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Dutkiewicz","year":"1980","journal-title":"Int Arch Occup Environ Health"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00377691","article-title":"Human Exposure to Styrene. VI. Percutaneous Absorption in Human Volunteers","volume":"55","author":"M. Berode","year":"1985","journal-title":"Int Arch Occup Environ Health"},{"key":"ref45","first-page":"499","article-title":"Percutaneous Absorption of 2-Butoxyethanol in Man","volume":"12","author":"G. Johanson","year":"1988","journal-title":"Scand J Work Environ Health"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00380781","article-title":"Uptake, Metabolism and Elimination of Cyclohexanone in Humans","volume":"66","author":"J. Mraz","year":"1994","journal-title":"Int Arch Occup Environ Health"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s004200050228","article-title":"Time-Resolved Cutaneous Absorption and Permeation Rates of Methanol in Human Volunteers","volume":"70","author":"S.A. Batterman","year":"1997","journal-title":"Int Arch Occup Environ Health"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/oem.54.1.38","article-title":"Dermal Absorption of Vaporous and Liquid 2-Methoxyethanol and 2-Ethoxyethanol in Volunteers","volume":"54","author":"S. Kezic","year":"1997","journal-title":"Occup Environ Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00420-003-0456-3","article-title":"Percutaneous Absorption of Neat and Aqueous Solutions of 2-Butoxyethanol in Volunteers","volume":"77","author":"I. Jakasa","year":"2004","journal-title":"Int Arch Occup Environ Health"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/1523-1747.ep12723090","article-title":"Mechanism of Percutaneous Absorption. IV. Penetration of Nonelectrolytes (Alcohols) from Aqueous Solutions and from Pure Liquids","volume":"60","author":"R.J. Scheuplein","year":"1973","journal-title":"J Invest Dermatol"},{"key":"ref51","first-page":"131","article-title":"Percutaneous Absorption Of Organic Solvents 2) A Method For Measuring The Penetration Rate Of Chlorinated Solvents Through Excised Rat Skin","volume":"15","author":"H. Tsuruta","year":"1977","journal-title":"Ind Health"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2486\/indhealth.20.335","article-title":"Percutaneous Absorption of Organic Solvents III. On the Penetration Rates of Hydrophobic Solvents through the Excised Rat Skin","volume":"20","author":"H. Tsuruta","year":"1982","journal-title":"Ind Health"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1289\/ehp.8457193","article-title":"Absorption of Some Glycol Ethers through Human Skin in Vitro","volume":"57","author":"P.H. Dugard","year":"1984","journal-title":"Environ Health Perspect"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1600-0773.1986.tb00126.x","article-title":"The in Vitro Permeability of Human Skin to Benzene, Ethylene Glycol, Formaldehyde, and n-Hexane","volume":"58","author":"M. Loden","year":"1986","journal-title":"Acta Pharmacol Toxicol. (Copenh)"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0278-6915(86)90007-4","article-title":"The Penetration of [14C]Ethanol and [14C]Methanol through Excised Guinea-Pig Skin in Vitro","volume":"24","author":"C.L. Gummer","year":"1986","journal-title":"Food Chem Toxicol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0272-0590(87)90100-X","article-title":"Percutaneous Absorption, Metabolism, and Hemolytic Activity of n-Butoxyethanol","volume":"8","author":"F.G. Bartnik","year":"1987","journal-title":"Fundam. Appl. Toxicol"},{"key":"ref57","first-page":"493","article-title":"A Comparative Study of the Rates of in Vitro Percutaneous Absorption of Eight Chemicals Using Rat and Human Skin Fundam Appl Toxicol","volume":"19","author":"E.D. Barber","year":"1992","journal-title":"A Comparative Study of the Rates of in Vitro Percutaneous Absorption of Eight Chemicals Using Rat and Human Skin Fundam Appl Toxicol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/15298669391355071","article-title":"An in Vitro Comparison of the Permeation of Chemicals in Vapor and Liquid Phase through Pig Skin","volume":"54","author":"R.R. Jacobs","year":"1993","journal-title":"Am Ind Hyg Assoc J"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/15428119591016665","article-title":"Permeability of Commercial Solvents through Living Human Skin","volume":"56","author":"C. Ursin","year":"1995","journal-title":"Am Ind Hyg Assoc J"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s004200050402","article-title":"Skin Absorption in Vitro of Glycol Ethers","volume":"72","author":"F. Larese Filon","year":"1999","journal-title":"Int Arch Occup Environ. Health"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0003-4878(99)00076-9","article-title":"Influence of Evaporation and Solvent Mixtures on the Absorption of Toluene and n-Butanol in Human Skin in Vitro","volume":"44","author":"A. Boman","year":"2000","journal-title":"Ann Occup Hyg"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0278-6915(00)00120-4","article-title":"Fate of Ethanol Topically Applied to Skin","volume":"39","author":"R.U. Pendlington","year":"2001","journal-title":"Food Chem Toxicol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/taap.2002.9373","article-title":"Percutaneous Penetration and Metabolism of 2-Ethoxyethanol","volume":"180","author":"D.J. Lockley","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00420-002-0367-8","article-title":"Effects of Experimental Conditions on Absorption of Glycol Ethers through Human Skin in Vitro","volume":"75","author":"S.C. 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