{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:20:44Z","timestamp":1773037244422,"version":"3.50.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009123","name":"Norwegian University of Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009123","id-type":"DOI","asserted-by":"crossref"}]},{"name":"St. Olavs Hospital, Clinic of Laboratory Medicine"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0205846","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T17:40:52Z","timestamp":1539884452000},"page":"e0205846","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic value of ErbB2\/HER2 in human meningiomas"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-0983","authenticated-orcid":true,"given":"Magnus B.","family":"Arnli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo L.","family":"Winther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stian","family":"Lydersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre H.","family":"Torp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"issue":"Suppl 2","key":"ref1","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1093\/neuonc\/not151","article-title":"CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006\u20132010","volume":"15","author":"QT Ostrom","year":"2013","journal-title":"Neuro-oncology"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00381-012-1759-z","article-title":"Pediatric meningiomas in The Netherlands 1974\u20132010: a descriptive epidemiological case study","volume":"28","author":"NB Thuijs","year":"2012","journal-title":"Childs Nerv Syst"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3171\/2016.1.JNS151842","article-title":"Relevance of Simpson grading system and recurrence-free survival after surgery for World Health Organization Grade I meningioma","volume":"126","author":"A Nanda","year":"2017","journal-title":"Journal of neurosurgery"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"a020768","DOI":"10.1101\/cshperspect.a020768","article-title":"The EGFR family: not so prototypical receptor tyrosine kinases","volume":"6","author":"MA Lemmon","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Y Yarden","year":"2001","journal-title":"Nature reviews Molecular cell biology"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3390\/membranes4030424","article-title":"The Mysterious Ways of ErbB2\/HER2 Trafficking","volume":"4","author":"V Bertelsen","year":"2014","journal-title":"Membranes"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"852748","DOI":"10.1155\/2014\/852748","article-title":"Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications","volume":"2014","author":"N Iqbal","year":"2014","journal-title":"Mol Biol Int"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejca.2017.01.017","article-title":"Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM)","volume":"75","author":"MJ Duffy","year":"2017","journal-title":"European journal of cancer"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1177\/1066896913492196","article-title":"C-erbB2\/HER2 in human gliomas, medulloblastomas, and meningiomas: a minireview","volume":"21","author":"IS Waage","year":"2013","journal-title":"International journal of surgical pathology"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/01.coc.0000128724.63600.c7","article-title":"Role of her-2\/neu overexpression and clinical features at presentation as predictive factors in meningiomas","volume":"27","author":"A Potti","year":"2004","journal-title":"American journal of clinical oncology"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3109\/02688697.2010.522743","article-title":"Recurrence of benign meningiomas: predictive value of proliferative index, BCL2, p53, hormonal receptors and HER2 expression","volume":"25","author":"E Abdelzaher","year":"2011","journal-title":"British journal of neurosurgery"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.prp.2012.01.009","article-title":"An immunohistochemical study of HER2 expression in meningioma and its correlation with tumor grade","volume":"208","author":"P Mahzouni","year":"2012","journal-title":"Pathology, research and practice"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.humpath.2005.12.020","article-title":"Prognostic value of HER2 expression in meningiomas: an immunohistochemical and fluorescence in situ hybridization study","volume":"37","author":"D Loussouarn","year":"2006","journal-title":"Human pathology"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/BF00228582","article-title":"Expression of the c-erbB-2-encoded oncoprotein and progesterone receptor in human meningiomas","volume":"86","author":"J Schlegel","year":"1993","journal-title":"Acta neuropathologica"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/0046-8177(94)90246-1","article-title":"Expression of neu\/c-erbB-2 in human brain tumors","volume":"25","author":"K Schwechheimer","year":"1994","journal-title":"Human pathology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00401-004-0875-6","article-title":"Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomas","volume":"108","author":"U Andersson","year":"2004","journal-title":"Acta neuropathologica"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00177474","article-title":"Immunohistochemical evaluation of erbB-2 and p53 protein expression in benign and atypical human meningiomas","volume":"27","author":"BS Chozick","year":"1996","journal-title":"Journal of neuro-oncology"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/0959-8049(93)90305-Y","article-title":"C-erbB-2\/HER-2 protein in human intracranial tumours","volume":"29A","author":"SH Torp","year":"1993","journal-title":"European journal of cancer"},{"issue":"4","key":"ref19","first-page":"e5125","article-title":"Expression of merlin, NDRG2, ERBB2, and c-MYC in meningiomas: relationship with tumor grade and recurrence","volume":"49","author":"BR Ongaratti","year":"2016","journal-title":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas"},{"issue":"3","key":"ref20","first-page":"231","article-title":"The histopathological spectrum of human meningiomas","volume":"5","author":"T Backer-Grondahl","year":"2012","journal-title":"International journal of clinical and experimental pathology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e3140","DOI":"10.7717\/peerj.3140","article-title":"Expression and clinical value of EGFR in human meningiomas","volume":"5","author":"MB Arnli","year":"2017","journal-title":"PeerJ"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/apm.12248","article-title":"Histopathology and prognosis in human meningiomas","volume":"122","author":"T Backer-Grondahl","year":"2014","journal-title":"APMIS: acta pathologica, microbiologica, et immunologica Scandinavica"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary","volume":"131","author":"DN Louis","year":"2016","journal-title":"Acta neuropathologica"},{"issue":"3","key":"ref24","first-page":"353","article-title":"Coexpression of c-erbB 1\u20134 receptor proteins in human glioblastomas. An immunohistochemical study","volume":"26","author":"SH Torp","year":"2007","journal-title":"Journal of experimental & clinical cancer research: CR"},{"issue":"13","key":"ref25","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/jnci\/djm024","article-title":"Endpoints in adjuvant treatment trials: a systematic review of the literature in colon cancer and proposed definitions for future trials","volume":"99","author":"CJ Punt","year":"2007","journal-title":"Journal of the National Cancer Institute"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1746-1596-5-18","article-title":"Overexpression of c-erbB2 is a negative prognostic factor in anaplastic astrocytomas","volume":"5","author":"S Gulati","year":"2010","journal-title":"Diagnostic pathology"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0046-8177(92)90032-X","article-title":"Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry","volume":"23","author":"TP Singleton","year":"1992","journal-title":"Human pathology"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/neup.12266","article-title":"Activation of multiple growth factor signalling pathways is frequent in meningiomas","volume":"36","author":"DA Hilton","year":"2016","journal-title":"Neuropathology: official journal of the Japanese Society of Neuropathology"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/07357900802709175","article-title":"Gene expression profiling of ErbB receptors and ligands in human meningiomas","volume":"27","author":"I Laurendeau","year":"2009","journal-title":"Cancer investigation"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.3892\/mmr.2015.3805","article-title":"Role of HER-2 activity in the regulation of malignant meningioma cell proliferation and motility","volume":"12","author":"W Wang","year":"2015","journal-title":"Molecular medicine reports"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12957-017-1132-5","article-title":"The clinicopathological parameters and prognostic significance of HER2 expression in gastric cancer patients: a meta-analysis of literature","volume":"15","author":"YY Lei","year":"2017","journal-title":"World journal of surgical oncology"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1200\/JCO.2006.09.2775","article-title":"American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer","volume":"25","author":"AC Wolff","year":"2007","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00701-013-1923-6","article-title":"Simpson grade: an opportunity to reassess the need for complete resection of meningiomas","volume":"156","author":"JB Heald","year":"2014","journal-title":"Acta neurochirurgica"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/neuonc\/nos013","article-title":"Impaired survival and long-term neurological problems in benign meningioma","volume":"14","author":"H van Alkemade","year":"2012","journal-title":"Neuro-oncology"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3171\/jns.1998.88.5.0831","article-title":"Factors associated with survival in patients with meningioma","volume":"88","author":"BJ McCarthy","year":"1998","journal-title":"Journal of neurosurgery"},{"issue":"2","key":"ref36","first-page":"135","article-title":"Her-2\/neu gene amplification in paraffin-embedded tissue sections of meningioma patients","volume":"19","author":"O Ozer","year":"2009","journal-title":"Turk Neurosurg"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"702","DOI":"10.5858\/2002-126-0702-EOTTMT","article-title":"Evaluation of the tissue microarray technique for immunohistochemical analysis in rectal cancer","volume":"126","author":"E Fernebro","year":"2002","journal-title":"Archives of pathology & laboratory medicine"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0002-9440(10)64075-8","article-title":"Validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumors","volume":"158","author":"A Hoos","year":"2001","journal-title":"The American journal of pathology"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00000478-200203000-00004","article-title":"Tissue microarray sampling strategy for prostate cancer biomarker analysis","volume":"26","author":"MA Rubin","year":"2002","journal-title":"The American journal of surgical pathology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0205846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T06:22:19Z","timestamp":1662272539000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0205846"}},"subtitle":[],"editor":[{"given":"Aamir","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,18]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0205846","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,18]]}}}