{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:49:01Z","timestamp":1791859741680,"version":"4.3.4"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/06444-9"],"award-info":[{"award-number":["2017\/06444-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0205535","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T18:29:09Z","timestamp":1541442549000},"page":"e0205535","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat"],"prefix":"10.1371","volume":"13","author":[{"given":"Marcia","family":"Rodrigues da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Schapochnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara","family":"Peres Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janete","family":"Esteves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bichels Hebeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Sandri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Pavani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carolina","family":"Ratto Tempestini Horliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra H. P.","family":"Farsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-2833","authenticated-orcid":true,"given":"Adriana","family":"Lino-dos-Santos-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"ref1","first-page":"2732","article-title":"Development of a physiologically based pharmacokinetic model of paraquat","author":"M Lohitnavy","year":"2017","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/ajim.22835","article-title":"Investigating global trends in paraquat intoxication research from 1962 to 2015 using bibliometric analysis","volume":"6","author":"SH Zyoud","year":"2018","journal-title":"Am J Ind Med."},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"e82695","DOI":"10.1371\/journal.pone.0082695","article-title":"Predictors of acute respiratory distress syndrome in patients with paraquat intoxication","volume":"8","author":"CH Weng","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3109\/15563650.2012.718783","article-title":"Effect of pirfenidone on pulmonary fibrosis due to paraquat poisoning in rats","volume":"50","author":"S Seifirad","year":"2012","journal-title":"Clin Toxicol(Phila)"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/01.CCM.0000195013.47004.A8","article-title":"Repeated pulse of methyl-prednisolone and cyclophosphamide with continuous dexamethasone therapy for patients with severe paraquat poisoning","volume":"34","author":"JL Lin","year":"2006","journal-title":"Crit Care Med"},{"key":"ref6","article-title":"Paraquat and Maneb Exposure Alters Rat Neural Stem Cell Proliferation by Inducing Oxidative Stress: New Insights on Pesticide-Induced Neurodevelopmental Toxicity","author":"D Colle","year":"2018","journal-title":"Neurotox Res"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.2147\/IJN.S143192","article-title":"SiO2 nanospheres treated paraquat-induced acute lung injury by resisting oxidative stress","volume":"27","author":"Y Zhu","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pestbp.2015.03.007","article-title":"NADPH oxidase mediated maneb- and paraquat-induced oxidative stress in rat polymorphs: Crosstalk with mitochondrial dysfunction","volume":"123","author":"S Shukla","year":"2015","journal-title":"Pestic Biochem Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"888","DOI":"10.7150\/ijbs.18468","article-title":"Crosstalk between Mitochondrial Fission and Oxidative Stress in Paraquat-Induced Apoptosis in Mouse Alveolar Type II Cells","volume":"13","author":"G Zhao","year":"2017","journal-title":"Int J Biol Sci"},{"key":"ref10","first-page":"386952","article-title":"DNaseI protects against Paraquat-induced acute lung injury and pulmonary fibrosis mediated by mitochondrial DNA","author":"G Li","year":"2015","journal-title":"Biomed Res Int."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2017.11.030","article-title":"Triptolide suppresses paraquat induced idiopathic pulmonary fibrosis by inhibiting TGFB1-dependent epithelial mesenchymal transition","volume":"284","author":"H Chen","year":"2018","journal-title":"Toxicol Lett."},{"issue":"11","key":"ref12","first-page":"4376","article-title":"Doxycycline attenuates paraquat-induced pulmonary fibrosis by downregulating the TGF-\u03b2 signaling pathway","author":"XF Hua","year":"2017","journal-title":"J Thorac Dis"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s41598-017-01069-9","article-title":"Paraquat poisoning induced pulmonary epithelial mesenchymal transition through Notch1 pathway","volume":"7","author":"T Li","year":"2017","journal-title":"Sci Rep."},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/tox.22146","article-title":"MAPK pathway mediates epithelial-mesenchymal transition induced by paraquat in alveolar epithelial cells","volume":"31","author":"M Huang","year":"2016","journal-title":"Environ Toxicol"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1513\/pats.201201-011AW","article-title":"Genesis of the myofibroblast in lung injury and fibrosis","volume":"9","author":"SH Phan","year":"2012","journal-title":"Proc Am Thorac Soc"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1164\/rccm.200501-017PP","article-title":"Oxidative stress in pulmonary fibrosis:a possible role for redox modulatory therapy","volume":"172","author":"VL Kinnula","year":"2005","journal-title":"Am J Respir Crit Care Med."},{"issue":"6","key":"ref17","first-page":"530","article-title":"Tryptophan metabolism in chronic inflammatory lung disease","volume":"126","author":"KC Meyer","year":"1995","journal-title":"J Lab Clin Med"},{"issue":"5","key":"ref18","first-page":"481","article-title":"Paraquat suicide in a young woman: results of therapy directed against the superoxide radical","volume":"50","author":"JB Harley","year":"1977","journal-title":"Yale J Biol Med"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1471-4914(01)01912-8","article-title":"Is oxidative stress central to the Pathogenesis of chronic obstructive pulmonary disease?","volume":"7","author":"W MacNee","year":"2001","journal-title":"Trends Mol Med"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1183\/09031936.02.00262402","article-title":"Glutathione deficiency of the lower respiratory tract in patients with idiopathic pulmonary fibrosis","volume":"19","author":"KM Beeh","year":"2002","journal-title":"Eur Respir J"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"L972","DOI":"10.1152\/ajplung.00010.2007","article-title":"Extracellular cysteine\/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta","volume":"293","author":"A Ramirez","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1465-9921-11-31","article-title":"Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1\/Th2 balance","volume":"18","author":"N Kikuchi","year":"2010","journal-title":"Respir Res"},{"issue":"4","key":"ref23","first-page":"727","article-title":"Oxidant-antioxidant imbalance as a potential contributor to the progression of human pulmonary fibrosis","volume":"10","author":"VL Kinnula","year":"2008"},{"issue":"22","key":"ref24","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1056\/NEJMoa1401739","article-title":"Randomized trial of acetylcysteine in idiopathic pulmonar fibrosis","volume":"370","author":"FJ Martinez","year":"2014","journal-title":"N Engl J Med."},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"E1211","DOI":"10.3390\/nu9111211","article-title":"Maggini S Vitamin C and Immune Function","volume":"9","author":"AC Carr","year":"2017","journal-title":"Nutrients"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1476-5381.2009.00282.x","article-title":"Vitamin C: update on physiology and pharmacology","volume":"157","author":"J Mandl","year":"2009","journal-title":"Br J Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.nu.06.070186.002053","article-title":"The biochemical functions of ascorbic acid","volume":"6","author":"S Englard","year":"1986","journal-title":"Annu Rev Nutr."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1631\/jzus.B1400229","article-title":"Effects of Rapamycin against Paraquat-Induced Pulmonary Fibrosis in Mice","author":"X Shao","year":"2015","journal-title":"Journal of Zhejiang University"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1476-5381.2012.02017.x","article-title":"Carvalho. Paraquat research: do recent advances in limiting its toxicity make its use safer","volume":"168","author":"T Baltazar","year":"2013","journal-title":"Br J Pharmacol."},{"issue":"300","key":"ref30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.taap.2016.03.010","article-title":"Beneficial effects of vitamin C treatment on pregnant rats exposed to formaldehyde: Reversal of immunosuppression in the offspring","volume":"1","author":"BS Ibrahim","year":"2016","journal-title":"Toxicol Appl Pharmacol."},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"E30","DOI":"10.3390\/toxics5040030","article-title":"Pilot Study in Cameroon to Understand Safe Uses of Pesticides in Agriculture, Risk Factors for Farmers&apos; Exposure and Management of Accidental Cases","volume":"5","author":"GB Pouokam","year":"2017","journal-title":"Toxics"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.toxlet.2011.10.019","article-title":"Protective effect of methylprednisolone on paraquat-induced A549 cell cytotoxicity via induction of efflux transporter, P-glycoprotein expression","volume":"208","author":"T Zerin","year":"2012","journal-title":"Toxicol Lett"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s10103-017-2281-z","article-title":"Photobiomodulation therapy improves both inflammatory and fibrotic parameters in experimental model of lung fibrosis in mice","volume":"32","author":"RA Brochetti","year":"2017","journal-title":"Lasers Med Sci."},{"issue":"1\u20132","key":"ref34","first-page":"213","article-title":"Ascorbic acid inhibits polymorphonuclear leukocytes influx to the place of inflammation\u2014possible protection of lung from phagocyte-mediated injury","volume":"37","author":"D Nowak","year":"1989","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"L20","DOI":"10.1152\/ajplung.00300.2011","article-title":"Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid","volume":"303","author":"B.J Fisher","year":"2011","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1189\/jlb.0806541","article-title":"Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1alpha","volume":"81","author":"M.C Vissers","year":"2007","journal-title":"J. Leukoc. Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1189\/jlb.0903415","article-title":"Ascorbate-mediated enhancement of reactive oxygen species generation from polymorphonuclear leukocytes: Modulatory effect of nitric oxide","volume":"75","author":"P Sharma","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1214S","DOI":"10.1093\/ajcn\/54.6.1214s","article-title":"Reduced bactericidal activity in neutrophils from scorbutic animals and the effect of ascorbic acid on these target bacteria in vivo and in vitro","volume":"54","author":"M.C Goldschmidt","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"ref39","first-page":"326","article-title":"The effect of ascorbic acid deficiency on leukocyte phagocytosis and killing of actinomyces viscosus","volume":"58","author":"M.C Goldschmidt","year":"1988","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1001\/archotol.1982.00790500058015","article-title":"Malignant external otitis and polymorphonuclear leukocyte migration impairment. Improvement with ascorbic acid","volume":"108","author":"J Corberand","year":"1982","journal-title":"Arch. Otolaryngol."},{"key":"ref41","first-page":"429","article-title":"Effects of ascorbate on leucocytes: Part III. In vitro and in vivo stimulation of abnormal neutrophil motility by ascorbate","volume":"56","author":"R Anderson","year":"1979","journal-title":"S. Afr. Med. J."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/jn\/107.8.1507","article-title":"Glycolytic, hexose monophosphate shunt and bactericidal activities of leukocytes in ascorbic acid deficient guinea pigs","volume":"107","author":"P.G Shilotri","year":"1977","journal-title":"J. Nutr."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/ajcn\/29.7.762","article-title":"Macrophage function in vitamin C-deficient guinea pigs","author":"R Ganguly","year":"1976","journal-title":"Am. J. Clin. Nutr."},{"key":"ref44","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1128\/IAI.12.2.252-256.1975","article-title":"Ascorbate and phagocyte function","volume":"12","author":"L Stankova","year":"1975","journal-title":"Infect. Immun."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3109\/10715762.2013.838321","article-title":"Treatment of acute paraquat intoxication using recommended megadose of vitamin C: a reappraisal","volume":"47","author":"JB Chang","year":"2013","journal-title":"Free Radic Res"},{"key":"ref46","article-title":"Signaling Pathways In Inflammation And Anti-Inflammatory Therapies","author":"YT Yeung","year":"2018","journal-title":"Curr Pharm Des"},{"key":"ref47","article-title":"Chemoattractants andcytokines in primary ciliary dyskinesia and cystic fibrosis: key players in chronic respiratory diseases","author":"M Cockx","year":"2017","journal-title":"Cell Mol Immunol"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1258\/ebm.2010.010231","article-title":"Targeting transforming growth factor \u03b2RII expression inhibits the activation of hepatic stellate cells and reduces collagen synthesis","volume":"236","author":"R Fu","year":"2011","journal-title":"Exp Biol Med (Maywood)"},{"issue":"8","key":"ref49","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.4049\/jimmunol.175.8.5390","article-title":"TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis","volume":"175","author":"P Bonniaud","year":"2005","journal-title":"J Immunol"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"370","DOI":"10.5114\/ceji.2017.72804","article-title":"Angiogenesis modulation by exogenous antioxidants","volume":"42","author":"DM Radomska-Lesniewska","year":"2017","journal-title":"Cent Eur J Immunol"},{"issue":"12","key":"ref51","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix indevelopment and disease","volume":"15","author":"C Bonnans","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1513\/pats.200601-012TK","article-title":"Matrix metalloproteases in aberrant fibrotic tissue remodeling","volume":"3","author":"A Pardo","year":"2006","journal-title":"Proc Am Thorac Soc"},{"issue":"29","key":"ref53","doi-asserted-by":"crossref","first-page":"E4208","DOI":"10.1073\/pnas.1600056113","article-title":"Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis","volume":"113","author":"I Gupta","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.taap.2016.08.004","article-title":"Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2\/Nox4 redox balance and TGF-\u03b21\/Smad3 signaling","volume":"309","author":"B Liu","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref55","article-title":"Determination of parameters of oxidative stress in vitro models of neurodegenerative diseases- A review","author":"CM Feitosa","year":"2018","journal-title":"Current clinical pharmacology, europepmc.org"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0205535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T18:57:56Z","timestamp":1605380276000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0205535"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Ryffel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":55,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0205535","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,5]]}}}