogenic <italic>Leptospira<\/italic> species in peri-domestic surface waters from south central Chile","volume":"10","author":"MR Mason","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.mimet.2007.02.005","article-title":"A detailed analysis of 16S ribosomal RNA gene segments for the diagnosis of pathogenic bacteria","volume":"69","author":"S Chakravorty","year":"2007","journal-title":"J Microbiol Methods"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0205068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T12:38:00Z","timestamp":1605184680000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0205068"}},"subtitle":[],"editor":[{"given":"Janet","family":"Foley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":47,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0205068","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]}}}