{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:12:11Z","timestamp":1790712731016,"version":"4.1.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programme Hospitalier de Recherche Clinique National of the French Ministry of Health","award":["AOM06022"],"award-info":[{"award-number":["AOM06022"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0205648","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T13:51:47Z","timestamp":1539265907000},"page":"e0205648","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["The TRKB rs2289656 genetic polymorphism is associated with acute suicide attempts in depressed patients: A transversal case control study"],"prefix":"10.1371","volume":"13","author":[{"given":"Eric","family":"Deflesselle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-4495","authenticated-orcid":true,"given":"Romain","family":"Colle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Rigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis J.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albane","family":"Vievard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Becquemont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Verstuyft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Corruble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/0006-3223(95)00295-2","article-title":"Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders","volume":"39","author":"YW Chen","year":"1996","journal-title":"Biol Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpsyc.56.7.617","article-title":"Prevalence of and risk factors for lifetime suicide attempts in the National Comorbidity Survey","volume":"56","author":"RC Kessler","year":"1999","journal-title":"Arch Gen Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1176\/appi.ajp.157.12.1925","article-title":"Affective disorders and suicide risk: a reexamination","volume":"157","author":"JM Bostwick","year":"2000","journal-title":"Am J Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jpsychires.2010.01.003","article-title":"A population-based longitudinal study of risk factors for suicide attempts in major depressive disorder","volume":"44","author":"JM Bolton","year":"2010","journal-title":"J Psychiatr Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.psc.2008.02.001","article-title":"Familial transmission of suicidal behavior","volume":"31","author":"DA Brent","year":"2008","journal-title":"Psychiatr Clin North Am"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/dneu.20758","article-title":"The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity","volume":"70","author":"E Castren","year":"2010","journal-title":"Dev Neurobiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e48046","DOI":"10.1371\/journal.pone.0048046","article-title":"Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight","volume":"7","author":"ML Molendijk","year":"2012","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1001\/archpsyc.60.8.804","article-title":"Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects","volume":"60","author":"Y Dwivedi","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000142361","article-title":"Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients","volume":"57","author":"M Sarchiapone","year":"2008","journal-title":"Neuropsychobiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00414-013-0835-6","article-title":"Neurobiology of suicide: do biomarkers exist?","volume":"128","author":"A Costanza","year":"2014","journal-title":"Int J Legal Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fpsyt.2016.00158","article-title":"Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions","volume":"7","author":"B Mirkovic","year":"2016","journal-title":"Front Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/YPG.0000000000000109","article-title":"Investigating the associations between polymorphisms in the NTRK2 and NGFR genes and completed suicide in the Slovenian sample","volume":"25","author":"S Ropret","year":"2015","journal-title":"Psychiatr Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.psychres.2014.07.036","article-title":"Tropomyosin-related kinase B receptor polymorphisms and isoforms expression in suicide victims","volume":"220","author":"F Zarrilli","year":"2014","journal-title":"Psychiatry Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1176\/appi.ajp.2010.10040541","article-title":"Genome-wide association study of suicide attempts in mood disorder patients","volume":"167","author":"RH Perlis","year":"2010","journal-title":"Am J Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/ajmg.b.32247","article-title":"Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study","volume":"165B","author":"N Mullins","year":"2014","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1001\/archgenpsychiatry.2009.201","article-title":"Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients","volume":"67","author":"MA Kohli","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e20690","DOI":"10.1371\/journal.pone.0020690","article-title":"Genomewide association scan of suicidal thoughts and behaviour in major depression","volume":"6","author":"A Schosser","year":"2011","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1744-9081-7-22","article-title":"Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &amp;NTRK2 polymorphisms","volume":"7","author":"TM Murphy","year":"2011","journal-title":"Behav Brain Funct"},{"key":"ref19","first-page":"19","article-title":"Neurotrophin Genes and Antidepressant-Worsening Suicidal Ideation: A Prospective Case-Control Study","author":"G Voegeli","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1741-7015-7-60","article-title":"Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial","volume":"7","author":"N Perroud","year":"2009","journal-title":"BMC Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/FPC.0b013e32832e4bcd","article-title":"Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients","volume":"19","author":"G Laje","year":"2009","journal-title":"Pharmacogenet Genomics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/tpj.2010.70","article-title":"Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project","volume":"12","author":"N Perroud","year":"2012","journal-title":"Pharmacogenomics J"},{"key":"ref23","first-page":"997","article-title":"Demographic and clinical characteristics of consistent and inconsistent longitudinal reporters of lifetime suicide attempts in adolescence through young adulthood","volume":"30","author":"SR Hart","year":"2013","journal-title":"Depress Anxiety"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/13811110600582539","article-title":"The accuracy of prevalence estimations for suicide attempts. how reliably do adolescents and young adults report their suicide attempts?","volume":"10","author":"B Christl","year":"2006","journal-title":"Arch Suicide Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/mpr.1423","article-title":"Reporting suicide attempts: consistency and its determinants in a large mental health study","volume":"23","author":"M Eikelenboom","year":"2014","journal-title":"Int J Methods Psychiatr Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1943-278X.2010.00005.x","article-title":"A closer look at self-reported suicide attempts: false positives and false negatives","volume":"41","author":"M Ploderl","year":"2011","journal-title":"Suicide Life Threat Behav"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/sltb.12068","article-title":"Differentiating suicide attempters from suicide ideators: a critical frontier for suicidology research","volume":"44","author":"ED Klonsky","year":"2014","journal-title":"Suicide Life Threat Behav"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/wps.20260","article-title":"Treating major depressive episodes with antidepressants can induce or worsen metabolic syndrome: results of the METADAP cohort","volume":"14","author":"E Corruble","year":"2015","journal-title":"World Psychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"M Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1440-1819.2004.01233.x","article-title":"Defense styles in depressed suicide attempters","volume":"58","author":"E Corruble","year":"2004","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3233\/JAD-2008-15105","article-title":"SNPs in neurotrophin system genes and Alzheimer&apos;s disease in an Italian population","volume":"15","author":"A Cozza","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/mp.2009.92","article-title":"Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans","volume":"14","author":"C Dong","year":"2009","journal-title":"Mol Psychiatry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.clpt.2006.01.007","article-title":"Environmental and genetic factors associated with morphine response in the postoperative period","volume":"79","author":"L Coulbault","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1093\/hmg\/11.17.2015","article-title":"Specific haplotypes of the P-selectin gene are associated with myocardial infarction","volume":"11","author":"DA Tregouet","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/mp.2015.187","article-title":"Polygenic associations of neurodevelopmental genes in suicide attempt","volume":"21","author":"M Sokolowski","year":"2016","journal-title":"Mol Psychiatry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/bs.pmbts.2018.01.007","article-title":"Understanding the Neuroepigenetic Constituents of Suicide Brain","volume":"157","author":"B Roy","year":"2018","journal-title":"Prog Mol Biol Transl Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/ajmg.b.32330","article-title":"A genome-wide association study of suicidal behavior","volume":"168","author":"H Galfalvy","year":"2015","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/ajmg.b.32594","article-title":"Genomewide association studies of suicide attempts in US soldiers","volume":"174","author":"MB Stein","year":"2017","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/070674371405900202","article-title":"From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment","volume":"59","author":"C Fabbri","year":"2014","journal-title":"Can J Psychiatry"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/mp.2011.4","article-title":"A genome-wide association study of attempted suicide","volume":"17","author":"VL Willour","year":"2012","journal-title":"Mol Psychiatry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrg1327","article-title":"Genomic variants in exons and introns: identifying the splicing spoilers","volume":"5","author":"F Pagani","year":"2004","journal-title":"Nat Rev Genet"},{"key":"ref42","article-title":"Deep intronic mutations and human disease","author":"R Vaz-Drago","year":"2017","journal-title":"Hum Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.mcn.2008.07.024","article-title":"Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system","volume":"39","author":"H Kumanogoh","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1176\/appi.ajp.2014.14020194","article-title":"Toward a biosignature for suicide","volume":"171","author":"MA Oquendo","year":"2014","journal-title":"Am J Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0205648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:44:43Z","timestamp":1588999483000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0205648"}},"subtitle":[],"editor":[{"given":"Kenji","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,11]]},"references-count":44,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0205648","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.17504\/protocols.io.ti2ekge","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,11]]}}}