{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:31:05Z","timestamp":1768793465130,"version":"3.49.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 15K00819"],"award-info":[{"award-number":["JP 15K00819"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0205865","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T17:36:23Z","timestamp":1539624983000},"page":"e0205865","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Host cellular unfolded protein response signaling regulates Campylobacter jejuni invasion"],"prefix":"10.1371","volume":"13","author":[{"given":"Aya","family":"Tentaku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7576-1144","authenticated-orcid":true,"given":"Takaaki","family":"Shimohata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Hatayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Kido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh Quoc","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuna","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiho","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Uebanso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketoshi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Mawatari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagakatsu","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"ref1","first-page":"121","article-title":"<italic>Campylobacter<\/italic>","author":"CR Friedman","year":"2000"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1128\/IAI.68.12.6535-6541.2000","article-title":"<italic>Campylobacter jejuni<\/italic> Cytolethal Distending Toxin Mediates Release of Interleukin-8 from Intestinal Epithelial Cells","volume":"68","author":"EH Thomas","year":"2000","journal-title":"Infect Immun"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1757-4749-1-2","article-title":"Campylobacter jejuni induces transcellular translocation of commensal bacteria via lipid rafts","volume":"1","author":"LD Kalischuk","year":"2009","journal-title":"Gut Pathog"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.vetmic.2010.08.009","article-title":"<italic>Campylobacter jejuni<\/italic> induces an anti-inflammatory response in human intestinal epithelial cells through activation of phosphatidylinositol 3-kinase\/Akt pathway","volume":"148","author":"YP Li","year":"2011","journal-title":"Vet Microbiol"},{"issue":"2\u20133","key":"ref5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1574-6968.1993.tb06406.x","article-title":"Studies on the pathophysiological mechanism of <italic>Campylobacter jejuni<\/italic>-induced fluid secretion in rat ileum","volume":"111","author":"R Kaur","year":"1993","journal-title":"FEMS Microbiol Lett"},{"issue":"Pt 8","key":"ref6","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1099\/mic.0.27979-0","article-title":"<italic>Campylobacter jejuni<\/italic> activates mitogen-activated protein kinases in Caco-2 cell monolayers and in vitro infected primary human colonic tissue","volume":"151","author":"A MacCallum","year":"2005","journal-title":"Microbiology"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1111\/j.1462-5822.2007.00971.x","article-title":"Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of <italic>Campylobacter jejuni<\/italic>","volume":"9","author":"M Krause-Gruszczynska","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1757-4749-6-16","article-title":"The impact of serine protease HtrA in apoptosis, intestinal immune responses and extra-intestinal histopathology during <italic>Campylobacter jejuni<\/italic> infection of infant mice","volume":"6","author":"MM Heimesaat","year":"2014","journal-title":"Gut Pathog"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/10466","article-title":"Integration of endoplasmic reticulum signaling in health and disease","volume":"5","author":"M Aridor","year":"1999","journal-title":"Nat. Nat Med"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.cdd.4401833","article-title":"Viruses, endoplasmic reticulum stress, and interferon responses","volume":"13","author":"B He","year":"2006","journal-title":"Cell Death Differ"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"GS Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.cellbio.18.011402.160624","article-title":"Transcriptional and translational control in the mammalian unfolded protein response","volume":"18","author":"HP Harding","year":"2002","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1101\/gad.13.10.1211","article-title":"Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcription and translational controls","volume":"13","author":"RJ Kaufman","year":"1999","journal-title":"Genes Dev"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"I Tabas","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0092-8674(93)90648-A","article-title":"Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase","volume":"73","author":"JS Cox","year":"1993","journal-title":"Cell"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0092-8674(93)90521-Q","article-title":"A transmembrane protein with a cdc2+\/CDC28-related kinase activity is required for signaling from the ER to the nucleus","volume":"74","author":"K Mori","year":"1993","journal-title":"Cell"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1101\/gad.12.12.1812","article-title":"A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase\/endoribonuclease (Ire1p) in mammalian cells","volume":"12","author":"W Tirasophon","year":"1998","journal-title":"Genes Dev"},{"issue":"19","key":"ref18","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1093\/emboj\/17.19.5708","article-title":"Cloning of mammalian Ire1 reveals diversity in the ER stress responses","volume":"17","author":"XZ Wang","year":"1998","journal-title":"EMBO J"},{"issue":"50","key":"ref19","doi-asserted-by":"crossref","first-page":"33741","DOI":"10.1074\/jbc.273.50.33741","article-title":"Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors","volume":"273","author":"H Yoshida","year":"1998","journal-title":"J Biol Chem"},{"issue":"6716","key":"ref20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic reticulum-resident kinase","volume":"397","author":"HP Harding","year":"1999","journal-title":"Nature"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","article-title":"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress","volume":"10","author":"K Haze","year":"1999","journal-title":"Mol Biol Cell"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/35014014","article-title":"Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response","volume":"2","author":"A Bertolotti","year":"2000","journal-title":"Nat Cell Biol"},{"issue":"21","key":"ref23","doi-asserted-by":"crossref","first-page":"18728","DOI":"10.1074\/jbc.M200903200","article-title":"Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress","volume":"277","author":"K Ma","year":"2002","journal-title":"J Biol Chem"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1534-5807(02)00203-4","article-title":"ER stress regulation of ATF6 localization by dissociation of BiP\/GRP78 binding and unmasking of Golgi localization signals","volume":"3","author":"J Shen","year":"2002","journal-title":"Dev Cell"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40348-016-0037-7","article-title":"Diverse roles of endoplasmic reticulum stress sensors in bacterial infection","volume":"3","author":"H Pillich","year":"2016","journal-title":"Mol Cell Pediatr"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1462-5822.2012.01769.x","article-title":"Activation of the unfolded protein response by <italic>Listeria monocytogenes<\/italic>","volume":"14","author":"H Pillich","year":"2012","journal-title":"Cell Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7887","DOI":"10.1038\/ncomms8887","article-title":"<italic>Legionella<\/italic> suppresses the host unfolded protein response via multiple mechanisms","volume":"6","author":"S Treacy-Abarca","year":"2015","journal-title":"Nat Commun"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.febslet.2010.04.050","article-title":"Endoplasmic reticulum stress response is involved in <italic>Mycobacterium tuberculosis<\/italic> protein ESAT-6-mediated apoptosis","volume":"584","author":"HH Choi","year":"2010","journal-title":"FEBS Lett"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1089\/10766290152652800","article-title":"Single or double mutational alterations of gyrA associated with fluoroquinolone resistance in <italic>Campylobacter jejuni<\/italic> and <italic>Campylobacter coli<\/italic>","volume":"7","author":"R Bachoual","year":"2001","journal-title":"Microb Drug Resist"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1128\/JB.01427-06","article-title":"CapA, an autotransporter protein of <italic>Campylobacter jejuni<\/italic> mediates association with human epithelial cells and colonization of the chicken gut","volume":"189","author":"SS Ashgar","year":"2007","journal-title":"J Bacteriol"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1046\/j.1365-2958.1997.4031771.x","article-title":"Identification and molecular cloning of a gene encoding a fibronectin-binding protein (CadF) from <italic>Campylobacter jejuni<\/italic>","volume":"24","author":"ME Konkel","year":"1997","journal-title":"Mol Microbiol"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"e81069","DOI":"10.1371\/journal.pone.0081069","article-title":"The <italic>Campylobacter jejuni<\/italic> Cj0268c Protein Is Required for Adhesion and Invasion In Vitro","volume":"8","author":"AM Tareen","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nm970","article-title":"A transgenic mouse model for monitoring endoplasmic reticulum stress","volume":"10","author":"T Iwawaki","year":"2004","journal-title":"Nat Med"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"H Yoshida","year":"2001","journal-title":"Cell"},{"issue":"6867","key":"ref35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/415092a","article-title":"IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA","volume":"415","author":"M Calfon","year":"2002","journal-title":"Nature"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1101\/gad.964702","article-title":"IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response","volume":"16","author":"K Lee","year":"2002","journal-title":"Genes Dev"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S1097-2765(00)00133-7","article-title":"ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs","volume":"6","author":"J Ye","year":"2000","journal-title":"Mol Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1478-811X-11-72","article-title":"Transmigration route of <italic>Campylobacter jejuni<\/italic> across polarized intestinal epithelial cells: paracellular, transcellular or both?","volume":"11","author":"S Backert","year":"2013","journal-title":"Cell Commun Signal"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1146\/annurev.biochem.78.081307.110540","article-title":"Mechanisms of endocytosis","volume":"78","author":"GJ Doherty","year":"2009","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbamcr.2005.10.003","article-title":"The role of lipid rafts in the pathogenesis of bacterial infections","volume":"1746","author":"DW Zaas","year":"2005","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1091\/mbc.10.4.961","article-title":"Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles","volume":"10","author":"SK Rodal","year":"1999","journal-title":"Mol Biol Cell"},{"issue":"Pt 9","key":"ref42","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1099\/mic.0.27866-0","article-title":"Ca<sup>2+<\/sup> release from host intracellular stores and related signal transduction during <italic>Campylobacter jejuni<\/italic> 81\u2013176 internalization into human intestinal cells","volume":"151","author":"L Hu","year":"2005","journal-title":"Microbiology"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1462-5822.2007.01083.x","article-title":"Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells","volume":"10","author":"SY Lee","year":"2008","journal-title":"Cell Microbiol"},{"issue":"7111","key":"ref44","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nature05124","article-title":"AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP","volume":"443","author":"AW Paton","year":"2006","journal-title":"Nature"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.chom.2018.03.005","article-title":"The unfolded protein response element IRE1alpha senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling","volume":"23","author":"JA Cho","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"10","key":"ref46","doi-asserted-by":"crossref","first-page":"e1000176","DOI":"10.1371\/journal.ppat.1000176","article-title":"Activation of the Unfolded Protein Response Is Required for Defenses against Bacterial Pore-Forming Toxin In Vivo","volume":"4","author":"LJ Bischof","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fcimb.2014.00105","article-title":"Induction of endoplasmic reticulum stress and unfolded protein response constitutes a pathogenic strategy of group A streptococcus","volume":"4","author":"M Baruch","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.chom.2008.10.002","article-title":"Metabolic diversity in <italic>Campylobacter jejuni<\/italic> enhances specific tissue colonization","volume":"4","author":"D Hofreuter","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.molcel.2017.01.020","article-title":"The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling","volume":"65","author":"AR van Vliet","year":"2017","journal-title":"Mol Cell"},{"issue":"9","key":"ref50","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.bbamcr.2017.05.018","article-title":"ER-plasma membrane junctions: Why and how do we study them?","volume":"1864","author":"CL Chang","year":"2017","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"e56900","DOI":"10.1371\/journal.pone.0056900","article-title":"Effects of lipooligosaccharide inner core truncation on bile resistance and chick colonization by <italic>Campylobacter jejuni<\/italic>","volume":"8","author":"T Iwata","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"ref52","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1128\/IAI.68.12.6535-6541.2000","article-title":"<italic>Campylobacter jejuni<\/italic> cytolethal distending toxin mediates release of interleukin-8 from intestinal epithelial cells","volume":"68","author":"TE Hickey","year":"2000","journal-title":"Infect Immun"},{"key":"ref53","article-title":"Investigating <italic>Campylobacter jejuni<\/italic> interactions with endoplasmic reticulum in intestinal epithelial cells resulting in induction of the unfolded protein response. Proceedings of 19 th International Workshop on Campylobacter","author":"G di Sario","year":"2017","journal-title":"Helicobacter and Related Organisms"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","article-title":"An integrated stress response regulates amino acid metabolism and resistance to oxidative stress","volume":"11","author":"HP Harding","year":"2003","journal-title":"Mol Cell"},{"issue":"9","key":"ref55","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1089\/jir.1997.17.503","article-title":"The double-stranded RNA-dependent protein kinase PKR: structure and function","volume":"17","author":"MJ Clemens","year":"1997","journal-title":"J Interferon Cytokine Res"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0925-5710(96)00544-0","article-title":"The PKR protein kinase\u2013an interferon-inducible regulator of cell growth and differentiation","volume":"65","author":"CE Samuel","year":"1997","journal-title":"Int J Hematol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/B978-0-12-396456-4.00003-1","article-title":"Phosphoproteins in stress-induced disease","volume":"106","author":"LE Dalton","year":"2012","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"HP Harding","year":"2000","journal-title":"Mol Cell"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/genetics\/154.2.787","article-title":"A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha","volume":"154","author":"R Sood","year":"2000","journal-title":"Genetics"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1046\/j.1432-1327.1999.00780.x","article-title":"Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase","volume":"265","author":"JJ Berlanga","year":"1999","journal-title":"Eur J Biochem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0205865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T01:26:26Z","timestamp":1662254786000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0205865"}},"subtitle":[],"editor":[{"given":"Dong-Yan","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,15]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0205865","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,15]]}}}