{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:13:28Z","timestamp":1764494008684,"version":"3.37.3"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taiwan Ministry of Science and Technology grant","award":["MOST104-2628-B-039-001-MY4"],"award-info":[{"award-number":["MOST104-2628-B-039-001-MY4"]}]},{"name":"Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence grant","award":["MOHW105-TDU-B-212-133019"],"award-info":[{"award-number":["MOHW105-TDU-B-212-133019"]}]},{"name":"China Medical University grant","award":["CMU105-S-41"],"award-info":[{"award-number":["CMU105-S-41"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0205502","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T17:46:29Z","timestamp":1539711989000},"page":"e0205502","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of age at appendectomy on development of type 2 diabetes: A population-based cohort study"],"prefix":"10.1371","volume":"13","author":[{"given":"Yang-Ming","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chew-Teng","family":"Kor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diko","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsueh-Chou","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Chu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5571-3302","authenticated-orcid":true,"given":"Wen-Lung","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"year":"2016","key":"ref1","article-title":"IDF Diabetes Atlas"},{"issue":"7121","key":"ref2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"GS Hotamisligil","year":"2006","journal-title":"Nature"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI25102","article-title":"Inflammation, stress, and diabetes","volume":"115","author":"KE Wellen","year":"2005","journal-title":"The Journal of clinical investigation"},{"issue":"7122","key":"ref4","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"RE Ley","year":"2006","journal-title":"Nature"},{"issue":"7122","key":"ref5","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"PJ Turnbaugh","year":"2006","journal-title":"Nature"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1073\/pnas.0605374104","article-title":"Mechanisms underlying the resistance to diet-induced obesity in germ-free mice","volume":"104","author":"F Backhed","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5717","key":"ref7","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"F Backhed","year":"2005","journal-title":"Science (New York, NY)"},{"issue":"44","key":"ref8","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"F Backhed","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice","volume":"57","author":"PD Cani","year":"2008","journal-title":"Diabetes"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cell.2014.05.052","article-title":"Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences","volume":"158","author":"LM Cox","year":"2014","journal-title":"Cell"},{"issue":"6150","key":"ref11","doi-asserted-by":"crossref","first-page":"1241214","DOI":"10.1126\/science.1241214","article-title":"Gut microbiota from twins discordant for obesity modulate metabolism in mice","volume":"341","author":"VK Ridaura","year":"2013","journal-title":"Science (New York, NY)"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jtbi.2007.08.032","article-title":"Biofilms in the large bowel suggest an apparent function of the human vermiform appendix","volume":"249","author":"R Randal Bollinger","year":"2007","journal-title":"Journal of theoretical biology"},{"issue":"Pt 1","key":"ref13","first-page":"83","article-title":"The True Caecal Apex, or the Vermiform Appendix: Its Minute and Comparative Anatomy","volume":"35","author":"RJ Berry","year":"1900","journal-title":"Journal of anatomy and physiology"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/gut.26.7.672","article-title":"Gut associated lymphoid tissue: a morphological and immunocytochemical study of the human appendix","volume":"26","author":"J Spencer","year":"1985","journal-title":"Gut"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ar.21357","article-title":"The cecal appendix: one more immune component with a function disturbed by post-industrial culture","volume":"294","author":"M Laurin","year":"2011","journal-title":"Anatomical record (Hoboken, NJ: 2007)"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"e0118411","DOI":"10.1371\/journal.pone.0118411","article-title":"Association between appendectomy and subsequent colorectal cancer development: an Asian population study","volume":"10","author":"SC Wu","year":"2015","journal-title":"PloS one"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1053\/gast.2003.50021","article-title":"Appendectomy is followed by increased risk of Crohn's disease","volume":"124","author":"RE Andersson","year":"2003","journal-title":"Gastroenterology"},{"issue":"26","key":"ref18","doi-asserted-by":"crossref","first-page":"e4015","DOI":"10.1097\/MD.0000000000004015","article-title":"Appendectomy correlates with increased risk of pyogenic liver abscess: A population-based cohort study in Taiwan","volume":"95","author":"KF Liao","year":"2016","journal-title":"Medicine"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"e0126816","DOI":"10.1371\/journal.pone.0126816","article-title":"An appendectomy increases the risk of rheumatoid arthritis: a five-year follow-up study","volume":"10","author":"YM Tzeng","year":"2015","journal-title":"PloS one"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s10096-014-2112-0","article-title":"Increased risk of pulmonary tuberculosis among patients with appendectomy in Taiwan","volume":"33","author":"SW Lai","year":"2014","journal-title":"European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology"},{"issue":"34","key":"ref21","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.3748\/wjg.v19.i34.5607","article-title":"Appendectomy and Clostridium difficile colitis: relationships revealed by clinical observations and immunology","volume":"19","author":"NL Sanders","year":"2013","journal-title":"World journal of gastroenterology"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/gut.2009.191320","article-title":"Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum\/necrophorum","volume":"60","author":"A Swidsinski","year":"2011","journal-title":"Gut"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00366-12","article-title":"Microbial composition of human appendices from patients following appendectomy","volume":"4","author":"CM Guinane","year":"2013","journal-title":"mBio"},{"issue":"12","key":"ref24","first-page":"5672","article-title":"Insulin resistance is associated with specific gut microbiota in appendix samples from morbidly obese patients","volume":"8","author":"I Moreno-Indias","year":"2016","journal-title":"American journal of translational research"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"e1001215","DOI":"10.1371\/journal.pbio.1001215","article-title":"Gut bacteria may override genetic protections against diabetes","volume":"9","author":"R Meadows","year":"2011","journal-title":"PLoS biology"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"E607","DOI":"10.1002\/oby.20466","article-title":"Human intestinal microbiota composition is associated with local and systemic inflammation in obesity","volume":"21","author":"FJ Verdam","year":"2013","journal-title":"Obesity (Silver Spring, Md)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0205502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:12:36Z","timestamp":1589044356000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0205502"}},"subtitle":[],"editor":[{"given":"Yu Ru","family":"Kou","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":26,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0205502","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,10,16]]}}}