{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:45:02Z","timestamp":1793065502041,"version":"4.5.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471564"],"award-info":[{"award-number":["81471564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2016FB037, 2017FB019"],"award-info":[{"award-number":["2016FB037, 2017FB019"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PUMC Youth Fund","award":["3332016114"],"award-info":[{"award-number":["3332016114"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["2016ZX350070"],"award-info":[{"award-number":["2016ZX350070"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2017-I2M-2-006"],"award-info":[{"award-number":["2017-I2M-2-006"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0205521","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T17:43:29Z","timestamp":1539020609000},"page":"e0205521","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["CXCL4 contributes to host defense against acute Pseudomonas aeruginosa lung infection"],"prefix":"10.1371","volume":"13","author":[{"given":"Lei","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longding","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Jun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5201-4373","authenticated-orcid":true,"given":"Zhongping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/icb.1995.65","article-title":"Pulmonary immunity to Pseudomonas aeruginosa","volume":"73","author":"AW Cripps","year":"1995","journal-title":"Immunology and cell biology"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0966-842X(93)90135-E","article-title":"Phagocytosis of Pseudomonas aeruginosa by macrophages: receptor-ligand interactions","volume":"1","author":"DP Speert","year":"1993","journal-title":"Trends in microbiology"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.4049\/jimmunol.181.8.5481","article-title":"NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection","volume":"181","author":"SC Wesselkamper","year":"2008","journal-title":"Journal of immunology"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1172\/JCI112587","article-title":"T lymphocyte-mediated protection against Pseudomonas aeruginosa infection in granulocytopenic mice","volume":"78","author":"WG Powderly","year":"1986","journal-title":"The Journal of clinical investigation"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1128\/IAI.71.8.4421-4431.2003","article-title":"Modification of in vivo and in vitro T- and B-cell-mediated immune responses by the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone","volume":"71","author":"AJ Ritchie","year":"2003","journal-title":"Infection and immunity"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.blre.2014.10.003","article-title":"Platelet secretion: From haemostasis to wound healing and beyond","volume":"29","author":"EM Golebiewska","year":"2015","journal-title":"Blood Rev"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/cea.12322","article-title":"Platelets and allergic inflammation","volume":"44","author":"C Page","year":"2014","journal-title":"Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/ni.2666","article-title":"Platelet-macrophage partnership in innate immunity and inflammation","volume":"14","author":"A Mantovani","year":"2013","journal-title":"Nature immunology"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2217\/fmb.09.112","article-title":"Bacterial-platelet interactions: virulence meets host defense","volume":"5","author":"MR Yeaman","year":"2010","journal-title":"Future microbiology"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/09537104.2014.997690","article-title":"The expanding field of platelet-bacterial interconnections","volume":"26","author":"SW Kerrigan","year":"2015","journal-title":"Platelets"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0049-3848(88)90115-6","article-title":"Platelet aggregation by a phospholipase C from Pseudomonas aeruginosa","volume":"51","author":"IR Coutinho","year":"1988","journal-title":"Thrombosis research"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"e00207","DOI":"10.1128\/mBio.00207-13","article-title":"Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia","volume":"4","author":"M Barbier","year":"2013","journal-title":"mBio"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/SHK.0b013e3181b2b0f4","article-title":"ExoU-induced vascular hyperpermeability and platelet activation in the course of experimental Pseudomonas aeruginosa pneumosepsis","volume":"33","author":"GB Machado","year":"2010","journal-title":"Shock"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1084\/jem.20021897","article-title":"An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4","volume":"197","author":"L Lasagni","year":"2003","journal-title":"The Journal of experimental medicine"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1182\/blood-2009-11-253591","article-title":"Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3","volume":"117","author":"S Struyf","year":"2011","journal-title":"Blood"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.4049\/jimmunol.0901368","article-title":"CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages","volume":"184","author":"CA Gleissner","year":"2010","journal-title":"Journal of immunology"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1056\/NEJMoa1114576","article-title":"Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis","volume":"370","author":"L van Bon","year":"2014","journal-title":"The New England journal of medicine"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1007\/s10753-014-9903-4","article-title":"Platelet factor 4 inhibits IL-17\/Stat3 pathway via upregulation of SOCS3 expression in melanoma","volume":"37","author":"S Fang","year":"2014","journal-title":"Inflammation"},{"issue":"6112","key":"ref19","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1126\/science.1228892","article-title":"Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum","volume":"338","author":"BJ McMorran","year":"2012","journal-title":"Science"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00018-009-0210-4","article-title":"Platelets in defense against bacterial pathogens","volume":"67","author":"MR Yeaman","year":"2010","journal-title":"Cellular and molecular life sciences: CMLS"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.2631","article-title":"Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance","volume":"14","author":"CH Wong","year":"2013","journal-title":"Nature immunology"},{"issue":"16","key":"ref22","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1182\/blood-2012-06-434985","article-title":"Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4\/heparin-like epitopes","volume":"120","author":"K Krauel","year":"2012","journal-title":"Blood"},{"issue":"20","key":"ref23","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1182\/blood-2013-11-540526","article-title":"Amplification of bacteria-induced platelet activation is triggered by FcgammaRIIA, integrin alphaIIbbeta3, and platelet factor 4","volume":"123","author":"M Arman","year":"2014","journal-title":"Blood"},{"issue":"6\u20137","key":"ref24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ejcb.2010.12.002","article-title":"Molecular pathways of platelet factor 4\/CXCL4 signaling","volume":"90","author":"B Kasper","year":"2011","journal-title":"European journal of cell biology"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"L698","DOI":"10.1152\/ajplung.00319.2013","article-title":"Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K\/Akt pathway to induce phagocytic engulfment","volume":"306","author":"RR Lovewell","year":"2014","journal-title":"American journal of physiology Lung cellular and molecular physiology"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1074\/jbc.M113.523167","article-title":"CD14 mediates Toll-like receptor 4 (TLR4) endocytosis and spleen tyrosine kinase (Syk) and interferon regulatory transcription factor 3 (IRF3) activation in epithelial cells and impairs neutrophil infiltration and Pseudomonas aeruginosa killing in vivo","volume":"289","author":"S Roy","year":"2014","journal-title":"The Journal of biological chemistry"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.4049\/jimmunol.1301294","article-title":"Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner","volume":"192","author":"D Losa","year":"2014","journal-title":"Journal of immunology"},{"issue":"15","key":"ref28","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.micinf.2005.05.012","article-title":"The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone stimulates phagocytic activity in human macrophages through the p38 MAPK pathway","volume":"7","author":"E Vikstrom","year":"2005","journal-title":"Microbes and infection \/ Institut Pasteur"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.4049\/jimmunol.1203196","article-title":"Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections","volume":"190","author":"RD Junkins","year":"2013","journal-title":"Journal of immunology"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.imbio.2007.11.007","article-title":"Signal transducer and activator of transcription 4 (STAT4), but not IL-12 contributes to Pseudomonas aeruginosa-induced lung inflammation in mice","volume":"213","author":"R O'Sullivan","year":"2008","journal-title":"Immunobiology"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1182\/blood-2003-11-3994","article-title":"Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin","volume":"104","author":"DE Eslin","year":"2004","journal-title":"Blood"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1046\/j.1365-2958.1998.01121.x","article-title":"Cellular function of elastase in Pseudomonas aeruginosa: role in the cleavage of nucleoside diphosphate kinase and in alginate synthesis","volume":"30","author":"S Kamath","year":"1998","journal-title":"Molecular microbiology"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1074\/jbc.M108623200","article-title":"Protein phosphatase 2A and protein kinase Calpha are physically associated and are involved in Pseudomonas aeruginosa-induced interleukin 6 production by mast cells","volume":"277","author":"RT Boudreau","year":"2002","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-1759(96)00143-3","article-title":"Quantitation of eosinophil and neutrophil infiltration into rat lung by specific assays for eosinophil peroxidase and myeloperoxidase. Application in a Brown Norway rat model of allergic pulmonary inflammation","volume":"198","author":"T Schneider","year":"1996","journal-title":"Journal of immunological methods"},{"issue":"13","key":"ref35","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1182\/blood-2011-08-376426","article-title":"Recruitment of monocytes\/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice","volume":"119","author":"AM Gil-Bernabe","year":"2012","journal-title":"Blood"},{"issue":"22","key":"ref36","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1111\/bph.13325","article-title":"Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage","volume":"172","author":"R Hwaiz","year":"2015","journal-title":"Br J Pharmacol"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s004080000031","article-title":"Virulence factors from Pseudomonas aeruginosa increase lung epithelial permeability","volume":"178","author":"AO Azghani","year":"2000","journal-title":"Lung"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1182\/blood-2005-01-015081","article-title":"Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection","volume":"109","author":"AD Gregory","year":"2007","journal-title":"Blood"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000444807","article-title":"Platelet Interaction with Innate Immune Cells","volume":"43","author":"JB Kral","year":"2016","journal-title":"Transfus Med Hemother"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens6010010","article-title":"Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis","volume":"6","author":"B. Rada","year":"2017","journal-title":"Pathogens"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1146\/annurev-physiol-030212-183752","article-title":"Platelets in lung biology","volume":"75","author":"AS Weyrich","year":"2013","journal-title":"Annu Rev Physiol"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1165\/rcmb.2015-0245OC","article-title":"Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury","volume":"56","author":"K Bdeir","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/j.ajpath.2014.05.009","article-title":"Mast cells protect against Pseudomonas aeruginosa-induced lung injury","volume":"184","author":"RD Junkins","year":"2014","journal-title":"Am J Pathol"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.ajpath.2016.01.005","article-title":"Protein Tyrosine Phosphatase-1B Negatively Impacts Host Defense against Pseudomonas aeruginosa Infection","volume":"186","author":"L Yue","year":"2016","journal-title":"Am J Pathol"},{"key":"ref45","article-title":"Platelet Depletion Impairs Host Defence to Pulmonary Infection with Pseudomonas aeruginosa in Mice","author":"RT Amison","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2010.10.011","article-title":"The role of the CXC chemokines platelet factor-4 (CXCL4\/PF-4) and its variant (CXCL4L1\/PF-4var) in inflammation, angiogenesis and cancer","volume":"22","author":"J Vandercappellen","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref47","article-title":"Platelet-derived chemokines in inflammation and atherosclerosis","author":"C Bakogiannis","year":"2017","journal-title":"Cytokine"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2012.00001","article-title":"Macrophage Phenotype Modulation by CXCL4 in Atherosclerosis","volume":"3","author":"CA Gleissner","year":"2012","journal-title":"Front Physiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.trsl.2016.04.006","article-title":"Platelet-derived CXCL4 regulates neutrophil infiltration and tissue damage in severe acute pancreatitis","volume":"176","author":"E Wetterholm","year":"2016","journal-title":"Transl Res"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/hep.23435","article-title":"CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis","volume":"51","author":"MM Zaldivar","year":"2010","journal-title":"Hepatology"},{"issue":"7","key":"ref51","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.celrep.2016.10.031","article-title":"PF4 Promotes Platelet Production and Lung Cancer Growth","volume":"17","author":"F Pucci","year":"2016","journal-title":"Cell Rep"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4049\/jimmunol.164.2.1037","article-title":"Macrophage inflammatory protein-2 is a mediator of polymorphonuclear neutrophil influx in ocular bacterial infection","volume":"164","author":"KA Kernacki","year":"2000","journal-title":"Journal of immunology"},{"issue":"11","key":"ref53","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1167\/iovs.12-10400","article-title":"CXCL1-deficient mice are highly sensitive to pseudomonas aeruginosa but not herpes simplex virus type 1 corneal infection","volume":"53","author":"KM Bryant-Hudson","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1164\/rccm.201207-1228OC","article-title":"Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantation","volume":"187","author":"AL Gregson","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref55","first-page":"1","article-title":"Platelets and vascular integrity","author":"C Deppermann","year":"2018","journal-title":"Platelets"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1538-7836.2011.04193.x","article-title":"Efficient phagocytosis of periodontopathogens by neutrophils requires plasma factors, platelets and TLR2","volume":"9","author":"A Assinger","year":"2011","journal-title":"Journal of thrombosis and haemostasis: JTH"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1128\/IAI.00508-15","article-title":"Platelet-Dependent Neutrophil Function Is Dysregulated by M Protein from Streptococcus pyogenes","volume":"83","author":"SM Hurley","year":"2015","journal-title":"Infection and immunity"},{"issue":"6","key":"ref58","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/mi.2017.1","article-title":"Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection","volume":"10","author":"L Guo","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"6","key":"ref59","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1164\/rccm.201108-1533OC","article-title":"Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury","volume":"185","author":"J Grommes","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1182\/blood-2010-08-301424","article-title":"Platelet factor 4 binds to bacteria, [corrected] inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia","volume":"117","author":"K Krauel","year":"2011","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0205521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T16:11:30Z","timestamp":1662221490000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0205521"}},"subtitle":[],"editor":[{"given":"Santanu","family":"Bose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0205521","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,8]]}}}