{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:13:37Z","timestamp":1787807617596,"version":"build-2784847793"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006315","name":"Reumafonds","doi-asserted-by":"publisher","award":["RF15-2-403"],"award-info":[{"award-number":["RF15-2-403"]}],"id":[{"id":"10.13039\/501100006315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0205902","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T17:42:44Z","timestamp":1539884564000},"page":"e0205902","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Tyro3\/Axl\/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7709-2167","authenticated-orcid":true,"given":"Claire E. J.","family":"Waterborg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marije I.","family":"Koenders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L. E. M.","family":"van Lent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"van der Kraan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5851-099X","authenticated-orcid":true,"given":"Fons A. J.","family":"van de Loo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"ref1","article-title":"The Tumor-Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine. Arthritis Rheumatol","author":"S You","year":"2017"},{"issue":"3","key":"ref2","first-page":"368","article-title":"One year in review 2017: pathogenesis of rheumatoid arthritis","volume":"35","author":"F Angelotti","year":"2017","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"R62","DOI":"10.1186\/ar3316","article-title":"Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis","volume":"13","author":"J Wu","year":"2011","journal-title":"Arthritis research & therapy"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"15877","DOI":"10.1038\/ncomms15877","article-title":"MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis","volume":"8","author":"M Kurowska-Stolarska","year":"2017","journal-title":"Nature communications"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/art.37786","article-title":"Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis","volume":"65","author":"BT van den Brand","year":"2013","journal-title":"Arthritis and rheumatism"},{"key":"ref6","article-title":"Diminished soluble levels of growth arrest specific protein 6 and tyrosine kinase receptor Axl in patients with rheumatoid arthritis","author":"IH Bassyouni","year":"2014","journal-title":"Int J Rheum Dis"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/annrheumdis-2012-202907","article-title":"Deletion of the receptor tyrosine kinase Tyro3 inhibits synovial hyperplasia and bone damage in arthritis","volume":"73","author":"G Ruiz-Heiland","year":"2014","journal-title":"Annals of the rheumatic diseases"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/cei.13082","article-title":"Soluble TAM receptor tyrosine kinases in rheumatoid arthritis: correlation with disease activity and bone destruction","volume":"192","author":"L Xu","year":"2018","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0002-9440(10)65369-2","article-title":"Expression of receptor tyrosine kinase Axl and its ligand Gas6 in rheumatoid arthritis: evidence for a novel endothelial cell survival pathway","volume":"154","author":"K O'Donnell","year":"1999","journal-title":"The American journal of pathology"},{"key":"ref10","article-title":"Protective role of the Mer Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models","volume":"9","author":"CEJ Waterborg","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-immunol-032414-112103","article-title":"TAM receptor signaling in immune homeostasis","volume":"33","author":"CV Rothlin","year":"2015","journal-title":"Annual review of immunology"},{"issue":"5528","key":"ref12","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.1061663","article-title":"Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family","volume":"293","author":"Q Lu","year":"2001","journal-title":"Science"},{"issue":"6729","key":"ref13","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/19554","article-title":"Tyro-3 family receptors are essential regulators of mammalian spermatogenesis","volume":"398","author":"Q Lu","year":"1999","journal-title":"Nature"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1172\/JCI32639","article-title":"Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis","volume":"118","author":"S Abdollahi-Roodsaz","year":"2008","journal-title":"J Clin Invest"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/ard.57.6.350","article-title":"Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom onset","volume":"57","author":"FM McQueen","year":"1998","journal-title":"Annals of the rheumatic diseases"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1002\/art.20314","article-title":"Diagnostic value of magnetic resonance imaging of the forefeet in early rheumatoid arthritis when findings on imaging of the metacarpophalangeal joints of the hands remain normal","volume":"50","author":"B Ostendorf","year":"2004","journal-title":"Arthritis and rheumatism"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1136\/ard.2007.071977","article-title":"Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression","volume":"67","author":"EA Haavardsholm","year":"2008","journal-title":"Annals of the rheumatic diseases"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/art.11162","article-title":"Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis","volume":"48","author":"FM McQueen","year":"2003","journal-title":"Arthritis and rheumatism"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/ard.2009.126953","article-title":"Prediction of MRI erosive progression: a comparison of modern imaging modalities in early rheumatoid arthritis patients","volume":"70","author":"P Boyesen","year":"2011","journal-title":"Annals of the rheumatic diseases"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/ard.2008.088245","article-title":"MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA)","volume":"68","author":"ML Hetland","year":"2009","journal-title":"Annals of the rheumatic diseases"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1136\/ard.2009.125534","article-title":"Radiographic progression and remission rates in early rheumatoid arthritis\u2014MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial","volume":"69","author":"ML Hetland","year":"2010","journal-title":"Annals of the rheumatic diseases"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1002\/art.30396","article-title":"Bone edema on magnetic resonance imaging is an independent predictor of rheumatoid arthritis development in patients with early undifferentiated arthritis","volume":"63","author":"A Duer-Jensen","year":"2011","journal-title":"Arthritis and rheumatism"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/ard.2009.124966","article-title":"Elevated number of recently activated T cells in bone marrow of patients with rheumatoid arthritis: a role for interleukin 15?","volume":"70","author":"E Kuca-Warnawin","year":"2011","journal-title":"Annals of the rheumatic diseases"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.175.4.2579","article-title":"Interaction between synovial inflammatory tissue and bone marrow in rheumatoid arthritis","volume":"175","author":"E Jimenez-Boj","year":"2005","journal-title":"Journal of immunology"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/art.22496","article-title":"Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis","volume":"56","author":"E Jimenez-Boj","year":"2007","journal-title":"Arthritis and rheumatism"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1136\/ard.2007.070326","article-title":"High-grade MRI bone oedema is common within the surgical field in rheumatoid arthritis patients undergoing joint replacement and is associated with osteitis in subchondral bone","volume":"66","author":"FM McQueen","year":"2007","journal-title":"Annals of the rheumatic diseases"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/ard.2008.096024","article-title":"Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease","volume":"68","author":"N Dalbeth","year":"2009","journal-title":"Annals of the rheumatic diseases"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1002\/art.21377","article-title":"Involvement of subchondral bone marrow in rheumatoid arthritis: lymphoid neogenesis and in situ relationship to subchondral bone marrow osteoclast recruitment","volume":"52","author":"S Bugatti","year":"2005","journal-title":"Arthritis and rheumatism"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/art.23546","article-title":"Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging","volume":"58","author":"ST Proulx","year":"2008","journal-title":"Arthritis and rheumatism"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/j.1601-183X.2012.00849.x","article-title":"Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4","volume":"11","author":"E Ey","year":"2012","journal-title":"Genes Brain Behav"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/femsre\/fuv036","article-title":"Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design","volume":"40","author":"D Laukens","year":"2016","journal-title":"FEMS microbiology reviews"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/BOR.0000000000000008","article-title":"Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity","volume":"26","author":"SB Brusca","year":"2014","journal-title":"Curr Opin Rheumatol"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/mi.2011.66","article-title":"Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis","volume":"5","author":"D Farquharson","year":"2012","journal-title":"Mucosal Immunol"},{"issue":"369","key":"ref34","doi-asserted-by":"crossref","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","article-title":"Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis","volume":"8","author":"MF Konig","year":"2016","journal-title":"Sci Transl Med"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"E337","DOI":"10.1073\/pnas.1614926114","article-title":"GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa","volume":"114","author":"M Nassar","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0205902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T14:32:14Z","timestamp":1720708334000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0205902"}},"subtitle":[],"editor":[{"given":"Pablo","family":"Garcia de Frutos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,18]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0205902","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,18]]}}}