{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:05:49Z","timestamp":1757455549778,"version":"3.37.3"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0206014","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T17:45:21Z","timestamp":1539884721000},"page":"e0206014","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oncogenic mutations in IKK\u03b2 function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation"],"prefix":"10.1371","volume":"13","author":[{"given":"April N.","family":"Meyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro H.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juyeon","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Cardenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelyn N.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Siari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre R.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Whisenant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4546-2175","authenticated-orcid":true,"given":"Daniel J.","family":"Donoghue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ccr.2007.07.010","article-title":"Multiple myeloma: lusting for NF-kappaB","volume":"12","author":"TD Gilmore","year":"2007","journal-title":"Cancer Cell"},{"issue":"7339","key":"ref2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature09837","article-title":"Initial genome sequencing and analysis of multiple myeloma","volume":"471","author":"MA Chapman","year":"2011","journal-title":"Nature"},{"issue":"18","key":"ref3","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1182\/blood-2011-06-359166","article-title":"Alteration of BIRC3 and multiple other NF-kappaB pathway genes in splenic marginal zone lymphoma","volume":"118","author":"D Rossi","year":"2011","journal-title":"Blood"},{"issue":"45","key":"ref4","doi-asserted-by":"crossref","first-page":"18250","DOI":"10.1073\/pnas.1314608110","article-title":"Landscape of somatic mutations and clonal evolution in mantle cell lymphoma","volume":"110","author":"S Bea","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"ref5","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.4161\/15384101.2014.988026","article-title":"Novel Lys63-linked ubiquitination of IKKbeta induces STAT3 signaling","volume":"13","author":"LH Gallo","year":"2014","journal-title":"Cell Cycle"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/BJ20140444","article-title":"An unexpected twist to the activation of IKKbeta: TAK1 primes IKKbeta for activation by autophosphorylation","volume":"461","author":"J Zhang","year":"2014","journal-title":"Biochem J"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1158\/1535-7163.MCT-15-0999","article-title":"Targeting IkappaB Kinase beta\/NF-kappaB Signaling in Human Prostate Cancer by a Novel IkappaB Kinase beta Inhibitor CmpdA","volume":"15","author":"Y Zhang","year":"2016","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1182\/blood-2015-07-658781","article-title":"Active IKKbeta promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma","volume":"127","author":"NK Agarwal","year":"2016","journal-title":"Blood"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: new and unexpected biological functions","volume":"14","author":"H Yu","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"e84497","DOI":"10.1371\/journal.pone.0084497","article-title":"Tyrosine Phosphorylation Allows Integration of Multiple Signaling Inputs by IKKbeta","volume":"8","author":"AN Meyer","year":"2013","journal-title":"PLoS One"},{"issue":"7343","key":"ref11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature09853","article-title":"Crystal structure of inhibitor of kappaB kinase beta","volume":"472","author":"G Xu","year":"2011","journal-title":"Nature"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"e1001581","DOI":"10.1371\/journal.pbio.1001581","article-title":"A Structural Basis for IkappaB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation","volume":"11","author":"S Polley","year":"2013","journal-title":"PLoS Biol"},{"key":"ref13","article-title":"Ubc13: the Lys63 ubiquitin chain building machine","author":"CD Hodge","year":"2016","journal-title":"Oncotarget"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1021\/acschembio.5b00222","article-title":"Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting","volume":"10","author":"CD Hodge","year":"2015","journal-title":"ACS Chem Biol"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1182\/blood-2012-02-406074","article-title":"Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A","volume":"120","author":"M Pulvino","year":"2012","journal-title":"Blood"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1021\/cb3005897","article-title":"Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol","volume":"8","author":"J Wu","year":"2013","journal-title":"ACS Chem Biol"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1182\/blood.V96.12.3907","article-title":"Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways","volume":"96","author":"M Mizuki","year":"2000","journal-title":"Blood"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13045-016-0306-x","article-title":"-receptor signaling induces cell death of primary myeloma cells in vitro","volume":"9","author":"TK Vatsveen","year":"2016","journal-title":"J Hematol Oncol"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"J Cox","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"S Tyanova","year":"2016","journal-title":"Nat Methods"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-1-4939-7493-1_7","article-title":"Perseus: A Bioinformatics Platform for Integrative Analysis of Proteomics Data in Cancer Research","volume":"1711","author":"S Tyanova","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nmeth.2557","article-title":"The CRAPome: a contaminant repository for affinity purification-mass spectrometry data","volume":"10","author":"D Mellacheruvu","year":"2013","journal-title":"Nat Methods"},{"issue":"43","key":"ref23","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"VK Mootha","year":"2003","journal-title":"Nat Genet"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/imr.12310","article-title":"Emerging roles of Lys63-linked polyubiquitylation in immune responses","volume":"266","author":"X Wu","year":"2015","journal-title":"Immunol Rev"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.coi.2012.12.005","article-title":"Regulation of NF-kappaB by ubiquitination","volume":"25","author":"J Chen","year":"2013","journal-title":"Curr Opin Immunol"},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrm3836","article-title":"Linear ubiquitin chains: NF-kappaB signalling, cell death and beyond","volume":"15","author":"K Iwai","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1074\/jbc.M109.076976","article-title":"Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK\/NF-kappaB and JNK\/AP-1 activation","volume":"285","author":"Y Fan","year":"2010","journal-title":"J Biol Chem"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cellsig.2012.09.003","article-title":"TAK1 ubiquitination regulates doxorubicin-induced NF-kappaB activation","volume":"25","author":"L Liang","year":"2013","journal-title":"Cell Signal"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cellsig.2010.11.017","article-title":"TAK1 Lys-158 but not Lys-209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and IKK\/NF-kappaB activation","volume":"23","author":"Y Fan","year":"2011","journal-title":"Cell Signal"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1038\/srep02344","article-title":"Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling","volume":"3","author":"L An","year":"2013","journal-title":"Scientific reports"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrc3760","article-title":"Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond","volume":"14","author":"M Holderfield","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"ref33","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0192-0561(99)00047-8","article-title":"Inhibition of endotoxin-induced TNF-alpha production in macrophages by 5Z-7-oxo-zeaenol and other fungal resorcylic acid lactones","volume":"21","author":"P Rawlins","year":"1999","journal-title":"Int J Immunopharmacol"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/cmdc.200800217","article-title":"Discovery of novel anticancer compounds based on a quinoxalinehydrazine pharmacophore","volume":"3","author":"J Deng","year":"2008","journal-title":"ChemMedChem"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bmc.2006.09.073","article-title":"Synthesis and antitumor activities of a series of novel quinoxalinhydrazides","volume":"15","author":"F Grande","year":"2007","journal-title":"Bioorg Med Chem"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0960-894X(02)00106-3","article-title":"Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor","volume":"12","author":"JE Thompson","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1182\/blood-2005-06-2413","article-title":"The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor","volume":"107","author":"IS Lucet","year":"2006","journal-title":"Blood"},{"issue":"19","key":"ref38","doi-asserted-by":"crossref","first-page":"9714","DOI":"10.1158\/0008-5472.CAN-05-4280","article-title":"Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells","volume":"66","author":"L Pedranzini","year":"2006","journal-title":"Cancer Res"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1158\/1078-0432.CCR-06-2313","article-title":"Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications","volume":"13","author":"S. Huang","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"14","key":"ref40","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1080\/15384101.2014.998067","article-title":"Ibrutinib inhibits BTK-driven NF-kappaB p65 activity to overcome bortezomib-resistance in multiple myeloma","volume":"14","author":"MY Murray","year":"2015","journal-title":"Cell Cycle"},{"issue":"46","key":"ref41","doi-asserted-by":"crossref","first-page":"42938","DOI":"10.1074\/jbc.M101968200","article-title":"CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation","volume":"276","author":"J Jiang","year":"2001","journal-title":"J Biol Chem"},{"issue":"5412","key":"ref42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.284.5412.321","article-title":"Severe liver degeneration in mice lacking the IkappaB kinase 2 gene","volume":"284","author":"Q Li","year":"1999","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.1002\/0471140864.ps1923s74","article-title":"BioID: a screen for protein-protein interactions","volume":"74","author":"KJ Roux","year":"2013","journal-title":"Current protocols in protein science \/ editorial board, John E Coligan"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: an integrated system for exploring gene sets in various biological contexts","volume":"33","author":"B Zhang","year":"2005","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"ref45","doi-asserted-by":"crossref","first-page":"W130","DOI":"10.1093\/nar\/gkx356","article-title":"WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit","volume":"45","author":"J Wang","year":"2017","journal-title":"Nucleic Acids Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0206014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:54:40Z","timestamp":1589000080000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0206014"}},"subtitle":[],"editor":[{"given":"Edward William","family":"Harhaj","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,18]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0206014","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,10,18]]}}}